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The map label for this gene is purL

Identifier: 15673512

GI number: 15673512

Start: 1574172

End: 1576391

Strand: Reverse

Name: purL

Synonym: L173921

Alternate gene names: 15673512

Gene position: 1576391-1574172 (Counterclockwise)

Preceding gene: 15673513

Following gene: 15673511

Centisome position: 66.64

GC content: 40.41

Gene sequence:

>2220_bases
ATGACTTTGGAGATGTCACCAGAACAGATTCAAGAAAGCAAAATATACCGTGAGTGGGGACTGACGGATGAAGAATATTT
GAAAATCAAGGATGAGATTCTTGATGGCCGTTTGCCAAACTTTACGGAAACTGGGATGTATGCCGTGATGTGGTCAGAAC
ATTGCTGCTACAAAAATTCAAAACCTGTCTTAAAAAAATTTCCGACGACTGGGCCACAAGTCTTGATGGGGCCTGGTGAA
GGAGCTGGGGTTGTGGATATTGGTGATGATTTAGCGGTTGTTTTCAAAGCTGAATCTCATAATCATCCATCTTACGTTGA
ACCTTATGAAGGTGCAGCAACTGGTTCTGGTGGTATTATTCGTGATATTTTTTCAATGGGAGCTCGTCCAATTGCAATTT
TGGATAGTTTACGTTTTGGGCCAATTGACAATGGTAAAACACGTCATATTGTGGACCAAGTGACAGCCGGGATTGCGGGA
TATGGAAACTGTATTGGAATTCCGACGGTTGGTGGCGAAGTAGCCTTTGATGAATCTTACGCTGGAAACCCTTTGGTGAA
TGTCATGTGTGTGGGTTTGATTGAACATAAACACATACAAAAAGGACAAGCTAAAGGTGTGGGAAATTCTATTTTTTATG
TCGGAGCGAAAACAGGACGTGACGGCATTCATGGGGCGTCTTTTGCTTCTAAAGAATTTGGTTCTGGTTCAGAAACACAA
CGTTCAGCGGTTCAAGTCGGTGATCCATTTATGGAAAAATTATTGCTTGAAGCTTGTATTGAAGTCATTCAAAATCATGG
CGATATTTTAGTCGGAATTCAAGATATGGGAGCAGCTGGATTGGTTTCATCTACATCAGAAATGGCTTCAAAAGCTGGGT
CAGGTCTGCGTCTTAACTTGGATAATGTGCCTCAGCGTGAAACAGAAATGATTCCTTATGAAATGATGTTGTCTGAGTCA
CAAGAACGTATGGTGCTTTGTGTCAAAAAAGGACATGAACAAGAAATTATTGATTTATTTAAAAAATACGACCTTGATGC
TGTGAATATTGGGCAAGTGACTGATGATGGCTTTTATACGCTTTATCATAAAGGGGAAATGGTGGCTCATGTTCCAGTTG
ATTCATTGGCGGAAGATGCTCCAACTTATTACCGTGAGGCAAAAGTTCCTGAGCGAATTCAAAAATTTACTGACAGCGAA
AAATATCTTCCAGAAATTACAGACAGCGCGGTCAGTGAAATTTTCAAAAAACTTTTGGCTCAACCGACAATTGCTAGCAA
GAAATCAATTTATGAAACTTATGATTCGCGCGTGATGACCAACACTGTTGTTGCACCAGGCTCAGATAGCGCAGTTTTAC
GAGTGCGTGGAACTAACAAAGCACTTGCGATGACAACGGACTGTAACGCTCGCTACCTCTATCTTGATCCAGAAAAAGGA
GGAGCAATCGCAGTTGCTGAAGCGGCTCGTAATATCGTGGCCTCTGGTGGAAAACCGCTTGCGATTACTGACTGTTTGAA
CTTTGGAAATCCGGAAAAACCAGAACAATTTTGGGAATTAACAACGGCGGCTGACGGAATTTCACGTTCTTGTTTGGCTC
TTGATACACCGGTTATTTCAGGAAATGTTAGTCTTTACAATGAAACAAACGGTTCAGCTATTTTACCTACGCCGATGATT
GGAATGGTTGGTTTGATTGAGAATGTAAAAAATATTACGACTCAAGAATTTAAAAAAGCAGGTGATTTGATTGTGCTAGT
CGGTCAAACCTTTGATGATTTTTCAGGTTCTGAACTTCAAAAAATGCTGATAGGCGAAATTTCTGGAAGAATTGATTTTG
ATTTAGAAACTGAAAAAATCAATCAAGATTTTGTTTTAAAAGCAATTACTGACGGATTGGTCAGCTCAGCACATGACTTG
GCAGAAGGAGGATTGGCGATTGCTCTAGCTGAATCTGCTTTTGCAAATGGCTTAGGCGTTGATGTGAAAGTTGATATAAC
CAATGCCCAATTATTCTCAGAAACGCAAGGTCGCTTTATACTCTCAATTTCACCAGAAAATCAAGCTACTTTTGAAAAAT
TACTGACAGAAAGTTCGGTCAGTGGCGAAGTAATCGGAAAAGTTACTGACAGCGGAATTTTGGAAATGAATGAACTTTCT
ATTTCTACTGACGAAGCTGTCAGCATTTATGAAGGAGCGTTGCCAGCTCTGATGAAATAA

Upstream 100 bases:

>100_bases
CTGTTGGAACGTATATTCTTTAGACTACTAATGCAGTAAATTGGGCTGTAGTTTTCTACGTTTTTAAGCAAGCGTTTCTC
ATATCTTATAGGAGAATAAC

Downstream 100 bases:

>100_bases
AAGTTGATATAGATGTCTTTTTTTACTTAAAATTAATAAAAATCATTTACTTTACACTAAAGAAACAAAGAAGTATAATT
TCGTTATATTTAATCGAAAG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 739; Mature: 738

Protein sequence:

>739_residues
MTLEMSPEQIQESKIYREWGLTDEEYLKIKDEILDGRLPNFTETGMYAVMWSEHCCYKNSKPVLKKFPTTGPQVLMGPGE
GAGVVDIGDDLAVVFKAESHNHPSYVEPYEGAATGSGGIIRDIFSMGARPIAILDSLRFGPIDNGKTRHIVDQVTAGIAG
YGNCIGIPTVGGEVAFDESYAGNPLVNVMCVGLIEHKHIQKGQAKGVGNSIFYVGAKTGRDGIHGASFASKEFGSGSETQ
RSAVQVGDPFMEKLLLEACIEVIQNHGDILVGIQDMGAAGLVSSTSEMASKAGSGLRLNLDNVPQRETEMIPYEMMLSES
QERMVLCVKKGHEQEIIDLFKKYDLDAVNIGQVTDDGFYTLYHKGEMVAHVPVDSLAEDAPTYYREAKVPERIQKFTDSE
KYLPEITDSAVSEIFKKLLAQPTIASKKSIYETYDSRVMTNTVVAPGSDSAVLRVRGTNKALAMTTDCNARYLYLDPEKG
GAIAVAEAARNIVASGGKPLAITDCLNFGNPEKPEQFWELTTAADGISRSCLALDTPVISGNVSLYNETNGSAILPTPMI
GMVGLIENVKNITTQEFKKAGDLIVLVGQTFDDFSGSELQKMLIGEISGRIDFDLETEKINQDFVLKAITDGLVSSAHDL
AEGGLAIALAESAFANGLGVDVKVDITNAQLFSETQGRFILSISPENQATFEKLLTESSVSGEVIGKVTDSGILEMNELS
ISTDEAVSIYEGALPALMK

Sequences:

>Translated_739_residues
MTLEMSPEQIQESKIYREWGLTDEEYLKIKDEILDGRLPNFTETGMYAVMWSEHCCYKNSKPVLKKFPTTGPQVLMGPGE
GAGVVDIGDDLAVVFKAESHNHPSYVEPYEGAATGSGGIIRDIFSMGARPIAILDSLRFGPIDNGKTRHIVDQVTAGIAG
YGNCIGIPTVGGEVAFDESYAGNPLVNVMCVGLIEHKHIQKGQAKGVGNSIFYVGAKTGRDGIHGASFASKEFGSGSETQ
RSAVQVGDPFMEKLLLEACIEVIQNHGDILVGIQDMGAAGLVSSTSEMASKAGSGLRLNLDNVPQRETEMIPYEMMLSES
QERMVLCVKKGHEQEIIDLFKKYDLDAVNIGQVTDDGFYTLYHKGEMVAHVPVDSLAEDAPTYYREAKVPERIQKFTDSE
KYLPEITDSAVSEIFKKLLAQPTIASKKSIYETYDSRVMTNTVVAPGSDSAVLRVRGTNKALAMTTDCNARYLYLDPEKG
GAIAVAEAARNIVASGGKPLAITDCLNFGNPEKPEQFWELTTAADGISRSCLALDTPVISGNVSLYNETNGSAILPTPMI
GMVGLIENVKNITTQEFKKAGDLIVLVGQTFDDFSGSELQKMLIGEISGRIDFDLETEKINQDFVLKAITDGLVSSAHDL
AEGGLAIALAESAFANGLGVDVKVDITNAQLFSETQGRFILSISPENQATFEKLLTESSVSGEVIGKVTDSGILEMNELS
ISTDEAVSIYEGALPALMK
>Mature_738_residues
TLEMSPEQIQESKIYREWGLTDEEYLKIKDEILDGRLPNFTETGMYAVMWSEHCCYKNSKPVLKKFPTTGPQVLMGPGEG
AGVVDIGDDLAVVFKAESHNHPSYVEPYEGAATGSGGIIRDIFSMGARPIAILDSLRFGPIDNGKTRHIVDQVTAGIAGY
GNCIGIPTVGGEVAFDESYAGNPLVNVMCVGLIEHKHIQKGQAKGVGNSIFYVGAKTGRDGIHGASFASKEFGSGSETQR
SAVQVGDPFMEKLLLEACIEVIQNHGDILVGIQDMGAAGLVSSTSEMASKAGSGLRLNLDNVPQRETEMIPYEMMLSESQ
ERMVLCVKKGHEQEIIDLFKKYDLDAVNIGQVTDDGFYTLYHKGEMVAHVPVDSLAEDAPTYYREAKVPERIQKFTDSEK
YLPEITDSAVSEIFKKLLAQPTIASKKSIYETYDSRVMTNTVVAPGSDSAVLRVRGTNKALAMTTDCNARYLYLDPEKGG
AIAVAEAARNIVASGGKPLAITDCLNFGNPEKPEQFWELTTAADGISRSCLALDTPVISGNVSLYNETNGSAILPTPMIG
MVGLIENVKNITTQEFKKAGDLIVLVGQTFDDFSGSELQKMLIGEISGRIDFDLETEKINQDFVLKAITDGLVSSAHDLA
EGGLAIALAESAFANGLGVDVKVDITNAQLFSETQGRFILSISPENQATFEKLLTESSVSGEVIGKVTDSGILEMNELSI
STDEAVSIYEGALPALMK

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=710, Percent_Identity=23.8028169014084, Blast_Score=94, Evalue=5e-19,
Organism=Escherichia coli, GI48994899, Length=773, Percent_Identity=25.8732212160414, Blast_Score=137, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17553022, Length=710, Percent_Identity=22.2535211267606, Blast_Score=92, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321498, Length=700, Percent_Identity=23.8571428571429, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_LACLA (Q9CFE8)

Other databases:

- EMBL:   AE005176
- PIR:   B86816
- RefSeq:   NP_267686.1
- ProteinModelPortal:   Q9CFE8
- SMR:   Q9CFE8
- GeneID:   1115187
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L173921
- NMPDR:   fig|272623.1.peg.1571
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   LLAC272623:L173921-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 79696; Mature: 79565

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLEMSPEQIQESKIYREWGLTDEEYLKIKDEILDGRLPNFTETGMYAVMWSEHCCYKNS
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCC
KPVLKKFPTTGPQVLMGPGEGAGVVDIGDDLAVVFKAESHNHPSYVEPYEGAATGSGGII
CCHHHHCCCCCCEEEECCCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHH
RDIFSMGARPIAILDSLRFGPIDNGKTRHIVDQVTAGIAGYGNCIGIPTVGGEVAFDESY
HHHHHCCCCCEEHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCEEECCCC
AGNPLVNVMCVGLIEHKHIQKGQAKGVGNSIFYVGAKTGRDGIHGASFASKEFGSGSETQ
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHH
RSAVQVGDPFMEKLLLEACIEVIQNHGDILVGIQDMGAAGLVSSTSEMASKAGSGLRLNL
HHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHCCHHHHHHHCCCCEEEEC
DNVPQRETEMIPYEMMLSESQERMVLCVKKGHEQEIIDLFKKYDLDAVNIGQVTDDGFYT
CCCCCCHHHCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCCEEE
LYHKGEMVAHVPVDSLAEDAPTYYREAKVPERIQKFTDSEKYLPEITDSAVSEIFKKLLA
EEECCCEEEECCHHHHHHCCCHHHHHCCCHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHC
QPTIASKKSIYETYDSRVMTNTVVAPGSDSAVLRVRGTNKALAMTTDCNARYLYLDPEKG
CCCCHHHHHHHHHHHCEEEEEEEECCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCC
GAIAVAEAARNIVASGGKPLAITDCLNFGNPEKPEQFWELTTAADGISRSCLALDTPVIS
CEEEHHHHHHHHHHCCCCCEEEEEHHCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCEEE
GNVSLYNETNGSAILPTPMIGMVGLIENVKNITTQEFKKAGDLIVLVGQTFDDFSGSELQ
CCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHH
KMLIGEISGRIDFDLETEKINQDFVLKAITDGLVSSAHDLAEGGLAIALAESAFANGLGV
HHHHHHHCCCEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCC
DVKVDITNAQLFSETQGRFILSISPENQATFEKLLTESSVSGEVIGKVTDSGILEMNELS
EEEEEECCHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCC
ISTDEAVSIYEGALPALMK
CCCCCHHHHHHCCHHHHCC
>Mature Secondary Structure 
TLEMSPEQIQESKIYREWGLTDEEYLKIKDEILDGRLPNFTETGMYAVMWSEHCCYKNS
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCC
KPVLKKFPTTGPQVLMGPGEGAGVVDIGDDLAVVFKAESHNHPSYVEPYEGAATGSGGII
CCHHHHCCCCCCEEEECCCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHH
RDIFSMGARPIAILDSLRFGPIDNGKTRHIVDQVTAGIAGYGNCIGIPTVGGEVAFDESY
HHHHHCCCCCEEHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCEEECCCC
AGNPLVNVMCVGLIEHKHIQKGQAKGVGNSIFYVGAKTGRDGIHGASFASKEFGSGSETQ
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHH
RSAVQVGDPFMEKLLLEACIEVIQNHGDILVGIQDMGAAGLVSSTSEMASKAGSGLRLNL
HHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHCCHHHHHHHCCCCEEEEC
DNVPQRETEMIPYEMMLSESQERMVLCVKKGHEQEIIDLFKKYDLDAVNIGQVTDDGFYT
CCCCCCHHHCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCCEEE
LYHKGEMVAHVPVDSLAEDAPTYYREAKVPERIQKFTDSEKYLPEITDSAVSEIFKKLLA
EEECCCEEEECCHHHHHHCCCHHHHHCCCHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHC
QPTIASKKSIYETYDSRVMTNTVVAPGSDSAVLRVRGTNKALAMTTDCNARYLYLDPEKG
CCCCHHHHHHHHHHHCEEEEEEEECCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCC
GAIAVAEAARNIVASGGKPLAITDCLNFGNPEKPEQFWELTTAADGISRSCLALDTPVIS
CEEEHHHHHHHHHHCCCCCEEEEEHHCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCEEE
GNVSLYNETNGSAILPTPMIGMVGLIENVKNITTQEFKKAGDLIVLVGQTFDDFSGSELQ
CCEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHH
KMLIGEISGRIDFDLETEKINQDFVLKAITDGLVSSAHDLAEGGLAIALAESAFANGLGV
HHHHHHHCCCEEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCC
DVKVDITNAQLFSETQGRFILSISPENQATFEKLLTESSVSGEVIGKVTDSGILEMNELS
EEEEEECCHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCC
ISTDEAVSIYEGALPALMK
CCCCCHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471