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The map label for this gene is pyrP [H]

Identifier: 15674867

GI number: 15674867

Start: 680894

End: 682153

Strand: Direct

Name: pyrP [H]

Synonym: SPy_0831

Alternate gene names: 15674867

Gene position: 680894-682153 (Clockwise)

Preceding gene: 15674866

Following gene: 15674868

Centisome position: 36.76

GC content: 39.05

Gene sequence:

>1260_bases
GTGAAAGATGTCATTTATGATGTGGAAGAAGTGCCAAAGGCAGGTATGTTAGTTGGTTTGTCCTTTCAGCACTTATTTGC
TATGTTTGGTGCGACTGTTCTGGTTCCCATTCTAGTTGGAATTGACCCATCAGTTGCTTTGTTATCTAGTGGTTTAGGAA
CCCTTGCCCACTTATCAGTGACCAAATTTAAAATTCCAGCCTACATGGGCTCAAGTTTTGCTTATATAGCAGCTATGCAG
TTACTGATGAAGACAAATGGTATTGGTGCTGTAGCTCAAGGGGCTATGACAGGAGGTCTCGTTTACCTGATTGTAGCTTT
GATTGTTAAAGCTATTGGCAATGATTGGATTGATAACATCTTACCACCGATTGTGGTTGGTCCGATTGTTATGGTCATTG
GTCTAAGCCTAGCTTCTACAGCTGTTAATGATGTCATGCTAAAAAATGGGAACTATAATCTGACTTATCTTGTTATTGGG
TTAGTCACCTTATTATCAGTTATTTTTTTCAATATTTATGGTAAGGGAATTGTTGCTATTGTACCGCTTTTATTAGGGCT
ATTAGTTGGTTATGTTGTAGCCCTTTTAGTGGGTGTTCTCACCGGTCAAGAAATTGTTGATTTTACCAATGTGGCTCAGG
CCAAATGGTTTAGTATCCCATCAGTGGAAATTCCTTTCTTAACCTACGGGGTTAAATTCTACCCAAGTGCCATTTTAACT
ATGGCACCCATTGCCTTTGTTACAATGACAGAACATTTTGGACACATTATGGTCTTAAATAGTTTGACAAAAAGAGATTA
TTTCAAGGATCCAGGACTTGAAAAGACTTTAACTGGTGATGGTTTTGCGCAAATCATTGCCGGCTTCTTAGGGGCACCTC
CGGTCACTTCTTATGGTGAAAACATCGGTGTAATGGCTTTGAATAAAATATTCTCGGTCTATGTTATTGCAGGTGCCGCA
GTGATTGCCGCTCTCCTCAGTTTTATCGGTAAGGTATCAGCCTTAATTCAATCTATTCCAACACCAGTTATTGGAGGTAT
ATCAGTTGCCTTGTTTGGTGTGATAGCTTCTAGCGGTTTGAAAATCTTGATTGAATCCAAAGTTGATATGGATAATAAGA
AAAACTTATTGATTGCTAGTGTTATTTTGGTCTCTGGGATTGGAGGATTGATGCTTCAAGTAAATGGTCTTCAAATTTCA
GGTGTCGCTTTCTCAACACTCCTTGGCATCATCTTATATCAGGTACTTCCTGAAAAATAG

Upstream 100 bases:

>100_bases
TCCAACAAGCAGTGTAGAAGAAATTGTTGTTGAGGTTGTCGAAGTCGATGGCCGTGATCGTGTTAGCATTATTGACTCAA
CATAAGAAAGAGGTTTTACT

Downstream 100 bases:

>100_bases
GAAGAATTGTTGTTAGACCACTTACATAGTCATCAGTCGTTAGTGATAAAGGGGATAATCATGTCAGTTGTAAATAATCG
CGTTGCACTTACCAATTTAG

Product: putative uracil permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MKDVIYDVEEVPKAGMLVGLSFQHLFAMFGATVLVPILVGIDPSVALLSSGLGTLAHLSVTKFKIPAYMGSSFAYIAAMQ
LLMKTNGIGAVAQGAMTGGLVYLIVALIVKAIGNDWIDNILPPIVVGPIVMVIGLSLASTAVNDVMLKNGNYNLTYLVIG
LVTLLSVIFFNIYGKGIVAIVPLLLGLLVGYVVALLVGVLTGQEIVDFTNVAQAKWFSIPSVEIPFLTYGVKFYPSAILT
MAPIAFVTMTEHFGHIMVLNSLTKRDYFKDPGLEKTLTGDGFAQIIAGFLGAPPVTSYGENIGVMALNKIFSVYVIAGAA
VIAALLSFIGKVSALIQSIPTPVIGGISVALFGVIASSGLKILIESKVDMDNKKNLLIASVILVSGIGGLMLQVNGLQIS
GVAFSTLLGIILYQVLPEK

Sequences:

>Translated_419_residues
MKDVIYDVEEVPKAGMLVGLSFQHLFAMFGATVLVPILVGIDPSVALLSSGLGTLAHLSVTKFKIPAYMGSSFAYIAAMQ
LLMKTNGIGAVAQGAMTGGLVYLIVALIVKAIGNDWIDNILPPIVVGPIVMVIGLSLASTAVNDVMLKNGNYNLTYLVIG
LVTLLSVIFFNIYGKGIVAIVPLLLGLLVGYVVALLVGVLTGQEIVDFTNVAQAKWFSIPSVEIPFLTYGVKFYPSAILT
MAPIAFVTMTEHFGHIMVLNSLTKRDYFKDPGLEKTLTGDGFAQIIAGFLGAPPVTSYGENIGVMALNKIFSVYVIAGAA
VIAALLSFIGKVSALIQSIPTPVIGGISVALFGVIASSGLKILIESKVDMDNKKNLLIASVILVSGIGGLMLQVNGLQIS
GVAFSTLLGIILYQVLPEK
>Mature_419_residues
MKDVIYDVEEVPKAGMLVGLSFQHLFAMFGATVLVPILVGIDPSVALLSSGLGTLAHLSVTKFKIPAYMGSSFAYIAAMQ
LLMKTNGIGAVAQGAMTGGLVYLIVALIVKAIGNDWIDNILPPIVVGPIVMVIGLSLASTAVNDVMLKNGNYNLTYLVIG
LVTLLSVIFFNIYGKGIVAIVPLLLGLLVGYVVALLVGVLTGQEIVDFTNVAQAKWFSIPSVEIPFLTYGVKFYPSAILT
MAPIAFVTMTEHFGHIMVLNSLTKRDYFKDPGLEKTLTGDGFAQIIAGFLGAPPVTSYGENIGVMALNKIFSVYVIAGAA
VIAALLSFIGKVSALIQSIPTPVIGGISVALFGVIASSGLKILIESKVDMDNKKNLLIASVILVSGIGGLMLQVNGLQIS
GVAFSTLLGIILYQVLPEK

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680143, Length=444, Percent_Identity=25, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI44680145, Length=437, Percent_Identity=24.4851258581236, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI44680148, Length=442, Percent_Identity=24.2081447963801, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI40316845, Length=442, Percent_Identity=24.2081447963801, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788843, Length=406, Percent_Identity=42.3645320197044, Blast_Score=314, Evalue=6e-87,
Organism=Escherichia coli, GI87081818, Length=424, Percent_Identity=37.9716981132075, Blast_Score=255, Evalue=4e-69,
Organism=Escherichia coli, GI87082181, Length=404, Percent_Identity=25.4950495049505, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI87082178, Length=388, Percent_Identity=26.0309278350515, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790087, Length=455, Percent_Identity=24.1758241758242, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21356175, Length=443, Percent_Identity=24.1534988713318, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44039; Mature: 44039

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDVIYDVEEVPKAGMLVGLSFQHLFAMFGATVLVPILVGIDPSVALLSSGLGTLAHLSV
CCCCHHCHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHH
TKFKIPAYMGSSFAYIAAMQLLMKTNGIGAVAQGAMTGGLVYLIVALIVKAIGNDWIDNI
HEEECCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHC
LPPIVVGPIVMVIGLSLASTAVNDVMLKNGNYNLTYLVIGLVTLLSVIFFNIYGKGIVAI
CCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
VPLLLGLLVGYVVALLVGVLTGQEIVDFTNVAQAKWFSIPSVEIPFLTYGVKFYPSAILT
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
MAPIAFVTMTEHFGHIMVLNSLTKRDYFKDPGLEKTLTGDGFAQIIAGFLGAPPVTSYGE
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
NIGVMALNKIFSVYVIAGAAVIAALLSFIGKVSALIQSIPTPVIGGISVALFGVIASSGL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
KILIESKVDMDNKKNLLIASVILVSGIGGLMLQVNGLQISGVAFSTLLGIILYQVLPEK
EEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCEEECHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKDVIYDVEEVPKAGMLVGLSFQHLFAMFGATVLVPILVGIDPSVALLSSGLGTLAHLSV
CCCCHHCHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHH
TKFKIPAYMGSSFAYIAAMQLLMKTNGIGAVAQGAMTGGLVYLIVALIVKAIGNDWIDNI
HEEECCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHC
LPPIVVGPIVMVIGLSLASTAVNDVMLKNGNYNLTYLVIGLVTLLSVIFFNIYGKGIVAI
CCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
VPLLLGLLVGYVVALLVGVLTGQEIVDFTNVAQAKWFSIPSVEIPFLTYGVKFYPSAILT
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
MAPIAFVTMTEHFGHIMVLNSLTKRDYFKDPGLEKTLTGDGFAQIIAGFLGAPPVTSYGE
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCC
NIGVMALNKIFSVYVIAGAAVIAALLSFIGKVSALIQSIPTPVIGGISVALFGVIASSGL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
KILIESKVDMDNKKNLLIASVILVSGIGGLMLQVNGLQISGVAFSTLLGIILYQVLPEK
EEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCEEECHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8206848 [H]