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The map label for this gene is pyrD

Identifier: 15668835

GI number: 15668835

Start: 582073

End: 582993

Strand: Reverse

Name: pyrD

Synonym: MJ0654

Alternate gene names: 15668835

Gene position: 582993-582073 (Counterclockwise)

Preceding gene: 15668841

Following gene: 15668833

Centisome position: 35.02

GC content: 34.42

Gene sequence:

>921_bases
TTGGGTGAATGTATGTTGAAAACAAACATCTGTGGAATAGAATTTAAAAATCCTGTTTTTTTAGCAAGTGGAATAATGGG
AGAAACTGGAAGTGCATTAAAAAGAATTGCTAAAGGAGGAGCTGGAGCTGTAACAACAAAATCTATTGGATTAAATCCAA
ATCCTGGACATAAAAATCCAACTATTGTAGAGGTTTATGGAGGATTTTTAAATGCCATGGGTTTGCCTAATCCTGGAGTT
GATGAGTATTTGGAGGAGATAGAAAAGGTTAGAGATGAGTTAAATAGGATGGATGTTAGAATTATTGGCTCAATCTATGG
GAAAGATGAGGAAGAATTTGCTGAAGTAGCTAAGAAAATGGAGAGGTATGTAGATATTATTGAGCTAAACATTTCCTGCC
CTCATGCTAAAGGTTATGGAGCTACCATAGGGCAAAATCCAGATTTGTCCTATGATGTTTGCAAGGCAGTTAAAAAAGCT
GTTAAAATTCCAGTTTTTGCTAAATTAACACCAAATGTTACAGATATTATTGAGATTGCTCAGGCAGTTGTAGATGCTGG
TGTTGATGGATTAGTAGCTATAAACACAGTTAGAGGAATGGCTATAGATATTAGAGCAAAAAAACCAATTTTAGCTAATA
AATTTGGAGGCTTAAGTGGGAAAGCAATAAAGTCAATTGGAATAAAAGTAGTTTGGGATTTGTATGAGAATTTTGATGTG
CCAATTATCGGTGTTGGAGGAATTATGAGTGGAGAGGATGCCATTGAGTATATGATGGCTGGAGCTTCAGCTGTTCAAAT
AGGAAGTGGAGTTTATTATAGAGGTTATGATATATTTAAAAAAGTTTGTGATGAAATAATAAGCTTTTTAAAAGAGGAAA
ATTTAACATTGGAAGAGATTGTTGGGATGGCTCATGAATAA

Upstream 100 bases:

>100_bases
TAATCATAGTGTGTATTTCTATAATGTTTTCTTAATTTTTAATTTACCATTAAAAATTTAATATCATAATACCATAAGAA
TTAGTATTTAAAACTTTTGG

Downstream 100 bases:

>100_bases
TTTTTTAATATTTAGTTCTTTTCAAAAAGTTGTTAAATTTTATTCCAAAATGTTTTGTAAAGAACTATTTATTCTTCTTT
TTCTTCAAATTCTTCTATGC

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MGECMLKTNICGIEFKNPVFLASGIMGETGSALKRIAKGGAGAVTTKSIGLNPNPGHKNPTIVEVYGGFLNAMGLPNPGV
DEYLEEIEKVRDELNRMDVRIIGSIYGKDEEEFAEVAKKMERYVDIIELNISCPHAKGYGATIGQNPDLSYDVCKAVKKA
VKIPVFAKLTPNVTDIIEIAQAVVDAGVDGLVAINTVRGMAIDIRAKKPILANKFGGLSGKAIKSIGIKVVWDLYENFDV
PIIGVGGIMSGEDAIEYMMAGASAVQIGSGVYYRGYDIFKKVCDEIISFLKEENLTLEEIVGMAHE

Sequences:

>Translated_306_residues
MGECMLKTNICGIEFKNPVFLASGIMGETGSALKRIAKGGAGAVTTKSIGLNPNPGHKNPTIVEVYGGFLNAMGLPNPGV
DEYLEEIEKVRDELNRMDVRIIGSIYGKDEEEFAEVAKKMERYVDIIELNISCPHAKGYGATIGQNPDLSYDVCKAVKKA
VKIPVFAKLTPNVTDIIEIAQAVVDAGVDGLVAINTVRGMAIDIRAKKPILANKFGGLSGKAIKSIGIKVVWDLYENFDV
PIIGVGGIMSGEDAIEYMMAGASAVQIGSGVYYRGYDIFKKVCDEIISFLKEENLTLEEIVGMAHE
>Mature_305_residues
GECMLKTNICGIEFKNPVFLASGIMGETGSALKRIAKGGAGAVTTKSIGLNPNPGHKNPTIVEVYGGFLNAMGLPNPGVD
EYLEEIEKVRDELNRMDVRIIGSIYGKDEEEFAEVAKKMERYVDIIELNISCPHAKGYGATIGQNPDLSYDVCKAVKKAV
KIPVFAKLTPNVTDIIEIAQAVVDAGVDGLVAINTVRGMAIDIRAKKPILANKFGGLSGKAIKSIGIKVVWDLYENFDVP
IIGVGGIMSGEDAIEYMMAGASAVQIGSGVYYRGYDIFKKVCDEIISFLKEENLTLEEIVGMAHE

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=302, Percent_Identity=31.4569536423841, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI45006951, Length=312, Percent_Identity=28.8461538461538, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI87082059, Length=320, Percent_Identity=32.5, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1787177, Length=306, Percent_Identity=29.0849673202614, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71984108, Length=308, Percent_Identity=34.0909090909091, Blast_Score=160, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17509475, Length=326, Percent_Identity=28.5276073619632, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322633, Length=291, Percent_Identity=29.8969072164948, Blast_Score=116, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24640763, Length=309, Percent_Identity=33.9805825242718, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI18858217, Length=309, Percent_Identity=33.9805825242718, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI281361352, Length=304, Percent_Identity=24.6710526315789, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17137316, Length=304, Percent_Identity=24.6710526315789, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_METJA (Q58070)

Other databases:

- EMBL:   L77117
- PIR:   F64381
- RefSeq:   NP_247638.1
- ProteinModelPortal:   Q58070
- SMR:   Q58070
- GeneID:   1451520
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0654
- NMPDR:   fig|243232.1.peg.675
- TIGR:   MJ0654
- HOGENOM:   HBG472415
- OMA:   NSIGLQN
- ProtClustDB:   PRK07259
- BioCyc:   MJAN243232:MJ_0654-MONOMER
- BRENDA:   1.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00224_A
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 32941; Mature: 32809

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 133-133

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGECMLKTNICGIEFKNPVFLASGIMGETGSALKRIAKGGAGAVTTKSIGLNPNPGHKNP
CCCEEEECCCCCEEECCCEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC
TIVEVYGGFLNAMGLPNPGVDEYLEEIEKVRDELNRMDVRIIGSIYGKDEEEFAEVAKKM
EEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHCCCHHHHHHHHHHH
ERYVDIIELNISCPHAKGYGATIGQNPDLSYDVCKAVKKAVKIPVFAKLTPNVTDIIEIA
HHHHEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHH
QAVVDAGVDGLVAINTVRGMAIDIRAKKPILANKFGGLSGKAIKSIGIKVVWDLYENFDV
HHHHHCCCCCEEEEEECCCEEEEEECCCCCHHHHCCCCCCHHHHHCCHHEEEEHHHCCCC
PIIGVGGIMSGEDAIEYMMAGASAVQIGSGVYYRGYDIFKKVCDEIISFLKEENLTLEEI
CEEEECCCCCCHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHCCCCHHHH
VGMAHE
HCCCCC
>Mature Secondary Structure 
GECMLKTNICGIEFKNPVFLASGIMGETGSALKRIAKGGAGAVTTKSIGLNPNPGHKNP
CCEEEECCCCCEEECCCEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCC
TIVEVYGGFLNAMGLPNPGVDEYLEEIEKVRDELNRMDVRIIGSIYGKDEEEFAEVAKKM
EEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHHHCCCHHHHHHHHHHH
ERYVDIIELNISCPHAKGYGATIGQNPDLSYDVCKAVKKAVKIPVFAKLTPNVTDIIEIA
HHHHEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHH
QAVVDAGVDGLVAINTVRGMAIDIRAKKPILANKFGGLSGKAIKSIGIKVVWDLYENFDV
HHHHHCCCCCEEEEEECCCEEEEEECCCCCHHHHCCCCCCHHHHHCCHHEEEEHHHCCCC
PIIGVGGIMSGEDAIEYMMAGASAVQIGSGVYYRGYDIFKKVCDEIISFLKEENLTLEEI
CEEEECCCCCCHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHCCCCHHHH
VGMAHE
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087