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The map label for this gene is pgmA [H]

Identifier: 15675188

GI number: 15675188

Start: 1008011

End: 1009729

Strand: Direct

Name: pgmA [H]

Synonym: SPy_1224

Alternate gene names: 15675188

Gene position: 1008011-1009729 (Clockwise)

Preceding gene: 15675187

Following gene: 15675195

Centisome position: 54.42

GC content: 38.05

Gene sequence:

>1719_bases
ATGACTTACACAGAAAATTTTCAAAAATGGTTAGATTTTGAGCAGCTTCCTGACTATCTTCGTCAAGAATTACTATCAAT
GGATGAAAAAACAAAAGAAGATGCTTTTTACACAAACTTAGAATTTGGTACTGCTGGTATGCGTGGTTATATTGGTGCTG
GTACAAATCGTATTAATATTTATGTTGTCCGTCAAGCAACCGAAGGATTAGCAAAATTAATCGAAACTAAGGGAGAGGAA
GCTAAAAAACGTGGTGTAGCTATCGCTTATGATTCGCGCCACTTCTCTCCAGAATTTGCTTTTGAGTCTGCACAGGTCTT
GGCACAGCATGGAATTAAATCTTACGTATTTGAAGCTCTTCGTCCAACACCAGAACTCTCTTTTGCTGTTCGCCATTTAA
ATGCCTATGCTGGTATTATGGTTACTGCAAGCCACAATCCAGCACCTTTCAATGGTTATAAAGTCTATGGACAAGACGGA
GGTCAACTACCACCAGCTGATGCTGATGCACTAACAGACTTTATCCGCGCTATTGAAAATCCATTTGCAGTTGAACTTGC
TGATTTAGATGAAAACAAATCATCAGGTCTTATTCAAGTTATCGGTGAAGATGTTGATATGGAATACCTTAGAGAGGTTA
AAGATGTTAATATCAATCAAGATTTAATCAATAACTTTGGAAAAGACATGAAAATTGTCTATACTCCTCTCCACGGAACT
GGTGAGATGTTGACACGCCGTGCCCTTGCTCAAGCCGGTTTTGAATCTGTTGTTGTAGTCGAATCACAAGCTAAGGCAGA
TCCAGACTTTTCTACTGTTAAATCGCCTAACCCTGAAAGCCAAGCTGCCTTTGCTCTTGCTGAAGAACTCGGACGAGAAG
TTGAGGCAGATGTCTTAGTAGCTACTGATCCTGATGCAGACCGCCTAGGCGTTGAAATTCGCCAACCAGATGGTTCTTAT
AAAAACCTTTCTGGAAATCAAATTGGAGCGATTATTGCGAAATACATCCTGGAAGCTCATAAAACAGCAGGAACACTTCC
AGAAAATGCTGCTCTCGCTAAATCAATCGTATCAACAGAATTAGTAACAAAAATTGCCGAAAGTTATGGCGCTACAATGT
TTAACGTTTTAACTGGATTCAAATTCATCGCTGAGAAAATTCAAGAGTTTGAAGAAAAACATAACCACACCTATATGTTT
GGTTTTGAAGAAAGCTTCGGATATCTTATTAAACCATTTGTCCGTGATAAAGACGCTATTCAAGCAGTTCTTTTGGTTGC
TGAGATCGCAGCTTATTACCGTTCGCGTGGTTTAACACTTGCAGATGGTATTGATGAAATTTACAAAGAATATGGCTATT
TTGCTGAAAAAACGATTTCAGTAACACTTTCAGGTGTGGATGGAGCTGCTGAAATTAAGAAGATTATGGACAAATTCCGT
GAAAATGGTCCAAAACAATTTAACAATACTGATATTGTATTATTAGAAGATTTCCAAAAACAAACCGCTACTAAAAATGA
TGGAACAATATCTAACTTAACAACTCCTCCAAGTAATGTTTTGAAGTACACGTTAGCTGATGATTCATGGATTGCAGTTC
GCCCTTCAGGAACTGAACCAAAAATCAAGTTCTATATTGCCACAATAGGTGATACTCTTGACATCGCTCAAGAAAAAATT
GCTAACATTGAAACAGAAATCAATACCTTTGTTGGCTAA

Upstream 100 bases:

>100_bases
AATATGGAAAAAGTTTTGTAAACAGCTGCAAATAATTAGTGTTTTTTTCCCTTCAAAATGATATAATGAAAGCGTTTATA
AATATTGAAGGAGTATTTCA

Downstream 100 bases:

>100_bases
AACAACTTAAGAGCTATCAGTAAAAACAAAAGACAAGCAAAAAGAACTAAGCCGCTGACTTAGTTCTTTTTAGTCTATTC
TTGCTTCTATTGTGATGGTG

Product: putative phosphoglucomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 572; Mature: 571

Protein sequence:

>572_residues
MTYTENFQKWLDFEQLPDYLRQELLSMDEKTKEDAFYTNLEFGTAGMRGYIGAGTNRINIYVVRQATEGLAKLIETKGEE
AKKRGVAIAYDSRHFSPEFAFESAQVLAQHGIKSYVFEALRPTPELSFAVRHLNAYAGIMVTASHNPAPFNGYKVYGQDG
GQLPPADADALTDFIRAIENPFAVELADLDENKSSGLIQVIGEDVDMEYLREVKDVNINQDLINNFGKDMKIVYTPLHGT
GEMLTRRALAQAGFESVVVVESQAKADPDFSTVKSPNPESQAAFALAEELGREVEADVLVATDPDADRLGVEIRQPDGSY
KNLSGNQIGAIIAKYILEAHKTAGTLPENAALAKSIVSTELVTKIAESYGATMFNVLTGFKFIAEKIQEFEEKHNHTYMF
GFEESFGYLIKPFVRDKDAIQAVLLVAEIAAYYRSRGLTLADGIDEIYKEYGYFAEKTISVTLSGVDGAAEIKKIMDKFR
ENGPKQFNNTDIVLLEDFQKQTATKNDGTISNLTTPPSNVLKYTLADDSWIAVRPSGTEPKIKFYIATIGDTLDIAQEKI
ANIETEINTFVG

Sequences:

>Translated_572_residues
MTYTENFQKWLDFEQLPDYLRQELLSMDEKTKEDAFYTNLEFGTAGMRGYIGAGTNRINIYVVRQATEGLAKLIETKGEE
AKKRGVAIAYDSRHFSPEFAFESAQVLAQHGIKSYVFEALRPTPELSFAVRHLNAYAGIMVTASHNPAPFNGYKVYGQDG
GQLPPADADALTDFIRAIENPFAVELADLDENKSSGLIQVIGEDVDMEYLREVKDVNINQDLINNFGKDMKIVYTPLHGT
GEMLTRRALAQAGFESVVVVESQAKADPDFSTVKSPNPESQAAFALAEELGREVEADVLVATDPDADRLGVEIRQPDGSY
KNLSGNQIGAIIAKYILEAHKTAGTLPENAALAKSIVSTELVTKIAESYGATMFNVLTGFKFIAEKIQEFEEKHNHTYMF
GFEESFGYLIKPFVRDKDAIQAVLLVAEIAAYYRSRGLTLADGIDEIYKEYGYFAEKTISVTLSGVDGAAEIKKIMDKFR
ENGPKQFNNTDIVLLEDFQKQTATKNDGTISNLTTPPSNVLKYTLADDSWIAVRPSGTEPKIKFYIATIGDTLDIAQEKI
ANIETEINTFVG
>Mature_571_residues
TYTENFQKWLDFEQLPDYLRQELLSMDEKTKEDAFYTNLEFGTAGMRGYIGAGTNRINIYVVRQATEGLAKLIETKGEEA
KKRGVAIAYDSRHFSPEFAFESAQVLAQHGIKSYVFEALRPTPELSFAVRHLNAYAGIMVTASHNPAPFNGYKVYGQDGG
QLPPADADALTDFIRAIENPFAVELADLDENKSSGLIQVIGEDVDMEYLREVKDVNINQDLINNFGKDMKIVYTPLHGTG
EMLTRRALAQAGFESVVVVESQAKADPDFSTVKSPNPESQAAFALAEELGREVEADVLVATDPDADRLGVEIRQPDGSYK
NLSGNQIGAIIAKYILEAHKTAGTLPENAALAKSIVSTELVTKIAESYGATMFNVLTGFKFIAEKIQEFEEKHNHTYMFG
FEESFGYLIKPFVRDKDAIQAVLLVAEIAAYYRSRGLTLADGIDEIYKEYGYFAEKTISVTLSGVDGAAEIKKIMDKFRE
NGPKQFNNTDIVLLEDFQKQTATKNDGTISNLTTPPSNVLKYTLADDSWIAVRPSGTEPKIKFYIATIGDTLDIAQEKIA
NIETEINTFVG

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=558, Percent_Identity=30.4659498207885, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI31377548, Length=560, Percent_Identity=32.1428571428571, Blast_Score=254, Evalue=2e-67,
Organism=Escherichia coli, GI1786904, Length=561, Percent_Identity=24.5989304812834, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71993870, Length=558, Percent_Identity=32.4372759856631, Blast_Score=231, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI71993878, Length=315, Percent_Identity=35.2380952380952, Blast_Score=154, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323934, Length=554, Percent_Identity=30.5054151624549, Blast_Score=209, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6323752, Length=388, Percent_Identity=26.0309278350515, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI20129809, Length=587, Percent_Identity=29.6422487223169, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24651977, Length=459, Percent_Identity=31.8082788671024, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24653722, Length=570, Percent_Identity=28.4210526315789, Blast_Score=214, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 63333; Mature: 63202

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYTENFQKWLDFEQLPDYLRQELLSMDEKTKEDAFYTNLEFGTAGMRGYIGAGTNRINI
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEECCCCCEEEE
YVVRQATEGLAKLIETKGEEAKKRGVAIAYDSRHFSPEFAFESAQVLAQHGIKSYVFEAL
EEEECHHHHHHHHHHCCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHCHHHHHHHHH
RPTPELSFAVRHLNAYAGIMVTASHNPAPFNGYKVYGQDGGQLPPADADALTDFIRAIEN
CCCCCHHHHHHHHHHHEEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCC
PFAVELADLDENKSSGLIQVIGEDVDMEYLREVKDVNINQDLINNFGKDMKIVYTPLHGT
CCEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHCCCCEEEEEECCCCC
GEMLTRRALAQAGFESVVVVESQAKADPDFSTVKSPNPESQAAFALAEELGREVEADVLV
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
ATDPDADRLGVEIRQPDGSYKNLSGNQIGAIIAKYILEAHKTAGTLPENAALAKSIVSTE
EECCCCHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LVTKIAESYGATMFNVLTGFKFIAEKIQEFEEKHNHTYMFGFEESFGYLIKPFVRDKDAI
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCHHHH
QAVLLVAEIAAYYRSRGLTLADGIDEIYKEYGYFAEKTISVTLSGVDGAAEIKKIMDKFR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHH
ENGPKQFNNTDIVLLEDFQKQTATKNDGTISNLTTPPSNVLKYTLADDSWIAVRPSGTEP
HCCCCCCCCCCEEEEECHHHHHCCCCCCCCCCCCCCHHHHEEEEECCCCEEEEECCCCCC
KIKFYIATIGDTLDIAQEKIANIETEINTFVG
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TYTENFQKWLDFEQLPDYLRQELLSMDEKTKEDAFYTNLEFGTAGMRGYIGAGTNRINI
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEECCCCCEEEE
YVVRQATEGLAKLIETKGEEAKKRGVAIAYDSRHFSPEFAFESAQVLAQHGIKSYVFEAL
EEEECHHHHHHHHHHCCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHCHHHHHHHHH
RPTPELSFAVRHLNAYAGIMVTASHNPAPFNGYKVYGQDGGQLPPADADALTDFIRAIEN
CCCCCHHHHHHHHHHHEEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCC
PFAVELADLDENKSSGLIQVIGEDVDMEYLREVKDVNINQDLINNFGKDMKIVYTPLHGT
CCEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHCCCCEEEEEECCCCC
GEMLTRRALAQAGFESVVVVESQAKADPDFSTVKSPNPESQAAFALAEELGREVEADVLV
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
ATDPDADRLGVEIRQPDGSYKNLSGNQIGAIIAKYILEAHKTAGTLPENAALAKSIVSTE
EECCCCHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LVTKIAESYGATMFNVLTGFKFIAEKIQEFEEKHNHTYMFGFEESFGYLIKPFVRDKDAI
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCHHHH
QAVLLVAEIAAYYRSRGLTLADGIDEIYKEYGYFAEKTISVTLSGVDGAAEIKKIMDKFR
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHH
ENGPKQFNNTDIVLLEDFQKQTATKNDGTISNLTTPPSNVLKYTLADDSWIAVRPSGTEP
HCCCCCCCCCCEEEEECHHHHHCCCCCCCCCCCCCCHHHHEEEEECCCCEEEEECCCCCC
KIKFYIATIGDTLDIAQEKIANIETEINTFVG
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]