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The map label for this gene is gmk

Identifier: 15673881

GI number: 15673881

Start: 1966398

End: 1967015

Strand: Reverse

Name: gmk

Synonym: L149828

Alternate gene names: 15673881

Gene position: 1967015-1966398 (Counterclockwise)

Preceding gene: 15673882

Following gene: 15673880

Centisome position: 83.15

GC content: 39.32

Gene sequence:

>618_bases
ATGCGTGAGCGTGGTTTATTAATTGTTTTTTCTGGACCTTCTGGTGTTGGAAAAGGAACAGTTCGTGCTAAAATTTTTGA
GAGTGAAAACAACTTTGAATATTCAGTGTCAATGACAACGCGTAAGCAACGTCCTGGCGAAGTAGATGGAAAAGATTATT
ATTTCCGGACACGTGATGAATTTGAAGAAATGATTCGCAATGGTCAGATGCTGGAATATGCTGAATATGTTGGAAATTAT
TACGGCACACCTTTAACTTATGTCAATCAGACATTGGACGAAGGAAAAGATGTTTTTCTAGAAATTGAAGTGCAAGGTGC
GCTTCAAGTGAAGGAAAAAGTTCCAGATGGTGTTTTTGTCTTCTTGACTCCACCAGATTTGGAAGAATTGCGTGGACGTT
TAGTTGGACGTGGGACAGATTCAGCTGAAGTCATTGCTTCACGACTTGAAAAAGCAAAAGAAGAAATTCGCTTGATGAGT
GAATATGATTATGCCGTCGTTAATGACAAAGTTGAACTTGCTGCCGAACGTGTTAAGAAGATTATTGAAGCTGAACATTA
CCGAGTGGACCGCGTGATTGAACGCTACGTTCATATGATTGATGATGTGAAAGTTTGA

Upstream 100 bases:

>100_bases
TTCTTTTTTATTACAAAAGCTAGTTTTAAGAGCTAGCTTTTGATAGAATGAATTTAATCGTTGATTAAGAGATGGAATTA
GAGATATATCGGAGGAAAAA

Downstream 100 bases:

>100_bases
TTTAATTGGAAAAATTACTGACAGATTTATCAGTTTAATGCGAAGGAGCTATCAATTCTACTGATAGTCCTGCCAGAAAT
GATTAAGTTGATAAATTTTA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MRERGLLIVFSGPSGVGKGTVRAKIFESENNFEYSVSMTTRKQRPGEVDGKDYYFRTRDEFEEMIRNGQMLEYAEYVGNY
YGTPLTYVNQTLDEGKDVFLEIEVQGALQVKEKVPDGVFVFLTPPDLEELRGRLVGRGTDSAEVIASRLEKAKEEIRLMS
EYDYAVVNDKVELAAERVKKIIEAEHYRVDRVIERYVHMIDDVKV

Sequences:

>Translated_205_residues
MRERGLLIVFSGPSGVGKGTVRAKIFESENNFEYSVSMTTRKQRPGEVDGKDYYFRTRDEFEEMIRNGQMLEYAEYVGNY
YGTPLTYVNQTLDEGKDVFLEIEVQGALQVKEKVPDGVFVFLTPPDLEELRGRLVGRGTDSAEVIASRLEKAKEEIRLMS
EYDYAVVNDKVELAAERVKKIIEAEHYRVDRVIERYVHMIDDVKV
>Mature_205_residues
MRERGLLIVFSGPSGVGKGTVRAKIFESENNFEYSVSMTTRKQRPGEVDGKDYYFRTRDEFEEMIRNGQMLEYAEYVGNY
YGTPLTYVNQTLDEGKDVFLEIEVQGALQVKEKVPDGVFVFLTPPDLEELRGRLVGRGTDSAEVIASRLEKAKEEIRLMS
EYDYAVVNDKVELAAERVKKIIEAEHYRVDRVIERYVHMIDDVKV

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=189, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI4504221, Length=189, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI226874831, Length=189, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=30.3370786516854, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI14780902, Length=193, Percent_Identity=28.4974093264249, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI21361598, Length=187, Percent_Identity=31.5508021390374, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI4505237, Length=182, Percent_Identity=32.4175824175824, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI262118259, Length=182, Percent_Identity=32.4175824175824, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI262118255, Length=182, Percent_Identity=32.4175824175824, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI262118263, Length=182, Percent_Identity=32.4175824175824, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI52630447, Length=176, Percent_Identity=28.9772727272727, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI111154074, Length=127, Percent_Identity=29.1338582677165, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1790080, Length=199, Percent_Identity=44.2211055276382, Blast_Score=167, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=38.953488372093, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=38.953488372093, Blast_Score=123, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17556244, Length=125, Percent_Identity=35.2, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71988048, Length=184, Percent_Identity=27.7173913043478, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71988041, Length=184, Percent_Identity=27.7173913043478, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=43.7158469945355, Blast_Score=147, Evalue=8e-37,
Organism=Drosophila melanogaster, GI21356141, Length=150, Percent_Identity=38.6666666666667, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI161077626, Length=193, Percent_Identity=27.979274611399, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24640542, Length=193, Percent_Identity=27.979274611399, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI45554489, Length=193, Percent_Identity=27.979274611399, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI45554481, Length=193, Percent_Identity=27.979274611399, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI85724806, Length=193, Percent_Identity=27.979274611399, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI116007136, Length=193, Percent_Identity=27.979274611399, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI85816106, Length=129, Percent_Identity=32.5581395348837, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI85816281, Length=129, Percent_Identity=32.5581395348837, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551002, Length=129, Percent_Identity=32.5581395348837, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330164, Length=126, Percent_Identity=29.3650793650794, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI221330166, Length=126, Percent_Identity=29.3650793650794, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI221330162, Length=126, Percent_Identity=29.3650793650794, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_LACLA (Q9CEE3)

Other databases:

- EMBL:   AE005176
- PIR:   C86862
- RefSeq:   NP_268056.1
- ProteinModelPortal:   Q9CEE3
- SMR:   Q9CEE3
- GeneID:   1115564
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L149828
- NMPDR:   fig|272623.1.peg.1945
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- ProtClustDB:   PRK00300
- BioCyc:   LLAC272623:L149828-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23623; Mature: 23623

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRERGLLIVFSGPSGVGKGTVRAKIFESENNFEYSVSMTTRKQRPGEVDGKDYYFRTRDE
CCCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCCCCCCEEEECHHH
FEEMIRNGQMLEYAEYVGNYYGTPLTYVNQTLDEGKDVFLEIEVQGALQVKEKVPDGVFV
HHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCHHHHHHHCCCCEEE
FLTPPDLEELRGRLVGRGTDSAEVIASRLEKAKEEIRLMSEYDYAVVNDKVELAAERVKK
EECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHH
IIEAEHYRVDRVIERYVHMIDDVKV
HHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRERGLLIVFSGPSGVGKGTVRAKIFESENNFEYSVSMTTRKQRPGEVDGKDYYFRTRDE
CCCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCCCCCCCCEEEECHHH
FEEMIRNGQMLEYAEYVGNYYGTPLTYVNQTLDEGKDVFLEIEVQGALQVKEKVPDGVFV
HHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCHHHHHHHCCCCEEE
FLTPPDLEELRGRLVGRGTDSAEVIASRLEKAKEEIRLMSEYDYAVVNDKVELAAERVKK
EECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHH
IIEAEHYRVDRVIERYVHMIDDVKV
HHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471