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The map label for this gene is mvaS.2 [H]

Identifier: 15674906

GI number: 15674906

Start: 728857

End: 730032

Strand: Reverse

Name: mvaS.2 [H]

Synonym: SPy_0881

Alternate gene names: 15674906

Gene position: 730032-728857 (Counterclockwise)

Preceding gene: 15674913

Following gene: 15674905

Centisome position: 39.41

GC content: 37.84

Gene sequence:

>1176_bases
ATGACAATTGGAATTGATAAGATTGGTTTTGCAACCAGTCAATATGTCTTGAAATTGGAAGATTTAGCGCTTGCACGCCA
AGTGGATCCAGCAAAATTTAGTCAAGGGCTACTCATTGAGTCTTTTAGTGTGGCACCAATCACTGAAGACATTATTACTT
TAGCTGCTTCTGCAGCAGATCAAATTTTAACCGACGAAGATCGAGCTAAGATTGATATGGTTATTTTGGCAACTGAATCG
AGTACTGATCAGTCAAAGGCATCAGCTATCTATGTACATCACTTAGTTGGTATCCAGCCTTTTGCACGTTCCTTTGAAGT
AAAACAAGCCTGCTATAGCGCAACTGCTGCTCTAGACTATGCTAAACTGCATGTGGCTTCTAAGCCAGATTCTCGTGTCC
TTGTTATTGCTAGTGATATTGCTAGATACGGTGTAGGATCTCCTGGGGAATCGACTCAAGGCTCTGGTAGTATTGCTCTT
TTGGTAACTGCTAACCCTCGTATTCTTGCTCTAAATGAAGATAATGTGGCTCAAACTAGGGATATTATGGACTTTTGGAG
GCCTAACTATAGTTTCACACCTTATGTTGATGGTATTTACTCTACCAAGCAATATCTCAATTGCTTAGAAACCACGTGGC
AAGCTTATCAGAAAAGAGAAAACCTTCAGTTATCTGATCTTGCTGCAGTTTGTTTCCATATTCCATTTCCCAAGTTAGCC
CTAAAAGGTCTAAATAACATTATGGATAACACAGTACCTCCTGAACACAGGGAAAAACTAATAGAAGCCTTTCAAGCTTC
TATTAGTTATAGCAAACAAATTGGAAATATTTATACTGGCTCACTTTATCTAGGATTGTTATCTTTACTTGAAAATAGTA
AAGTATTACAATCTGGAGATAAAATTGGTTTTTTTAGCTATGGTTCCGGTGCCGTAAGTGAATTTTATTCCGGTCAGTTA
GTTGCTGGGTACGATAAAATGTTAATGACTAATCGACAAGCTTTACTGGATCAACGAACACGTCTTTCTGTTTCTAAATA
CGAAGACCTTTTCTACGAACAAGTCCAATTAGATGATAATGGTAATGCCAATTTTGACATTTACTTAACTGGAAAATTTG
CTCTAACAGCCATCAAGGAGCATCGAAGGATCTATCATACCAATGACAAAAACTAA

Upstream 100 bases:

>100_bases
AACTATTAAAGGATAAAACAAATAACTTTATCAGTCTAATTTTGCAGTAAAATGTGATAGAATGGGTAAGACTATAAAAA
TAACTAAAAGAAGGACAAAT

Downstream 100 bases:

>100_bases
TCTTAACTGGAGCGGTTTTTCAAAGAAAACATTCGAAGAACGCCTCCAACTTATCGAAAAATTTAAACTACTTAATGCTG
AAAACTTAAATCAACTCAAA

Product: putative 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMG-CoA synthase)

Products: (S)-3-hydroxy-3-methylglutaryl-CoA; CoA

Alternate protein names: HMG synthase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MTIGIDKIGFATSQYVLKLEDLALARQVDPAKFSQGLLIESFSVAPITEDIITLAASAADQILTDEDRAKIDMVILATES
STDQSKASAIYVHHLVGIQPFARSFEVKQACYSATAALDYAKLHVASKPDSRVLVIASDIARYGVGSPGESTQGSGSIAL
LVTANPRILALNEDNVAQTRDIMDFWRPNYSFTPYVDGIYSTKQYLNCLETTWQAYQKRENLQLSDLAAVCFHIPFPKLA
LKGLNNIMDNTVPPEHREKLIEAFQASISYSKQIGNIYTGSLYLGLLSLLENSKVLQSGDKIGFFSYGSGAVSEFYSGQL
VAGYDKMLMTNRQALLDQRTRLSVSKYEDLFYEQVQLDDNGNANFDIYLTGKFALTAIKEHRRIYHTNDKN

Sequences:

>Translated_391_residues
MTIGIDKIGFATSQYVLKLEDLALARQVDPAKFSQGLLIESFSVAPITEDIITLAASAADQILTDEDRAKIDMVILATES
STDQSKASAIYVHHLVGIQPFARSFEVKQACYSATAALDYAKLHVASKPDSRVLVIASDIARYGVGSPGESTQGSGSIAL
LVTANPRILALNEDNVAQTRDIMDFWRPNYSFTPYVDGIYSTKQYLNCLETTWQAYQKRENLQLSDLAAVCFHIPFPKLA
LKGLNNIMDNTVPPEHREKLIEAFQASISYSKQIGNIYTGSLYLGLLSLLENSKVLQSGDKIGFFSYGSGAVSEFYSGQL
VAGYDKMLMTNRQALLDQRTRLSVSKYEDLFYEQVQLDDNGNANFDIYLTGKFALTAIKEHRRIYHTNDKN
>Mature_390_residues
TIGIDKIGFATSQYVLKLEDLALARQVDPAKFSQGLLIESFSVAPITEDIITLAASAADQILTDEDRAKIDMVILATESS
TDQSKASAIYVHHLVGIQPFARSFEVKQACYSATAALDYAKLHVASKPDSRVLVIASDIARYGVGSPGESTQGSGSIALL
VTANPRILALNEDNVAQTRDIMDFWRPNYSFTPYVDGIYSTKQYLNCLETTWQAYQKRENLQLSDLAAVCFHIPFPKLAL
KGLNNIMDNTVPPEHREKLIEAFQASISYSKQIGNIYTGSLYLGLLSLLENSKVLQSGDKIGFFSYGSGAVSEFYSGQLV
AGYDKMLMTNRQALLDQRTRLSVSKYEDLFYEQVQLDDNGNANFDIYLTGKFALTAIKEHRRIYHTNDKN

Specific function: Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the aldol condensation between the acetyl group attached to the acyl-carrier-protein AcpK (Ac- AcpK) and

COG id: COG3425

COG function: function code I; 3-hydroxy-3-methylglutaryl CoA synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA synthase family [H]

Homologues:

Organism=Homo sapiens, GI148298764, Length=450, Percent_Identity=26.8888888888889, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI148298677, Length=450, Percent_Identity=26.8888888888889, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI5031751, Length=446, Percent_Identity=26.0089686098655, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17560126, Length=394, Percent_Identity=23.6040609137056, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6323509, Length=377, Percent_Identity=24.9336870026525, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24654139, Length=445, Percent_Identity=26.7415730337079, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24654137, Length=445, Percent_Identity=26.7415730337079, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24654133, Length=445, Percent_Identity=26.7415730337079, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24654135, Length=445, Percent_Identity=26.7415730337079, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI17933694, Length=445, Percent_Identity=26.7415730337079, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013746
- InterPro:   IPR013528
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08540 HMG_CoA_synt_C; PF01154 HMG_CoA_synt_N [H]

EC number: 2.3.3.10

Molecular weight: Translated: 43357; Mature: 43225

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIGIDKIGFATSQYVLKLEDLALARQVDPAKFSQGLLIESFSVAPITEDIITLAASAAD
CEECCCCCCCCCHHHHEEHHHHHHHHCCCHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
QILTDEDRAKIDMVILATESSTDQSKASAIYVHHLVGIQPFARSFEVKQACYSATAALDY
HHCCCCCCCEEEEEEEEECCCCCCHHHHEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AKLHVASKPDSRVLVIASDIARYGVGSPGESTQGSGSIALLVTANPRILALNEDNVAQTR
HHEEECCCCCCCEEEEECHHHHHCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCHHHHH
DIMDFWRPNYSFTPYVDGIYSTKQYLNCLETTWQAYQKRENLQLSDLAAVCFHIPFPKLA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHH
LKGLNNIMDNTVPPEHREKLIEAFQASISYSKQIGNIYTGSLYLGLLSLLENSKVLQSGD
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCHHHHCCC
KIGFFSYGSGAVSEFYSGQLVAGYDKMLMTNRQALLDQRTRLSVSKYEDLFYEQVQLDDN
CEEEEECCCHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
GNANFDIYLTGKFALTAIKEHRRIYHTNDKN
CCCEEEEEEECHHHHHHHHHCCCEECCCCCC
>Mature Secondary Structure 
TIGIDKIGFATSQYVLKLEDLALARQVDPAKFSQGLLIESFSVAPITEDIITLAASAAD
EECCCCCCCCCHHHHEEHHHHHHHHCCCHHHHCCCCEEECCCCCCHHHHHHHHHHHHHH
QILTDEDRAKIDMVILATESSTDQSKASAIYVHHLVGIQPFARSFEVKQACYSATAALDY
HHCCCCCCCEEEEEEEEECCCCCCHHHHEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AKLHVASKPDSRVLVIASDIARYGVGSPGESTQGSGSIALLVTANPRILALNEDNVAQTR
HHEEECCCCCCCEEEEECHHHHHCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCHHHHH
DIMDFWRPNYSFTPYVDGIYSTKQYLNCLETTWQAYQKRENLQLSDLAAVCFHIPFPKLA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHH
LKGLNNIMDNTVPPEHREKLIEAFQASISYSKQIGNIYTGSLYLGLLSLLENSKVLQSGD
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCHHHHCCC
KIGFFSYGSGAVSEFYSGQLVAGYDKMLMTNRQALLDQRTRLSVSKYEDLFYEQVQLDDN
CEEEEECCCHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
GNANFDIYLTGKFALTAIKEHRRIYHTNDKN
CCCEEEEEEECHHHHHHHHHCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acetyl-CoA; H2O; acetoacetyl-CoA

Specific reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7704258; 9384377 [H]