Click here to switch to the map view.

The map label for this gene is tpiA [H]

Identifier: 15674692

GI number: 15674692

Start: 493639

End: 494397

Strand: Direct

Name: tpiA [H]

Synonym: SPy_0613

Alternate gene names: 15674692

Gene position: 493639-494397 (Clockwise)

Preceding gene: 15674691

Following gene: 15674698

Centisome position: 26.65

GC content: 42.16

Gene sequence:

>759_bases
ATGTCACGTAAACCAATTATTGCTGGTAACTGGAAAATGAACAAAAACCCTCAAGAAGCAAAAGCATTCGTTGAGGCTGT
AGCAAGCAAATTACCTTCAACTGACCTTGTTGATGTTGCCGTAGCAGCCCCAGCTGTTGATTTGGTAACCACTATTGAAG
CTGCTAAAGATTCAGTTCTTAAAGTTGCTGCACAAAACTGCTACTTTGAAAACACAGGGGCATTCACTGGTGAAACATCA
CCAAAAGTGCTTGCTGAAATGGGAGCTGACTATGTTGTGATTGGTCACTCAGAACGCCGTGATTACTTCCATGAAACAGA
TGAAGACATTAATAAAAAAGCCAAAGCAATCTTTGCTAACGGTTTAACTCCAATTGTTTGTTGTGGTGAGTCTCTTGAAA
CTTATGAAGCTGGTAAAGCCGTTGAGTTTGTAGGTGCGCAAGTTTCAGCAGCACTTGCAGGTCTTTCAGCAGAGCAAGTA
GCTTCACTTGTTTTAGCTTATGAGCCAATCTGGGCTATCGGTACTGGTAAATCAGCTACTCAAGATGATGCTCAAAACAT
GTGTAAAGCTGTTCGTGATGTGGTAGCAGCAGACTTTGGGCAAGAAGTTGCTGATAAAGTTCGCGTTCAATACGGTGGTT
CTGTAAAACCTGAAAACGTTAAAGATTACATGGCTTGTCCAGATGTTGACGGTGCCCTTGTAGGTGGTGCATCACTTGAA
GCTGATAGCTTCCTTGCTTTGCTTGATTTCCTTAACTAA

Upstream 100 bases:

>100_bases
TATTTGTGAAAATATTCCTAAAATATAAGCAATTCCTTTTAATCGTCGGTCATTTGTGCTAAAATAGAAGATATAAATAA
AAAAAGAAGAGGTATGTGAT

Downstream 100 bases:

>100_bases
GTCATCTAAAAAAGAAAAGGTTAAATCCTTTTCTTTTTTAGATGACTTAACTCTTACTATAAGAGAATAAAGGTGATTCT
ACAGGCAAATGCATTAGCCT

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSRKPIIAGNWKMNKNPQEAKAFVEAVASKLPSTDLVDVAVAAPAVDLVTTIEAAKDSVLKVAAQNCYFENTGAFTGETS
PKVLAEMGADYVVIGHSERRDYFHETDEDINKKAKAIFANGLTPIVCCGESLETYEAGKAVEFVGAQVSAALAGLSAEQV
ASLVLAYEPIWAIGTGKSATQDDAQNMCKAVRDVVAADFGQEVADKVRVQYGGSVKPENVKDYMACPDVDGALVGGASLE
ADSFLALLDFLN

Sequences:

>Translated_252_residues
MSRKPIIAGNWKMNKNPQEAKAFVEAVASKLPSTDLVDVAVAAPAVDLVTTIEAAKDSVLKVAAQNCYFENTGAFTGETS
PKVLAEMGADYVVIGHSERRDYFHETDEDINKKAKAIFANGLTPIVCCGESLETYEAGKAVEFVGAQVSAALAGLSAEQV
ASLVLAYEPIWAIGTGKSATQDDAQNMCKAVRDVVAADFGQEVADKVRVQYGGSVKPENVKDYMACPDVDGALVGGASLE
ADSFLALLDFLN
>Mature_251_residues
SRKPIIAGNWKMNKNPQEAKAFVEAVASKLPSTDLVDVAVAAPAVDLVTTIEAAKDSVLKVAAQNCYFENTGAFTGETSP
KVLAEMGADYVVIGHSERRDYFHETDEDINKKAKAIFANGLTPIVCCGESLETYEAGKAVEFVGAQVSAALAGLSAEQVA
SLVLAYEPIWAIGTGKSATQDDAQNMCKAVRDVVAADFGQEVADKVRVQYGGSVKPENVKDYMACPDVDGALVGGASLEA
DSFLALLDFLN

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=252, Percent_Identity=40.8730158730159, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI226529917, Length=252, Percent_Identity=40.8730158730159, Blast_Score=172, Evalue=2e-43,
Organism=Escherichia coli, GI1790353, Length=246, Percent_Identity=43.0894308943089, Blast_Score=197, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17536593, Length=250, Percent_Identity=40.8, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6320255, Length=253, Percent_Identity=39.1304347826087, Blast_Score=181, Evalue=1e-46,
Organism=Drosophila melanogaster, GI28572008, Length=257, Percent_Identity=41.2451361867704, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI28572006, Length=257, Percent_Identity=41.2451361867704, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI28572004, Length=257, Percent_Identity=41.2451361867704, Blast_Score=180, Evalue=6e-46,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26618; Mature: 26487

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKPIIAGNWKMNKNPQEAKAFVEAVASKLPSTDLVDVAVAAPAVDLVTTIEAAKDSVL
CCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHH
KVAAQNCYFENTGAFTGETSPKVLAEMGADYVVIGHSERRDYFHETDEDINKKAKAIFAN
HHHHHHCEECCCCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHCCCHHHHHHHHHHHHHC
GLTPIVCCGESLETYEAGKAVEFVGAQVSAALAGLSAEQVASLVLAYEPIWAIGTGKSAT
CCCEEEECCCCHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCCC
QDDAQNMCKAVRDVVAADFGQEVADKVRVQYGGSVKPENVKDYMACPDVDGALVGGASLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCEECCCCCC
ADSFLALLDFLN
HHHHHHHHHHCC
>Mature Secondary Structure 
SRKPIIAGNWKMNKNPQEAKAFVEAVASKLPSTDLVDVAVAAPAVDLVTTIEAAKDSVL
CCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHH
KVAAQNCYFENTGAFTGETSPKVLAEMGADYVVIGHSERRDYFHETDEDINKKAKAIFAN
HHHHHHCEECCCCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHCCCHHHHHHHHHHHHHC
GLTPIVCCGESLETYEAGKAVEFVGAQVSAALAGLSAEQVASLVLAYEPIWAIGTGKSAT
CCCEEEECCCCHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCCC
QDDAQNMCKAVRDVVAADFGQEVADKVRVQYGGSVKPENVKDYMACPDVDGALVGGASLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCEECCCCCC
ADSFLALLDFLN
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA