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The map label for this gene is guaA

Identifier: 15673468

GI number: 15673468

Start: 1516220

End: 1517761

Strand: Reverse

Name: guaA

Synonym: L115968

Alternate gene names: 15673468

Gene position: 1517761-1516220 (Counterclockwise)

Preceding gene: 15673469

Following gene: 15673467

Centisome position: 64.16

GC content: 41.5

Gene sequence:

>1542_bases
TTGTCCGACACTACACTTGAAAAAATCATTGTACTCGACTATGGTTCACAATACAATCAACTTATTGCGCGTCGTATCCG
AGAAATCGGTGTTTTCTCAGAACTCATGAGTCACAAAGTTACAGCCAAAGAAATTCGTGAGATTAATCCAATCGGTATTA
TTCTTTCAGGCGGTCCAAATTCAGTTTATGATGAGGGTTCATTCGATATTGATCCTGAAATCTTTGAACTTGGTTTGCCA
GTTCTTGGTATTTGCTACGGAATGCAATTGTTGAGCTACAAGCTCGGCGGTATGGTAGAAGCAGCAGGCGAACGCGAATA
CGGTGTTGCCCCACTTCAACTTACTGGAAAATCAGCATTGTTTGCAGGAACTCCCGAAGTTCAAGATGTTTTGATGAGCC
ACGGTGACCGTGTAACAGCTATTCCTGAAGGTTTCCACGTTGTCGGAACTTCACCAAACAGTCCATTTGCTGCTGTTGAA
AATACAGAACGCAACTTGTACGGTATCCAATTCCACCCAGAAGTTCGTCATTCAGTTCACGGGACAGAAATGCTCAGAAA
CTTTGCGCTTAACATTTGTGGAGCAAAAGGGAACTGGTCAATGGAAAACTTCATTGATATGCAAATCAAAAATATTCGTG
AAAAAGTTGGCGATAAAAAAGTTCTTCTTGGACTTTCAGGTGGTGTTGATTCATCAGTTGTAGGTGTACTTTTACAACGT
GCCATCGGTGACCAATTGACATCAATCTTTGTTGACCACGGTTTCCTTCGTAAAGGCGAAGCTGACCAAGTCATGGAGAC
ATTGGGCGGAAAATTTGGTCTTAATATCATCAAAGTAGATGCTCAAAAACGCTTCATGGACAAACTTGTTGGCCTTTCAG
ACCCAGAAACAAAACGTAAAATTATCGGTAACGAATTTGTTTATGTTTTTGATGATGAAGCAAACAAATTAGAAGGTGTT
GACTTCCTTGCCCAAGGAACACTCTACACCGACGTCATTGAATCAGGAACAGATACAGCTCAAACAATCAAATCACACCA
TAACGTTGGTGGACTTCCTGAAGATATGCAATTCCAATTGATTGAACCATTGAATACACTCTTTAAAGATGAAGTTCGTG
CGCTTGGAACACAACTTGGAATGCCTGATGAAATCGTTTGGCGTCAACCTTTCCCTGGACCAGGACTTGCCATTCGTGTC
CTTGGTGATTTAACAGAAGAAAAACTAGAAACTGTTCGTGAATCAGATGCAATTCTTCGTGAAGAAATTGCTGCTGCAGG
TCTTGAACGTGATGTTTGGCAATATTTCACAGTAAATACAGATGTGAAATCAGTCGGTGTCATGGGAGACCAACGAACAT
ATGACTATACACTAGCTATTCGTGCCATCACTTCAATTGATGGAATGACAGCTGACTTTGCCCAACTTCCTTGGGATCTT
CTCCAAAAAATCTCAAAACGTATCGTTAATGAGGTGGACCACGTCAACCGTATCGTCTATGATATTACGAGCAAACCACC
AGCAACTGTTGAGTGGCAATAG

Upstream 100 bases:

>100_bases
CATTAAATTATGATAGAATAAATCTAATAAAATAATTGAACAAAAGTTCGAACTTTCCAACAGGAATTCGGACTTTTGCA
CCTTATTAGAGGAGGGTCCC

Downstream 100 bases:

>100_bases
AATAAAAAATTTTAAAACTAGCACTCATTGTTCAATAGCATTATTTCCTAAAAGATTACGTAATATTAATCAATTTTATC
GCTTTGAAAGCGCTATACTT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MSDTTLEKIIVLDYGSQYNQLIARRIREIGVFSELMSHKVTAKEIREINPIGIILSGGPNSVYDEGSFDIDPEIFELGLP
VLGICYGMQLLSYKLGGMVEAAGEREYGVAPLQLTGKSALFAGTPEVQDVLMSHGDRVTAIPEGFHVVGTSPNSPFAAVE
NTERNLYGIQFHPEVRHSVHGTEMLRNFALNICGAKGNWSMENFIDMQIKNIREKVGDKKVLLGLSGGVDSSVVGVLLQR
AIGDQLTSIFVDHGFLRKGEADQVMETLGGKFGLNIIKVDAQKRFMDKLVGLSDPETKRKIIGNEFVYVFDDEANKLEGV
DFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFQLIEPLNTLFKDEVRALGTQLGMPDEIVWRQPFPGPGLAIRV
LGDLTEEKLETVRESDAILREEIAAAGLERDVWQYFTVNTDVKSVGVMGDQRTYDYTLAIRAITSIDGMTADFAQLPWDL
LQKISKRIVNEVDHVNRIVYDITSKPPATVEWQ

Sequences:

>Translated_513_residues
MSDTTLEKIIVLDYGSQYNQLIARRIREIGVFSELMSHKVTAKEIREINPIGIILSGGPNSVYDEGSFDIDPEIFELGLP
VLGICYGMQLLSYKLGGMVEAAGEREYGVAPLQLTGKSALFAGTPEVQDVLMSHGDRVTAIPEGFHVVGTSPNSPFAAVE
NTERNLYGIQFHPEVRHSVHGTEMLRNFALNICGAKGNWSMENFIDMQIKNIREKVGDKKVLLGLSGGVDSSVVGVLLQR
AIGDQLTSIFVDHGFLRKGEADQVMETLGGKFGLNIIKVDAQKRFMDKLVGLSDPETKRKIIGNEFVYVFDDEANKLEGV
DFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFQLIEPLNTLFKDEVRALGTQLGMPDEIVWRQPFPGPGLAIRV
LGDLTEEKLETVRESDAILREEIAAAGLERDVWQYFTVNTDVKSVGVMGDQRTYDYTLAIRAITSIDGMTADFAQLPWDL
LQKISKRIVNEVDHVNRIVYDITSKPPATVEWQ
>Mature_512_residues
SDTTLEKIIVLDYGSQYNQLIARRIREIGVFSELMSHKVTAKEIREINPIGIILSGGPNSVYDEGSFDIDPEIFELGLPV
LGICYGMQLLSYKLGGMVEAAGEREYGVAPLQLTGKSALFAGTPEVQDVLMSHGDRVTAIPEGFHVVGTSPNSPFAAVEN
TERNLYGIQFHPEVRHSVHGTEMLRNFALNICGAKGNWSMENFIDMQIKNIREKVGDKKVLLGLSGGVDSSVVGVLLQRA
IGDQLTSIFVDHGFLRKGEADQVMETLGGKFGLNIIKVDAQKRFMDKLVGLSDPETKRKIIGNEFVYVFDDEANKLEGVD
FLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFQLIEPLNTLFKDEVRALGTQLGMPDEIVWRQPFPGPGLAIRVL
GDLTEEKLETVRESDAILREEIAAAGLERDVWQYFTVNTDVKSVGVMGDQRTYDYTLAIRAITSIDGMTADFAQLPWDLL
QKISKRIVNEVDHVNRIVYDITSKPPATVEWQ

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=547, Percent_Identity=36.9287020109689, Blast_Score=315, Evalue=5e-86,
Organism=Escherichia coli, GI1788854, Length=517, Percent_Identity=52.9980657640232, Blast_Score=563, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI71992710, Length=567, Percent_Identity=37.9188712522046, Blast_Score=328, Evalue=5e-90,
Organism=Caenorhabditis elegans, GI71992717, Length=567, Percent_Identity=37.9188712522046, Blast_Score=328, Evalue=5e-90,
Organism=Caenorhabditis elegans, GI133901714, Length=567, Percent_Identity=37.9188712522046, Blast_Score=327, Evalue=8e-90,
Organism=Saccharomyces cerevisiae, GI6323873, Length=519, Percent_Identity=51.6377649325626, Blast_Score=521, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6322638, Length=163, Percent_Identity=28.8343558282209, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI281365319, Length=547, Percent_Identity=37.4771480804388, Blast_Score=316, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_LACLA (Q9CFJ0)

Other databases:

- EMBL:   AE005176
- PIR:   F86810
- RefSeq:   NP_267642.1
- ProteinModelPortal:   Q9CFJ0
- SMR:   Q9CFJ0
- GeneID:   1115143
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L115968
- NMPDR:   fig|272623.1.peg.1527
- HOGENOM:   HBG391775
- OMA:   VVNAAHS
- ProtClustDB:   PRK00074
- BioCyc:   LLAC272623:L115968-MONOMER
- BRENDA:   6.3.5.2
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 56782; Mature: 56650

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 85-85 ACT_SITE 172-172 ACT_SITE 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTTLEKIIVLDYGSQYNQLIARRIREIGVFSELMSHKVTAKEIREINPIGIILSGGPN
CCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCC
SVYDEGSFDIDPEIFELGLPVLGICYGMQLLSYKLGGMVEAAGEREYGVAPLQLTGKSAL
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEECCCCEE
FAGTPEVQDVLMSHGDRVTAIPEGFHVVGTSPNSPFAAVENTERNLYGIQFHPEVRHSVH
ECCCHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCEEEECCCCCEEEEEECHHHHHHCC
GTEMLRNFALNICGAKGNWSMENFIDMQIKNIREKVGDKKVLLGLSGGVDSSVVGVLLQR
HHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTSIFVDHGFLRKGEADQVMETLGGKFGLNIIKVDAQKRFMDKLVGLSDPETKRK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHH
IIGNEFVYVFDDEANKLEGVDFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFQL
HCCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHH
IEPLNTLFKDEVRALGTQLGMPDEIVWRQPFPGPGLAIRVLGDLTEEKLETVRESDAILR
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
EEIAAAGLERDVWQYFTVNTDVKSVGVMGDQRTYDYTLAIRAITSIDGMTADFAQLPWDL
HHHHHCCCCHHHHHEEEECCCHHHHCCCCCCCCEEEEEEEEEHHHCCCCCCHHHHCCHHH
LQKISKRIVNEVDHVNRIVYDITSKPPATVEWQ
HHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC
>Mature Secondary Structure 
SDTTLEKIIVLDYGSQYNQLIARRIREIGVFSELMSHKVTAKEIREINPIGIILSGGPN
CCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEECCCC
SVYDEGSFDIDPEIFELGLPVLGICYGMQLLSYKLGGMVEAAGEREYGVAPLQLTGKSAL
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEECCCCEE
FAGTPEVQDVLMSHGDRVTAIPEGFHVVGTSPNSPFAAVENTERNLYGIQFHPEVRHSVH
ECCCHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCEEEECCCCCEEEEEECHHHHHHCC
GTEMLRNFALNICGAKGNWSMENFIDMQIKNIREKVGDKKVLLGLSGGVDSSVVGVLLQR
HHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTSIFVDHGFLRKGEADQVMETLGGKFGLNIIKVDAQKRFMDKLVGLSDPETKRK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHH
IIGNEFVYVFDDEANKLEGVDFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFQL
HCCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHH
IEPLNTLFKDEVRALGTQLGMPDEIVWRQPFPGPGLAIRVLGDLTEEKLETVRESDAILR
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
EEIAAAGLERDVWQYFTVNTDVKSVGVMGDQRTYDYTLAIRAITSIDGMTADFAQLPWDL
HHHHHCCCCHHHHHEEEECCCHHHHCCCCCCCCEEEEEEEEEHHHCCCCCCHHHHCCHHH
LQKISKRIVNEVDHVNRIVYDITSKPPATVEWQ
HHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471