Click here to switch to the map view.

The map label for this gene is fhuD [H]

Identifier: 15674531

GI number: 15674531

Start: 328629

End: 329561

Strand: Reverse

Name: fhuD [H]

Synonym: SPy_0385

Alternate gene names: 15674531

Gene position: 329561-328629 (Counterclockwise)

Preceding gene: 15674532

Following gene: 15674530

Centisome position: 17.79

GC content: 38.05

Gene sequence:

>933_bases
ATGAAAAAATTAACTCTACTATTAACACTCTGTTTGACAACTATTACCTTAATCGCCTGTGGTAATCAAGCAACTAATCA
TTCTAACACCGCCTCAAAAAGTTTATCGCCTATGCCTCAAATTGCTGGTGTGACTTATTACGGAGATATTCCTAAACAGC
CTAAGCGAGTAGTCAGTCTGGCTTCAACTTACACTGGTTACCTCAAAAAATTAGATATGAATCTAGTCGGGGTTACTTCT
TATGACAAGAAAAACCCCATCTTAGCAAAGACTGTAAAAAAAGCAAAGCAAGTTGCTGCAACTGATTTAGAAGCCGTTAC
AACGCTTAAGCCTGACCTCATTGTTGTTGGCTCTACAGAAGAAAATATTAAACAATTGGCAGAAATTGCGCCTGTTATCT
CGATTGAATACCGCAAACGTGATTATTTACAAGTGTTATCTGACTTCGGCCGCATCTTTAACAAAGAAGACAAAGCCAAG
AAGTGGTTAAAAGATTGGAAAACTAAAACAGCAGCTTATGAAAAAGAAGTCAAGGCCGTTACAGGTGACAAAGCAACCTT
TACTATTATGGGGCTTTATGAAAAAGACGTTTACCTTTTTGGTAAAGACTGGGGACGTGGCGGAGAGATTATCCATCAAG
CTTTCCATTATGATGCTCCTGAAAAAGTGAAGACTGAAGTTTTTAAACAAGGTTACCTGTCATTGTCGCAGGAAGTCTTG
CCAGACTATATTGGTGATTATGTCGTCGTTGCTGCAGAAGATGATAAGACTGGTTCTGCTCTATATGAAAGCAAGCTATG
GCAATCCATTCCAGCTGTGAAAAAACACCATGTGATCAAAGTCAATGCCAATGTTTTTTACTTTACTGATCCTCTTTCTT
TAGAATATCAATTAGAGACTTTACGAGAGGCAATCTTATCAAGTGAAAACTAA

Upstream 100 bases:

>100_bases
TTCCAAATCAAACCGGTACTGGTTGATGATCCTATCCACAACTGTCCTATAGTGCTGACTTATCAGCTTCAATAACTTTA
TTCTAGGAGAATTAGCATAC

Downstream 100 bases:

>100_bases
GCATCCCTTTTTGTGTCTCGAGCGTTTTTGCTTAAAAAAAACGCAGATAATCACTAAGTCACATATCTTTTGGCTTGTCT
TTGTGCTACTTAGTTTTAGC

Product: ferrichrome ABC transporter ferrichrome-binding protein

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein D; Ferrichrome-binding protein; Iron(III)-hydroxamate-binding protein fhuD [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKKLTLLLTLCLTTITLIACGNQATNHSNTASKSLSPMPQIAGVTYYGDIPKQPKRVVSLASTYTGYLKKLDMNLVGVTS
YDKKNPILAKTVKKAKQVAATDLEAVTTLKPDLIVVGSTEENIKQLAEIAPVISIEYRKRDYLQVLSDFGRIFNKEDKAK
KWLKDWKTKTAAYEKEVKAVTGDKATFTIMGLYEKDVYLFGKDWGRGGEIIHQAFHYDAPEKVKTEVFKQGYLSLSQEVL
PDYIGDYVVVAAEDDKTGSALYESKLWQSIPAVKKHHVIKVNANVFYFTDPLSLEYQLETLREAILSSEN

Sequences:

>Translated_310_residues
MKKLTLLLTLCLTTITLIACGNQATNHSNTASKSLSPMPQIAGVTYYGDIPKQPKRVVSLASTYTGYLKKLDMNLVGVTS
YDKKNPILAKTVKKAKQVAATDLEAVTTLKPDLIVVGSTEENIKQLAEIAPVISIEYRKRDYLQVLSDFGRIFNKEDKAK
KWLKDWKTKTAAYEKEVKAVTGDKATFTIMGLYEKDVYLFGKDWGRGGEIIHQAFHYDAPEKVKTEVFKQGYLSLSQEVL
PDYIGDYVVVAAEDDKTGSALYESKLWQSIPAVKKHHVIKVNANVFYFTDPLSLEYQLETLREAILSSEN
>Mature_310_residues
MKKLTLLLTLCLTTITLIACGNQATNHSNTASKSLSPMPQIAGVTYYGDIPKQPKRVVSLASTYTGYLKKLDMNLVGVTS
YDKKNPILAKTVKKAKQVAATDLEAVTTLKPDLIVVGSTEENIKQLAEIAPVISIEYRKRDYLQVLSDFGRIFNKEDKAK
KWLKDWKTKTAAYEKEVKAVTGDKATFTIMGLYEKDVYLFGKDWGRGGEIIHQAFHYDAPEKVKTEVFKQGYLSLSQEVL
PDYIGDYVVVAAEDDKTGSALYESKLWQSIPAVKKHHVIKVNANVFYFTDPLSLEYQLETLREAILSSEN

Specific function: Part of the ABC transporter complex fhuCBGD involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of ferrichrome and coprogen [H]

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 34747; Mature: 34747

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50983 FE_B12_PBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLTLLLTLCLTTITLIACGNQATNHSNTASKSLSPMPQIAGVTYYGDIPKQPKRVVSL
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHHCCEEEECCCCCCHHHHHHH
ASTYTGYLKKLDMNLVGVTSYDKKNPILAKTVKKAKQVAATDLEAVTTLKPDLIVVGSTE
HHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCH
ENIKQLAEIAPVISIEYRKRDYLQVLSDFGRIFNKEDKAKKWLKDWKTKTAAYEKEVKAV
HHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TGDKATFTIMGLYEKDVYLFGKDWGRGGEIIHQAFHYDAPEKVKTEVFKQGYLSLSQEVL
CCCCEEEEEEEEEECCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
PDYIGDYVVVAAEDDKTGSALYESKLWQSIPAVKKHHVIKVNANVFYFTDPLSLEYQLET
HHHCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHCEEEEEECEEEEEECCCCHHHHHHH
LREAILSSEN
HHHHHHCCCC
>Mature Secondary Structure
MKKLTLLLTLCLTTITLIACGNQATNHSNTASKSLSPMPQIAGVTYYGDIPKQPKRVVSL
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHHCCEEEECCCCCCHHHHHHH
ASTYTGYLKKLDMNLVGVTSYDKKNPILAKTVKKAKQVAATDLEAVTTLKPDLIVVGSTE
HHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCH
ENIKQLAEIAPVISIEYRKRDYLQVLSDFGRIFNKEDKAKKWLKDWKTKTAAYEKEVKAV
HHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TGDKATFTIMGLYEKDVYLFGKDWGRGGEIIHQAFHYDAPEKVKTEVFKQGYLSLSQEVL
CCCCEEEEEEEEEECCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
PDYIGDYVVVAAEDDKTGSALYESKLWQSIPAVKKHHVIKVNANVFYFTDPLSLEYQLET
HHHCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHCEEEEEECEEEEEECCCCHHHHHHH
LREAILSSEN
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8388528; 9639930; 9384377 [H]