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The map label for this gene is prsA

Identifier: 15675314

GI number: 15675314

Start: 1153087

End: 1154142

Strand: Reverse

Name: prsA

Synonym: SPy_1390

Alternate gene names: 15675314

Gene position: 1154142-1153087 (Counterclockwise)

Preceding gene: 15675315

Following gene: 15675313

Centisome position: 62.3

GC content: 35.98

Gene sequence:

>1056_bases
ATGAAAAACTCAAATAAACTCATTGCTAGTGTTGTGACATTGGCCTCAGTGATGGCTTTAGCAGCTTGTCAATCAACTAA
TGACAATACTAAGGTTATTTCGATGAAAGGTGATACAATTAGCGTTAGTGATTTTTACAATGAAACAAAAAACACAGAAG
TATCGCAAAAAGCGATGCTAAATCTGGTAATTAGTCGTGTTTTTGAAGCTCAATATGGTGATAAGGTTTCAAAAAAAGAA
GTTGAAAAGGCGTATCATAAAACAGCTGAACAGTATGGCGCTTCATTCTCTGCTGCTTTGGCACAATCAAGCTTGACACC
TGAGACTTTTAAGCGTCAGATCCGCTCTTCAAAATTAGTAGAATATGCGGTTAAAGAAGCAGCTAAAAAAGAATTGACAA
CACAAGAATATAAGAAAGCATATGAATCTTATACTCCAACAATGGCAGTCGAAATGATTACTTTAGATAATGAAGAGACA
GCTAAATCAGTCTTAGAGGAACTAAAAGCCGAAGGCGCAGACTTTACAGCTATTGCTAAAGAAAAAACAACAACACCTGA
GAAAAAAGTGACCTATAAATTTGATTCAGGTGCGACAAATGTACCGACTGATGTCGTAAAAGCGGCTTCAAGTTTGAATG
AGGGTGGCATATCAGACGTTATCTCGGTTTTAGATCCAACTTCTTATCAAAAGAAGTTTTACATTGTTAAGGTGACTAAA
AAAGCAGAAAAAAAATCAGATTGGCAAGAATATAAGAAACGTTTGAAAGCTATCATTATAGCTGAAAAATCAAAAGATAT
GAATTTCCAAAACAAGGTTATTGCAAATGCATTGGATAAAGCTAATGTAAAAATTAAAGACAAAGCTTTTGCTAATATTT
TGGCGCAATATGCAAATCTTGGTCAAAAAACTAAAGCTGCAAGTGAAAGTTCAACAACCAGCGAATCATCAAAAGCTGCA
GAAGAGAACCCATCAGAATCAGAGCAAACACAGACATCATCAGCTGAAGAACCAACTGAGACTGAGGCTCAGACGCAAGA
GCCAGCTGCACAATAA

Upstream 100 bases:

>100_bases
TTCGTAAAAATCAAGCAGATATTGTATTACCAGATTAAGTAACATTGATAAATTTATGTTATAATAAATTAGTTAAAGAT
AAAAAGGAGCTCAGAAGTAA

Downstream 100 bases:

>100_bases
GTAGGATTTTATTGACTAATCAGTTAAAAAAACTTATAATAATTTAGTTAAGAATTGTTTATCAAGGATTAGATACAGAA
AAGTGACGGTTGCTGCGAGT

Product: foldase protein PrsA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MKNSNKLIASVVTLASVMALAACQSTNDNTKVISMKGDTISVSDFYNETKNTEVSQKAMLNLVISRVFEAQYGDKVSKKE
VEKAYHKTAEQYGASFSAALAQSSLTPETFKRQIRSSKLVEYAVKEAAKKELTTQEYKKAYESYTPTMAVEMITLDNEET
AKSVLEELKAEGADFTAIAKEKTTTPEKKVTYKFDSGATNVPTDVVKAASSLNEGGISDVISVLDPTSYQKKFYIVKVTK
KAEKKSDWQEYKKRLKAIIIAEKSKDMNFQNKVIANALDKANVKIKDKAFANILAQYANLGQKTKAASESSTTSESSKAA
EENPSESEQTQTSSAEEPTETEAQTQEPAAQ

Sequences:

>Translated_351_residues
MKNSNKLIASVVTLASVMALAACQSTNDNTKVISMKGDTISVSDFYNETKNTEVSQKAMLNLVISRVFEAQYGDKVSKKE
VEKAYHKTAEQYGASFSAALAQSSLTPETFKRQIRSSKLVEYAVKEAAKKELTTQEYKKAYESYTPTMAVEMITLDNEET
AKSVLEELKAEGADFTAIAKEKTTTPEKKVTYKFDSGATNVPTDVVKAASSLNEGGISDVISVLDPTSYQKKFYIVKVTK
KAEKKSDWQEYKKRLKAIIIAEKSKDMNFQNKVIANALDKANVKIKDKAFANILAQYANLGQKTKAASESSTTSESSKAA
EENPSESEQTQTSSAEEPTETEAQTQEPAAQ
>Mature_351_residues
MKNSNKLIASVVTLASVMALAACQSTNDNTKVISMKGDTISVSDFYNETKNTEVSQKAMLNLVISRVFEAQYGDKVSKKE
VEKAYHKTAEQYGASFSAALAQSSLTPETFKRQIRSSKLVEYAVKEAAKKELTTQEYKKAYESYTPTMAVEMITLDNEET
AKSVLEELKAEGADFTAIAKEKTTTPEKKVTYKFDSGATNVPTDVVKAASSLNEGGISDVISVLDPTSYQKKFYIVKVTK
KAEKKSDWQEYKKRLKAIIIAEKSKDMNFQNKVIANALDKANVKIKDKAFANILAQYANLGQKTKAASESSTTSESSKAA
EENPSESEQTQTSSAEEPTETEAQTQEPAAQ

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PRSA1_STRP1 (P60811)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269488.1
- RefSeq:   YP_282496.1
- ProteinModelPortal:   P60811
- EnsemblBacteria:   EBSTRT00000000845
- EnsemblBacteria:   EBSTRT00000028918
- GeneID:   3571757
- GeneID:   901457
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1390
- KEGG:   spz:M5005_Spy_1133
- GeneTree:   EBGT00050000028078
- HOGENOM:   HBG712792
- OMA:   KAKSQYG
- ProtClustDB:   PRK01326
- BioCyc:   SPYO160490:SPY1390-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1133-MONOMER
- HAMAP:   MF_01145
- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR008880

Pfam domain/function: SSF109998 Trigger_fac_C_bac

EC number: =5.2.1.8

Molecular weight: Translated: 38535; Mature: 38535

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS01096 PPIC_PPIASE_1; PS50198 PPIC_PPIASE_2; PS51257 PROKAR_LIPOPROTEIN; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNSNKLIASVVTLASVMALAACQSTNDNTKVISMKGDTISVSDFYNETKNTEVSQKAML
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEHHHHHHHHCCCHHHHHHHH
NLVISRVFEAQYGDKVSKKEVEKAYHKTAEQYGASFSAALAQSSLTPETFKRQIRSSKLV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
EYAVKEAAKKELTTQEYKKAYESYTPTMAVEMITLDNEETAKSVLEELKAEGADFTAIAK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEECC
EKTTTPEKKVTYKFDSGATNVPTDVVKAASSLNEGGISDVISVLDPTSYQKKFYIVKVTK
CCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECC
KAEKKSDWQEYKKRLKAIIIAEKSKDMNFQNKVIANALDKANVKIKDKAFANILAQYANL
HHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCC
GQKTKAASESSTTSESSKAAEENPSESEQTQTSSAEEPTETEAQTQEPAAQ
CHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MKNSNKLIASVVTLASVMALAACQSTNDNTKVISMKGDTISVSDFYNETKNTEVSQKAML
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEHHHHHHHHCCCHHHHHHHH
NLVISRVFEAQYGDKVSKKEVEKAYHKTAEQYGASFSAALAQSSLTPETFKRQIRSSKLV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
EYAVKEAAKKELTTQEYKKAYESYTPTMAVEMITLDNEETAKSVLEELKAEGADFTAIAK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEECC
EKTTTPEKKVTYKFDSGATNVPTDVVKAASSLNEGGISDVISVLDPTSYQKKFYIVKVTK
CCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECC
KAEKKSDWQEYKKRLKAIIIAEKSKDMNFQNKVIANALDKANVKIKDKAFANILAQYANL
HHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCC
GQKTKAASESSTTSESSKAAEENPSESEQTQTSSAEEPTETEAQTQEPAAQ
CHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11296296