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The map label for this gene is truD1 [H]

Identifier: 15668768

GI number: 15668768

Start: 520114

End: 521406

Strand: Reverse

Name: truD1 [H]

Synonym: MJ0588

Alternate gene names: 15668768

Gene position: 521406-520114 (Counterclockwise)

Preceding gene: 15668782

Following gene: 15668767

Centisome position: 31.32

GC content: 32.33

Gene sequence:

>1293_bases
ATGTATTTTTTGATTCAGCAGAGAAAGGAAGAAAGTGAAAAAAATTTGAAAGAAAAATTAAAAAGATATAGAAAAAAATT
AAGAGACAGCAGAATTAAAGAAAAGCTAAAAGAAATGCCATTAAACATGAATAAATACTTAACTGATGCTTATACAGGAG
GAATTATTAAAAAATATCCAGAGGATTTTATTGTTGAAGAGATAACTCCAGAAGGAATTATTTTAGAAGTTGGAAAGAGT
ATAGAATTTAAAGATGAAGAAAATTGGAAGGGAAATTATATACACTTCACATTAGAGAAGAGGAATTGGACAACTTTAGA
TGCCATTAGAGAAATAGCAAACAGAGTAGGAAAGCAGAGAAAGCATTTTGGATTTGCTGGCAATAAGGATAAATATGCCG
TAACTACTCAAAGAGTGGGCTGTTTTAATGTAAAGTTAGAAGATTTAATGAAAGTTAAGATTAAAGGCATAATATTGAGA
GATTTCCAAAAAACAAATAGAAAAATAAGGTTGGGGGATTTGTGGGGGAATAGATTTACTATAAGAGTTAGAGAGCCTGA
GCTTAAAGGAAAAGAATTGGAAGAAGCTTTAAATAAGTTATGTAAGCTAAAATACTTCTTAAATTACTATGGTGTTCAAA
GGTTTGGAACTACAAGGCCAATAACTCACATAGTTGGGAGGTTTATTATAGAGAGAGACTGGGAGGGAGCTTTCCATGCA
TATTGTGGAACTCCCCTTCCTTACGATGACAAAAAATCAAAGTTGGCAAGGGAGTTGGTGGATGAAGAGAATTTTAAAGA
GGCGTATAAAAAATTCCCAAAGGCTTTCTTTTATGAAAGAAGGATGATTAAAGCTTATATAGAAACTGGGAGCTATCAAA
AGGCATTTATGATTCTTCCACCATACTTAAGGTGCATGTTTATAAATGCTTATCAATCCTATTTATTCAATGAGATAATC
AATAGAAGGTTTGAGTATGGCTTTGAACCTATGGAAGGGGATATTTTAATTGATAATGTGCCGAGTGGGGCATTGTTTGG
ATATAAAACAAGGTTTGCATCTGGAATACAAGGAGAGATTGAGAGAGAGATTTATGAGAGAGAAAATCTAAGTCCAGAGG
ATTTCAAGATTGGTGAGTTTGGTTCATTTATTGGAGATAGAAGGGCGATGATTGGAAAAATATACAATATGAAATATTGG
ATTGAAGATGACAGCTATGTTTTGCAGTTTTGTTTAAAAAAAGGAAATTATGCAACCTCTGTTTTGAGGGAGTTTATAGA
AAAGAAGGATTAA

Upstream 100 bases:

>100_bases
TTTTGCTATCTCTAACAACTCTCTCCAGACCTCTTTAGGTCTCACACTATCACCAAATTAAGATTTAACTAATTACTATT
AAAGTATTGTAGGTGATTAT

Downstream 100 bases:

>100_bases
AAGATTCAGTAAGAAGTTTTAGGAAAATAATAAAAATAATAAAAGGAAAAATTATTGTGGGATTTAAATATCTCTTAAAA
AATTAGGAAAATAAAAAAAT

Product: hypothetical protein

Products: NA

Alternate protein names: tRNA pseudouridylate synthase D 1; tRNA-uridine isomerase D 1 [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MYFLIQQRKEESEKNLKEKLKRYRKKLRDSRIKEKLKEMPLNMNKYLTDAYTGGIIKKYPEDFIVEEITPEGIILEVGKS
IEFKDEENWKGNYIHFTLEKRNWTTLDAIREIANRVGKQRKHFGFAGNKDKYAVTTQRVGCFNVKLEDLMKVKIKGIILR
DFQKTNRKIRLGDLWGNRFTIRVREPELKGKELEEALNKLCKLKYFLNYYGVQRFGTTRPITHIVGRFIIERDWEGAFHA
YCGTPLPYDDKKSKLARELVDEENFKEAYKKFPKAFFYERRMIKAYIETGSYQKAFMILPPYLRCMFINAYQSYLFNEII
NRRFEYGFEPMEGDILIDNVPSGALFGYKTRFASGIQGEIEREIYERENLSPEDFKIGEFGSFIGDRRAMIGKIYNMKYW
IEDDSYVLQFCLKKGNYATSVLREFIEKKD

Sequences:

>Translated_430_residues
MYFLIQQRKEESEKNLKEKLKRYRKKLRDSRIKEKLKEMPLNMNKYLTDAYTGGIIKKYPEDFIVEEITPEGIILEVGKS
IEFKDEENWKGNYIHFTLEKRNWTTLDAIREIANRVGKQRKHFGFAGNKDKYAVTTQRVGCFNVKLEDLMKVKIKGIILR
DFQKTNRKIRLGDLWGNRFTIRVREPELKGKELEEALNKLCKLKYFLNYYGVQRFGTTRPITHIVGRFIIERDWEGAFHA
YCGTPLPYDDKKSKLARELVDEENFKEAYKKFPKAFFYERRMIKAYIETGSYQKAFMILPPYLRCMFINAYQSYLFNEII
NRRFEYGFEPMEGDILIDNVPSGALFGYKTRFASGIQGEIEREIYERENLSPEDFKIGEFGSFIGDRRAMIGKIYNMKYW
IEDDSYVLQFCLKKGNYATSVLREFIEKKD
>Mature_430_residues
MYFLIQQRKEESEKNLKEKLKRYRKKLRDSRIKEKLKEMPLNMNKYLTDAYTGGIIKKYPEDFIVEEITPEGIILEVGKS
IEFKDEENWKGNYIHFTLEKRNWTTLDAIREIANRVGKQRKHFGFAGNKDKYAVTTQRVGCFNVKLEDLMKVKIKGIILR
DFQKTNRKIRLGDLWGNRFTIRVREPELKGKELEEALNKLCKLKYFLNYYGVQRFGTTRPITHIVGRFIIERDWEGAFHA
YCGTPLPYDDKKSKLARELVDEENFKEAYKKFPKAFFYERRMIKAYIETGSYQKAFMILPPYLRCMFINAYQSYLFNEII
NRRFEYGFEPMEGDILIDNVPSGALFGYKTRFASGIQGEIEREIYERENLSPEDFKIGEFGSFIGDRRAMIGKIYNMKYW
IEDDSYVLQFCLKKGNYATSVLREFIEKKD

Specific function: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs [H]

COG id: COG0585

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRUD domain [H]

Homologues:

Organism=Homo sapiens, GI50727002, Length=255, Percent_Identity=30.5882352941176, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI148762985, Length=400, Percent_Identity=25.5, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI148762961, Length=400, Percent_Identity=25.5, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI148762948, Length=400, Percent_Identity=25.5, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1789102, Length=166, Percent_Identity=31.3253012048193, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17557232, Length=319, Percent_Identity=26.3322884012539, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324817, Length=299, Percent_Identity=32.1070234113712, Blast_Score=136, Evalue=6e-33,
Organism=Drosophila melanogaster, GI21355799, Length=260, Percent_Identity=28.4615384615385, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR001656
- InterPro:   IPR011760 [H]

Pfam domain/function: PF01142 TruD [H]

EC number: NA

Molecular weight: Translated: 51215; Mature: 51215

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS50984 TRUD ; PS01268 UPF0024

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYFLIQQRKEESEKNLKEKLKRYRKKLRDSRIKEKLKEMPLNMNKYLTDAYTGGIIKKYP
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCC
EDFIVEEITPEGIILEVGKSIEFKDEENWKGNYIHFTLEKRNWTTLDAIREIANRVGKQR
HHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
KHFGFAGNKDKYAVTTQRVGCFNVKLEDLMKVKIKGIILRDFQKTNRKIRLGDLWGNRFT
HHCCCCCCCCCEEEEECCCCEEECCHHHHHHHHHHHHHEECHHHCCCEEEEEEECCCEEE
IRVREPELKGKELEEALNKLCKLKYFLNYYGVQRFGTTRPITHIVGRFIIERDWEGAFHA
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHH
YCGTPLPYDDKKSKLARELVDEENFKEAYKKFPKAFFYERRMIKAYIETGSYQKAFMILP
HCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
PYLRCMFINAYQSYLFNEIINRRFEYGFEPMEGDILIDNVPSGALFGYKTRFASGIQGEI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEECHHHHHHCCCHHHH
EREIYERENLSPEDFKIGEFGSFIGDRRAMIGKIYNMKYWIEDDSYVLQFCLKKGNYATS
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHCCCHHHH
VLREFIEKKD
HHHHHHHCCC
>Mature Secondary Structure
MYFLIQQRKEESEKNLKEKLKRYRKKLRDSRIKEKLKEMPLNMNKYLTDAYTGGIIKKYP
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCC
EDFIVEEITPEGIILEVGKSIEFKDEENWKGNYIHFTLEKRNWTTLDAIREIANRVGKQR
HHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
KHFGFAGNKDKYAVTTQRVGCFNVKLEDLMKVKIKGIILRDFQKTNRKIRLGDLWGNRFT
HHCCCCCCCCCEEEEECCCCEEECCHHHHHHHHHHHHHEECHHHCCCEEEEEEECCCEEE
IRVREPELKGKELEEALNKLCKLKYFLNYYGVQRFGTTRPITHIVGRFIIERDWEGAFHA
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHH
YCGTPLPYDDKKSKLARELVDEENFKEAYKKFPKAFFYERRMIKAYIETGSYQKAFMILP
HCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
PYLRCMFINAYQSYLFNEIINRRFEYGFEPMEGDILIDNVPSGALFGYKTRFASGIQGEI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEECHHHHHHCCCHHHH
EREIYERENLSPEDFKIGEFGSFIGDRRAMIGKIYNMKYWIEDDSYVLQFCLKKGNYATS
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHCCCHHHH
VLREFIEKKD
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]