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The map label for this gene is dxs [C]

Identifier: 15668860

GI number: 15668860

Start: 605284

End: 606234

Strand: Reverse

Name: dxs [C]

Synonym: MJ0679

Alternate gene names: 15668860

Gene position: 606234-605284 (Counterclockwise)

Preceding gene: 15668861

Following gene: 15668859

Centisome position: 36.41

GC content: 36.91

Gene sequence:

>951_bases
ATGGTTAAGTTGAGTGGAGTTTATAAGGGGATGAGGAAAGGGTATGGAGAAACATTGATAGAGTTAGGGAAAAAGTATGA
AAATTTGGTAGTTTTAGATGCTGATTTATCTGGTTCTACACAAACAGCCATGTTTGCTAAGGAATTTCCAGAGAGGTTTT
TCAATGCAGGAGTTGCAGAGCAGAACATGATTGGAATGGCAGCGGGATTAGCAACAACTGGTAAGATAGTTTTTGCTTCG
TCATTCTCCATGTTTGCATCTGGAAGAGCATGGGAGATAATAAGGAATTTAGTGGCATATCCAAAGTTGAATGTGAAGAT
TGTTGCTACTCATGCTGGAATTACAGTTGGAGAGGATGGAGCTTCCCATCAGATGTGTGAGGACATAGCTATAATGAGAG
CAATCCCAAACATGGTTGTTATTGCCCCAACTGATTACTATCACACAAAAAATGTTATTAGAACTATAGCAGAGTATAAA
GGCCCTGTTTATGTAAGAATGCCAAGAAGAGACACTGAGATAATTTATGAAAATGAGGAGGAAGCAACATTTGAAATAGG
AAAAGGAAAGATTTTAGTTGATGGAGAGGATTTAACCATTATAGCAACTGGAGAGGAAGTGCCAGAAGCTTTAAGGGCAG
GAGAAATATTAAAGGAGAATGGAATATCAGCTGAGATTGTGGAGATGGCTACAATAAAACCAATAGATGAGGAAATTATT
AAAAAATCAAAGGATTTTGTTGTTACTGTTGAAGACCATAGCATTATAGGAGGTTTAGGAGGAGCAGTTGCTGAGGTTAT
TGCCTCAAACGGCTTAAATAAAAAACTATTAAGAATTGGAATTAATGATGTATTTGGAAGAAGTGGAAAGGCAGATGAAC
TTTTAAAATACTATGGCTTAGATGGGGAGAGCATAGCTAAGAGAATCATGGAAGAAATGAAAAAAGAATAA

Upstream 100 bases:

>100_bases
AGAAGCTTTAAACAAAGATTTTTTAACTAAAAGCTTTAATTCAAATGAAGAAAAACAGTAAAAACAAAAATAATAAATTA
ATTATTTTGGGTGAAAAATC

Downstream 100 bases:

>100_bases
AAATAAAATAAATAAAATAAAATTATTATTCTATTTTCAAATAAACTTTTATTGTTGGGATTATGAAACTTAGATTTATT
GAGTGCCATATACCTAAGCA

Product: transketolase''

Products: NA

Alternate protein names: TK

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MVKLSGVYKGMRKGYGETLIELGKKYENLVVLDADLSGSTQTAMFAKEFPERFFNAGVAEQNMIGMAAGLATTGKIVFAS
SFSMFASGRAWEIIRNLVAYPKLNVKIVATHAGITVGEDGASHQMCEDIAIMRAIPNMVVIAPTDYYHTKNVIRTIAEYK
GPVYVRMPRRDTEIIYENEEEATFEIGKGKILVDGEDLTIIATGEEVPEALRAGEILKENGISAEIVEMATIKPIDEEII
KKSKDFVVTVEDHSIIGGLGGAVAEVIASNGLNKKLLRIGINDVFGRSGKADELLKYYGLDGESIAKRIMEEMKKE

Sequences:

>Translated_316_residues
MVKLSGVYKGMRKGYGETLIELGKKYENLVVLDADLSGSTQTAMFAKEFPERFFNAGVAEQNMIGMAAGLATTGKIVFAS
SFSMFASGRAWEIIRNLVAYPKLNVKIVATHAGITVGEDGASHQMCEDIAIMRAIPNMVVIAPTDYYHTKNVIRTIAEYK
GPVYVRMPRRDTEIIYENEEEATFEIGKGKILVDGEDLTIIATGEEVPEALRAGEILKENGISAEIVEMATIKPIDEEII
KKSKDFVVTVEDHSIIGGLGGAVAEVIASNGLNKKLLRIGINDVFGRSGKADELLKYYGLDGESIAKRIMEEMKKE
>Mature_316_residues
MVKLSGVYKGMRKGYGETLIELGKKYENLVVLDADLSGSTQTAMFAKEFPERFFNAGVAEQNMIGMAAGLATTGKIVFAS
SFSMFASGRAWEIIRNLVAYPKLNVKIVATHAGITVGEDGASHQMCEDIAIMRAIPNMVVIAPTDYYHTKNVIRTIAEYK
GPVYVRMPRRDTEIIYENEEEATFEIGKGKILVDGEDLTIIATGEEVPEALRAGEILKENGISAEIVEMATIKPIDEEII
KKSKDFVVTVEDHSIIGGLGGAVAEVIASNGLNKKLLRIGINDVFGRSGKADELLKYYGLDGESIAKRIMEEMKKE

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family

Homologues:

Organism=Homo sapiens, GI205277463, Length=306, Percent_Identity=36.6013071895425, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI4507521, Length=306, Percent_Identity=36.6013071895425, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI225637461, Length=301, Percent_Identity=37.2093023255814, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI225637459, Length=301, Percent_Identity=37.2093023255814, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI225637463, Length=301, Percent_Identity=37.2093023255814, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI133778974, Length=300, Percent_Identity=35.3333333333333, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1786622, Length=313, Percent_Identity=32.9073482428115, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI48994911, Length=274, Percent_Identity=28.1021897810219, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788808, Length=313, Percent_Identity=27.4760383386581, Blast_Score=74, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17539652, Length=301, Percent_Identity=34.21926910299, Blast_Score=160, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6325331, Length=262, Percent_Identity=27.8625954198473, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6319593, Length=265, Percent_Identity=28.6792452830189, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45551847, Length=312, Percent_Identity=33.6538461538462, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45550715, Length=312, Percent_Identity=33.6538461538462, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24645119, Length=312, Percent_Identity=33.6538461538462, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24666278, Length=313, Percent_Identity=33.5463258785943, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TKTC_METJA (Q58092)

Other databases:

- EMBL:   L77117
- PIR:   G64384
- RefSeq:   NP_247663.1
- ProteinModelPortal:   Q58092
- SMR:   Q58092
- GeneID:   1451545
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0679
- NMPDR:   fig|243232.1.peg.700
- TIGR:   MJ0679
- HOGENOM:   HBG414546
- OMA:   RFFQMGM
- ProtClustDB:   CLSK876290
- BioCyc:   MJAN243232:MJ_0679-MONOMER
- BRENDA:   2.2.1.1
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.1

Molecular weight: Translated: 34580; Mature: 34580

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLSGVYKGMRKGYGETLIELGKKYENLVVLDADLSGSTQTAMFAKEFPERFFNAGVAE
CEEEHHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCC
QNMIGMAAGLATTGKIVFASSFSMFASGRAWEIIRNLVAYPKLNVKIVATHAGITVGEDG
CHHHHHHHCCCCCCEEEEEECHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCEEECCCC
ASHQMCEDIAIMRAIPNMVVIAPTDYYHTKNVIRTIAEYKGPVYVRMPRRDTEIIYENEE
CCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCC
EATFEIGKGKILVDGEDLTIIATGEEVPEALRAGEILKENGISAEIVEMATIKPIDEEII
CCEEEECCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCHHHHH
KKSKDFVVTVEDHSIIGGLGGAVAEVIASNGLNKKLLRIGINDVFGRSGKADELLKYYGL
CCCCCEEEEEECCCEECHHHHHHHHHHHHCCCCHHHHHCCCHHHHCCCCCHHHHHHHHCC
DGESIAKRIMEEMKKE
CHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVKLSGVYKGMRKGYGETLIELGKKYENLVVLDADLSGSTQTAMFAKEFPERFFNAGVAE
CEEEHHHHHHHHHCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCC
QNMIGMAAGLATTGKIVFASSFSMFASGRAWEIIRNLVAYPKLNVKIVATHAGITVGEDG
CHHHHHHHCCCCCCEEEEEECHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCEEECCCC
ASHQMCEDIAIMRAIPNMVVIAPTDYYHTKNVIRTIAEYKGPVYVRMPRRDTEIIYENEE
CCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCC
EATFEIGKGKILVDGEDLTIIATGEEVPEALRAGEILKENGISAEIVEMATIKPIDEEII
CCEEEECCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCHHHHH
KKSKDFVVTVEDHSIIGGLGGAVAEVIASNGLNKKLLRIGINDVFGRSGKADELLKYYGL
CCCCCEEEEEECCCEECHHHHHHHHHHHHCCCCHHHHHCCCHHHHCCCCCHHHHHHHHCC
DGESIAKRIMEEMKKE
CHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087