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The map label for this gene is ntpD

Identifier: 15674364

GI number: 15674364

Start: 142504

End: 143130

Strand: Direct

Name: ntpD

Synonym: SPy_0157

Alternate gene names: 15674364

Gene position: 142504-143130 (Clockwise)

Preceding gene: 15674363

Following gene: 15674367

Centisome position: 7.69

GC content: 38.6

Gene sequence:

>627_bases
ATGGCACGATTAAATGTTAAACCAACACGCATGGAACTTAGTAACTTGAAAAATCGCTTGAAGACAGCTACAAGAGGTCA
TAAATTATTAAAGGACAAGCGGGATGAGTTGATGCGCCGCTTCGTTGATTTAATTCGTGAAAACAATGAGCTTCGGCAAA
CTATCGAAAAAGAACTTGCTGCCAATATGAAGGAGTTTGTCTTGGCAAAAGCATCCGAAAATAGTCTAATGGTAGAAGAA
CTCTTTGCTGTTCCAGTCCATGAAGTGACCTTATGGATTGATATTGAAAATATCATGAGTGTCAATGTGCCTAAATTCCA
TGTCCAGTCTAATACGGCAAGAGAGCAAGAACAAGGTGAGTTTGCTTATAGTTACCTCAGCTCAAATAGTGAGATGGACA
ATACTATCCAAAAGACAAAAGAACTATTAGAAAAGCTCTTACGGTTAGCTGAAGTTGAAAAAACTTGTCAACTAATGGCT
GATGACATTGAAAAGACTAGACGTCGCGTCAATGGCTTAGAGTATTCTATTATCCCGCAACTGAAAGAGACGATTCACTA
CATTGAGTTGAAATTAGAAGAGGCCGAGCGTGCGAGCCTTGTTCGTATTATGAAAATAACATCATAA

Upstream 100 bases:

>100_bases
GTTATTTGCCTAAAGCAGATACCACGATGACAAAGGTTTTTGTTGCAAATGATTGAGTTGACCATGCAATTTCAAGCCCT
TGACGAAAGGAGTTATATCA

Downstream 100 bases:

>100_bases
AAGATAAGTGTTATATCAAACAAGGCGATTATTCGTTAAGTAGTAAAAAAGCAAGCCATCAAAGGGATTAACCTAACTGA
TGGCTTGCTTTTTAAGTAGC

Product: V-type ATP synthase subunit D

Products: ADP; phosphate; H+

Alternate protein names: V-ATPase subunit D

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MARLNVKPTRMELSNLKNRLKTATRGHKLLKDKRDELMRRFVDLIRENNELRQTIEKELAANMKEFVLAKASENSLMVEE
LFAVPVHEVTLWIDIENIMSVNVPKFHVQSNTAREQEQGEFAYSYLSSNSEMDNTIQKTKELLEKLLRLAEVEKTCQLMA
DDIEKTRRRVNGLEYSIIPQLKETIHYIELKLEEAERASLVRIMKITS

Sequences:

>Translated_208_residues
MARLNVKPTRMELSNLKNRLKTATRGHKLLKDKRDELMRRFVDLIRENNELRQTIEKELAANMKEFVLAKASENSLMVEE
LFAVPVHEVTLWIDIENIMSVNVPKFHVQSNTAREQEQGEFAYSYLSSNSEMDNTIQKTKELLEKLLRLAEVEKTCQLMA
DDIEKTRRRVNGLEYSIIPQLKETIHYIELKLEEAERASLVRIMKITS
>Mature_207_residues
ARLNVKPTRMELSNLKNRLKTATRGHKLLKDKRDELMRRFVDLIRENNELRQTIEKELAANMKEFVLAKASENSLMVEEL
FAVPVHEVTLWIDIENIMSVNVPKFHVQSNTAREQEQGEFAYSYLSSNSEMDNTIQKTKELLEKLLRLAEVEKTCQLMAD
DIEKTRRRVNGLEYSIIPQLKETIHYIELKLEEAERASLVRIMKITS

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane

COG id: COG1394

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit D

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the V-ATPase D subunit family

Homologues:

Organism=Homo sapiens, GI7706757, Length=209, Percent_Identity=28.2296650717703, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17553636, Length=214, Percent_Identity=31.7757009345794, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320784, Length=211, Percent_Identity=28.436018957346, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI20128937, Length=207, Percent_Identity=28.5024154589372, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21355551, Length=208, Percent_Identity=28.3653846153846, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): VATD_STRP1 (Q9A1Q1)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268538.1
- RefSeq:   YP_281497.1
- ProteinModelPortal:   Q9A1Q1
- EnsemblBacteria:   EBSTRT00000000797
- EnsemblBacteria:   EBSTRT00000028959
- GeneID:   3572795
- GeneID:   900482
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0157
- KEGG:   spz:M5005_Spy_0133
- GeneTree:   EBGT00050000029439
- HOGENOM:   HBG732046
- OMA:   GEVMKEA
- ProtClustDB:   PRK00373
- BioCyc:   SPYO160490:SPY0157-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0133-MONOMER
- HAMAP:   MF_00271
- InterPro:   IPR002699
- PANTHER:   PTHR11671
- TIGRFAMs:   TIGR00309

Pfam domain/function: PF01813 ATP-synt_D

EC number: 3.6.3.14

Molecular weight: Translated: 24348; Mature: 24216

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLNVKPTRMELSNLKNRLKTATRGHKLLKDKRDELMRRFVDLIRENNELRQTIEKELA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ANMKEFVLAKASENSLMVEELFAVPVHEVTLWIDIENIMSVNVPKFHVQSNTAREQEQGE
HHHHHHHHHHCCCCHHHHHHHHHCCHHHEEEEEEHHHHHHCCCCEEEECCCCHHHHHHHH
FAYSYLSSNSEMDNTIQKTKELLEKLLRLAEVEKTCQLMADDIEKTRRRVNGLEYSIIPQ
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LKETIHYIELKLEEAERASLVRIMKITS
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARLNVKPTRMELSNLKNRLKTATRGHKLLKDKRDELMRRFVDLIRENNELRQTIEKELA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ANMKEFVLAKASENSLMVEELFAVPVHEVTLWIDIENIMSVNVPKFHVQSNTAREQEQGE
HHHHHHHHHHCCCCHHHHHHHHHCCHHHEEEEEEHHHHHHCCCCEEEECCCCHHHHHHHH
FAYSYLSSNSEMDNTIQKTKELLEKLLRLAEVEKTCQLMADDIEKTRRRVNGLEYSIIPQ
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LKETIHYIELKLEEAERASLVRIMKITS
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296