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The map label for this gene is aroD

Identifier: 15673624

GI number: 15673624

Start: 1689931

End: 1690611

Strand: Reverse

Name: aroD

Synonym: L0062

Alternate gene names: 15673624

Gene position: 1690611-1689931 (Counterclockwise)

Preceding gene: 15673625

Following gene: 15673623

Centisome position: 71.47

GC content: 34.95

Gene sequence:

>681_bases
ATGAGAAAAACAAAAATTGTTGTTCCAATCATGCTGACAGAGTTAGCAGAGCTTGAGAAAGTTTCTGTCAGTGATTATCG
AACAGCAGATATTGTTGAATGGCGTGCCGATTTTTTGTCAGCAGATGAAATTTTAGAGATGGCTCCTAAATTCTTTGAAA
AATTTAAAGAAAGTAAGATTTTATTTACTTTAAGAACAGTCAGAGAAGGCGGAAATATTCAAGTTTCTGAAAAAAAATAT
TTACAGATTTTAAAAGAAATTTTGACTTACAATCCCGCATATATCGATGTCGAATTCTTTACGCATGGCCCTTCATTTGC
CGCTTTGAAAGATTTTCGGGATAAAATGGTGCTTTCTTATCATAATTTTGATGAAGTTCCGTCCGATTTAACCAATCGGT
TGATTAAAATGCACGAAGAAGGAACTGCCTTTGTTAAAGTTGCTGTGATGCCAGAACGTGAATGTGATGTTCTTGATTTA
TTACAAATCACTCGTGATATGACTTTAGAATACGGTGATCATTTTATCAGCATGGCAATGGGTGACTTAGGACGACTTTC
AAGAATTTCTGGCTATTTGACTGGCTCTTGCTGGACTTTTGCAAGTTTAGAAAATTCTAGTGCGCCTGGGCAAATTTCTC
TCAAAGAAACAGAGTATATTTTGGATATCTTAGAAAAATAG

Upstream 100 bases:

>100_bases
CCAGTAAAAAAACGTAAAAGGAAACGCTGTTTCCTTTTTTCTTTTTGCGAAAATATGCTAGAATAAGGTAAAACATTTAT
GAAAATGTAAGGAGAAGTTT

Downstream 100 bases:

>100_bases
AGAATGATATAATCAGAGATATTGTTCGGTTATGACAGATAATTTTTTTACTTTTATTAGGACAAGTAGAATGGACCAAA
AGCTTTATAAGTGAAAATGT

Product: 3-dehydroquinate dehydratase

Products: NA

Alternate protein names: 3-dehydroquinase; Type I DHQase

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MRKTKIVVPIMLTELAELEKVSVSDYRTADIVEWRADFLSADEILEMAPKFFEKFKESKILFTLRTVREGGNIQVSEKKY
LQILKEILTYNPAYIDVEFFTHGPSFAALKDFRDKMVLSYHNFDEVPSDLTNRLIKMHEEGTAFVKVAVMPERECDVLDL
LQITRDMTLEYGDHFISMAMGDLGRLSRISGYLTGSCWTFASLENSSAPGQISLKETEYILDILEK

Sequences:

>Translated_226_residues
MRKTKIVVPIMLTELAELEKVSVSDYRTADIVEWRADFLSADEILEMAPKFFEKFKESKILFTLRTVREGGNIQVSEKKY
LQILKEILTYNPAYIDVEFFTHGPSFAALKDFRDKMVLSYHNFDEVPSDLTNRLIKMHEEGTAFVKVAVMPERECDVLDL
LQITRDMTLEYGDHFISMAMGDLGRLSRISGYLTGSCWTFASLENSSAPGQISLKETEYILDILEK
>Mature_226_residues
MRKTKIVVPIMLTELAELEKVSVSDYRTADIVEWRADFLSADEILEMAPKFFEKFKESKILFTLRTVREGGNIQVSEKKY
LQILKEILTYNPAYIDVEFFTHGPSFAALKDFRDKMVLSYHNFDEVPSDLTNRLIKMHEEGTAFVKVAVMPERECDVLDL
LQITRDMTLEYGDHFISMAMGDLGRLSRISGYLTGSCWTFASLENSSAPGQISLKETEYILDILEK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; third step. [C]

COG id: COG0710

COG function: function code E; 3-dehydroquinate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-I 3-dehydroquinase family

Homologues:

Organism=Escherichia coli, GI1787984, Length=238, Percent_Identity=32.7731092436975, Blast_Score=118, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROD_LACLA (Q9CF39)

Other databases:

- EMBL:   AE005176
- PIR:   B86830
- RefSeq:   NP_267798.1
- ProteinModelPortal:   Q9CF39
- SMR:   Q9CF39
- GeneID:   1115302
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0062
- NMPDR:   fig|272623.1.peg.1684
- HOGENOM:   HBG732926
- OMA:   SYHNFDE
- ProtClustDB:   PRK02412
- BioCyc:   LLAC272623:L0062-MONOMER
- BRENDA:   4.2.1.10
- HAMAP:   MF_00214
- InterPro:   IPR013785
- InterPro:   IPR001381
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01093

Pfam domain/function: PF01487 DHquinase_I

EC number: =4.2.1.10

Molecular weight: Translated: 25974; Mature: 25974

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS01028 DEHYDROQUINASE_I

Important sites: ACT_SITE 121-121 ACT_SITE 146-146

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTKIVVPIMLTELAELEKVSVSDYRTADIVEWRADFLSADEILEMAPKFFEKFKESKI
CCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEE
LFTLRTVREGGNIQVSEKKYLQILKEILTYNPAYIDVEFFTHGPSFAALKDFRDKMVLSY
EEEEEEHHCCCCEEECHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHEEEE
HNFDEVPSDLTNRLIKMHEEGTAFVKVAVMPERECDVLDLLQITRDMTLEYGDHFISMAM
CCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GDLGRLSRISGYLTGSCWTFASLENSSAPGQISLKETEYILDILEK
HHHHHHHHHHHEECCCEEEEEECCCCCCCCEEEEHHHHHHHHHHCC
>Mature Secondary Structure
MRKTKIVVPIMLTELAELEKVSVSDYRTADIVEWRADFLSADEILEMAPKFFEKFKESKI
CCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEE
LFTLRTVREGGNIQVSEKKYLQILKEILTYNPAYIDVEFFTHGPSFAALKDFRDKMVLSY
EEEEEEHHCCCCEEECHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHEEEE
HNFDEVPSDLTNRLIKMHEEGTAFVKVAVMPERECDVLDLLQITRDMTLEYGDHFISMAM
CCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GDLGRLSRISGYLTGSCWTFASLENSSAPGQISLKETEYILDILEK
HHHHHHHHHHHEECCCEEEEEECCCCCCCCEEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471