Click here to switch to the map view.

The map label for this gene is deoA [C]

Identifier: 15668848

GI number: 15668848

Start: 592702

End: 594213

Strand: Direct

Name: deoA [C]

Synonym: MJ0667

Alternate gene names: 15668848

Gene position: 592702-594213 (Clockwise)

Preceding gene: 15668845

Following gene: 15668854

Centisome position: 35.6

GC content: 34.72

Gene sequence:

>1512_bases
ATGCTATTTCTAAAAGTTAGAGTTTTAGATATTGACTTGGAGAATTTGGTTTTAATTAATTCTGAAGACTTAAAAAGCTC
TCAGTATTTCCCTCAAGATAGAGTAGTTGTGGAGTTTAAAGGAAAAGAAGTTATTGGAATCCTACATTCTTCAACCACAT
TGATAAACAGAGGAGAAATAGGGCTTCCACAAAAAGTAGTTAAAGAGTTAGGTGTTAAAGAAGGGGATATTGTTACAATA
AAACATGCTGAAAAACCTAAATCTCTCCCATATATAAGAAAAAAGATGGATGGAAATAAATTAAAAAAAGAGGAAATTTT
TGAAATTATAGATGAGATGGTGGATGGAAAGCTAACAAATATTGAAATATCTGCCTTTGTCACCTCATTATATATAAATG
GAATGGATATGGATGAGATTGAAGCAATGACAATTAGAATGGCTGAAACTGGAGAGATGGTTAATTGGGAGGGGCATATA
TTTGACGTGCATTCAATTGGAGGAGTTCCTGGAAACAAATATGCTTTATTAGTCGTGCCAATAGTTGCCTCTGCTGGCTT
AAAGATTCCAAAAACATCTTCAAGGGCAATAACTTCAGCGGCAGGAACAGCAGATGTTGTTGAAGTTTTAACAAGAGTGG
ATTTAACCATTGAAGAAATAAAAAGAGTTGTTAAAGAAACAAACGGTTGTATGGTATGGGGAGGGGCTTTAGATTTAGCT
CCTGCAGATGATATAACAATAAATGTTGAAAGACCTCTTGGCATAGACCCAGAGCCCTTATTATTATCAAGTGTCATGGC
AAAAAAATTAGCTATGGGTGTTAATAAGCTATTGATTGATATTCCAACAGGATATGGAGCAAAAGTTAAATCTATAAAAG
AGGCATCAAGCTTAGCAAGGAAGTTTATTGAATTGAGTGATAGATTGAGGATAGTTACTGAATGTGCTATAACTTACGGA
GGACAGCCAATTGGAAGAGCTATTGGTCCAGCTTTAGAAGCAAAAGAGGCATTATTGGCTTTGGAAGATTATACTCAAGC
CCCTACAAGCCTTGTTGAGAAATCTATTTCATTAGCTGGAATTTTGTTAGAGATGGGAGGAGTAGCTCCTACTGGAGAAG
GTAAAGAGTTAGCTGAAGATTTATTAGCAAGAGGGAAGGCACATGACAAATTTATGGAGATTATTGTAGCTCAGGGAGGA
AAAGAAGTTAGTTCAGATGAAATTGAGGTTGGAAAATATAAAGCTGATATTCACTCACCAATTGATGGGTATGTTACAAG
AATATCAAATGCTGGAATTACAAAAATTGCCAAAGAAGCTGGAGCTCCAAATGATAAAAAAGCTGGTATCTATCTAAACG
TAAAAGTAGGAAATAAAGTTGAAAAAGGAGATGTTTTATACACCATATACTCTGACTCTGAAGAAAGGCTAAAATCAGCT
ATTAAATTAGCAAGAATATTGTATCCAATCAAAGTTGAGGGCATGTTACTCCAAAAAATTTCAAGATTCTAA

Upstream 100 bases:

>100_bases
AAGCTTCATGTTTTCACCAATGAGAAGTAATATTAAAGAAAATATATAAAGTTTAGAAAATATAAAAATTTAATAGATAA
AGAAATTAGTGGTGATTTAA

Downstream 100 bases:

>100_bases
ATAGGACCTTCCCGCAGTTTATATACAATTCTGTTTGAACTTAAATACCAAAAGACATCATATTTCAATAAAACATTTAT
TAAAAGTTCTATTAATTTAA

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MLFLKVRVLDIDLENLVLINSEDLKSSQYFPQDRVVVEFKGKEVIGILHSSTTLINRGEIGLPQKVVKELGVKEGDIVTI
KHAEKPKSLPYIRKKMDGNKLKKEEIFEIIDEMVDGKLTNIEISAFVTSLYINGMDMDEIEAMTIRMAETGEMVNWEGHI
FDVHSIGGVPGNKYALLVVPIVASAGLKIPKTSSRAITSAAGTADVVEVLTRVDLTIEEIKRVVKETNGCMVWGGALDLA
PADDITINVERPLGIDPEPLLLSSVMAKKLAMGVNKLLIDIPTGYGAKVKSIKEASSLARKFIELSDRLRIVTECAITYG
GQPIGRAIGPALEAKEALLALEDYTQAPTSLVEKSISLAGILLEMGGVAPTGEGKELAEDLLARGKAHDKFMEIIVAQGG
KEVSSDEIEVGKYKADIHSPIDGYVTRISNAGITKIAKEAGAPNDKKAGIYLNVKVGNKVEKGDVLYTIYSDSEERLKSA
IKLARILYPIKVEGMLLQKISRF

Sequences:

>Translated_503_residues
MLFLKVRVLDIDLENLVLINSEDLKSSQYFPQDRVVVEFKGKEVIGILHSSTTLINRGEIGLPQKVVKELGVKEGDIVTI
KHAEKPKSLPYIRKKMDGNKLKKEEIFEIIDEMVDGKLTNIEISAFVTSLYINGMDMDEIEAMTIRMAETGEMVNWEGHI
FDVHSIGGVPGNKYALLVVPIVASAGLKIPKTSSRAITSAAGTADVVEVLTRVDLTIEEIKRVVKETNGCMVWGGALDLA
PADDITINVERPLGIDPEPLLLSSVMAKKLAMGVNKLLIDIPTGYGAKVKSIKEASSLARKFIELSDRLRIVTECAITYG
GQPIGRAIGPALEAKEALLALEDYTQAPTSLVEKSISLAGILLEMGGVAPTGEGKELAEDLLARGKAHDKFMEIIVAQGG
KEVSSDEIEVGKYKADIHSPIDGYVTRISNAGITKIAKEAGAPNDKKAGIYLNVKVGNKVEKGDVLYTIYSDSEERLKSA
IKLARILYPIKVEGMLLQKISRF
>Mature_503_residues
MLFLKVRVLDIDLENLVLINSEDLKSSQYFPQDRVVVEFKGKEVIGILHSSTTLINRGEIGLPQKVVKELGVKEGDIVTI
KHAEKPKSLPYIRKKMDGNKLKKEEIFEIIDEMVDGKLTNIEISAFVTSLYINGMDMDEIEAMTIRMAETGEMVNWEGHI
FDVHSIGGVPGNKYALLVVPIVASAGLKIPKTSSRAITSAAGTADVVEVLTRVDLTIEEIKRVVKETNGCMVWGGALDLA
PADDITINVERPLGIDPEPLLLSSVMAKKLAMGVNKLLIDIPTGYGAKVKSIKEASSLARKFIELSDRLRIVTECAITYG
GQPIGRAIGPALEAKEALLALEDYTQAPTSLVEKSISLAGILLEMGGVAPTGEGKELAEDLLARGKAHDKFMEIIVAQGG
KEVSSDEIEVGKYKADIHSPIDGYVTRISNAGITKIAKEAGAPNDKKAGIYLNVKVGNKVEKGDVLYTIYSDSEERLKSA
IKLARILYPIKVEGMLLQKISRF

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI166158925, Length=421, Percent_Identity=27.5534441805226, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI4503445, Length=421, Percent_Identity=27.5534441805226, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI166158922, Length=421, Percent_Identity=27.5534441805226, Blast_Score=149, Evalue=6e-36,
Organism=Escherichia coli, GI1790842, Length=417, Percent_Identity=27.5779376498801, Blast_Score=126, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH_METJA (Q58081)

Other databases:

- EMBL:   L77117
- PIR:   C64383
- RefSeq:   NP_247651.1
- ProteinModelPortal:   Q58081
- SMR:   Q58081
- GeneID:   1451533
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0667
- NMPDR:   fig|243232.1.peg.688
- TIGR:   MJ0667
- HOGENOM:   HBG460532
- OMA:   GGTADLM
- ProtClustDB:   PRK04350
- BioCyc:   MJAN243232:MJ_0667-MONOMER
- BRENDA:   2.4.2.4
- HAMAP:   MF_00703
- InterPro:   IPR017713
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR03327
- TIGRFAMs:   TIGR02645

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 54723; Mature: 54723

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFLKVRVLDIDLENLVLINSEDLKSSQYFPQDRVVVEFKGKEVIGILHSSTTLINRGEI
CEEEEEEEEEECCCCEEEECCCCCCCCCCCCCCCEEEEECCCEEEEEEECCCEEEECCCC
GLPQKVVKELGVKEGDIVTIKHAEKPKSLPYIRKKMDGNKLKKEEIFEIIDEMVDGKLTN
CCCHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCEECE
IEISAFVTSLYINGMDMDEIEAMTIRMAETGEMVNWEGHIFDVHSIGGVPGNKYALLVVP
EEHHHEEEEHHCCCCCHHHHHEEEEEEECCCCEEECCCCEEEECCCCCCCCCCEEEEEEE
IVASAGLKIPKTSSRAITSAAGTADVVEVLTRVDLTIEEIKRVVKETNGCMVWGGALDLA
EHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCEEECC
PADDITINVERPLGIDPEPLLLSSVMAKKLAMGVNKLLIDIPTGYGAKVKSIKEASSLAR
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH
KFIELSDRLRIVTECAITYGGQPIGRAIGPALEAKEALLALEDYTQAPTSLVEKSISLAG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
ILLEMGGVAPTGEGKELAEDLLARGKAHDKFMEIIVAQGGKEVSSDEIEVGKYKADIHSP
HHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEEECEEECCCCCC
IDGYVTRISNAGITKIAKEAGAPNDKKAGIYLNVKVGNKVEKGDVLYTIYSDSEERLKSA
HHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEEECCEECCCCEEEEEECCCHHHHHHH
IKLARILYPIKVEGMLLQKISRF
HHHHHHHCCCEECHHHHHHHHCC
>Mature Secondary Structure
MLFLKVRVLDIDLENLVLINSEDLKSSQYFPQDRVVVEFKGKEVIGILHSSTTLINRGEI
CEEEEEEEEEECCCCEEEECCCCCCCCCCCCCCCEEEEECCCEEEEEEECCCEEEECCCC
GLPQKVVKELGVKEGDIVTIKHAEKPKSLPYIRKKMDGNKLKKEEIFEIIDEMVDGKLTN
CCCHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCEECE
IEISAFVTSLYINGMDMDEIEAMTIRMAETGEMVNWEGHIFDVHSIGGVPGNKYALLVVP
EEHHHEEEEHHCCCCCHHHHHEEEEEEECCCCEEECCCCEEEECCCCCCCCCCEEEEEEE
IVASAGLKIPKTSSRAITSAAGTADVVEVLTRVDLTIEEIKRVVKETNGCMVWGGALDLA
EHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCEEECC
PADDITINVERPLGIDPEPLLLSSVMAKKLAMGVNKLLIDIPTGYGAKVKSIKEASSLAR
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHH
KFIELSDRLRIVTECAITYGGQPIGRAIGPALEAKEALLALEDYTQAPTSLVEKSISLAG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
ILLEMGGVAPTGEGKELAEDLLARGKAHDKFMEIIVAQGGKEVSSDEIEVGKYKADIHSP
HHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEEECEEECCCCCC
IDGYVTRISNAGITKIAKEAGAPNDKKAGIYLNVKVGNKVEKGDVLYTIYSDSEERLKSA
HHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEEECCEECCCCEEEEEECCCHHHHHHH
IKLARILYPIKVEGMLLQKISRF
HHHHHHHCCCEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087