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The map label for this gene is rpiA

Identifier: 15674914

GI number: 15674914

Start: 737243

End: 737926

Strand: Direct

Name: rpiA

Synonym: SPy_0889

Alternate gene names: 15674914

Gene position: 737243-737926 (Clockwise)

Preceding gene: 15674912

Following gene: 15674915

Centisome position: 39.8

GC content: 42.98

Gene sequence:

>684_bases
ATGGAAGCACTCAAAAAAATTGCCGGTGTTACCGCTGCGCAATATGTGACTGATGGCATGACCATTGGGCTTGGAACTGG
GTCAACGGCTTACTATTTTGTTGAGGAAATTGGCCGTCGCGTAAAGCAAGAAGGACTGCAAGTGGTTGGTGTGACTACGT
CAAGTGTGACTAGCAAGCAAGCAGAAGTCTTGGGCATTCCTTTAAAATCGATAGATGATATTGATAGCATTGACCTCACC
GTAGATGGTGCTGATGAAGTGGATAAGAATTTCAATGGAATCAAGGGTGGCGGCGCAGCCTTACTAATGGAAAAAATTGT
TGCAACACCAACAAAAGAATACATCTGGGTTGTTGATGCTTCTAAAATGGTAGAGCATCTGGGTGCCTTTAAGTTACCAG
TCGAAGTCGTTCAATATGGTGCTGATCGTTTGTTCCGTGTCTTTGAAAAAGCTGGTTACAAACCGTCTTTTCGTATGAAA
GGTGATAGTCGTTTGGTGACAGACATGCAAAACTATATTATTGATCTTGATTTGGGTTGTATTAAAGATCCTGTTGCTTT
TGGTCACCTGCTAGATGGAACAGTTGGTGTTGTGGAACACGGTCTCTTTAATGGTATGGTTGATAAGGTGATTGTTGCTA
GTAAAGACGGCGTTACTGTTTTAGAAGCGCCTACAGCAGGCTAG

Upstream 100 bases:

>100_bases
TAGGCTGTCAATGAGAGAAAAACAAATGTTTTCATTAACAAGTTGGCGCTTTCATGGTATAATAAAGTGCTAAGACGCAA
TTCTATTATAAGGGGGAATC

Downstream 100 bases:

>100_bases
TCTTAGCATATAACAGCGTTAATATATTTTATAGGTATTGGGGAGTCAACCGTAACCTCCCCTAGATTGGAGACTTATGT
CAAAATTTAATCGTATTCAC

Product: ribose-5-phosphate isomerase A

Products: NA

Alternate protein names: Phosphoriboisomerase A; PRI

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MEALKKIAGVTAAQYVTDGMTIGLGTGSTAYYFVEEIGRRVKQEGLQVVGVTTSSVTSKQAEVLGIPLKSIDDIDSIDLT
VDGADEVDKNFNGIKGGGAALLMEKIVATPTKEYIWVVDASKMVEHLGAFKLPVEVVQYGADRLFRVFEKAGYKPSFRMK
GDSRLVTDMQNYIIDLDLGCIKDPVAFGHLLDGTVGVVEHGLFNGMVDKVIVASKDGVTVLEAPTAG

Sequences:

>Translated_227_residues
MEALKKIAGVTAAQYVTDGMTIGLGTGSTAYYFVEEIGRRVKQEGLQVVGVTTSSVTSKQAEVLGIPLKSIDDIDSIDLT
VDGADEVDKNFNGIKGGGAALLMEKIVATPTKEYIWVVDASKMVEHLGAFKLPVEVVQYGADRLFRVFEKAGYKPSFRMK
GDSRLVTDMQNYIIDLDLGCIKDPVAFGHLLDGTVGVVEHGLFNGMVDKVIVASKDGVTVLEAPTAG
>Mature_227_residues
MEALKKIAGVTAAQYVTDGMTIGLGTGSTAYYFVEEIGRRVKQEGLQVVGVTTSSVTSKQAEVLGIPLKSIDDIDSIDLT
VDGADEVDKNFNGIKGGGAALLMEKIVATPTKEYIWVVDASKMVEHLGAFKLPVEVVQYGADRLFRVFEKAGYKPSFRMK
GDSRLVTDMQNYIIDLDLGCIKDPVAFGHLLDGTVGVVEHGLFNGMVDKVIVASKDGVTVLEAPTAG

Specific function: Nonoxidative branch of the pentose phosphate pathway. [C]

COG id: COG0120

COG function: function code G; Ribose 5-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose 5-phosphate isomerase family

Homologues:

Organism=Homo sapiens, GI94536842, Length=231, Percent_Identity=35.0649350649351, Blast_Score=108, Evalue=6e-24,
Organism=Escherichia coli, GI1789280, Length=220, Percent_Identity=39.0909090909091, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17551758, Length=225, Percent_Identity=36.4444444444444, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6324669, Length=214, Percent_Identity=36.4485981308411, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281364072, Length=221, Percent_Identity=32.1266968325792, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: 740 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): RPIA_STRP1 (P66697)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269088.1
- RefSeq:   YP_282058.1
- ProteinModelPortal:   P66697
- SMR:   P66697
- EnsemblBacteria:   EBSTRT00000000723
- EnsemblBacteria:   EBSTRT00000028202
- GeneID:   3572207
- GeneID:   901047
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0889
- KEGG:   spz:M5005_Spy_0695
- GeneTree:   EBGT00050000027278
- HOGENOM:   HBG515603
- OMA:   MVVIADA
- ProtClustDB:   PRK00702
- BioCyc:   SPYO160490:SPY0889-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0695-MONOMER
- HAMAP:   MF_00170
- InterPro:   IPR004788
- InterPro:   IPR020672
- PANTHER:   PTHR11934
- TIGRFAMs:   TIGR00021

Pfam domain/function: PF06026 Rib_5-P_isom_A

EC number: =5.3.1.6

Molecular weight: Translated: 24277; Mature: 24277

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEALKKIAGVTAAQYVTDGMTIGLGTGSTAYYFVEEIGRRVKQEGLQVVGVTTSSVTSKQ
CHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHCCCC
AEVLGIPLKSIDDIDSIDLTVDGADEVDKNFNGIKGGGAALLMEKIVATPTKEYIWVVDA
HHEEECCCHHCCCCCCEEEEECCHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEH
SKMVEHLGAFKLPVEVVQYGADRLFRVFEKAGYKPSFRMKGDSRLVTDMQNYIIDLDLGC
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHEEECCCCH
IKDPVAFGHLLDGTVGVVEHGLFNGMVDKVIVASKDGVTVLEAPTAG
HCCHHHHHHHHCCHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCC
>Mature Secondary Structure
MEALKKIAGVTAAQYVTDGMTIGLGTGSTAYYFVEEIGRRVKQEGLQVVGVTTSSVTSKQ
CHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECHHHCCCC
AEVLGIPLKSIDDIDSIDLTVDGADEVDKNFNGIKGGGAALLMEKIVATPTKEYIWVVDA
HHEEECCCHHCCCCCCEEEEECCHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEH
SKMVEHLGAFKLPVEVVQYGADRLFRVFEKAGYKPSFRMKGDSRLVTDMQNYIIDLDLGC
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHEEECCCCH
IKDPVAFGHLLDGTVGVVEHGLFNGMVDKVIVASKDGVTVLEAPTAG
HCCHHHHHHHHCCHHHHHHHHHHHHHHHHEEEECCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296