Definition | Streptococcus pyogenes M1 GAS chromosome, complete genome. |
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Accession | NC_002737 |
Length | 1,852,441 |
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The map label for this gene is parC
Identifier: 15674931
GI number: 15674931
Start: 754392
End: 756851
Strand: Direct
Name: parC
Synonym: SPy_0910
Alternate gene names: 15674931
Gene position: 754392-756851 (Clockwise)
Preceding gene: 15674930
Following gene: 15674932
Centisome position: 40.72
GC content: 40.24
Gene sequence:
>2460_bases ATGTCAAACATTCAAAACATGTCCCTTGAGGATATTATGGGAGAACGCTTCGGCCGTTATTCCAAGTATATTATTCAGGA ACGGGCACTTCCTGATATTCGAGATGGATTGAAACCCGTTCAGCGTCGGATTCTTTATTCGATGAATAAGGATGGCAATA CTTTTGAAAAAGGTTACCGTAAATCAGCCAAATCAGTTGGTAATATTATGGGGAATTTCCACCCACATGGGGATTCCTCT ATTTATGATGCCATGGTACGGATGAGTCAAGATTGGAAGAACCGTGAAATCCTTGTTGAAATGCACGGAAATAATGGTTC AATGGATGGTGATCCGCCTGCGGCTATGCGTTATACAGAAGCTCGCTTGTCTGAAATTGCGGGTTATCTTCTTCAAGACA TTGAGAAAAATACGGTCTCTTTTGCTTGGAACTTTGATGACACAGAAAAAGAACCCACCGTTTTACCAGCAGCTTTTCCT AACTTACTTGTCAATGGGTCTTCTGGTATTTCCGCAGGCTATGCGACAGATATTCCACCGCACAATTTGTCAGAAGTGAT TGATGCTGTTGTGTATATGATTGATCATCCCAAAGCTAGTTTAGAGAAATTAATGGAGTTTTTACCAGGACCAGATTTCC CGACAGGAGGCATTATCCAAGGAGCTGACGAAATCAAAAAAGCCTACGAAACAGGTAAGGGACGTGTCGTTGTTCGCTCT AGGACAGAAATCGAGGAACTTAAAGGTGGTAAACAACAAATTATTGTCACTGAGATTCCTTATGAAGTTAACAAAGCAGT CTTGGTCAAAAAGATTGACGATGTGCGTGTTAACAATAAAGTCCCAGGCATCGTAGAAGTACGCGATGAATCTGATCGCA CAGGTCTTCGCATAGCTATTGAGTTGAAAAAAGAGGCTGATAGCCAAACCATTCTAAATTATTTGTTGAAATACACAGAC CTTCAAGTTAATTATAATTTTAACATGGTTGCTATTGACCACTTCACACCACGTCAAGTAGGACTTCAAAAAATACTATC AAGCTATATCAGTCACCGTAAAGATATTATTATTGAGCGGTCTAAATTCGATAAAGCCAAAGCTGAAAAACGCCTCCACA TTGTTGAAGGATTGATTCGTGTCTTGTCCATCTTAGATGAGATTATTGCTTTGATTAGATCGTCTGACAATAAGGCTGAT GCTAAAGAAAATCTGAAAGTCAGCTATGATTTCTCTGAGGAACAAGCAGAAGCGATTGTAACCTTGCAGCTTTATCGTTT AACTAATACCGATATTGTTACTCTCCAAAATGAAGAAAATGATTTAAGAGACTTAATCACGACCCTTTCCGCTATTATCG GTGACGAAGCAACCATGTATAACGTCATGAAACGTGAATTAAGAGAGGTGAAAAAGAAATTCGCCAATCCTCGTTTATCA GAGTTACAAGCAGAAAGTCAAATCATTGAGATTGACACTGCCAGCTTGATTGCAGAGGAAGAAACTTTTGTTAGTGTGAC ACGGGGCGGATACCTCAAAAGAACCAGCCCACGATCCTTCAATGCGTCTAGTTTGGAAGAAGTTGGCAAGAGAGATGATG ACGAACTCATCTTCGTTAAACAGGCCAAAACAACAGAACACCTTTTGTTATTTACAACTTTAGGCAATGTCATTTACCGG CCAATCCATGAATTGACCGATTTACGTTGGAAGGATATCGGTGAACATTTATCACAAACCATTTCAAACTTCGCGACAGA AGAAGAGATTCTCTACGCTGATATTGTGACTTCCTTTGACCAGGGCTTGTATGTGGCTGTCACACAAAATGGTTTTATCA AACGCTTTGATCGTAAAGAACTAAGTCCTTGGCGAACTTATAAATCTAAATCAACCAAATATGTGAAGCTAAAGGATGAC AAAGACCGCGTGGTTACCTTGTCACCAGTTATTATGGAAGACCTCCTATTAGTGACTAAAAATGGTTATGCTTTGCGATT CTCCAGTCAGGAAGTGCCTATTCAAGGGTTGAAATCTGCTGGTGTTAAAGGCATTAACTTGAAAAACGATGACAGCCTTG CCTCAGCCTTTGCTGTGACAAGTAACTCTTTCTTTGTCTTAACTCAGAGGGGTTCTCTCAAACGGATGGCTGTCGATGAT ATTCCTCAGACAAGTCGTGCCAATCGTGGACTATTGGTCCTACGAGAGTTAAAAACCAAACCTCATAGAGTTTTTCTGGC CGGAGGCGTTCAATCAGATACTTCAGCTGAGCAGTTTGATTTGTTCACTGATATACCTGAAGAAGAAACTAATCAACAAA TGCTTGAAGTCATTAGTAAGACTGGTCAAACCTACGAGATTGCTTTAGAAACGCTTTCGTTATCGGAAAGAATCAGCAAC GGCTCCTTTATTTCAGACACTATTTCGGATCAAGAAGTACTGGTAGCTAGAACACGTTAA
Upstream 100 bases:
>100_bases GGTGTTTTAGTCATACAAGTTTCTCACAGATAATTACAAGTGCTAAAGACGATTGTTTTTTAGGTAATTAATAAATAATG AAAAAGAAAGCTATTTGAAT
Downstream 100 bases:
>100_bases AAAGAGTGAAAACTCTTTTTAATTTTATGATAAATTTAGAATATTAATACAAAAGAATAGAATAAACTTGAAAATTATTG AAAAAAAGTTACAATAGAAA
Product: DNA topoisomerase IV subunit A
Products: NA
Alternate protein names: Topoisomerase IV subunit A
Number of amino acids: Translated: 819; Mature: 818
Protein sequence:
>819_residues MSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYRKSAKSVGNIMGNFHPHGDSS IYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFP NLLVNGSSGISAGYATDIPPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRS RTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAIELKKEADSQTILNYLLKYTD LQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKAD AKENLKVSYDFSEEQAEAIVTLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLS ELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVKQAKTTEHLLLFTTLGNVIYR PIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFDQGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDD KDRVVTLSPVIMEDLLLVTKNGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDD IPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISKTGQTYEIALETLSLSERISN GSFISDTISDQEVLVARTR
Sequences:
>Translated_819_residues MSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYRKSAKSVGNIMGNFHPHGDSS IYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFP NLLVNGSSGISAGYATDIPPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRS RTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAIELKKEADSQTILNYLLKYTD LQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKAD AKENLKVSYDFSEEQAEAIVTLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLS ELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVKQAKTTEHLLLFTTLGNVIYR PIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFDQGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDD KDRVVTLSPVIMEDLLLVTKNGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDD IPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISKTGQTYEIALETLSLSERISN GSFISDTISDQEVLVARTR >Mature_818_residues SNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYRKSAKSVGNIMGNFHPHGDSSI YDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFPN LLVNGSSGISAGYATDIPPHNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRSR TEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAIELKKEADSQTILNYLLKYTDL QVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIERSKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKADA KENLKVSYDFSEEQAEAIVTLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLSE LQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVKQAKTTEHLLLFTTLGNVIYRP IHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFDQGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDDK DRVVTLSPVIMEDLLLVTKNGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDDI PQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISKTGQTYEIALETLSLSERISNG SFISDTISDQEVLVARTR
Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cell membrane; Peripheral membrane protein
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family
Homologues:
Organism=Homo sapiens, GI19913408, Length=318, Percent_Identity=25.1572327044025, Blast_Score=84, Evalue=4e-16, Organism=Homo sapiens, GI19913406, Length=318, Percent_Identity=24.5283018867925, Blast_Score=79, Evalue=2e-14, Organism=Escherichia coli, GI1788562, Length=804, Percent_Identity=37.3134328358209, Blast_Score=508, Evalue=1e-145, Organism=Escherichia coli, GI1789396, Length=728, Percent_Identity=32.2802197802198, Blast_Score=350, Evalue=2e-97, Organism=Caenorhabditis elegans, GI17535065, Length=181, Percent_Identity=29.2817679558011, Blast_Score=74, Evalue=3e-13, Organism=Caenorhabditis elegans, GI212645657, Length=179, Percent_Identity=29.0502793296089, Blast_Score=73, Evalue=6e-13, Organism=Caenorhabditis elegans, GI212645845, Length=398, Percent_Identity=25.1256281407035, Blast_Score=72, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6324241, Length=187, Percent_Identity=26.7379679144385, Blast_Score=68, Evalue=5e-12, Organism=Drosophila melanogaster, GI17136538, Length=231, Percent_Identity=26.8398268398268, Blast_Score=67, Evalue=4e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): PARC_STRP1 (Q9L7Q4)
Other databases:
- EMBL: AF220946 - EMBL: AE004092 - EMBL: CP000017 - RefSeq: NP_269105.1 - RefSeq: YP_282075.1 - ProteinModelPortal: Q9L7Q4 - EnsemblBacteria: EBSTRT00000000531 - EnsemblBacteria: EBSTRT00000028997 - GeneID: 3572188 - GeneID: 901064 - GenomeReviews: AE004092_GR - GenomeReviews: CP000017_GR - KEGG: spy:SPy_0910 - KEGG: spz:M5005_Spy_0712 - GeneTree: EBGT00050000028052 - HOGENOM: HBG635183 - OMA: EVMGDRF - ProtClustDB: PRK05561 - BioCyc: SPYO160490:SPY0910-MONOMER - BioCyc: SPYO293653:M5005_SPY0712-MONOMER - GO: GO:0005694 - InterPro: IPR020899 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013760 - InterPro: IPR005741 - Gene3D: G3DSA:3.30.1360.40 - Gene3D: G3DSA:3.90.199.10 - SMART: SM00434 - TIGRFAMs: TIGR01061
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV; SSF56719 Topo_IIA_cen
EC number: 5.99.1.-
Molecular weight: Translated: 92479; Mature: 92348
Theoretical pI: Translated: 5.40; Mature: 5.40
Prosite motif: NA
Important sites: ACT_SITE 118-118
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.2 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYR CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH KSAKSVGNIMGNFHPHGDSSIYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTE HHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHH ARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFPNLLVNGSSGISAGYATDIPP HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEECCCCCHHEEECCCCCCCCCCCCCCC HNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRS CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEC RTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAI CHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCEEECCCCCCEEEECCCCCCCCEEEEE ELKKEADSQTILNYLLKYTDLQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIER EECCCCCHHHHHHHHHHHHEEEEEECEEEEEEECCCCHHHHHHHHHHHHHCCCHHEEEEC SKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKADAKENLKVSYDFSEEQAEAIV CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHEEE TLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLS EEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHH ELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVK HHHCCCEEEEEEHHHHHCCCCCEEEEECCCEEECCCCCCCCHHHHHHHCCCCCCCEEEEE QAKTTEHLLLFTTLGNVIYRPIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFD ECCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC QGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDDKDRVVTLSPVIMEDLLLVTK CCEEEEEECCCHHHHCCHHCCCHHHHHHCCCCEEEEEECCCCCEEEECHHHHHHHHHEEC NGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDD CCEEEEECCCCCCHHHHHHCCCCCCCCCCCCHHHHHHEEECCCEEEEECCCCCCHHHHHC IPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISK CCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHH TGQTYEIALETLSLSERISNGSFISDTISDQEVLVARTR CCCEEEEHHHHHHHHHHCCCCCEEECCCCCCEEEEEECC >Mature Secondary Structure SNIQNMSLEDIMGERFGRYSKYIIQERALPDIRDGLKPVQRRILYSMNKDGNTFEKGYR CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH KSAKSVGNIMGNFHPHGDSSIYDAMVRMSQDWKNREILVEMHGNNGSMDGDPPAAMRYTE HHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHH ARLSEIAGYLLQDIEKNTVSFAWNFDDTEKEPTVLPAAFPNLLVNGSSGISAGYATDIPP HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEECCCCCHHEEECCCCCCCCCCCCCCC HNLSEVIDAVVYMIDHPKASLEKLMEFLPGPDFPTGGIIQGADEIKKAYETGKGRVVVRS CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEC RTEIEELKGGKQQIIVTEIPYEVNKAVLVKKIDDVRVNNKVPGIVEVRDESDRTGLRIAI CHHHHHHCCCCEEEEEEECCCCCCCEEEEEECCCEEECCCCCCEEEECCCCCCCCEEEEE ELKKEADSQTILNYLLKYTDLQVNYNFNMVAIDHFTPRQVGLQKILSSYISHRKDIIIER EECCCCCHHHHHHHHHHHHEEEEEECEEEEEEECCCCHHHHHHHHHHHHHCCCHHEEEEC SKFDKAKAEKRLHIVEGLIRVLSILDEIIALIRSSDNKADAKENLKVSYDFSEEQAEAIV CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHEEE TLQLYRLTNTDIVTLQNEENDLRDLITTLSAIIGDEATMYNVMKRELREVKKKFANPRLS EEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHH ELQAESQIIEIDTASLIAEEETFVSVTRGGYLKRTSPRSFNASSLEEVGKRDDDELIFVK HHHCCCEEEEEEHHHHHCCCCCEEEEECCCEEECCCCCCCCHHHHHHHCCCCCCCEEEEE QAKTTEHLLLFTTLGNVIYRPIHELTDLRWKDIGEHLSQTISNFATEEEILYADIVTSFD ECCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC QGLYVAVTQNGFIKRFDRKELSPWRTYKSKSTKYVKLKDDKDRVVTLSPVIMEDLLLVTK CCEEEEEECCCHHHHCCHHCCCHHHHHHCCCCEEEEEECCCCCEEEECHHHHHHHHHEEC NGYALRFSSQEVPIQGLKSAGVKGINLKNDDSLASAFAVTSNSFFVLTQRGSLKRMAVDD CCEEEEECCCCCCHHHHHHCCCCCCCCCCCCHHHHHHEEECCCEEEEECCCCCCHHHHHC IPQTSRANRGLLVLRELKTKPHRVFLAGGVQSDTSAEQFDLFTDIPEEETNQQMLEVISK CCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHH TGQTYEIALETLSLSERISNGSFISDTISDQEVLVARTR CCCEEEEHHHHHHHHHHCCCCCEEECCCCCCEEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 11296296