Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is miaA

Identifier: 15674941

GI number: 15674941

Start: 764223

End: 765122

Strand: Direct

Name: miaA

Synonym: SPy_0921

Alternate gene names: 15674941

Gene position: 764223-765122 (Clockwise)

Preceding gene: 15674939

Following gene: 15674942

Centisome position: 41.25

GC content: 42.44

Gene sequence:

>900_bases
ATGACAAAAATAAAAATAGTTGTGATTGTTGGTCCGACAGCGGTTGGAAAAACAGCACTTGGGATTAGTTTAGCCAAGGC
TTTTAATGGAGAAATTATTTCAGGAGATAGCCAGCAAGTTTATCGACAGTTGGATATTGGAACAGCCAAGGCCACTCAAG
AAGAGCAAGAAGCAGCGGTTCATCACTTAATTGATATTCGTGAGGTGACGGAGTCTTATTCGGCCTACGATTTTGTTCAA
GATGCTCAAAAATCTATTTCAGATATTGTTAGTCGTGGGAAATTACCAATTATTGTAGGTGGAACTGGTCTTTACTTACA
AAGTTTACTCGAAGGTTATCATCTAGGAGGTCAAGTTGATCAAGAGGCGGTAAAAGCCTATCGGAATGAGTTGGAGCAAT
TGGACGATCACGACTTGTATGAACGCTTGCAAGTCAATAACATTACCATTGAGCAGGTGAATCGCAGACGGGCGATCCGA
GCCCTTGAATTGGCTCAGTTTGCTGATGAATTAGAGAATGCCGAGACGGCTTATGAGCCGCTTATTATCGGCTTGAATGA
TGACCGCCAAGTCATCTATGACCGTATCAATCAGCGCGTGAATCGTATGATTGAAAACGGCTTATTGGAAGAAGCAAAAT
GGTTATATGAGCATTACCCGACTGTTCAGGCTAGTCGTGGCATAGGTTATAAGGAATTATTCCCCTATTTTGTAGGTGAA
ATGACTTTGGCAGAAGCTAGTGATCAATTAAAACAAAACACGAGACGTTTTGCCAAGCGACAGCTAACTTGGTTCCGCAA
TCGAATGGCTGTTAGCTTCACTGCCATAACGGCTCCTGATTACCCACAGGTAGTACATGATAGGGTCAGGGATTTTCTTG
GTCAGAAAGAGAAGTCATGA

Upstream 100 bases:

>100_bases
GGTCCTTAATCTTATGTTATAATATATGGTAGCGAAAAATAAGCTAATTTTCAAGTAAAAGGCGTTTTTGGACACGCTTT
TCTAATAGAAAGACAAGAAA

Downstream 100 bases:

>100_bases
CGCAAAATTAGCAGAATCTGTTGAAGATATGTTATAATAGAATTTACGGAATTTGGAGGATTGGTAAAGGTGATGATTGA
GACAAAGCGTCAGCAAGAAA

Product: tRNA delta(2)-isopentenylpyrophosphate transferase

Products: NA

Alternate protein names: Dimethylallyl diphosphate:tRNA dimethylallyltransferase; DMAPP:tRNA dimethylallyltransferase; DMATase; Isopentenyl-diphosphate:tRNA isopentenyltransferase; IPP transferase; IPPT; IPTase

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTKIKIVVIVGPTAVGKTALGISLAKAFNGEIISGDSQQVYRQLDIGTAKATQEEQEAAVHHLIDIREVTESYSAYDFVQ
DAQKSISDIVSRGKLPIIVGGTGLYLQSLLEGYHLGGQVDQEAVKAYRNELEQLDDHDLYERLQVNNITIEQVNRRRAIR
ALELAQFADELENAETAYEPLIIGLNDDRQVIYDRINQRVNRMIENGLLEEAKWLYEHYPTVQASRGIGYKELFPYFVGE
MTLAEASDQLKQNTRRFAKRQLTWFRNRMAVSFTAITAPDYPQVVHDRVRDFLGQKEKS

Sequences:

>Translated_299_residues
MTKIKIVVIVGPTAVGKTALGISLAKAFNGEIISGDSQQVYRQLDIGTAKATQEEQEAAVHHLIDIREVTESYSAYDFVQ
DAQKSISDIVSRGKLPIIVGGTGLYLQSLLEGYHLGGQVDQEAVKAYRNELEQLDDHDLYERLQVNNITIEQVNRRRAIR
ALELAQFADELENAETAYEPLIIGLNDDRQVIYDRINQRVNRMIENGLLEEAKWLYEHYPTVQASRGIGYKELFPYFVGE
MTLAEASDQLKQNTRRFAKRQLTWFRNRMAVSFTAITAPDYPQVVHDRVRDFLGQKEKS
>Mature_298_residues
TKIKIVVIVGPTAVGKTALGISLAKAFNGEIISGDSQQVYRQLDIGTAKATQEEQEAAVHHLIDIREVTESYSAYDFVQD
AQKSISDIVSRGKLPIIVGGTGLYLQSLLEGYHLGGQVDQEAVKAYRNELEQLDDHDLYERLQVNNITIEQVNRRRAIRA
LELAQFADELENAETAYEPLIIGLNDDRQVIYDRINQRVNRMIENGLLEEAKWLYEHYPTVQASRGIGYKELFPYFVGEM
TLAEASDQLKQNTRRFAKRQLTWFRNRMAVSFTAITAPDYPQVVHDRVRDFLGQKEKS

Specific function: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)

COG id: COG0324

COG function: function code J; tRNA delta(2)-isopentenylpyrophosphate transferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IPP transferase family

Homologues:

Organism=Homo sapiens, GI31581534, Length=330, Percent_Identity=31.8181818181818, Blast_Score=136, Evalue=2e-32,
Organism=Escherichia coli, GI1790613, Length=291, Percent_Identity=33.3333333333333, Blast_Score=151, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI25144712, Length=300, Percent_Identity=28.3333333333333, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324848, Length=290, Percent_Identity=32.0689655172414, Blast_Score=145, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24649830, Length=341, Percent_Identity=31.3782991202346, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MIAA_STRP1 (Q9A059)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269115.1
- RefSeq:   YP_282085.1
- ProteinModelPortal:   Q9A059
- SMR:   Q9A059
- EnsemblBacteria:   EBSTRT00000000309
- EnsemblBacteria:   EBSTRT00000029092
- GeneID:   3572201
- GeneID:   901074
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0921
- KEGG:   spz:M5005_Spy_0722
- GeneTree:   EBGT00050000027823
- HOGENOM:   HBG559459
- OMA:   VNADSMQ
- ProtClustDB:   PRK00091
- BioCyc:   SPYO160490:SPY0921-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0722-MONOMER
- HAMAP:   MF_00185
- InterPro:   IPR002627
- InterPro:   IPR018022
- PANTHER:   PTHR11088
- TIGRFAMs:   TIGR00174

Pfam domain/function: PF01715 IPPT

EC number: =2.5.1.75

Molecular weight: Translated: 34009; Mature: 33878

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIKIVVIVGPTAVGKTALGISLAKAFNGEIISGDSQQVYRQLDIGTAKATQEEQEAAV
CCEEEEEEEECCCHHCHHHHHHHHHHHHCCCEECCCHHHHHHHHCCCCHHHHHHHHHHHH
HHLIDIREVTESYSAYDFVQDAQKSISDIVSRGKLPIIVGGTGLYLQSLLEGYHLGGQVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCCC
QEAVKAYRNELEQLDDHDLYERLQVNNITIEQVNRRRAIRALELAQFADELENAETAYEP
HHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCC
LIIGLNDDRQVIYDRINQRVNRMIENGLLEEAKWLYEHYPTVQASRGIGYKELFPYFVGE
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
MTLAEASDQLKQNTRRFAKRQLTWFRNRMAVSFTAITAPDYPQVVHDRVRDFLGQKEKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TKIKIVVIVGPTAVGKTALGISLAKAFNGEIISGDSQQVYRQLDIGTAKATQEEQEAAV
CEEEEEEEECCCHHCHHHHHHHHHHHHCCCEECCCHHHHHHHHCCCCHHHHHHHHHHHH
HHLIDIREVTESYSAYDFVQDAQKSISDIVSRGKLPIIVGGTGLYLQSLLEGYHLGGQVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCCC
QEAVKAYRNELEQLDDHDLYERLQVNNITIEQVNRRRAIRALELAQFADELENAETAYEP
HHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCC
LIIGLNDDRQVIYDRINQRVNRMIENGLLEEAKWLYEHYPTVQASRGIGYKELFPYFVGE
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
MTLAEASDQLKQNTRRFAKRQLTWFRNRMAVSFTAITAPDYPQVVHDRVRDFLGQKEKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296