Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is ftsX [H]

Identifier: 15674715

GI number: 15674715

Start: 517886

End: 518824

Strand: Direct

Name: ftsX [H]

Synonym: SPy_0645

Alternate gene names: 15674715

Gene position: 517886-518824 (Clockwise)

Preceding gene: 15674714

Following gene: 15674717

Centisome position: 27.96

GC content: 35.89

Gene sequence:

>939_bases
ATGGTTACGATGATTAGATACTTTTTCCGTCATATTTGGGAATCCATTAAAAATCTTAAACGCAACTTTTGGATGACATT
TGCTTCAGTTAGTATGGTGGCTGTTACATTGACTTTAGTTGGTGTTTTTGCGGCGACATTGTTGAATATACAGCGTGTTG
CTTCGGGTGTTGAAAATAATGTCCATATCAATACCTACTTACAAGTTGATTCAACTGATGCTGCAAAAGTTATTCAAAAT
ACTGCCGGTGAACCTGTTAATAACGATAACTACCACAGTGTTTACGACAAAATTGCTCAGATAAAAGGTGTCAAAAAGAT
TACATTTTCTAGCAAGGATGAACAATTGAAAAAATTGCAAGAAACCTTAGGTGATGTTTGGAATATGTATGACCAAGACA
CTAATCCGCTCCAAGATATCTATCTTATTGAGACCCAGACGCCTAAACAAGTTAAGGCGATCACTAAAAAGATCAGAACG
ATTGAAGGCGTAGAAGCCGCAGATTATGGAGGGATTAACTCCGATAAACTATTTAAGTTTTCAACATTAATTCAAACTTG
GGGGCTGATCGGAACAGCAATGCTATTATTTGTAGCTGTCTTTCTCATTTCAAACACTATTCGTATGACTATTATGTCTC
GTAAACGTGACATTGAAATTATGCGGTTAGTTGGTGCTAAAAATTCTTATATTCGAGGGCCTTTCTTTTTTGAAGGGGCT
TGGGTTGGCTTGTTAGGAGCTGTTTTACCATCTCTTCTGATTTATTATGGATATGATCTTGTTTATAAGCATTTTGCACA
AGAATTACAACGTAATAATCTCTCGATGTATCCGCTTGATCCTTATGTATATTACCTGATTGGTGCTTTGTTTGTCATAG
GTATTATGATTGGTTCGCTTGGTTCAGTGCTTTCTATGAGACGTTATTTAAAATTCTAA

Upstream 100 bases:

>100_bases
TTAATGGCGACACACAACAGTCATATTGTGAATACATTCCGTCATCGTGTTGTTGCTATTGAAGATGGTCGCATAGTACG
TGATGAAGAAAAAGGAGATT

Downstream 100 bases:

>100_bases
AAAAAGCGCTGCTGACGAAACGTAGCGACCCTCAAAAGTTGGACCTCTTATGTTATTCCAAGGACCTCGTTTTGTATTGC
ACAGGACTGGTCCTTTTCAT

Product: putative cell-division protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MVTMIRYFFRHIWESIKNLKRNFWMTFASVSMVAVTLTLVGVFAATLLNIQRVASGVENNVHINTYLQVDSTDAAKVIQN
TAGEPVNNDNYHSVYDKIAQIKGVKKITFSSKDEQLKKLQETLGDVWNMYDQDTNPLQDIYLIETQTPKQVKAITKKIRT
IEGVEAADYGGINSDKLFKFSTLIQTWGLIGTAMLLFVAVFLISNTIRMTIMSRKRDIEIMRLVGAKNSYIRGPFFFEGA
WVGLLGAVLPSLLIYYGYDLVYKHFAQELQRNNLSMYPLDPYVYYLIGALFVIGIMIGSLGSVLSMRRYLKF

Sequences:

>Translated_312_residues
MVTMIRYFFRHIWESIKNLKRNFWMTFASVSMVAVTLTLVGVFAATLLNIQRVASGVENNVHINTYLQVDSTDAAKVIQN
TAGEPVNNDNYHSVYDKIAQIKGVKKITFSSKDEQLKKLQETLGDVWNMYDQDTNPLQDIYLIETQTPKQVKAITKKIRT
IEGVEAADYGGINSDKLFKFSTLIQTWGLIGTAMLLFVAVFLISNTIRMTIMSRKRDIEIMRLVGAKNSYIRGPFFFEGA
WVGLLGAVLPSLLIYYGYDLVYKHFAQELQRNNLSMYPLDPYVYYLIGALFVIGIMIGSLGSVLSMRRYLKF
>Mature_312_residues
MVTMIRYFFRHIWESIKNLKRNFWMTFASVSMVAVTLTLVGVFAATLLNIQRVASGVENNVHINTYLQVDSTDAAKVIQN
TAGEPVNNDNYHSVYDKIAQIKGVKKITFSSKDEQLKKLQETLGDVWNMYDQDTNPLQDIYLIETQTPKQVKAITKKIRT
IEGVEAADYGGINSDKLFKFSTLIQTWGLIGTAMLLFVAVFLISNTIRMTIMSRKRDIEIMRLVGAKNSYIRGPFFFEGA
WVGLLGAVLPSLLIYYGYDLVYKHFAQELQRNNLSMYPLDPYVYYLIGALFVIGIMIGSLGSVLSMRRYLKF

Specific function: Part of the ABC transporter ftsEX involved in sporulation. May act as an importer, possibly at the top of a hierarchical cascade leading to the correct temporal initiation of sporulation. Acts upstream of the histidine kinases KinA, KinB and KInC, the Rap

COG id: COG2177

COG function: function code D; Cell division protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable). Note=Unlike the E.coli ortholog, localization is not restricted to division septa, nor is it dependent on ftsZ [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789872, Length=257, Percent_Identity=26.4591439688716, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 35560; Mature: 35560

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTMIRYFFRHIWESIKNLKRNFWMTFASVSMVAVTLTLVGVFAATLLNIQRVASGVENN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VHINTYLQVDSTDAAKVIQNTAGEPVNNDNYHSVYDKIAQIKGVKKITFSSKDEQLKKLQ
EEEEEEEEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHEECCCHHHHHHHHH
ETLGDVWNMYDQDTNPLQDIYLIETQTPKQVKAITKKIRTIEGVEAADYGGINSDKLFKF
HHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHH
STLIQTWGLIGTAMLLFVAVFLISNTIRMTIMSRKRDIEIMRLVGAKNSYIRGPFFFEGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHH
WVGLLGAVLPSLLIYYGYDLVYKHFAQELQRNNLSMYPLDPYVYYLIGALFVIGIMIGSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GSVLSMRRYLKF
HHHHHHHHHHCC
>Mature Secondary Structure
MVTMIRYFFRHIWESIKNLKRNFWMTFASVSMVAVTLTLVGVFAATLLNIQRVASGVENN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VHINTYLQVDSTDAAKVIQNTAGEPVNNDNYHSVYDKIAQIKGVKKITFSSKDEQLKKLQ
EEEEEEEEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHEECCCHHHHHHHHH
ETLGDVWNMYDQDTNPLQDIYLIETQTPKQVKAITKKIRTIEGVEAADYGGINSDKLFKF
HHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHH
STLIQTWGLIGTAMLLFVAVFLISNTIRMTIMSRKRDIEIMRLVGAKNSYIRGPFFFEGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHH
WVGLLGAVLPSLLIYYGYDLVYKHFAQELQRNNLSMYPLDPYVYYLIGALFVIGIMIGSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
GSVLSMRRYLKF
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]