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The map label for this gene is coaA

Identifier: 15675195

GI number: 15675195

Start: 1016677

End: 1017597

Strand: Direct

Name: coaA

Synonym: SPy_1233

Alternate gene names: 15675195

Gene position: 1016677-1017597 (Clockwise)

Preceding gene: 15675188

Following gene: 15675196

Centisome position: 54.88

GC content: 31.92

Gene sequence:

>921_bases
ATGTCAAATGAATTTATTAACTTTGAAAAAATTTCTAGAGAGTCTTGGAAAACATTACATCAAAAGGCAAAAGCTCTCCT
CACACAAGAGGAACTTAAAAGTATTACTAGCTTAAATGATAACATCAGTATTAACGATGTCATTGATATCTACCTTCCAT
TAATTAATCTGATCCAGGTTTACAAAATTGCGCAAGAAAATCTTTCTTTTTCTAAAAGCCTTTTTCTAAAAAAAGACATT
CAATTAAGGCCTTTTATTATTGGAATTTCTGGTTCAGTAGCTGTTGGTAAATCAACAACTAGTCGTCTTTTACAACTTTT
ATTATCACGAACGCACCCCAATAGTCAAGTCGAACTGGTAACGACTGATGGTTTTTTATATCCTAATCAGTTTCTTATTG
AACAAGGACTGTTAAATCGTAAAGGATTTCCAGAATCTTATAACATGGAACTTCTCTTAGATTTTCTAGATTCCATCAAA
AATGGTCAAACTGCTTTTGCACCCGTCTATTCTCATGATATTTACGATATTATCCCAAATCAAAAACAATCATTTAATAA
CCCTGACTTCCTTATCGTCGAAGGTATTAACGTTTTTCAAAATCAACAAAACAATCGTTTATATATGAGTGATTACTTTG
ATTTTTCTATTTATATTGATGCAGACAGCAGTCACATCGAAACCTGGTACATTGAACGGTTTCTAAGCATTTTAAAATTA
GCAAAACGTGACCCTCATAATTATTATGCCCAATATGCACAATTACCTCGATCTGAGGCTATAGCATTTGCGCGCAACGT
TTGGAAAACCGTTAATTTAGAAAATCTTGAAAAATTCATTGAACCTACACGTAACCGTGCTGAATTAATTTTACATAAAA
GTGCTGATCATAAAATTGATGAAATTTACCTCAAAAAGTGA

Upstream 100 bases:

>100_bases
AGTTAATTGTATTAATTTTCGTGTAAATACTAACGAAAAATTATTTATTTTTTAACTAAAATGGTATAATGTAAGCACTG
TCAAATGATTAGGAGCTACC

Downstream 100 bases:

>100_bases
TAAAGGGTTGCCAAACGCATATATTTTCTATATAATAATGTAGTTAGATTAATTTGGAGGTGAAAACATTGGCAAATATT
AAATCAGCTATTAAACGCGC

Product: pantothenate kinase

Products: NA

Alternate protein names: Pantothenic acid kinase

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MSNEFINFEKISRESWKTLHQKAKALLTQEELKSITSLNDNISINDVIDIYLPLINLIQVYKIAQENLSFSKSLFLKKDI
QLRPFIIGISGSVAVGKSTTSRLLQLLLSRTHPNSQVELVTTDGFLYPNQFLIEQGLLNRKGFPESYNMELLLDFLDSIK
NGQTAFAPVYSHDIYDIIPNQKQSFNNPDFLIVEGINVFQNQQNNRLYMSDYFDFSIYIDADSSHIETWYIERFLSILKL
AKRDPHNYYAQYAQLPRSEAIAFARNVWKTVNLENLEKFIEPTRNRAELILHKSADHKIDEIYLKK

Sequences:

>Translated_306_residues
MSNEFINFEKISRESWKTLHQKAKALLTQEELKSITSLNDNISINDVIDIYLPLINLIQVYKIAQENLSFSKSLFLKKDI
QLRPFIIGISGSVAVGKSTTSRLLQLLLSRTHPNSQVELVTTDGFLYPNQFLIEQGLLNRKGFPESYNMELLLDFLDSIK
NGQTAFAPVYSHDIYDIIPNQKQSFNNPDFLIVEGINVFQNQQNNRLYMSDYFDFSIYIDADSSHIETWYIERFLSILKL
AKRDPHNYYAQYAQLPRSEAIAFARNVWKTVNLENLEKFIEPTRNRAELILHKSADHKIDEIYLKK
>Mature_305_residues
SNEFINFEKISRESWKTLHQKAKALLTQEELKSITSLNDNISINDVIDIYLPLINLIQVYKIAQENLSFSKSLFLKKDIQ
LRPFIIGISGSVAVGKSTTSRLLQLLLSRTHPNSQVELVTTDGFLYPNQFLIEQGLLNRKGFPESYNMELLLDFLDSIKN
GQTAFAPVYSHDIYDIIPNQKQSFNNPDFLIVEGINVFQNQQNNRLYMSDYFDFSIYIDADSSHIETWYIERFLSILKLA
KRDPHNYYAQYAQLPRSEAIAFARNVWKTVNLENLEKFIEPTRNRAELILHKSADHKIDEIYLKK

Specific function: Coenzyme A (CoA) biosynthesis; first step. [C]

COG id: COG1072

COG function: function code H; Panthothenate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic pantothenate kinase family

Homologues:

Organism=Escherichia coli, GI1790409, Length=302, Percent_Identity=45.6953642384106, Blast_Score=265, Evalue=4e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAA_STRP1 (Q99ZH1)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269369.1
- RefSeq:   YP_282308.1
- ProteinModelPortal:   Q99ZH1
- SMR:   Q99ZH1
- EnsemblBacteria:   EBSTRT00000000866
- EnsemblBacteria:   EBSTRT00000027676
- GeneID:   3571959
- GeneID:   901335
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1233
- KEGG:   spz:M5005_Spy_0945
- GeneTree:   EBGT00050000027704
- HOGENOM:   HBG732538
- OMA:   GLNVLQP
- ProtClustDB:   PRK05439
- BioCyc:   SPYO160490:SPY1233-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0945-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00215
- InterPro:   IPR004566
- InterPro:   IPR006083
- PANTHER:   PTHR10285:SF7
- PIRSF:   PIRSF000545
- TIGRFAMs:   TIGR00554

Pfam domain/function: PF00485 PRK

EC number: =2.7.1.33

Molecular weight: Translated: 35610; Mature: 35479

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNEFINFEKISRESWKTLHQKAKALLTQEELKSITSLNDNISINDVIDIYLPLINLIQV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
YKIAQENLSFSKSLFLKKDIQLRPFIIGISGSVAVGKSTTSRLLQLLLSRTHPNSQVELV
HHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCEEECCHHHHHHHHHHHHCCCCCCEEEEE
TTDGFLYPNQFLIEQGLLNRKGFPESYNMELLLDFLDSIKNGQTAFAPVYSHDIYDIIPN
EECCEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCHHHCCCC
QKQSFNNPDFLIVEGINVFQNQQNNRLYMSDYFDFSIYIDADSSHIETWYIERFLSILKL
CCCCCCCCCEEEEECCHHHCCCCCCEEEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHH
AKRDPHNYYAQYAQLPRSEAIAFARNVWKTVNLENLEKFIEPTRNRAELILHKSADHKID
HHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEECCCCCCCH
EIYLKK
HEEECC
>Mature Secondary Structure 
SNEFINFEKISRESWKTLHQKAKALLTQEELKSITSLNDNISINDVIDIYLPLINLIQV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
YKIAQENLSFSKSLFLKKDIQLRPFIIGISGSVAVGKSTTSRLLQLLLSRTHPNSQVELV
HHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCEEECCHHHHHHHHHHHHCCCCCCEEEEE
TTDGFLYPNQFLIEQGLLNRKGFPESYNMELLLDFLDSIKNGQTAFAPVYSHDIYDIIPN
EECCEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHCCHHHCCCC
QKQSFNNPDFLIVEGINVFQNQQNNRLYMSDYFDFSIYIDADSSHIETWYIERFLSILKL
CCCCCCCCCEEEEECCHHHCCCCCCEEEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHH
AKRDPHNYYAQYAQLPRSEAIAFARNVWKTVNLENLEKFIEPTRNRAELILHKSADHKID
HHCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEECCCCCCCH
EIYLKK
HEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296