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The map label for this gene is fhuB.1 [H]

Identifier: 15674530

GI number: 15674530

Start: 327698

End: 328618

Strand: Reverse

Name: fhuB.1 [H]

Synonym: SPy_0384

Alternate gene names: 15674530

Gene position: 328618-327698 (Counterclockwise)

Preceding gene: 15674531

Following gene: 15674529

Centisome position: 17.74

GC content: 42.24

Gene sequence:

>921_bases
TTGTGTCTCGAGCGTTTTTGCTTAAAAAAAACGCAGATAATCACTAAGTCACATATCTTTTGGCTTGTCTTTGTGCTACT
TAGTTTTAGCTTATGTGTTGCTATTTACTGTCATCTGCGCTTTGGAGCCGTTGCTTTATCACATCAGGATCTTAACTCTA
TTTTATTTGGAAAGCAAAACGGCCATAAAGCCAATGTTTTACTCGCTATACGATTACCGAGACTTTTTGGTGCTACCTTA
ACTGGCTCTGCGTTAGCTGTTTCTGGAACTATCATGCAAGCAATCACACGTAATCCTATCGCTGAGCCTGGCCTTTTAGG
CATTAATGCTGGAGCAGGACTAGCCTTGGTACTGGCTTATGCGTTTGTACCTCACTTGCACTATTCCCTCATTATTCTGC
TTTCGTTGTTAGGGTCTAGCCTGGCAGCAACCTTAGTCTTTGGCCTTTCTTATCAATCTGGCAAAGGCTACCATCAGCTC
CGCCTTGTCTTAGCAGGAGCTATGGTTTCCATACTGCTATCAGCATTAGGTCAAGGTATTACCAATTACTATCATCTGGC
AAATGCTGTTATCGGCTGGCAAGCAGGAGGTCTTGTCGGGGTCAATTGGCAAATGATCGGCTATATTGCTCCTCTTATTA
TTCTTAGTCTTTGTTTAGCCCAGCTATTATCTTATCACCTGACCGTCCTTAGTCTAAGTGAGTCTCAGGCAAAAGCTCTT
GGGCAAAAAACCAACTTGATCAGTGCAGTCTTTATGATTTTGGTTCTTATTTTATCATCAGCAGCTGTAGCCATTGCTGG
AAGCATTTCTTTTATCGGCTTAGTCATTCCTCATCTTATGAAACATTTTACACCTCATCATTACCGATACCTTTTGCCGC
TTTGTGCAGTTTCTGGCGCTAGTTTCAATGGTATGGGTTGA

Upstream 100 bases:

>100_bases
AATGCCAATGTTTTTTACTTTACTGATCCTCTTTCTTTAGAATATCAATTAGAGACTTTACGAGAGGCAATCTTATCAAG
TGAAAACTAAGCATCCCTTT

Downstream 100 bases:

>100_bases
TATTGCTTGTCGTAATCTCAATCCGCCTTATGAAACCCCTCTTGGGGCATTGGTTAGCTTAATTGGTTTTCCATGCTTTT
TATGGGTAATAAGAAGAGGA

Product: putative ferrichrome ABC transporter permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MCLERFCLKKTQIITKSHIFWLVFVLLSFSLCVAIYCHLRFGAVALSHQDLNSILFGKQNGHKANVLLAIRLPRLFGATL
TGSALAVSGTIMQAITRNPIAEPGLLGINAGAGLALVLAYAFVPHLHYSLIILLSLLGSSLAATLVFGLSYQSGKGYHQL
RLVLAGAMVSILLSALGQGITNYYHLANAVIGWQAGGLVGVNWQMIGYIAPLIILSLCLAQLLSYHLTVLSLSESQAKAL
GQKTNLISAVFMILVLILSSAAVAIAGSISFIGLVIPHLMKHFTPHHYRYLLPLCAVSGASFNGMG

Sequences:

>Translated_306_residues
MCLERFCLKKTQIITKSHIFWLVFVLLSFSLCVAIYCHLRFGAVALSHQDLNSILFGKQNGHKANVLLAIRLPRLFGATL
TGSALAVSGTIMQAITRNPIAEPGLLGINAGAGLALVLAYAFVPHLHYSLIILLSLLGSSLAATLVFGLSYQSGKGYHQL
RLVLAGAMVSILLSALGQGITNYYHLANAVIGWQAGGLVGVNWQMIGYIAPLIILSLCLAQLLSYHLTVLSLSESQAKAL
GQKTNLISAVFMILVLILSSAAVAIAGSISFIGLVIPHLMKHFTPHHYRYLLPLCAVSGASFNGMG
>Mature_306_residues
MCLERFCLKKTQIITKSHIFWLVFVLLSFSLCVAIYCHLRFGAVALSHQDLNSILFGKQNGHKANVLLAIRLPRLFGATL
TGSALAVSGTIMQAITRNPIAEPGLLGINAGAGLALVLAYAFVPHLHYSLIILLSLLGSSLAATLVFGLSYQSGKGYHQL
RLVLAGAMVSILLSALGQGITNYYHLANAVIGWQAGGLVGVNWQMIGYIAPLIILSLCLAQLLSYHLTVLSLSESQAKAL
GQKTNLISAVFMILVLILSSAAVAIAGSISFIGLVIPHLMKHFTPHHYRYLLPLCAVSGASFNGMG

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=284, Percent_Identity=33.4507042253521, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1786804, Length=266, Percent_Identity=33.4586466165414, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1786805, Length=242, Percent_Identity=32.6446280991736, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790741, Length=296, Percent_Identity=32.7702702702703, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788004, Length=233, Percent_Identity=34.7639484978541, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786347, Length=239, Percent_Identity=27.6150627615063, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 32663; Mature: 32663

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCLERFCLKKTQIITKSHIFWLVFVLLSFSLCVAIYCHLRFGAVALSHQDLNSILFGKQN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
GHKANVLLAIRLPRLFGATLTGSALAVSGTIMQAITRNPIAEPGLLGINAGAGLALVLAY
CCCEEEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHH
AFVPHLHYSLIILLSLLGSSLAATLVFGLSYQSGKGYHQLRLVLAGAMVSILLSALGQGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TNYYHLANAVIGWQAGGLVGVNWQMIGYIAPLIILSLCLAQLLSYHLTVLSLSESQAKAL
HHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
GQKTNLISAVFMILVLILSSAAVAIAGSISFIGLVIPHLMKHFTPHHYRYLLPLCAVSGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
SFNGMG
CCCCCC
>Mature Secondary Structure
MCLERFCLKKTQIITKSHIFWLVFVLLSFSLCVAIYCHLRFGAVALSHQDLNSILFGKQN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
GHKANVLLAIRLPRLFGATLTGSALAVSGTIMQAITRNPIAEPGLLGINAGAGLALVLAY
CCCEEEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHH
AFVPHLHYSLIILLSLLGSSLAATLVFGLSYQSGKGYHQLRLVLAGAMVSILLSALGQGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TNYYHLANAVIGWQAGGLVGVNWQMIGYIAPLIILSLCLAQLLSYHLTVLSLSESQAKAL
HHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
GQKTNLISAVFMILVLILSSAAVAIAGSISFIGLVIPHLMKHFTPHHYRYLLPLCAVSGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
SFNGMG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]