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The map label for this gene is ffh [H]

Identifier: 15675165

GI number: 15675165

Start: 983086

End: 984645

Strand: Reverse

Name: ffh [H]

Synonym: SPy_1200

Alternate gene names: 15675165

Gene position: 984645-983086 (Counterclockwise)

Preceding gene: 15675166

Following gene: 15675163

Centisome position: 53.15

GC content: 40.06

Gene sequence:

>1560_bases
ATGGCTTTTGAAAGCTTAACCCAACGTTTGCAAGATGTGTTTAAACACATTCGCGGTAAAAAGAAATTATCAGAATCAGA
TGTTCAAGAAGTGACAAAAGAGATTCGTCTAGCTCTTTTAGAAGCCGATGTCGCTTTACCAGTTGTTAAAACCTTTATTA
AGCGCGTACGTGAGCGCGCTATTGGCCATGAGATTATTGATACTCTTGATCCAACACAACAAATTCTTAAGATTGTTAAT
GAAGAATTAACGAGTATTTTAGGCTCAGAAACTGCAGAGATTGATAAATCTCCAAAAATTCCAACTATTATCATGATGGT
CGGTTTGCAAGGGGCTGGTAAAACAACTTTTGCAGGAAAACTCGCTAATAAATTAATTAAAGAAGAAAACGCGCGACCAC
TGATGATTGCTGCCGATATTTACCGTCCAGCGGCCATTGATCAGTTAAAAACACTGGGGCAACAAATCAATGTACCTGTT
TTTGATATGGGGACAGACCACTCAGCAGTCGATATTGTCAGAAAAGGTTTGGAACAAGCTCGTGAAAACCACAATGACTA
TGTCTTGATTGATACTGCGGGTCGCTTGCAAATTGATGAAAAACTGATGGGAGAGCTGCGCGATGTCAAGGCTTTAGCAC
AACCAAATGAAATTCTTTTGGTTGTAGATAGCATGATTGGTCAAGAAGCTGCCAATGTAGCCTACGAGTTTAATCATCAG
TTGAGCATCACAGGGGTTGTGTTAACAAAGATTGATGGTGATACACGTGGAGGTGCGGCGCTATCTGTCCGTGAAATCAC
TGGGAAACCAATTAAATTTACAGGTATTGGTGAAAAAATCACAGATATTGAAACATTTCACCCAGACCGCATGTCCAGTC
GGATTTTGGGAATGGGGGATTTGCTTACCCTCATTGAAAAAGCTAGCCAGGAATATGATGAGAAAAAATCCTTAGAGTTA
GCTGAAAAAATGCGTGAAAACACCTTTGATTTCAATGATTTTATTGAACAGTTAGATCAAGTGCAAAATATGGGGCCTAT
GGAAGACCTCTTGAAAATGATTCCAGGAATGGCTGGTAACCCAGCTTTGGCCAATATCAAAGTTGACGAAAACCAAATTG
CTCGCAAACGTGCTATTGTCTCTTCAATGACACCCGCTGAACGTGAAAATCCTGACTTACTAAACCCGAGTCGTCGCCGT
CGTATTGCAGCTGGTTCCGGGAACAGCTTTGTAGATAATAAATTTATCAAAGACTTTAACCAAGCCAAAAGCATGATGCA
AGGGGTTATGTCGGGCGATATGTCTAAAATGATGAAAGATATGGGTATTAATCCCAATAATCTTCCTAAAAACATGCCTG
CTGGTATGCCAGATATGTCTTCCTTAGAAGGAATGATGGGACAAGGTGGTATGCCTGATTTATCTGGCCTTGGTGGTGAT
ATGGATATGAGTCAACTATTTGGTAAAGGGTTTAAAGGAAAAATTGGCCAATTTGCCATGAAACAGGCCATGAAACGGCA
GGCTAACAAACTAAAAAAAGCAAAGAAAAAACGAAAATAA

Upstream 100 bases:

>100_bases
TTGACGACATGATTGCTCACTACCCTCATGATGAGTATTTGCAAGAAAAAATTTCCATTCTAACCAGTATTGACAATAGA
GAGTAAGAGGAGTTTTGACT

Downstream 100 bases:

>100_bases
AAGAGACGAAAATTTTCGTCTCTTTTTGATGTGAAATTCATTTATCTTGTATACAAGATTATTAAAATTACGGAAGACCG
TGTTACATACCATGATGAGT

Product: putative signal recognition particle

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 519; Mature: 518

Protein sequence:

>519_residues
MAFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERAIGHEIIDTLDPTQQILKIVN
EELTSILGSETAEIDKSPKIPTIIMMVGLQGAGKTTFAGKLANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPV
FDMGTDHSAVDIVRKGLEQARENHNDYVLIDTAGRLQIDEKLMGELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLEL
AEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGNPALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRR
RIAAGSGNSFVDNKFIKDFNQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSGLGGD
MDMSQLFGKGFKGKIGQFAMKQAMKRQANKLKKAKKKRK

Sequences:

>Translated_519_residues
MAFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERAIGHEIIDTLDPTQQILKIVN
EELTSILGSETAEIDKSPKIPTIIMMVGLQGAGKTTFAGKLANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPV
FDMGTDHSAVDIVRKGLEQARENHNDYVLIDTAGRLQIDEKLMGELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLEL
AEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGNPALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRR
RIAAGSGNSFVDNKFIKDFNQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSGLGGD
MDMSQLFGKGFKGKIGQFAMKQAMKRQANKLKKAKKKRK
>Mature_518_residues
AFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERAIGHEIIDTLDPTQQILKIVNE
ELTSILGSETAEIDKSPKIPTIIMMVGLQGAGKTTFAGKLANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPVF
DMGTDHSAVDIVRKGLEQARENHNDYVLIDTAGRLQIDEKLMGELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQL
SITGVVLTKIDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLELA
EKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGNPALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRRR
IAAGSGNSFVDNKFIKDFNQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSGLGGDM
DMSQLFGKGFKGKIGQFAMKQAMKRQANKLKKAKKKRK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=455, Percent_Identity=30.7692307692308, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI226371618, Length=392, Percent_Identity=31.8877551020408, Blast_Score=179, Evalue=8e-45,
Organism=Homo sapiens, GI23308697, Length=308, Percent_Identity=28.5714285714286, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI295424842, Length=308, Percent_Identity=28.5714285714286, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI89061728, Length=146, Percent_Identity=35.6164383561644, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1788963, Length=420, Percent_Identity=48.3333333333333, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1789874, Length=269, Percent_Identity=33.0855018587361, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=494, Percent_Identity=27.1255060728745, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI193206261, Length=299, Percent_Identity=29.4314381270903, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6325345, Length=466, Percent_Identity=30.2575107296137, Blast_Score=197, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6320498, Length=316, Percent_Identity=25.9493670886076, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17647949, Length=493, Percent_Identity=29.8174442190669, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24641198, Length=311, Percent_Identity=30.2250803858521, Blast_Score=119, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 57417; Mature: 57285

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERA
CCHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGHEIIDTLDPTQQILKIVNEELTSILGSETAEIDKSPKIPTIIMMVGLQGAGKTTFAGK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEECCCCCCCHHHHH
LANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPVFDMGTDHSAVDIVRKGLEQA
HHHHHHHHCCCCCEEEEHHHHCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHH
RENHNDYVLIDTAGRLQIDEKLMGELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
HHCCCCEEEEECCCCCEECHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHEECCE
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGD
EEEEEEEEEEECCCCCCCCEEEEHCCCCCCEEEECCCCHHHHHHHCCCHHHHHHHCCHHH
LLTLIEKASQEYDEKKSLELAEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRRRIAAGSGNSFVDNKFIKDFN
CCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCEEECCCCCCHHHHHHHHHHH
QAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSGLGGD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
MDMSQLFGKGFKGKIGQFAMKQAMKRQANKLKKAKKKRK
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERA
CHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGHEIIDTLDPTQQILKIVNEELTSILGSETAEIDKSPKIPTIIMMVGLQGAGKTTFAGK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEECCCCCCCHHHHH
LANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPVFDMGTDHSAVDIVRKGLEQA
HHHHHHHHCCCCCEEEEHHHHCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHH
RENHNDYVLIDTAGRLQIDEKLMGELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
HHCCCCEEEEECCCCCEECHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHEECCE
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGD
EEEEEEEEEEECCCCCCCCEEEEHCCCCCCEEEECCCCHHHHHHHCCCHHHHHHHCCHHH
LLTLIEKASQEYDEKKSLELAEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRRRIAAGSGNSFVDNKFIKDFN
CCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCEEECCCCCCHHHHHHHHHHH
QAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSGLGGD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
MDMSQLFGKGFKGKIGQFAMKQAMKRQANKLKKAKKKRK
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]