Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

Click here to switch to the map view.

The map label for this gene is purA [H]

Identifier: 15674367

GI number: 15674367

Start: 145841

End: 147133

Strand: Direct

Name: purA [H]

Synonym: SPy_0160

Alternate gene names: 15674367

Gene position: 145841-147133 (Clockwise)

Preceding gene: 15674364

Following gene: 15674368

Centisome position: 7.87

GC content: 43.23

Gene sequence:

>1293_bases
ATGACATCTGTAGTTGTTGTTGGTACCCAGTGGGGTGACGAAGGTAAAGGTAAAATCACTGATTTCTTGTCAGCGGATGC
AGAAGTAATTGCACGCTATCAAGGTGGTGATAATGCTGGTCATACGATCGTGATTGATGGTAAGAAGTTTAAACTTCACT
TGATCCCATCAGGAATTTTCTTCCCGCAAAAAATTTCCGTTATTGGTAATGGCGTTGTGGTCAACCCCAAATCTTTGGTC
AAAGAGTTGGCGTACCTGCATGATGAAGGAGTGACGACAGATAACCTTCGCATTTCAGACCGAGCTCATGTCATTTTACC
TTATCATATCCAGCTGGATCAACTGCAAGAAGATGCAAAAGGTGACAATAAAATCGGAACAACTATTAAAGGGATTGGTC
CAGCTTATATGGATAAAGCTGCTCGAGTTGGTATCCGTATCGCAGATTTACTGGATAAGGATATCTTTGCAGAGCGCCTA
CGCATTAATTTAGCTGAGAAAAACCGTTTATTTGAAAAAATGTATGACAGTACACCTCTTGATTTTGATGCTATTTTTGA
AGAATACTATGCTTACGGTCAAGAAATCAAGCAATATGTGACAGATACTTCTGTAATTTTAAATGATGCACTTGATGCCG
GTAAACGTGTTCTTTTTGAAGGTGCACAAGGGGTTATGCTTGATATTGACCAAGGAACGTACCCATTTGTAACGTCTTCA
AACCCAGTTGCTGGTGGTGTAACCATTGGTTCTGGTGTTGGCCCAAATAAAATCAACAAAGTAGTTGGTGTCTGTAAAGC
CTACACAAGCCGTGTCGGTGATGGGCCATTCCCTACAGAACTCTTTGATGAAGTGGGTGAGCGCATTCGTGAAGTGGGTC
ATGAGTACGGGACAACGACCGGCCGTCCACGTCGTGTCGGTTGGTTTGATTCGGTTGTCATGCGCCACAGTCGTCGTGTA
TCAGGTATTACTAACCTCTCTCTGAATTCAATTGATGTTCTTTCAGGGCTTGATACGGTTAAGATTTGTGTGGCTTATGA
CCTTGATGGGAAACGTATTGACTATTACCCAGCAAACCTTGAACAACTCAAACGTTGCAAACCAATCTATGAAGAATTAC
CAGGCTGGCAAGAGGACATCACAGGTGTTCGTAGCCTTGATGAGCTTCCTGAAAATGCCCGCAACTACGTTCGTCGTGTT
GGAGAATTGGTTGGCGTTCGCATTTCAACCTTCTCAGTTGGTCCAGGGCGTGAACAGACCAATATTCTTGAGTCAGTCTG
GGCATCTATCTAA

Upstream 100 bases:

>100_bases
TGATCTTACAGATCTGACCTTCTTTTTGGTTTTTAAGCAGTGGTTAGCTTGCCTATGATTTTTATTGAGAATAAGTGTTT
CAGAAAGTTAGGACAATGAT

Downstream 100 bases:

>100_bases
GGTGTCTAGTATGACAAAGAGTTGGATAGCGTTTCCAGCTCTTTTTACCGTTTGTTGGATTGTATAGTTAGTCATGCTAT
TACTAGTTGCTTGAGTTTTG

Product: adenylosuccinate synthetase

Products: NA

Alternate protein names: AMPSase; AdSS; IMP--aspartate ligase [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MTSVVVVGTQWGDEGKGKITDFLSADAEVIARYQGGDNAGHTIVIDGKKFKLHLIPSGIFFPQKISVIGNGVVVNPKSLV
KELAYLHDEGVTTDNLRISDRAHVILPYHIQLDQLQEDAKGDNKIGTTIKGIGPAYMDKAARVGIRIADLLDKDIFAERL
RINLAEKNRLFEKMYDSTPLDFDAIFEEYYAYGQEIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSS
NPVAGGVTIGSGVGPNKINKVVGVCKAYTSRVGDGPFPTELFDEVGERIREVGHEYGTTTGRPRRVGWFDSVVMRHSRRV
SGITNLSLNSIDVLSGLDTVKICVAYDLDGKRIDYYPANLEQLKRCKPIYEELPGWQEDITGVRSLDELPENARNYVRRV
GELVGVRISTFSVGPGREQTNILESVWASI

Sequences:

>Translated_430_residues
MTSVVVVGTQWGDEGKGKITDFLSADAEVIARYQGGDNAGHTIVIDGKKFKLHLIPSGIFFPQKISVIGNGVVVNPKSLV
KELAYLHDEGVTTDNLRISDRAHVILPYHIQLDQLQEDAKGDNKIGTTIKGIGPAYMDKAARVGIRIADLLDKDIFAERL
RINLAEKNRLFEKMYDSTPLDFDAIFEEYYAYGQEIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSS
NPVAGGVTIGSGVGPNKINKVVGVCKAYTSRVGDGPFPTELFDEVGERIREVGHEYGTTTGRPRRVGWFDSVVMRHSRRV
SGITNLSLNSIDVLSGLDTVKICVAYDLDGKRIDYYPANLEQLKRCKPIYEELPGWQEDITGVRSLDELPENARNYVRRV
GELVGVRISTFSVGPGREQTNILESVWASI
>Mature_429_residues
TSVVVVGTQWGDEGKGKITDFLSADAEVIARYQGGDNAGHTIVIDGKKFKLHLIPSGIFFPQKISVIGNGVVVNPKSLVK
ELAYLHDEGVTTDNLRISDRAHVILPYHIQLDQLQEDAKGDNKIGTTIKGIGPAYMDKAARVGIRIADLLDKDIFAERLR
INLAEKNRLFEKMYDSTPLDFDAIFEEYYAYGQEIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSN
PVAGGVTIGSGVGPNKINKVVGVCKAYTSRVGDGPFPTELFDEVGERIREVGHEYGTTTGRPRRVGWFDSVVMRHSRRVS
GITNLSLNSIDVLSGLDTVKICVAYDLDGKRIDYYPANLEQLKRCKPIYEELPGWQEDITGVRSLDELPENARNYVRRVG
ELVGVRISTFSVGPGREQTNILESVWASI

Specific function: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP [H]

COG id: COG0104

COG function: function code F; Adenylosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylosuccinate synthetase family [H]

Homologues:

Organism=Homo sapiens, GI22748717, Length=421, Percent_Identity=46.7933491686461, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI34577063, Length=423, Percent_Identity=43.4988179669031, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI40316944, Length=392, Percent_Identity=45.4081632653061, Blast_Score=332, Evalue=4e-91,
Organism=Escherichia coli, GI1790620, Length=423, Percent_Identity=48.6997635933806, Blast_Score=414, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI25146553, Length=426, Percent_Identity=44.131455399061, Blast_Score=341, Evalue=4e-94,
Organism=Caenorhabditis elegans, GI25146555, Length=426, Percent_Identity=44.131455399061, Blast_Score=341, Evalue=5e-94,
Organism=Saccharomyces cerevisiae, GI6324109, Length=424, Percent_Identity=42.4528301886792, Blast_Score=358, Evalue=1e-99,
Organism=Drosophila melanogaster, GI21356033, Length=419, Percent_Identity=44.8687350835322, Blast_Score=364, Evalue=1e-101,

Paralogues:

None

Copy number: 940 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018220
- InterPro:   IPR001114 [H]

Pfam domain/function: PF00709 Adenylsucc_synt [H]

EC number: =6.3.4.4 [H]

Molecular weight: Translated: 47462; Mature: 47331

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS01266 ADENYLOSUCCIN_SYN_1 ; PS00513 ADENYLOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVVVVGTQWGDEGKGKITDFLSADAEVIARYQGGDNAGHTIVIDGKKFKLHLIPSGIF
CCCEEEEEECCCCCCCCCHHHHHHCCHHHEEEECCCCCCCCEEEEECCEEEEEEECCCCC
FPQKISVIGNGVVVNPKSLVKELAYLHDEGVTTDNLRISDRAHVILPYHIQLDQLQEDAK
CCCCHHEECCCEEECHHHHHHHHHHHHCCCCCCCCEEECCCEEEEEEEEEEHHHHHHHCC
GDNKIGTTIKGIGPAYMDKAARVGIRIADLLDKDIFAERLRINLAEKNRLFEKMYDSTPL
CCCCCCCEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DFDAIFEEYYAYGQEIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCEEECC
NPVAGGVTIGSGVGPNKINKVVGVCKAYTSRVGDGPFPTELFDEVGERIREVGHEYGTTT
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
GRPRRVGWFDSVVMRHSRRVSGITNLSLNSIDVLSGLDTVKICVAYDLDGKRIDYYPANL
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEEEEEECCCCCEEEECCCCH
EQLKRCKPIYEELPGWQEDITGVRSLDELPENARNYVRRVGELVGVRISTFSVGPGREQT
HHHHHCCHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCEEEEEEECCCCCHHH
NILESVWASI
HHHHHHHHCC
>Mature Secondary Structure 
TSVVVVGTQWGDEGKGKITDFLSADAEVIARYQGGDNAGHTIVIDGKKFKLHLIPSGIF
CCEEEEEECCCCCCCCCHHHHHHCCHHHEEEECCCCCCCCEEEEECCEEEEEEECCCCC
FPQKISVIGNGVVVNPKSLVKELAYLHDEGVTTDNLRISDRAHVILPYHIQLDQLQEDAK
CCCCHHEECCCEEECHHHHHHHHHHHHCCCCCCCCEEECCCEEEEEEEEEEHHHHHHHCC
GDNKIGTTIKGIGPAYMDKAARVGIRIADLLDKDIFAERLRINLAEKNRLFEKMYDSTPL
CCCCCCCEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DFDAIFEEYYAYGQEIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCEEECC
NPVAGGVTIGSGVGPNKINKVVGVCKAYTSRVGDGPFPTELFDEVGERIREVGHEYGTTT
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
GRPRRVGWFDSVVMRHSRRVSGITNLSLNSIDVLSGLDTVKICVAYDLDGKRIDYYPANL
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEEEEEECCCCCEEEECCCCH
EQLKRCKPIYEELPGWQEDITGVRSLDELPENARNYVRRVGELVGVRISTFSVGPGREQT
HHHHHCCHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCEEEEEEECCCCCHHH
NILESVWASI
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA