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The map label for this gene is folP

Identifier: 15675081

GI number: 15675081

Start: 898613

End: 899413

Strand: Direct

Name: folP

Synonym: SPy_1098

Alternate gene names: 15675081

Gene position: 898613-899413 (Clockwise)

Preceding gene: 15675080

Following gene: 15675082

Centisome position: 48.51

GC content: 44.57

Gene sequence:

>801_bases
ATGAAAATTGGAAAGTTTGTGATTGAGGGCAATGCGGCTATCATGGGGATTTTAAATGTGACTCCAGATTCTTTTTCAGA
TGGGGGGTCTTACACTACTGTGCAAAAAGCATTAGATCACGTTGAGCAAATGATTGCTGATGGGGCTAAAATCATCGACG
TTGGTGGAGAATCAACACGTCCAGGTTGCCAATTTGTAAGCGCTACCGATGAAATTGACCGGGTGGTTCCTGTGATCAAG
GCCATCAAAGAAAACTATGATATTCTAATCAGCATTGATACCTATAAAACCGAAACAGCTAGAGCAGCTTTAGAGGCGGG
TGCCGATATTCTCAATGATGTTTGGGCAGGTTTGTACGACGGTCAAATGTTTGCCTTAGCAGCCGAGTACGATGCGCCTA
TCATCTTGATGCATAACCAAGACGAAGAAGTTTATCAAGAGGTAACACAAGACGTTTGTGATTTTCTAGGCAATAGAGCA
CAAGCAGCTCTTGATGCTGGCGTGCCAAAAAACAATATTTGGGTTGATCCAGGATTTGGATTTGCCAAATCTGTTCAACA
GAATACGGAGTTATTAAAAGGATTGGACCGCGTCTGTCAGTTGGGCTATCCTGTCTTGTTTGGTATTTCGAGAAAGCGTG
TCGTAGATGCCTTGTTAGGCGGCAACACCAAAGCTAAAGAGCGAGACGGAGCGACAGCAGCCTTGTCTGCTTATGCCCTT
GGAAAAGGCTGTCAGATTGTACGCGTACACGATGTCAAGGCTAATCAAGACATTGTGGCTGTGTTGAGCCAGTTGATGTG
A

Upstream 100 bases:

>100_bases
GTAGTAAAACCATTACCACCACTGCCAGAGGCTTATATAAGGAAAGTCGTGCTGAGAGGCAAGAAGTTATTTCTCTAATG
ACAAAAGATTAGGAGAACTT

Downstream 100 bases:

>100_bases
GGACTTATGGATAAAATCGTATTAGAAGGTTGCCGTTTTTATGGCTACCATGGAGCCTTTAAAGAAGAACAGACCCTTGG
GCAAATTTTTCTGGTTGATT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MKIGKFVIEGNAAIMGILNVTPDSFSDGGSYTTVQKALDHVEQMIADGAKIIDVGGESTRPGCQFVSATDEIDRVVPVIK
AIKENYDILISIDTYKTETARAALEAGADILNDVWAGLYDGQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRA
QAALDAGVPKNNIWVDPGFGFAKSVQQNTELLKGLDRVCQLGYPVLFGISRKRVVDALLGGNTKAKERDGATAALSAYAL
GKGCQIVRVHDVKANQDIVAVLSQLM

Sequences:

>Translated_266_residues
MKIGKFVIEGNAAIMGILNVTPDSFSDGGSYTTVQKALDHVEQMIADGAKIIDVGGESTRPGCQFVSATDEIDRVVPVIK
AIKENYDILISIDTYKTETARAALEAGADILNDVWAGLYDGQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRA
QAALDAGVPKNNIWVDPGFGFAKSVQQNTELLKGLDRVCQLGYPVLFGISRKRVVDALLGGNTKAKERDGATAALSAYAL
GKGCQIVRVHDVKANQDIVAVLSQLM
>Mature_266_residues
MKIGKFVIEGNAAIMGILNVTPDSFSDGGSYTTVQKALDHVEQMIADGAKIIDVGGESTRPGCQFVSATDEIDRVVPVIK
AIKENYDILISIDTYKTETARAALEAGADILNDVWAGLYDGQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRA
QAALDAGVPKNNIWVDPGFGFAKSVQQNTELLKGLDRVCQLGYPVLFGISRKRVVDALLGGNTKAKERDGATAALSAYAL
GKGCQIVRVHDVKANQDIVAVLSQLM

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain

Homologues:

Organism=Escherichia coli, GI87082224, Length=256, Percent_Identity=40.234375, Blast_Score=185, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324073, Length=303, Percent_Identity=33.993399339934, Blast_Score=152, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHPS_STRP1 (P0C0G1)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269255.1
- RefSeq:   YP_282185.1
- ProteinModelPortal:   P0C0G1
- SMR:   P0C0G1
- EnsemblBacteria:   EBSTRT00000000588
- EnsemblBacteria:   EBSTRT00000029016
- GeneID:   3572070
- GeneID:   901219
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1098
- KEGG:   spz:M5005_Spy_0822
- GeneTree:   EBGT00050000028266
- HOGENOM:   HBG754410
- OMA:   VPICLMH
- ProtClustDB:   CLSK797490
- BioCyc:   SPYO160490:SPY1098-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0822-MONOMER
- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489
- Gene3D:   G3DSA:3.20.20.20
- PANTHER:   PTHR20941:SF1
- TIGRFAMs:   TIGR01496

Pfam domain/function: PF00809 Pterin_bind; SSF51717 DHP_synth_like

EC number: =2.5.1.15

Molecular weight: Translated: 28642; Mature: 28642

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00792 DHPS_1; PS00793 DHPS_2; PS50972 PTERIN_BINDING

Important sites: BINDING 27-27 BINDING 93-93 BINDING 112-112 BINDING 176-176 BINDING 212-212 BINDING 248-248 BINDING 250-250

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGKFVIEGNAAIMGILNVTPDSFSDGGSYTTVQKALDHVEQMIADGAKIIDVGGESTR
CCCCCEEEECCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
PGCQFVSATDEIDRVVPVIKAIKENYDILISIDTYKTETARAALEAGADILNDVWAGLYD
CCCEEECCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
GQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRAQAALDAGVPKNNIWVDPGFG
CEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEECCCCC
FAKSVQQNTELLKGLDRVCQLGYPVLFGISRKRVVDALLGGNTKAKERDGATAALSAYAL
HHHHHHHHHHHHHHHHHHHHCCCHHEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
GKGCQIVRVHDVKANQDIVAVLSQLM
CCCCEEEEEECCCCCCHHHHHHHHHC
>Mature Secondary Structure
MKIGKFVIEGNAAIMGILNVTPDSFSDGGSYTTVQKALDHVEQMIADGAKIIDVGGESTR
CCCCCEEEECCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
PGCQFVSATDEIDRVVPVIKAIKENYDILISIDTYKTETARAALEAGADILNDVWAGLYD
CCCEEECCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
GQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRAQAALDAGVPKNNIWVDPGFG
CEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEECCCCC
FAKSVQQNTELLKGLDRVCQLGYPVLFGISRKRVVDALLGGNTKAKERDGATAALSAYAL
HHHHHHHHHHHHHHHHHHHHCCCHHEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
GKGCQIVRVHDVKANQDIVAVLSQLM
CCCCEEEEEECCCCCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296