Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is clpL [H]

Identifier: 15674913

GI number: 15674913

Start: 734764

End: 736863

Strand: Reverse

Name: clpL [H]

Synonym: SPy_0888

Alternate gene names: 15674913

Gene position: 736863-734764 (Counterclockwise)

Preceding gene: 15674920

Following gene: 15674906

Centisome position: 39.78

GC content: 38.48

Gene sequence:

>2100_bases
ATGACACATTTTTCTGGTAAAGATCCTTTTGTAAATATGGATGATATTTTCAATCAATTAATGGCAAACATGGGTGGTTA
TCGTAGCGAAAATCCCCGCTATCTCGTTAACGGTCGCGAAATAACTCCCGAAGAATTCCAACACTATCGTCAAACAGGAC
AACTCCCTGTAGCGACAACCAAAGCAACAAATTCTCAAATGTTAACACCTAAAGCTGATAGTGTATTGACTCAACTCGGA
ACTAACTTAACACAAGAAGCTCGTCAAGGGCATCTTGACCCCGTCATTGGTCGTAACAAAGAAATTCAAGATACCGCTGA
AATCTTGGCACGACGAACTAAAAATAATCCTGTCCTTGTCGGAGATGCTGGTGTCGGTAAAACTGCAGTCATTGAAGGTT
TAGCTCAAGCCATTGTTAATGGAGATGTCCCAGCTGCTATTAAAAACAAGGAAATCGTATCAATTGATATTTCTAGTCTT
GAAGCTGGTACACAGTATCGTGGTTCCTTTGAAGAGACCATTCAAAACTTGATTCAAGAAGTAAAAGAAGCTGGGAATAT
CATCTTATTTTTTGATGAAATTCATCAAATAGTTGGTGCTGGTGCCACAAGCAGTGATTCAGGCTCAAAGGGACTTGCAG
ATATTCTTAAACCAGCCTTGTCACGAGGAGAATTAACACTGATTGGTGCTACTACTCAAGACGAATACCGCAATACTATT
TTAAAAAATGCTGCTCTTGCTCGTCGCTTTAATGAAGTTAAAGTGAATGCACCATCAGCTGAAGATACTTTTCACATTTT
AATGGGTATTCGTAATCTTTATGAACAACACCACCATATTACCCTTCCTGATAATGTTCTAAAAGCTGCTGTTGATTATT
CTATTCAATACATCCCACAGCGTAGCCTGCCAGATAAAGCAATTGACTTACTGGATATGACAGCTGCTCATTTAGCTGCG
CAACACCCGGTCACTGACTTAAAAACACTCGAAACTGAAATAGCTAAACAAAAAGAGAGTCAAGAAAAAGCTGTCGCCAA
AGAAGACTTTGAAAAAGCTTTAGCAGCAAAAACACGGATTGAAACATTACAAAAGCAAATTGAGCAACATAACCAAAGCC
AAAATGTCACTGCTACAGTCAATGATATCGCAGAGTCTGTAGAGCGCTTAACTGGTATTCCTGTCTCTAACATGGGGACT
AATGATTTAGAAAGGCTCAAAGGAATTAGCAGCCGCTTAAAAAGCCATGTCATCGGACAAGATGAGGCTGTCGCAGCAGT
AGCACGTGCTATTCGACGAAATCGGGCAGGTTTTGATGATGGTAAACGTCCAATAGGTTCTTTCCTTTTTGTGGGTCCAA
CTGGTGTTGGTAAAACAGAGTTAGCTAAACAATTAGCACTTGATTTATTTGGTTCCAAAGATGCTATTATTCGACTTGAT
ATGTCCGAATATAACGATCGCACTGCTGTGTCAAAATTGATTGGGACAACGGCTGGTTATGTTGGCTACGATGATAATAA
TAATACCCTAACTGAGCGTGTTCGTCGTAACCCTTATGCTATTGTCTTACTAGATGAAATTGAAAAAGCTGATCCTCAAA
TTATTACACTTCTTCTACAAGTATTAGATGATGGACGATTGACAGATGGACAAGGAAATACTATTAACTTTAAAAATACC
GTTATTATTGCTACATCAAATGCCGGTTTTGGCCAACAAGATACGGAAACTTCTGAGTCTAACATTATGGATCGCATTGC
ACCTTATTTCAGACCAGAGTTTTTGAACCGTTTTAATAGTATCATTAAATTTAATCATCTGCAAAAAGAAAGTTTAGAAG
AAATTGTTGATTTAATGCTAGCTGAAGTAAATCAAACCACCGCAAAAAAAGGTATTAGTTTAACGATTACTGATGACGCT
AAAGCTCATTTGATAGATTTAGGGTACAATCACGCTATGGGAGCTCGTCCATTACGACGTATTATCGAACAGGAAATTCG
TGACCGTATAACTGATTATTATCTTGACCATCCAGAAGTCAAAAAACTTCAGGCAATCCTAAAAGAAGGACAACTAGTGA
TTAGGCAAAACGATCAGTAA

Upstream 100 bases:

>100_bases
TTTATTAGCAAAGGATTTCCTATCATGTGAAATCCTAACAACGATTCTGCGACTGCTTACAAACATCTTATAGTCTATTT
TTTATTGCGAGGTAACTGAT

Downstream 100 bases:

>100_bases
TAAACTTCTTCAATTGAATAATTTTCAAAACATGAAAAAATCCGTCTTGTGACTACGTTATACACTTGACGGACTTTTTT
TTAGCGCTTTTTTAAAAATA

Product: putative ATP-dependent Clp proteinase ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 699; Mature: 698

Protein sequence:

>699_residues
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATTKATNSQMLTPKADSVLTQLG
TNLTQEARQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSL
EAGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAA
QHPVTDLKTLETEIAKQKESQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGT
NDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGKRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNT
VIIATSNAGFGQQDTETSESNIMDRIAPYFRPEFLNRFNSIIKFNHLQKESLEEIVDLMLAEVNQTTAKKGISLTITDDA
KAHLIDLGYNHAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ

Sequences:

>Translated_699_residues
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATTKATNSQMLTPKADSVLTQLG
TNLTQEARQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSL
EAGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAA
QHPVTDLKTLETEIAKQKESQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGT
NDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGKRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNT
VIIATSNAGFGQQDTETSESNIMDRIAPYFRPEFLNRFNSIIKFNHLQKESLEEIVDLMLAEVNQTTAKKGISLTITDDA
KAHLIDLGYNHAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ
>Mature_698_residues
THFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATTKATNSQMLTPKADSVLTQLGT
NLTQEARQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSLE
AGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTIL
KNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAAQ
HPVTDLKTLETEIAKQKESQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGTN
DLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGKRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLDM
SEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNTV
IIATSNAGFGQQDTETSESNIMDRIAPYFRPEFLNRFNSIIKFNHLQKESLEEIVDLMLAEVNQTTAKKGISLTITDDAK
AHLIDLGYNHAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ

Specific function: Part Of A Stress-Induced Multi-Chaperone System, It Is Involved In The Recovery Of The Cell From Heat-Induced Damage, In Cooperation With Dnak, Dnaj And Grpe. Acts Before Dnak, In The Processing Of Protein Aggregates. Protein Binding Stimulates The Atpase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family. ClpC subfamily [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=303, Percent_Identity=34.6534653465347, Blast_Score=172, Evalue=1e-42,
Organism=Escherichia coli, GI1788943, Length=678, Percent_Identity=41.0029498525074, Blast_Score=484, Evalue=1e-138,
Organism=Escherichia coli, GI1787109, Length=602, Percent_Identity=40.1993355481728, Blast_Score=446, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6323002, Length=708, Percent_Identity=38.5593220338983, Blast_Score=466, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6320464, Length=711, Percent_Identity=37.6933895921238, Blast_Score=436, Evalue=1e-123,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR019489 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 77348; Mature: 77217

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATT
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEE
KATNSQMLTPKADSVLTQLGTNLTQEARQGHLDPVIGRNKEIQDTAEILARRTKNNPVLV
CCCCCCCCCCCHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEE
GDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSLEAGTQYRGSFEETIQNLIQE
ECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCCCCCCCCCHHHHHHHHHHH
VKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
HHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHH
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQ
HHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
RSLPDKAIDLLDMTAAHLAAQHPVTDLKTLETEIAKQKESQEKAVAKEDFEKALAAKTRI
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGTNDLERLKGISSRLKSHVIGQ
HHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
DEAVAAVARAIRRNRAGFDDGKRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEE
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQ
HHHCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHH
VLDDGRLTDGQGNTINFKNTVIIATSNAGFGQQDTETSESNIMDRIAPYFRPEFLNRFNS
HHCCCCEECCCCCEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHH
IIKFNHLQKESLEEIVDLMLAEVNQTTAKKGISLTITDDAKAHLIDLGYNHAMGARPLRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCCHHHHHH
IIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCC
>Mature Secondary Structure 
THFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATT
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEE
KATNSQMLTPKADSVLTQLGTNLTQEARQGHLDPVIGRNKEIQDTAEILARRTKNNPVLV
CCCCCCCCCCCHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEE
GDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSLEAGTQYRGSFEETIQNLIQE
ECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHCCCCCCCCCCHHHHHHHHHHH
VKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
HHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHH
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQ
HHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
RSLPDKAIDLLDMTAAHLAAQHPVTDLKTLETEIAKQKESQEKAVAKEDFEKALAAKTRI
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGTNDLERLKGISSRLKSHVIGQ
HHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
DEAVAAVARAIRRNRAGFDDGKRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEE
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQ
HHHCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHH
VLDDGRLTDGQGNTINFKNTVIIATSNAGFGQQDTETSESNIMDRIAPYFRPEFLNRFNS
HHCCCCEECCCCCEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHH
IIKFNHLQKESLEEIVDLMLAEVNQTTAKKGISLTITDDAKAHLIDLGYNHAMGARPLRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCCHHHHHH
IIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA