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The map label for this gene is rnr1 [H]

Identifier: 15674608

GI number: 15674608

Start: 403871

End: 406204

Strand: Direct

Name: rnr1 [H]

Synonym: SPy_0503

Alternate gene names: 15674608

Gene position: 403871-406204 (Clockwise)

Preceding gene: 15674607

Following gene: 15674609

Centisome position: 21.8

GC content: 41.6

Gene sequence:

>2334_bases
ATGATGAAAGAAAGAATTATGACTTACCTCAAGGAGCATGGCAAGTCCAATGTGAACGACTTGGCTGCGGCCTTGGAGAT
GGCTGGAGCTAAGCATTTTCCCAGCCTTATTAAAACCATTTCCAAAATGGAAAGTCAGAGCCTGTTACGGTTTTCAGATG
ATGGCAGTCTGGCTCTTAGAAAAGAGCGTGAAAAGAAAAAAGAACCTACTGTTCAGGGTGTTTTTCGTGCCAATAAAGCA
GGCTTTGGTTTCTTACATGTGGATGAGAATGAAGATGACATGTTTATCGGTCGTAATGATGTTGGGTATGCTATTGATGG
TGATACTGTCGAAGTAGTGGTTAAAAAGCCAGCAGACCGTCTCAAAGGCACAGCGGCTGAAGCTAAGGTCGTTGCTATTG
TTGACCGTTCTTTAAAAACAGCTGTTGGAACCTTTATTTTAGATGATGACAAACCAAAATATGCTGGTTATATCAGGTCC
AAAAACCAAAAGATTCAACAAAAAATCTATATCAAAAAAGAACCTGTTGTGCTTAAAGGCACTGAAATCATCAAGGTTGA
TATTGATAAATACCCGATACGCGGGCACGATTATTTTGTAGCCAGTGTGCGTGATATCGTAGGCCATCAAGGAGACGTTG
GAATTGATGTCCTAGAAGTCCTTGAATCGATGGATATCGTGTCAGAATTTCCAGCAGAAGTTTTAGCTGAGGCCAATGCT
ATTTCAGAAGCACCAACTGCTAAAGATTTAATAGGCCGTGTGGATTTGCGTCAAGAAACCACCATTACTATTGATGGTGC
GGACGCCAAAGACTTAGATGATGCTATCCATATTAAGCTATTGGATAACGGGAATTATGAACTTGGGGTACATATTGCGG
ATGTCTCATATTATGTGACAGAAGGATCTGCCCTTGATAAGGAAGCTATCGCCCGTGGCACTTCTGTCTATGTCACCGAT
CGTGTGGTTCCGATGTTACCAGAGCGTTTGTCAAATGGCATCTGCTCTTTGAACCCTAACATTGATCGTTTGACCCAGTC
AGCCTTGATGGAAATTAATTCTCAAGGGCATGTGGTCAATTATCAAATCTGTCAATCAGTGATTAAGACAACTTACCGAA
TGACGTATAGTACGGTCAATGACATGATTGCAGGAGATGAAGAAGCGCTCCAAGAATTCGCTAGCATTGCTGATGATGTG
ACCCTCATGGTGGCTTTGCATAGGATTTTGGAAGCTATGCGGTCAAAACGAGGCGCCTTGAATTTTGATACGCAAGAAGC
AAAAATTATTGTTAATGACAAAGGAATGCCGGTTGATGTGGTGCTTCGTCAAAGGGGCATTGCGGAGCGGATGATTGAAT
CCTTTATGCTAGCAGCCAATGAGTGTGTTGCGGAGCATTTTGCAAAAGCTAAGTTACCGTTTATCTACCGTATTCACGAA
GAACCAAAGGCCGAAAAACTTCAACAATTTATTGATTACGCTAGCACCTTTGGTATTCACATTCAAGGAACAGCCAACAA
GATTTCTCAGGAAGCCTTGCAAGCCTTTATGGCAAAAGTCGAAGGTCAACCAGGAGCAGAAGTGCTCAACATGATGCTTC
TACGTTCCATGCAACAAGCGAGGTATTCTGAACATAATCATGGCCATTACGGTTTGGCCGCAGAATATTACACTCACTTT
ACCAGTCCGATTCGTCGTTACCCTGACTTATTGGTTCACCGCATGGTTCGTGAGTACAATCAACCTAGTCAAGAAAAGCG
CGACCATTTTGCTCAGATCATTCCAGAATTAGCAACATCTTCTTCACAGTTAGAGCGTCGTGCTATTGATGCTGAACGCG
TGGTTGAAGCCATGAAAAAAGCTGAGTATATGGCAGAGTATGTCGGCGAAGAATTTGACGGTATCGTTTCCAGTGTCGTT
AAATTTGGTTTTTTTGTAGAATTGCCAAATACGATTGAAGGTTTGGTTCATATCACTAGCTTACCGGAATACTATCACTT
TAATGAAAGAACGCTAAGCCTTCAAGGTGAAAAATCAGGTAAGGTCTTTAAGGTCGGTCAACCTATTCGTGTGAAATTGG
TTAAGGCTGACAAGGAAACTGGTGACATTGACTTTGAGTATTTACCTAGCGACTTTGATGTGGTTGAAAAAATCAAGATG
TCGGATAAAGCTAGTCGACGAGATCGCCGTAAATCCTCAAAATCATCTAAAGGGACAAAGAAAAAAGAACCTAAAGAAGT
AGCCAAGGCAAAAACCAAGGGTAAAACTAAAAAAGGGTCTAAAAAACCATTTTACAAAGAACAAGCAAAAAAGAAGAGTC
GTAAAAGGAGTTAA

Upstream 100 bases:

>100_bases
TAAATAAGGAGTGAGCTTGACAGAGTTAGTCTAGCTCATTTTTTTATCAGCGAAACGGATTGATATCCTCCAACAAACAA
AACAGAAATAGAAATTAGGT

Downstream 100 bases:

>100_bases
CTATGGCAAAAGGTGAAGGTCATATACTGGCGCAAAATAAAAAGGCTAGACATGATTATCACATTGTTGAAACCGTTGAA
GCAGGGATTGTCTTAACGGG

Product: putative exoribonuclease R

Products: NA

Alternate protein names: RNase R 1; VacB protein homolog 1 [H]

Number of amino acids: Translated: 777; Mature: 777

Protein sequence:

>777_residues
MMKERIMTYLKEHGKSNVNDLAAALEMAGAKHFPSLIKTISKMESQSLLRFSDDGSLALRKEREKKKEPTVQGVFRANKA
GFGFLHVDENEDDMFIGRNDVGYAIDGDTVEVVVKKPADRLKGTAAEAKVVAIVDRSLKTAVGTFILDDDKPKYAGYIRS
KNQKIQQKIYIKKEPVVLKGTEIIKVDIDKYPIRGHDYFVASVRDIVGHQGDVGIDVLEVLESMDIVSEFPAEVLAEANA
ISEAPTAKDLIGRVDLRQETTITIDGADAKDLDDAIHIKLLDNGNYELGVHIADVSYYVTEGSALDKEAIARGTSVYVTD
RVVPMLPERLSNGICSLNPNIDRLTQSALMEINSQGHVVNYQICQSVIKTTYRMTYSTVNDMIAGDEEALQEFASIADDV
TLMVALHRILEAMRSKRGALNFDTQEAKIIVNDKGMPVDVVLRQRGIAERMIESFMLAANECVAEHFAKAKLPFIYRIHE
EPKAEKLQQFIDYASTFGIHIQGTANKISQEALQAFMAKVEGQPGAEVLNMMLLRSMQQARYSEHNHGHYGLAAEYYTHF
TSPIRRYPDLLVHRMVREYNQPSQEKRDHFAQIIPELATSSSQLERRAIDAERVVEAMKKAEYMAEYVGEEFDGIVSSVV
KFGFFVELPNTIEGLVHITSLPEYYHFNERTLSLQGEKSGKVFKVGQPIRVKLVKADKETGDIDFEYLPSDFDVVEKIKM
SDKASRRDRRKSSKSSKGTKKKEPKEVAKAKTKGKTKKGSKKPFYKEQAKKKSRKRS

Sequences:

>Translated_777_residues
MMKERIMTYLKEHGKSNVNDLAAALEMAGAKHFPSLIKTISKMESQSLLRFSDDGSLALRKEREKKKEPTVQGVFRANKA
GFGFLHVDENEDDMFIGRNDVGYAIDGDTVEVVVKKPADRLKGTAAEAKVVAIVDRSLKTAVGTFILDDDKPKYAGYIRS
KNQKIQQKIYIKKEPVVLKGTEIIKVDIDKYPIRGHDYFVASVRDIVGHQGDVGIDVLEVLESMDIVSEFPAEVLAEANA
ISEAPTAKDLIGRVDLRQETTITIDGADAKDLDDAIHIKLLDNGNYELGVHIADVSYYVTEGSALDKEAIARGTSVYVTD
RVVPMLPERLSNGICSLNPNIDRLTQSALMEINSQGHVVNYQICQSVIKTTYRMTYSTVNDMIAGDEEALQEFASIADDV
TLMVALHRILEAMRSKRGALNFDTQEAKIIVNDKGMPVDVVLRQRGIAERMIESFMLAANECVAEHFAKAKLPFIYRIHE
EPKAEKLQQFIDYASTFGIHIQGTANKISQEALQAFMAKVEGQPGAEVLNMMLLRSMQQARYSEHNHGHYGLAAEYYTHF
TSPIRRYPDLLVHRMVREYNQPSQEKRDHFAQIIPELATSSSQLERRAIDAERVVEAMKKAEYMAEYVGEEFDGIVSSVV
KFGFFVELPNTIEGLVHITSLPEYYHFNERTLSLQGEKSGKVFKVGQPIRVKLVKADKETGDIDFEYLPSDFDVVEKIKM
SDKASRRDRRKSSKSSKGTKKKEPKEVAKAKTKGKTKKGSKKPFYKEQAKKKSRKRS
>Mature_777_residues
MMKERIMTYLKEHGKSNVNDLAAALEMAGAKHFPSLIKTISKMESQSLLRFSDDGSLALRKEREKKKEPTVQGVFRANKA
GFGFLHVDENEDDMFIGRNDVGYAIDGDTVEVVVKKPADRLKGTAAEAKVVAIVDRSLKTAVGTFILDDDKPKYAGYIRS
KNQKIQQKIYIKKEPVVLKGTEIIKVDIDKYPIRGHDYFVASVRDIVGHQGDVGIDVLEVLESMDIVSEFPAEVLAEANA
ISEAPTAKDLIGRVDLRQETTITIDGADAKDLDDAIHIKLLDNGNYELGVHIADVSYYVTEGSALDKEAIARGTSVYVTD
RVVPMLPERLSNGICSLNPNIDRLTQSALMEINSQGHVVNYQICQSVIKTTYRMTYSTVNDMIAGDEEALQEFASIADDV
TLMVALHRILEAMRSKRGALNFDTQEAKIIVNDKGMPVDVVLRQRGIAERMIESFMLAANECVAEHFAKAKLPFIYRIHE
EPKAEKLQQFIDYASTFGIHIQGTANKISQEALQAFMAKVEGQPGAEVLNMMLLRSMQQARYSEHNHGHYGLAAEYYTHF
TSPIRRYPDLLVHRMVREYNQPSQEKRDHFAQIIPELATSSSQLERRAIDAERVVEAMKKAEYMAEYVGEEFDGIVSSVV
KFGFFVELPNTIEGLVHITSLPEYYHFNERTLSLQGEKSGKVFKVGQPIRVKLVKADKETGDIDFEYLPSDFDVVEKIKM
SDKASRRDRRKSSKSSKGTKKKEPKEVAKAKTKGKTKKGSKKPFYKEQAKKKSRKRS

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=471, Percent_Identity=30.7855626326964, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI190014625, Length=471, Percent_Identity=30.7855626326964, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI134288890, Length=394, Percent_Identity=32.2335025380711, Blast_Score=202, Evalue=1e-51,
Organism=Homo sapiens, GI19115966, Length=407, Percent_Identity=28.7469287469287, Blast_Score=154, Evalue=4e-37,
Organism=Homo sapiens, GI219521928, Length=407, Percent_Identity=28.7469287469287, Blast_Score=154, Evalue=4e-37,
Organism=Homo sapiens, GI156105695, Length=561, Percent_Identity=23.7076648841355, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI156105693, Length=366, Percent_Identity=23.4972677595628, Blast_Score=81, Evalue=4e-15,
Organism=Escherichia coli, GI87082383, Length=722, Percent_Identity=32.2714681440443, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1787542, Length=681, Percent_Identity=25.9911894273128, Blast_Score=165, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17553506, Length=409, Percent_Identity=31.2958435207824, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI212645896, Length=472, Percent_Identity=29.8728813559322, Blast_Score=180, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324552, Length=606, Percent_Identity=29.7029702970297, Blast_Score=183, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6320499, Length=319, Percent_Identity=26.6457680250784, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323943, Length=429, Percent_Identity=22.6107226107226, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24649634, Length=564, Percent_Identity=30.1418439716312, Blast_Score=211, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24654592, Length=546, Percent_Identity=28.5714285714286, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI19922976, Length=546, Percent_Identity=28.5714285714286, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24654597, Length=546, Percent_Identity=28.5714285714286, Blast_Score=171, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 87329; Mature: 87329

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKERIMTYLKEHGKSNVNDLAAALEMAGAKHFPSLIKTISKMESQSLLRFSDDGSLALR
CCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCEEHH
KEREKKKEPTVQGVFRANKAGFGFLHVDENEDDMFIGRNDVGYAIDGDTVEVVVKKPADR
HHHHHHCCCCHHHHHHCCCCCCEEEEECCCCCCEEECCCCCCEEECCCEEEEEEECCHHH
LKGTAAEAKVVAIVDRSLKTAVGTFILDDDKPKYAGYIRSKNQKIQQKIYIKKEPVVLKG
HCCCHHHCEEEEEHHHHHHHHHCEEEECCCCCCHHHHHHCCCHHHHHHHEEECCCEEEEC
TEIIKVDIDKYPIRGHDYFVASVRDIVGHQGDVGIDVLEVLESMDIVSEFPAEVLAEANA
CEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHH
ISEAPTAKDLIGRVDLRQETTITIDGADAKDLDDAIHIKLLDNGNYELGVHIADVSYYVT
HCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCEEEEEEEEEEEEEEE
EGSALDKEAIARGTSVYVTDRVVPMLPERLSNGICSLNPNIDRLTQSALMEINSQGHVVN
CCCCCCHHHHHCCCEEEEECCHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCEEE
YQICQSVIKTTYRMTYSTVNDMIAGDEEALQEFASIADDVTLMVALHRILEAMRSKRGAL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NFDTQEAKIIVNDKGMPVDVVLRQRGIAERMIESFMLAANECVAEHFAKAKLPFIYRIHE
CCCCCCCEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
EPKAEKLQQFIDYASTFGIHIQGTANKISQEALQAFMAKVEGQPGAEVLNMMLLRSMQQA
CCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
RYSEHNHGHYGLAAEYYTHFTSPIRRYPDLLVHRMVREYNQPSQEKRDHFAQIIPELATS
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
SSQLERRAIDAERVVEAMKKAEYMAEYVGEEFDGIVSSVVKFGFFVELPNTIEGLVHITS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHC
LPEYYHFNERTLSLQGEKSGKVFKVGQPIRVKLVKADKETGDIDFEYLPSDFDVVEKIKM
CCHHHCCCCEEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCCEEECCCCHHHHHHHHH
SDKASRRDRRKSSKSSKGTKKKEPKEVAKAKTKGKTKKGSKKPFYKEQAKKKSRKRS
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MMKERIMTYLKEHGKSNVNDLAAALEMAGAKHFPSLIKTISKMESQSLLRFSDDGSLALR
CCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHEEECCCCCEEHH
KEREKKKEPTVQGVFRANKAGFGFLHVDENEDDMFIGRNDVGYAIDGDTVEVVVKKPADR
HHHHHHCCCCHHHHHHCCCCCCEEEEECCCCCCEEECCCCCCEEECCCEEEEEEECCHHH
LKGTAAEAKVVAIVDRSLKTAVGTFILDDDKPKYAGYIRSKNQKIQQKIYIKKEPVVLKG
HCCCHHHCEEEEEHHHHHHHHHCEEEECCCCCCHHHHHHCCCHHHHHHHEEECCCEEEEC
TEIIKVDIDKYPIRGHDYFVASVRDIVGHQGDVGIDVLEVLESMDIVSEFPAEVLAEANA
CEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHH
ISEAPTAKDLIGRVDLRQETTITIDGADAKDLDDAIHIKLLDNGNYELGVHIADVSYYVT
HCCCCCHHHHHHHCCCCCCCEEEECCCCCCCCCCEEEEEEEECCCEEEEEEEEEEEEEEE
EGSALDKEAIARGTSVYVTDRVVPMLPERLSNGICSLNPNIDRLTQSALMEINSQGHVVN
CCCCCCHHHHHCCCEEEEECCHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCEEE
YQICQSVIKTTYRMTYSTVNDMIAGDEEALQEFASIADDVTLMVALHRILEAMRSKRGAL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NFDTQEAKIIVNDKGMPVDVVLRQRGIAERMIESFMLAANECVAEHFAKAKLPFIYRIHE
CCCCCCCEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
EPKAEKLQQFIDYASTFGIHIQGTANKISQEALQAFMAKVEGQPGAEVLNMMLLRSMQQA
CCCHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
RYSEHNHGHYGLAAEYYTHFTSPIRRYPDLLVHRMVREYNQPSQEKRDHFAQIIPELATS
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
SSQLERRAIDAERVVEAMKKAEYMAEYVGEEFDGIVSSVVKFGFFVELPNTIEGLVHITS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHC
LPEYYHFNERTLSLQGEKSGKVFKVGQPIRVKLVKADKETGDIDFEYLPSDFDVVEKIKM
CCHHHCCCCEEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCCEEECCCCHHHHHHHHH
SDKASRRDRRKSSKSSKGTKKKEPKEVAKAKTKGKTKKGSKKPFYKEQAKKKSRKRS
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]