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The map label for this gene is moeA [C]

Identifier: 15668847

GI number: 15668847

Start: 591414

End: 592610

Strand: Reverse

Name: moeA [C]

Synonym: MJ0666

Alternate gene names: 15668847

Gene position: 592610-591414 (Counterclockwise)

Preceding gene: 15668849

Following gene: 15668846

Centisome position: 35.59

GC content: 30.74

Gene sequence:

>1197_bases
ATGAAGCTTATAAAAAATTTAATGCCCTTAAAAAGTGCTGAAAAGATTGTTTTTGAAAAATTATCAGAGTATTTGGATGA
GAATAAAAAAGTTAAAGAAGTTGATATTGTTGAAGCTTTAAACAGGATATCTGCTGAAGATATTAAAGCTCCAATTGATT
TACCTTATTTTAATAAGGCTGCGATGGATGGTTATGCTGTTATAGCGGAAGATACTTTTGGAGCTTCTGAAACAAACCCA
ATAATACTAAATCTTGCTGATGGAGATGAAATAACTTATGGAGAAGCTAAAAAAATATTCACTGGAGATAAACTACCAAA
AAATGCCAATGCTGTTGTTATGAAAGAGTTTTGCAATGAAGTTGATGATTTTGTTGAAGTTTATAAAACTGTTCATCCAA
ACGAAAATGTCTCAAGGATTGGGGAGGATGTTAAAAAGGGAGATGTAGTTTTGAAAAAGGGGGAGATTATTAATCCTTAT
CATCTAAATATGCTCGCATCTTTAGGAATTAAAAAAATTAAGGTTTATGATTTAAGTTTTGGTATAATATCTACGGGAGA
TGAGCTCATCAATTTGGATGAAATTAGGGATATTGAGGAAGATATTAGTAAATTAGATGGGAAAATTATAAATTCCAATT
CATATATGTTATATGGTTTAGTAAAAAATCTTGGGTTTAATGCAAAAATTTATGATATTGTTAAAGATGATAAAGAAAAA
CTAAAGAAAGCTATTAAAACAGCTTTGAGTGAAAATGACGCTTTATTAATAACTGGAGGAACTTCTGTGAGTGAGAGAGA
TATAACTGTTGAGACTGTCAGAGAATTGGGAGATGTTATAGTTCATGGTGTAAATATAAGACCTGGAAAACCATTTGGAT
TTGGAATAATTAATGATAAACCAGTCTTCATGCTGTCTGGCTATCCTGTAGCTTCAGCTGTTCAATTTGAGTTATTTATT
CAAAGATTTTTTATAGAAAGGAAGAAAGTTACCTTACCTTTAAAAAGAAATATGGCCTCTGAGCTTGGTAGAGTTGATTT
TGTTAGAGTTAAGGTGGATATAGAAGTAGAACCTATAAGAATTACTGGAAGTGGAGTTATTTCCTCGTTAATAAAAAGTG
ACGGCTATATCTTAATTCCAGAAAATGTTGAAGGTTATGAAAAAGGAGAGCTTGTAGATGTGTATTTGCTAAAATGA

Upstream 100 bases:

>100_bases
AAATAGCATTTAAATCACCACTAATTTCTTTATCTATTAAATTTTTATATTTTCTAAACTTTATATATTTTCTTTAATAT
TACTTCTCATTGGTGAAAAC

Downstream 100 bases:

>100_bases
TTATTTATAATTATTGATGGGTGATTAACTTGGATGTGTGGATTGATTTAACAACCATAGGGCTTCGCCCTATTGGGATA
TCCAGAGCGGGATTGCCTTT

Product: molybdenum cofactor biosynthesis protein MoeA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKLIKNLMPLKSAEKIVFEKLSEYLDENKKVKEVDIVEALNRISAEDIKAPIDLPYFNKAAMDGYAVIAEDTFGASETNP
IILNLADGDEITYGEAKKIFTGDKLPKNANAVVMKEFCNEVDDFVEVYKTVHPNENVSRIGEDVKKGDVVLKKGEIINPY
HLNMLASLGIKKIKVYDLSFGIISTGDELINLDEIRDIEEDISKLDGKIINSNSYMLYGLVKNLGFNAKIYDIVKDDKEK
LKKAIKTALSENDALLITGGTSVSERDITVETVRELGDVIVHGVNIRPGKPFGFGIINDKPVFMLSGYPVASAVQFELFI
QRFFIERKKVTLPLKRNMASELGRVDFVRVKVDIEVEPIRITGSGVISSLIKSDGYILIPENVEGYEKGELVDVYLLK

Sequences:

>Translated_398_residues
MKLIKNLMPLKSAEKIVFEKLSEYLDENKKVKEVDIVEALNRISAEDIKAPIDLPYFNKAAMDGYAVIAEDTFGASETNP
IILNLADGDEITYGEAKKIFTGDKLPKNANAVVMKEFCNEVDDFVEVYKTVHPNENVSRIGEDVKKGDVVLKKGEIINPY
HLNMLASLGIKKIKVYDLSFGIISTGDELINLDEIRDIEEDISKLDGKIINSNSYMLYGLVKNLGFNAKIYDIVKDDKEK
LKKAIKTALSENDALLITGGTSVSERDITVETVRELGDVIVHGVNIRPGKPFGFGIINDKPVFMLSGYPVASAVQFELFI
QRFFIERKKVTLPLKRNMASELGRVDFVRVKVDIEVEPIRITGSGVISSLIKSDGYILIPENVEGYEKGELVDVYLLK
>Mature_398_residues
MKLIKNLMPLKSAEKIVFEKLSEYLDENKKVKEVDIVEALNRISAEDIKAPIDLPYFNKAAMDGYAVIAEDTFGASETNP
IILNLADGDEITYGEAKKIFTGDKLPKNANAVVMKEFCNEVDDFVEVYKTVHPNENVSRIGEDVKKGDVVLKKGEIINPY
HLNMLASLGIKKIKVYDLSFGIISTGDELINLDEIRDIEEDISKLDGKIINSNSYMLYGLVKNLGFNAKIYDIVKDDKEK
LKKAIKTALSENDALLITGGTSVSERDITVETVRELGDVIVHGVNIRPGKPFGFGIINDKPVFMLSGYPVASAVQFELFI
QRFFIERKKVTLPLKRNMASELGRVDFVRVKVDIEVEPIRITGSGVISSLIKSDGYILIPENVEGYEKGELVDVYLLK

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family

Homologues:

Organism=Homo sapiens, GI10880983, Length=400, Percent_Identity=27.75, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI66932975, Length=400, Percent_Identity=27.75, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1787049, Length=399, Percent_Identity=29.0726817042606, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25147659, Length=333, Percent_Identity=30.9309309309309, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136978, Length=329, Percent_Identity=26.7477203647416, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24638841, Length=329, Percent_Identity=26.7477203647416, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y666_METJA (Q58080)

Other databases:

- EMBL:   L77117
- PIR:   B64383
- RefSeq:   NP_247650.1
- ProteinModelPortal:   Q58080
- GeneID:   1451532
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0666
- NMPDR:   fig|243232.1.peg.687
- TIGR:   MJ0666
- HOGENOM:   HBG731522
- OMA:   VKHALAK
- ProtClustDB:   CLSK876285
- BioCyc:   MJAN243232:MJ_0666-MONOMER
- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453
- Gene3D:   G3DSA:3.40.980.10
- SMART:   SM00852
- TIGRFAMs:   TIGR00177

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N; SSF53218 MoCF_biosynth; SSF63867 MoeA_C; SSF63882 MoeA_N

EC number: NA

Molecular weight: Translated: 44419; Mature: 44419

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIKNLMPLKSAEKIVFEKLSEYLDENKKVKEVDIVEALNRISAEDIKAPIDLPYFNKA
CCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCC
AMDGYAVIAEDTFGASETNPIILNLADGDEITYGEAKKIFTGDKLPKNANAVVMKEFCNE
CCCCEEEEEECCCCCCCCCCEEEEECCCCEEECCCCCEEECCCCCCCCCCCHHHHHHHHH
VDDFVEVYKTVHPNENVSRIGEDVKKGDVVLKKGEIINPYHLNMLASLGIKKIKVYDLSF
HHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCEEEEEEEEEE
GIISTGDELINLDEIRDIEEDISKLDGKIINSNSYMLYGLVKNLGFNAKIYDIVKDDKEK
EEEECCHHHCCHHHHHHHHHHHHHHCCEEECCCCEEEEEEHHHCCCCCEEEHHHHCHHHH
LKKAIKTALSENDALLITGGTSVSERDITVETVRELGDVIVHGVNIRPGKPFGFGIINDK
HHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCEEEEECCC
PVFMLSGYPVASAVQFELFIQRFFIERKKVTLPLKRNMASELGRVDFVRVKVDIEVEPIR
CEEEEECCCHHHHHHHHHHHHHHHHHHHCEECCHHHHHHHHCCCEEEEEEEEEEEEEEEE
ITGSGVISSLIKSDGYILIPENVEGYEKGELVDVYLLK
EECHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MKLIKNLMPLKSAEKIVFEKLSEYLDENKKVKEVDIVEALNRISAEDIKAPIDLPYFNKA
CCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCCCCCC
AMDGYAVIAEDTFGASETNPIILNLADGDEITYGEAKKIFTGDKLPKNANAVVMKEFCNE
CCCCEEEEEECCCCCCCCCCEEEEECCCCEEECCCCCEEECCCCCCCCCCCHHHHHHHHH
VDDFVEVYKTVHPNENVSRIGEDVKKGDVVLKKGEIINPYHLNMLASLGIKKIKVYDLSF
HHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCEEEEEEEEEE
GIISTGDELINLDEIRDIEEDISKLDGKIINSNSYMLYGLVKNLGFNAKIYDIVKDDKEK
EEEECCHHHCCHHHHHHHHHHHHHHCCEEECCCCEEEEEEHHHCCCCCEEEHHHHCHHHH
LKKAIKTALSENDALLITGGTSVSERDITVETVRELGDVIVHGVNIRPGKPFGFGIINDK
HHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCEEEEECCC
PVFMLSGYPVASAVQFELFIQRFFIERKKVTLPLKRNMASELGRVDFVRVKVDIEVEPIR
CEEEEECCCHHHHHHHHHHHHHHHHHHHCEECCHHHHHHHHCCCEEEEEEEEEEEEEEEE
ITGSGVISSLIKSDGYILIPENVEGYEKGELVDVYLLK
EECHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087