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The map label for this gene is aroD

Identifier: 15674851

GI number: 15674851

Start: 666496

End: 667182

Strand: Direct

Name: aroD

Synonym: SPy_0809

Alternate gene names: 15674851

Gene position: 666496-667182 (Clockwise)

Preceding gene: 15674850

Following gene: 15674852

Centisome position: 35.98

GC content: 37.55

Gene sequence:

>687_bases
ATGAGAATTGTAGCACCAGTCATGCCAAGACATTTTGACGAGGCTCAAGCCATTGATATTTCTAAATATGAAGATGTTAA
TTTAATTGAATGGCGAGCAGACTTTCTTCCCAAGGATGAGATTGTCGCAGTAGCACCAGCTATTTTTGAAAAATTTGCCG
GAAAAGAAATTATCTTTACCCTTCGGACCGTTCAAGAAGGGGGGAATATTACCCTTTCAAGTCAGGAGTATGTTGATATT
ATCAAAGAAATCAATGCTATTTATAATCCAGACTATATTGACTTTGAGTATTTTACGCACAAGTCAGTATTTCAAGAAAT
GCTTGATTTTCCAAATCTTATTTTGTCTTATCACAACTTTGAAGAGACTCCTGAAAATTTAATGGAAGCTTTTTCAGAAA
TGACCAAGTTGGCACCGCGTGTGGTTAAAATTGCTGTGATGCCCCAGAGTGAACAAGATGTTCTAGATTTGATGAACTAT
ACCAGAGGCTTTAAGACGCTCAATCCTGAGCAAGAATTTGCAACTATATCTATGGGGAAATTAGGAAGATTGTCTCGTTT
TGCGGGAGATGTCATTGGCTCTTCCTGGACATACGTTTCATTAGATCATGTTAGCGGTCCAGGTCAAGTGACTCTCAATG
ATATGAAACGTATTATTGAGGTCTTAGAAATGGATATCTCTAACTAG

Upstream 100 bases:

>100_bases
CTGAGTCTATGACTCTCCAGCAGCTTCCGAGTGACTTTACTATCAATAAAGCAGATGAAAGAAGTAACTATTTAAAGGTA
TTTACTATAAAGGTACGAGA

Downstream 100 bases:

>100_bases
TGAATGGTCTAAAAATATTATTTCTACAATAGTTAAGAAATGATGTTTTTAGATTAATGTTTTTAAAATAAGTGGAACCA
AAAAGGAGAAAAATTGCGTT

Product: 3-dehydroquinate dehydratase

Products: NA

Alternate protein names: 3-dehydroquinase; Type I DHQase

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MRIVAPVMPRHFDEAQAIDISKYEDVNLIEWRADFLPKDEIVAVAPAIFEKFAGKEIIFTLRTVQEGGNITLSSQEYVDI
IKEINAIYNPDYIDFEYFTHKSVFQEMLDFPNLILSYHNFEETPENLMEAFSEMTKLAPRVVKIAVMPQSEQDVLDLMNY
TRGFKTLNPEQEFATISMGKLGRLSRFAGDVIGSSWTYVSLDHVSGPGQVTLNDMKRIIEVLEMDISN

Sequences:

>Translated_228_residues
MRIVAPVMPRHFDEAQAIDISKYEDVNLIEWRADFLPKDEIVAVAPAIFEKFAGKEIIFTLRTVQEGGNITLSSQEYVDI
IKEINAIYNPDYIDFEYFTHKSVFQEMLDFPNLILSYHNFEETPENLMEAFSEMTKLAPRVVKIAVMPQSEQDVLDLMNY
TRGFKTLNPEQEFATISMGKLGRLSRFAGDVIGSSWTYVSLDHVSGPGQVTLNDMKRIIEVLEMDISN
>Mature_228_residues
MRIVAPVMPRHFDEAQAIDISKYEDVNLIEWRADFLPKDEIVAVAPAIFEKFAGKEIIFTLRTVQEGGNITLSSQEYVDI
IKEINAIYNPDYIDFEYFTHKSVFQEMLDFPNLILSYHNFEETPENLMEAFSEMTKLAPRVVKIAVMPQSEQDVLDLMNY
TRGFKTLNPEQEFATISMGKLGRLSRFAGDVIGSSWTYVSLDHVSGPGQVTLNDMKRIIEVLEMDISN

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; third step. [C]

COG id: COG0710

COG function: function code E; 3-dehydroquinate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-I 3-dehydroquinase family

Homologues:

Organism=Escherichia coli, GI1787984, Length=209, Percent_Identity=30.622009569378, Blast_Score=114, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROD_STRP1 (P63590)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269025.1
- RefSeq:   YP_281987.1
- PDB:   2OCZ
- PDBsum:   2OCZ
- ProteinModelPortal:   P63590
- SMR:   P63590
- EnsemblBacteria:   EBSTRT00000000207
- EnsemblBacteria:   EBSTRT00000028056
- GeneID:   3572292
- GeneID:   900982
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0809
- KEGG:   spz:M5005_Spy_0624
- GeneTree:   EBGT00050000027890
- HOGENOM:   HBG732926
- OMA:   SYHNFDE
- ProtClustDB:   PRK02412
- BioCyc:   SPYO160490:SPY0809-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0624-MONOMER
- HAMAP:   MF_00214
- InterPro:   IPR013785
- InterPro:   IPR001381
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01093

Pfam domain/function: PF01487 DHquinase_I

EC number: =4.2.1.10

Molecular weight: Translated: 26101; Mature: 26101

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: PS01028 DEHYDROQUINASE_I

Important sites: ACT_SITE 118-118 ACT_SITE 143-143

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVAPVMPRHFDEAQAIDISKYEDVNLIEWRADFLPKDEIVAVAPAIFEKFAGKEIIFT
CCCCCCCCCCCCCCCCEECCCCCCCCCEEEEHHHCCCCCHHHHHHHHHHHHHCCCEEEEE
LRTVQEGGNITLSSQEYVDIIKEINAIYNPDYIDFEYFTHKSVFQEMLDFPNLILSYHNF
EEEHHCCCCEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCC
EETPENLMEAFSEMTKLAPRVVKIAVMPQSEQDVLDLMNYTRGFKTLNPEQEFATISMGK
CCCHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHEEECCHH
LGRLSRFAGDVIGSSWTYVSLDHVSGPGQVTLNDMKRIIEVLEMDISN
HHHHHHHHHHHHCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIVAPVMPRHFDEAQAIDISKYEDVNLIEWRADFLPKDEIVAVAPAIFEKFAGKEIIFT
CCCCCCCCCCCCCCCCEECCCCCCCCCEEEEHHHCCCCCHHHHHHHHHHHHHCCCEEEEE
LRTVQEGGNITLSSQEYVDIIKEINAIYNPDYIDFEYFTHKSVFQEMLDFPNLILSYHNF
EEEHHCCCCEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCC
EETPENLMEAFSEMTKLAPRVVKIAVMPQSEQDVLDLMNYTRGFKTLNPEQEFATISMGK
CCCHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHEEECCHH
LGRLSRFAGDVIGSSWTYVSLDHVSGPGQVTLNDMKRIIEVLEMDISN
HHHHHHHHHHHHCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296