Definition Lactococcus lactis subsp. lactis Il1403, complete genome.
Accession NC_002662
Length 2,365,589

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The map label for this gene is tyrS

Identifier: 15672367

GI number: 15672367

Start: 390031

End: 391290

Strand: Reverse

Name: tyrS

Synonym: L0359

Alternate gene names: 15672367

Gene position: 391290-390031 (Counterclockwise)

Preceding gene: 15672369

Following gene: 15672366

Centisome position: 16.54

GC content: 36.43

Gene sequence:

>1260_bases
ATGAACATTTTTGACGAACTTAAAGCACGTGGTTTGGTTTTCCAAACAACGGACGAAGCTGCGCTTTCTAAAGCGCTGAC
GGAGGACATGGTTTCCTATTATGTAGGATATGACCCTACCGCTGATTCCCTTCATTTAGGTAATCTTGTACTAATTTTGA
CAATGAAACGTCTACAAATGGCTGGACATAAACCTTATGCGCTTGTTGGTGGTGCAACTGGTTTGATTGGTGATCCTTCT
TTCAAAGATTCAGAACGTTCACTTCAAACAAAAGACACTGTAACAAAATGGTCTGGAAAAATCCGTAGTCAGCTTGAGCG
TTTCCTGGATTTTGAAAATGGTGAAAATAAGGCAGAAATGACCAATAACTACAACTGGTTTGAAAATCTGACTTTTATTG
ATTTCCTCAGAGATGTGGGTAAACATTTCACCGTTAACTACATGATTTCTAAAGACTCTGTAAAATCACGGATGGAAAGT
GGAATTTCTTATACAGAATTTGCTTACCAAATTATGCAAGGTTATGATTTCTACGAATTGAACCAATTGCACAATGTTAC
TTTACAACTTGGTGGTTCTGATCAATGGGGAAATATGACTGCTGGAACAGAGCTTTTACGTCGTAAAGCGAACAAGCAAG
GTCATGTTATTACTATTCCATTAATTACAGATTCAACTGGTAAAAAATTCGGTAAATCAGAAGGAAATGCAATTTGGCTT
GATGCTGATAAAACATCTCCTTATGAAATGTACCAATTTTGGCTTAATGTTGATGATGCAGATGCTGTAAAAATGTTGAA
AATTTTCACCTTCCTTTCATTAGAAGAGATTGCTGAAATTGAAGAACAATTTGAAGCAGCTCGTCATGAGCGTTTGGCCC
AAAAAGTTTTGGCTCGTGAAGTTGTCAGCTTAGTTCACGGAAAAGCAGCTTATGAACAAGCAGTTAAAACATCAGAAATC
TTATTTGGCGGCGGAGATTTGCGTCAATTAGATGCTAAATCAATCTTAACTGGTCTTAAAGCAGCTCCACAACATCAAGT
TACTGATGATGAAGATTTAACTTTAGTTGAACTTTTAATCTCTGCTGGAATAGCTCCTTCAAAAAGACAAGCTCGTGAAG
ATATTACAAATGGTGCGATTTATATCAATGGTGAACGTGTTCAAGCACTTGATTATGTTATTACAGATTCAGATAAAATT
GAAAATCGTTTAACTGTCATTCGTCGTGGGAAAAAGAAAAACTTCGTTTTGACTTATTAA

Upstream 100 bases:

>100_bases
AATTTTTTTTATTAATTTGTTATAATGTAAAACAGTGCTGTTAATTTTTTTACTTTTTATCCAAAGTGGACAGCTCAATC
ATTATAGAAAGGATTTTTTT

Downstream 100 bases:

>100_bases
TAAAACAAAAATTCTGTTCTAAATGGGACAGATTTTTTTTATTAAAAAATTTGAGCATTGCTCTTTCTTTTAGGCCACAA
TATGTTATAATAACTGTACT

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MNIFDELKARGLVFQTTDEAALSKALTEDMVSYYVGYDPTADSLHLGNLVLILTMKRLQMAGHKPYALVGGATGLIGDPS
FKDSERSLQTKDTVTKWSGKIRSQLERFLDFENGENKAEMTNNYNWFENLTFIDFLRDVGKHFTVNYMISKDSVKSRMES
GISYTEFAYQIMQGYDFYELNQLHNVTLQLGGSDQWGNMTAGTELLRRKANKQGHVITIPLITDSTGKKFGKSEGNAIWL
DADKTSPYEMYQFWLNVDDADAVKMLKIFTFLSLEEIAEIEEQFEAARHERLAQKVLAREVVSLVHGKAAYEQAVKTSEI
LFGGGDLRQLDAKSILTGLKAAPQHQVTDDEDLTLVELLISAGIAPSKRQAREDITNGAIYINGERVQALDYVITDSDKI
ENRLTVIRRGKKKNFVLTY

Sequences:

>Translated_419_residues
MNIFDELKARGLVFQTTDEAALSKALTEDMVSYYVGYDPTADSLHLGNLVLILTMKRLQMAGHKPYALVGGATGLIGDPS
FKDSERSLQTKDTVTKWSGKIRSQLERFLDFENGENKAEMTNNYNWFENLTFIDFLRDVGKHFTVNYMISKDSVKSRMES
GISYTEFAYQIMQGYDFYELNQLHNVTLQLGGSDQWGNMTAGTELLRRKANKQGHVITIPLITDSTGKKFGKSEGNAIWL
DADKTSPYEMYQFWLNVDDADAVKMLKIFTFLSLEEIAEIEEQFEAARHERLAQKVLAREVVSLVHGKAAYEQAVKTSEI
LFGGGDLRQLDAKSILTGLKAAPQHQVTDDEDLTLVELLISAGIAPSKRQAREDITNGAIYINGERVQALDYVITDSDKI
ENRLTVIRRGKKKNFVLTY
>Mature_419_residues
MNIFDELKARGLVFQTTDEAALSKALTEDMVSYYVGYDPTADSLHLGNLVLILTMKRLQMAGHKPYALVGGATGLIGDPS
FKDSERSLQTKDTVTKWSGKIRSQLERFLDFENGENKAEMTNNYNWFENLTFIDFLRDVGKHFTVNYMISKDSVKSRMES
GISYTEFAYQIMQGYDFYELNQLHNVTLQLGGSDQWGNMTAGTELLRRKANKQGHVITIPLITDSTGKKFGKSEGNAIWL
DADKTSPYEMYQFWLNVDDADAVKMLKIFTFLSLEEIAEIEEQFEAARHERLAQKVLAREVVSLVHGKAAYEQAVKTSEI
LFGGGDLRQLDAKSILTGLKAAPQHQVTDDEDLTLVELLISAGIAPSKRQAREDITNGAIYINGERVQALDYVITDSDKI
ENRLTVIRRGKKKNFVLTY

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain

Homologues:

Organism=Homo sapiens, GI94681057, Length=436, Percent_Identity=35.3211009174312, Blast_Score=239, Evalue=4e-63,
Organism=Escherichia coli, GI1787925, Length=429, Percent_Identity=48.2517482517483, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI25145802, Length=420, Percent_Identity=34.2857142857143, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI25145805, Length=324, Percent_Identity=32.4074074074074, Blast_Score=167, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6325160, Length=440, Percent_Identity=37.5, Blast_Score=289, Evalue=6e-79,
Organism=Drosophila melanogaster, GI20130383, Length=437, Percent_Identity=38.9016018306636, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYY_LACLA (Q9CIH5)

Other databases:

- EMBL:   AE005176
- PIR:   A86673
- RefSeq:   NP_266541.1
- ProteinModelPortal:   Q9CIH5
- SMR:   Q9CIH5
- PhosSite:   Q9CIH5
- GeneID:   1113996
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0359
- NMPDR:   fig|272623.1.peg.393
- HOGENOM:   HBG288125
- OMA:   TFYIGFD
- ProtClustDB:   PRK05912
- BioCyc:   LLAC272623:L0359-MONOMER
- BRENDA:   6.1.1.1
- GO:   GO:0005737
- HAMAP:   MF_02006
- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11766
- PRINTS:   PR01040
- SMART:   SM00363
- TIGRFAMs:   TIGR00234

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b

EC number: =6.1.1.1

Molecular weight: Translated: 47251; Mature: 47251

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00178 AA_TRNA_LIGASE_I; PS50889 S4

Important sites: BINDING 34-34 BINDING 169-169 BINDING 173-173 BINDING 232-232

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIFDELKARGLVFQTTDEAALSKALTEDMVSYYVGYDPTADSLHLGNLVLILTMKRLQM
CCHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHH
AGHKPYALVGGATGLIGDPSFKDSERSLQTKDTVTKWSGKIRSQLERFLDFENGENKAEM
CCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
TNNYNWFENLTFIDFLRDVGKHFTVNYMISKDSVKSRMESGISYTEFAYQIMQGYDFYEL
CCCCCHHHCCHHHHHHHHHCCCEEEEEEEEHHHHHHHHHCCCCHHHHHHHHHHCCCHHHH
NQLHNVTLQLGGSDQWGNMTAGTELLRRKANKQGHVITIPLITDSTGKKFGKSEGNAIWL
HHHCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCEEEE
DADKTSPYEMYQFWLNVDDADAVKMLKIFTFLSLEEIAEIEEQFEAARHERLAQKVLARE
ECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSLVHGKAAYEQAVKTSEILFGGGDLRQLDAKSILTGLKAAPQHQVTDDEDLTLVELLI
HHHHHHCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
SAGIAPSKRQAREDITNGAIYINGERVQALDYVITDSDKIENRLTVIRRGKKKNFVLTY
HCCCCCCHHHHHHHHCCCEEEEECCEEEEEEEEECCCHHHHHHHHHHHCCCCCCEEEEC
>Mature Secondary Structure
MNIFDELKARGLVFQTTDEAALSKALTEDMVSYYVGYDPTADSLHLGNLVLILTMKRLQM
CCHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHH
AGHKPYALVGGATGLIGDPSFKDSERSLQTKDTVTKWSGKIRSQLERFLDFENGENKAEM
CCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
TNNYNWFENLTFIDFLRDVGKHFTVNYMISKDSVKSRMESGISYTEFAYQIMQGYDFYEL
CCCCCHHHCCHHHHHHHHHCCCEEEEEEEEHHHHHHHHHCCCCHHHHHHHHHHCCCHHHH
NQLHNVTLQLGGSDQWGNMTAGTELLRRKANKQGHVITIPLITDSTGKKFGKSEGNAIWL
HHHCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCEEEE
DADKTSPYEMYQFWLNVDDADAVKMLKIFTFLSLEEIAEIEEQFEAARHERLAQKVLARE
ECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSLVHGKAAYEQAVKTSEILFGGGDLRQLDAKSILTGLKAAPQHQVTDDEDLTLVELLI
HHHHHHCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
SAGIAPSKRQAREDITNGAIYINGERVQALDYVITDSDKIENRLTVIRRGKKKNFVLTY
HCCCCCCHHHHHHHHCCCEEEEECCEEEEEEEEECCCHHHHHHHHHHHCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471