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The map label for this gene is llrF

Identifier: 15673657

GI number: 15673657

Start: 1726969

End: 1727646

Strand: Reverse

Name: llrF

Synonym: L0135

Alternate gene names: 15673657

Gene position: 1727646-1726969 (Counterclockwise)

Preceding gene: 15673658

Following gene: 15673656

Centisome position: 73.03

GC content: 31.12

Gene sequence:

>678_bases
ATGGATTCAATGATTAAAATTTTATTAGTGGAGGATGATTTATCACTCTCAAAATCTGTTTACGATTTCTTAAAATCATT
TGCGCAAGTCAAACAGGTTTATGATGGAGTTGAAGGACTCTATGAGGCAGAATTGGGAATTTATGATTTAATTTTGCTTG
ATTTAATGCTTCCAGAAAAGAATGGTTTTGAAGTCTTAAAGGAATTACGTGAGCAAAATGTAGATACGCCAGTCTTAATC
ATGACTGCTAAGGAATCTTTGGATGATAAAATGCACGGATTCGACATTGGAGCAGATGATTATTTAACAAAACCTTTCTA
TTTAGATGAACTAAAAGCACGTATTCAAGCACTTTTGAAACGGACAGGTAAATTAGAAGATTCAAACGGTTTAACTTATG
GAAATATTCGTTTGAATTTATCAAATAAATCAACTTTAGTTGATGATCAACCTGTTGATTTAATCGGAAAAGAATTTGAT
TTAGTCGTTTATTTAATGCAAAATCAAAACGTTATTTTGCCAAAAGAGCAAATTTTTGACCGGATTTGGGGTTATGACAG
TGATACAACAGTAACTGTTGTTGAAGTTTATATGAGTAAAATTCGGAAAAAATTGAAAGATACAGAATTTGTCAATAATC
TTTCAACCTTGCGAAATGTTGGCTATATCTTGAGATAA

Upstream 100 bases:

>100_bases
GTAAAATAATAGAAAGGGTTGGGCGCAGTTTTATTGACTTTCCAAGCAATTTAACTAAAAATAATTTATAAATTATGAGC
CCTAAAAAATGTGAAAAGGG

Downstream 100 bases:

>100_bases
AATTTTACTGACAGCTTGTTGTATAGAGATGAAAGTCATCTATAAATTAACAAAAAGTTCTGTCAGTAAATCTATCTAGA
AATGAGACCTCTTTGAAGAA

Product: two-component system regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MDSMIKILLVEDDLSLSKSVYDFLKSFAQVKQVYDGVEGLYEAELGIYDLILLDLMLPEKNGFEVLKELREQNVDTPVLI
MTAKESLDDKMHGFDIGADDYLTKPFYLDELKARIQALLKRTGKLEDSNGLTYGNIRLNLSNKSTLVDDQPVDLIGKEFD
LVVYLMQNQNVILPKEQIFDRIWGYDSDTTVTVVEVYMSKIRKKLKDTEFVNNLSTLRNVGYILR

Sequences:

>Translated_225_residues
MDSMIKILLVEDDLSLSKSVYDFLKSFAQVKQVYDGVEGLYEAELGIYDLILLDLMLPEKNGFEVLKELREQNVDTPVLI
MTAKESLDDKMHGFDIGADDYLTKPFYLDELKARIQALLKRTGKLEDSNGLTYGNIRLNLSNKSTLVDDQPVDLIGKEFD
LVVYLMQNQNVILPKEQIFDRIWGYDSDTTVTVVEVYMSKIRKKLKDTEFVNNLSTLRNVGYILR
>Mature_225_residues
MDSMIKILLVEDDLSLSKSVYDFLKSFAQVKQVYDGVEGLYEAELGIYDLILLDLMLPEKNGFEVLKELREQNVDTPVLI
MTAKESLDDKMHGFDIGADDYLTKPFYLDELKARIQALLKRTGKLEDSNGLTYGNIRLNLSNKSTLVDDQPVDLIGKEFD
LVVYLMQNQNVILPKEQIFDRIWGYDSDTTVTVVEVYMSKIRKKLKDTEFVNNLSTLRNVGYILR

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=36.1233480176211, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=36.0730593607306, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=31.981981981982, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=33.9366515837104, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=30.4932735426009, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=29.7297297297297, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=28.0542986425339, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=30.1801801801802, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1789809, Length=234, Percent_Identity=28.6324786324786, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=35.2173913043478, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=28.1938325991189, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=28.0701754385965, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787229, Length=209, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790437, Length=119, Percent_Identity=34.453781512605, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1788713, Length=89, Percent_Identity=34.8314606741573, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788550, Length=158, Percent_Identity=29.1139240506329, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788191, Length=126, Percent_Identity=28.5714285714286, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25850; Mature: 25850

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSMIKILLVEDDLSLSKSVYDFLKSFAQVKQVYDGVEGLYEAELGIYDLILLDLMLPEK
CCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NGFEVLKELREQNVDTPVLIMTAKESLDDKMHGFDIGADDYLTKPFYLDELKARIQALLK
CCHHHHHHHHHCCCCCCEEEEECHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHH
RTGKLEDSNGLTYGNIRLNLSNKSTLVDDQPVDLIGKEFDLVVYLMQNQNVILPKEQIFD
HHCCCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHCCCEEEEEEEECCCCEECCHHHHHH
RIWGYDSDTTVTVVEVYMSKIRKKLKDTEFVNNLSTLRNVGYILR
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDSMIKILLVEDDLSLSKSVYDFLKSFAQVKQVYDGVEGLYEAELGIYDLILLDLMLPEK
CCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NGFEVLKELREQNVDTPVLIMTAKESLDDKMHGFDIGADDYLTKPFYLDELKARIQALLK
CCHHHHHHHHHCCCCCCEEEEECHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHH
RTGKLEDSNGLTYGNIRLNLSNKSTLVDDQPVDLIGKEFDLVVYLMQNQNVILPKEQIFD
HHCCCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHCCCEEEEEEEECCCCEECCHHHHHH
RIWGYDSDTTVTVVEVYMSKIRKKLKDTEFVNNLSTLRNVGYILR
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]