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The map label for this gene is lysQ

Identifier: 15672348

GI number: 15672348

Start: 369615

End: 371048

Strand: Direct

Name: lysQ

Synonym: L169610

Alternate gene names: 15672348

Gene position: 369615-371048 (Clockwise)

Preceding gene: 15672346

Following gene: 15672349

Centisome position: 15.62

GC content: 38.15

Gene sequence:

>1434_bases
ATGGAAAATCAAAATCAGGTCAAGCGCAACCTTAAACAGCGCCACATCACCATGATTGCATTGGGTGGTACAATTGGAAC
AGGTTTATTTTTAACTTCAGGAGCAACAATTAGTCAAGCAGGTCCCTGGGGCGCAGTTCTTGCTTATTGTTTTATTGGTA
TTATGGTTTACTTCGTAATGACTTCCTTAGGTGAGATGGCGACATATTTGCCTACCTCAGGTTCATTCTCCGATTATGGC
GGTCGTTATGTTGATCCTGCTTTTGGCTTTGCATTAGGGTGGAACTATTGGCTCAATGGAGCGATTACCATTGCCGTGGA
TTTAACGACAGCAGGATTGATTACGCAGTTTTGGTTCCCGCACCTTCCGTCTTGGATATTTTCAGGAATTGCGACGGTCT
TAATTTTTATTATTAATGTTATGGCGGTTGGAGCATTCGGGGAAACAGAATATTGGTTATCAACGATTAAAGTGATTACG
ATTGTCCTCTTTTTAGCTATTGGTTTACTTACCATTTTTGGAGTTTTGGGACAAGGAAATGTTGATGTCGTTGCCAATTT
AAGTGCTGGCAATCATGGCTTTGTTGGTGGAATTTCAGGATTTGTTGGAGTTTTACTTATTGCCGGATTCTCTTTTCAAG
GAACTGAGCTTTTAGGGATTACCGCAGGTGAATCTGAAGACCCAGGTAAGTCAATTCCTAAAGCAATGAACTCTATTTTC
TGGCGTATCTTACTTTTTTACATCTTTTCAATCATTGTGATTGCTGCAATTATCAATTTTAAAGACCCTCGCTTGTTAAA
TCCAAATTCGACAGCTGTCATGAGTCCATTTACTATTGTCTTTAAAAATATTGGCTTTGCAGTTGCAGCTTCAGTTATGA
ATGCGGTCATTCTTACTTCGGTAATTTCATCAGCAAATTCAGTAATGTATGCTTCAACACGTATTCTTTATTCATTGGGA
CAAGAAAAAGGCGCACCAAAATTCTTTGGACGAACAGCAAAAAATGGAATTCCTTTTTATGCCCTATTAGCCACAACAAT
TATTTGTTTTATTGCTTTCTTAACTGGAATATTTGGAACGCAAATTTATCTTTTCTTGGTTGATTTATCATCACTAACAG
GCTTTCTTGCTTGGCTTGGAATTTCTATCAGTCATATCCGTTTTAGAAGAGCCTATATTGCTCAAGGGAAAAAATTGGAA
GATCTTCCTTACAAAGCTAAATGGTTCCCATTTGGTCCAATTGTTGCGCTCTTGATGACTGCGGCGATTGCCATTAATCT
TGACCCAGCCATGCTCTTTAGTGAGCACTGGGGTGAAGGCTTAGCTTTATACGCTGCAATTCCTATTTTCATTATTCTTT
ATTTTGGTTATAAATGGAAGTATAATACAAAAATTATTCCACTTGAAGAAGTAGATTTGAGTCGGGAAAAATAA

Upstream 100 bases:

>100_bases
GCCGGTGATTCTCAAGAGACCGGTTGTAAAGACAACTGGTCTTTTTATTTGTTCGTGCTCTGGTTTGTAGAAAAAAACAA
GAGATTAGAAAGCAAAGATT

Downstream 100 bases:

>100_bases
TATCTGAATCACAATTCGTATAGAGTTGTGGTTTTTTATTTATAATATAAAGAGAAGTAAGGACATTTTTTAAGAGTTAC
TTACCCAAAATTACCAAGTG

Product: lysine specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MENQNQVKRNLKQRHITMIALGGTIGTGLFLTSGATISQAGPWGAVLAYCFIGIMVYFVMTSLGEMATYLPTSGSFSDYG
GRYVDPAFGFALGWNYWLNGAITIAVDLTTAGLITQFWFPHLPSWIFSGIATVLIFIINVMAVGAFGETEYWLSTIKVIT
IVLFLAIGLLTIFGVLGQGNVDVVANLSAGNHGFVGGISGFVGVLLIAGFSFQGTELLGITAGESEDPGKSIPKAMNSIF
WRILLFYIFSIIVIAAIINFKDPRLLNPNSTAVMSPFTIVFKNIGFAVAASVMNAVILTSVISSANSVMYASTRILYSLG
QEKGAPKFFGRTAKNGIPFYALLATTIICFIAFLTGIFGTQIYLFLVDLSSLTGFLAWLGISISHIRFRRAYIAQGKKLE
DLPYKAKWFPFGPIVALLMTAAIAINLDPAMLFSEHWGEGLALYAAIPIFIILYFGYKWKYNTKIIPLEEVDLSREK

Sequences:

>Translated_477_residues
MENQNQVKRNLKQRHITMIALGGTIGTGLFLTSGATISQAGPWGAVLAYCFIGIMVYFVMTSLGEMATYLPTSGSFSDYG
GRYVDPAFGFALGWNYWLNGAITIAVDLTTAGLITQFWFPHLPSWIFSGIATVLIFIINVMAVGAFGETEYWLSTIKVIT
IVLFLAIGLLTIFGVLGQGNVDVVANLSAGNHGFVGGISGFVGVLLIAGFSFQGTELLGITAGESEDPGKSIPKAMNSIF
WRILLFYIFSIIVIAAIINFKDPRLLNPNSTAVMSPFTIVFKNIGFAVAASVMNAVILTSVISSANSVMYASTRILYSLG
QEKGAPKFFGRTAKNGIPFYALLATTIICFIAFLTGIFGTQIYLFLVDLSSLTGFLAWLGISISHIRFRRAYIAQGKKLE
DLPYKAKWFPFGPIVALLMTAAIAINLDPAMLFSEHWGEGLALYAAIPIFIILYFGYKWKYNTKIIPLEEVDLSREK
>Mature_477_residues
MENQNQVKRNLKQRHITMIALGGTIGTGLFLTSGATISQAGPWGAVLAYCFIGIMVYFVMTSLGEMATYLPTSGSFSDYG
GRYVDPAFGFALGWNYWLNGAITIAVDLTTAGLITQFWFPHLPSWIFSGIATVLIFIINVMAVGAFGETEYWLSTIKVIT
IVLFLAIGLLTIFGVLGQGNVDVVANLSAGNHGFVGGISGFVGVLLIAGFSFQGTELLGITAGESEDPGKSIPKAMNSIF
WRILLFYIFSIIVIAAIINFKDPRLLNPNSTAVMSPFTIVFKNIGFAVAASVMNAVILTSVISSANSVMYASTRILYSLG
QEKGAPKFFGRTAKNGIPFYALLATTIICFIAFLTGIFGTQIYLFLVDLSSLTGFLAWLGISISHIRFRRAYIAQGKKLE
DLPYKAKWFPFGPIVALLMTAAIAINLDPAMLFSEHWGEGLALYAAIPIFIILYFGYKWKYNTKIIPLEEVDLSREK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=475, Percent_Identity=51.1578947368421, Blast_Score=489, Evalue=1e-139,
Organism=Escherichia coli, GI87081708, Length=463, Percent_Identity=35.6371490280778, Blast_Score=301, Evalue=8e-83,
Organism=Escherichia coli, GI1786789, Length=412, Percent_Identity=38.3495145631068, Blast_Score=271, Evalue=1e-73,
Organism=Escherichia coli, GI1786302, Length=468, Percent_Identity=36.5384615384615, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI48994972, Length=438, Percent_Identity=36.0730593607306, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1790653, Length=353, Percent_Identity=40.2266288951841, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1789017, Length=400, Percent_Identity=33.25, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1786602, Length=392, Percent_Identity=37.7551020408163, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI87081915, Length=419, Percent_Identity=32.6968973747017, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI87082250, Length=437, Percent_Identity=25.629290617849, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082023, Length=443, Percent_Identity=23.0248306997743, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=419, Percent_Identity=43.1980906921241, Blast_Score=321, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6324061, Length=485, Percent_Identity=36.9072164948454, Blast_Score=315, Evalue=9e-87,
Organism=Saccharomyces cerevisiae, GI6324990, Length=491, Percent_Identity=35.234215885947, Blast_Score=279, Evalue=9e-76,
Organism=Saccharomyces cerevisiae, GI6324059, Length=492, Percent_Identity=35.3658536585366, Blast_Score=275, Evalue=9e-75,
Organism=Saccharomyces cerevisiae, GI6324924, Length=495, Percent_Identity=32.1212121212121, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6321629, Length=496, Percent_Identity=32.258064516129, Blast_Score=249, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6322892, Length=487, Percent_Identity=34.0862422997947, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6321053, Length=490, Percent_Identity=31.6326530612245, Blast_Score=235, Evalue=9e-63,
Organism=Saccharomyces cerevisiae, GI6324553, Length=403, Percent_Identity=33.7468982630273, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6320717, Length=492, Percent_Identity=31.5040650406504, Blast_Score=227, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6319824, Length=511, Percent_Identity=29.9412915851272, Blast_Score=225, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6319543, Length=492, Percent_Identity=31.0975609756098, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6320251, Length=512, Percent_Identity=29.1015625, Blast_Score=216, Evalue=9e-57,
Organism=Saccharomyces cerevisiae, GI6319542, Length=493, Percent_Identity=30.2231237322515, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319608, Length=497, Percent_Identity=25.9557344064386, Blast_Score=203, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6322967, Length=467, Percent_Identity=30.1927194860814, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6324981, Length=482, Percent_Identity=31.9502074688797, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320364, Length=553, Percent_Identity=26.5822784810127, Blast_Score=177, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51956; Mature: 51956

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENQNQVKRNLKQRHITMIALGGTIGTGLFLTSGATISQAGPWGAVLAYCFIGIMVYFVM
CCCHHHHHHHHHHHCEEEEEECCCHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
TSLGEMATYLPTSGSFSDYGGRYVDPAFGFALGWNYWLNGAITIAVDLTTAGLITQFWFP
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCHHHHCCCEEEEEEECHHHHHHHHHHHH
HLPSWIFSGIATVLIFIINVMAVGAFGETEYWLSTIKVITIVLFLAIGLLTIFGVLGQGN
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VDVVANLSAGNHGFVGGISGFVGVLLIAGFSFQGTELLGITAGESEDPGKSIPKAMNSIF
EEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHH
WRILLFYIFSIIVIAAIINFKDPRLLNPNSTAVMSPFTIVFKNIGFAVAASVMNAVILTS
HHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VISSANSVMYASTRILYSLGQEKGAPKFFGRTAKNGIPFYALLATTIICFIAFLTGIFGT
HHHCCCCCHHHHHHHHHHHHHCCCCCHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
QIYLFLVDLSSLTGFLAWLGISISHIRFRRAYIAQGKKLEDLPYKAKWFPFGPIVALLMT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
AAIAINLDPAMLFSEHWGEGLALYAAIPIFIILYFGYKWKYNTKIIPLEEVDLSREK
HHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEECCEEEEHHHCCCCCCC
>Mature Secondary Structure
MENQNQVKRNLKQRHITMIALGGTIGTGLFLTSGATISQAGPWGAVLAYCFIGIMVYFVM
CCCHHHHHHHHHHHCEEEEEECCCHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHH
TSLGEMATYLPTSGSFSDYGGRYVDPAFGFALGWNYWLNGAITIAVDLTTAGLITQFWFP
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCHHHHCCCEEEEEEECHHHHHHHHHHHH
HLPSWIFSGIATVLIFIINVMAVGAFGETEYWLSTIKVITIVLFLAIGLLTIFGVLGQGN
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VDVVANLSAGNHGFVGGISGFVGVLLIAGFSFQGTELLGITAGESEDPGKSIPKAMNSIF
EEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHH
WRILLFYIFSIIVIAAIINFKDPRLLNPNSTAVMSPFTIVFKNIGFAVAASVMNAVILTS
HHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHH
VISSANSVMYASTRILYSLGQEKGAPKFFGRTAKNGIPFYALLATTIICFIAFLTGIFGT
HHHCCCCCHHHHHHHHHHHHHCCCCCHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
QIYLFLVDLSSLTGFLAWLGISISHIRFRRAYIAQGKKLEDLPYKAKWFPFGPIVALLMT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
AAIAINLDPAMLFSEHWGEGLALYAAIPIFIILYFGYKWKYNTKIIPLEEVDLSREK
HHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEECCEEEEHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]