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The map label for this gene is pyrR

Identifier: 15674866

GI number: 15674866

Start: 680357

End: 680878

Strand: Direct

Name: pyrR

Synonym: SPy_0830

Alternate gene names: 15674866

Gene position: 680357-680878 (Clockwise)

Preceding gene: 15674865

Following gene: 15674867

Centisome position: 36.73

GC content: 41.57

Gene sequence:

>522_bases
ATGAAAACTAAGGAAATTGTTGATGACGTGACCATGAAACGCGCCATTACCCGTATTACTTATGAAATTATTGAACGTAA
TAAACAATTAGACAATGTGGTTTTGGCAGGCATCAAAACGAGAGGTGTTTTTCTAGCTCGTCGCATTCAAGAAAGACTGC
ATCAATTAGAAGGGTTGGATTTACCAATTGGTGAGTTAGACATCAAGCCTTTTAGAGATGACATGAGAGTTGAGGAAGAC
ACAACTCTGATGTCAGTAGATATTACAGGCAAGGATGTGATTTTGATTGATGATGTGCTTTATACTGGTCGTACCATCCG
CGCAGCCATCGATAACTTAGTGAGTTTAGGTCGACCAGCCCGTGTTAGTCTAGCTGTTTTGGTGGATCGTGGCCATCGGG
AATTACCGATTCGCGCGGATTACGTTGGGAAAAATATTCCAACAAGCAGTGTAGAAGAAATTGTTGTTGAGGTTGTCGAA
GTCGATGGCCGTGATCGTGTTAGCATTATTGACTCAACATAA

Upstream 100 bases:

>100_bases
TTAAAAACATGCATCATGATACTTAATTGTGCTATATTTTGCTGAATCTCCTTGTTTCCAAGGAGATCTTTTTATTTGAA
TTTTTAGAGGAGGTTTCAAC

Downstream 100 bases:

>100_bases
GAAAGAGGTTTTACTGTGAAAGATGTCATTTATGATGTGGAAGAAGTGCCAAAGGCAGGTATGTTAGTTGGTTTGTCCTT
TCAGCACTTATTTGCTATGT

Product: bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase

Products: NA

Alternate protein names: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase; UPRTase

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MKTKEIVDDVTMKRAITRITYEIIERNKQLDNVVLAGIKTRGVFLARRIQERLHQLEGLDLPIGELDIKPFRDDMRVEED
TTLMSVDITGKDVILIDDVLYTGRTIRAAIDNLVSLGRPARVSLAVLVDRGHRELPIRADYVGKNIPTSSVEEIVVEVVE
VDGRDRVSIIDST

Sequences:

>Translated_173_residues
MKTKEIVDDVTMKRAITRITYEIIERNKQLDNVVLAGIKTRGVFLARRIQERLHQLEGLDLPIGELDIKPFRDDMRVEED
TTLMSVDITGKDVILIDDVLYTGRTIRAAIDNLVSLGRPARVSLAVLVDRGHRELPIRADYVGKNIPTSSVEEIVVEVVE
VDGRDRVSIIDST
>Mature_173_residues
MKTKEIVDDVTMKRAITRITYEIIERNKQLDNVVLAGIKTRGVFLARRIQERLHQLEGLDLPIGELDIKPFRDDMRVEED
TTLMSVDITGKDVILIDDVLYTGRTIRAAIDNLVSLGRPARVSLAVLVDRGHRELPIRADYVGKNIPTSSVEEIVVEVVE
VDGRDRVSIIDST

Specific function: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant

COG id: COG2065

COG function: function code F; Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRR_STRP1 (Q9A0D0)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269040.1
- RefSeq:   YP_282002.1
- ProteinModelPortal:   Q9A0D0
- SMR:   Q9A0D0
- EnsemblBacteria:   EBSTRT00000000764
- EnsemblBacteria:   EBSTRT00000027400
- GeneID:   3572268
- GeneID:   900997
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0830
- KEGG:   spz:M5005_Spy_0639
- GeneTree:   EBGT00050000028313
- HOGENOM:   HBG641958
- OMA:   ILDITLY
- ProtClustDB:   PRK05205
- BioCyc:   SPYO160490:SPY0830-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0639-MONOMER
- HAMAP:   MF_01219
- InterPro:   IPR000836
- InterPro:   IPR023050

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 19519; Mature: 19519

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKEIVDDVTMKRAITRITYEIIERNKQLDNVVLAGIKTRGVFLARRIQERLHQLEGLD
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
LPIGELDIKPFRDDMRVEEDTTLMSVDITGKDVILIDDVLYTGRTIRAAIDNLVSLGRPA
CCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECHHHCCCHHHHHHHHHHHCCCCC
RVSLAVLVDRGHRELPIRADYVGKNIPTSSVEEIVVEVVEVDGRDRVSIIDST
CEEEEEEEECCCCCCCEEHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MKTKEIVDDVTMKRAITRITYEIIERNKQLDNVVLAGIKTRGVFLARRIQERLHQLEGLD
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCC
LPIGELDIKPFRDDMRVEEDTTLMSVDITGKDVILIDDVLYTGRTIRAAIDNLVSLGRPA
CCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECHHHCCCHHHHHHHHHHHCCCCC
RVSLAVLVDRGHRELPIRADYVGKNIPTSSVEEIVVEVVEVDGRDRVSIIDST
CEEEEEEEECCCCCCCEEHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296