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The map label for this gene is hemC

Identifier: 15668749

GI number: 15668749

Start: 505220

End: 506098

Strand: Reverse

Name: hemC

Synonym: MJ0569

Alternate gene names: 15668749

Gene position: 506098-505220 (Counterclockwise)

Preceding gene: 15668750

Following gene: 15668747

Centisome position: 30.4

GC content: 31.29

Gene sequence:

>879_bases
ATGATTAGAATAGGGACAAGAGGTAGTAAATTGGCATTATATCAAGCTAACAAAGTGGCTGAACTATTAAAAAATCTTGG
TTATAAGGTAGAAATAAAGATAATTAAAACTACTGGAGATAGGGTTTTAGATAAAAAGCTATCGGATATAGGTATTGGCG
TTTTTACAAAGGAGTTAGATTTAGCCATGTTAAATAACGAAATTGATATAGCAGTTCATAGCTTAAAAGACATTCCAACT
ATTTGGAATGAAAATTTAATGGTTGGGGCTGTTTTGGAGAGAGATAGCTATCACGACTTGCTAATATGGAATAAGGATAT
AGATTTTAATGAAGATAGTAAAATAGTTATAGGAACTTCAAGTATGAGGAGGAGGGCTTTTTTAAAGTTTATTTATCCAA
ATGCAAAATTTGAGTTATTGAGGGGAAATGTAGATACAAGATTAAGAAAGCTAAAAGAAGGGCTTTATGATGCTATTGTT
TTATCTGAAGCTGGAATAATAAGATTGGGAGTTAGTTTAGAGGATTTTAACTATAAAAGATTGGATATCCTTCCAGCTCC
TGCTCAAGGAATTATAGCCGTTGCTTGCAAAAGAGATGATGAGGAAATGAAAAGCATCTTAAAAGAGATTAACCATGAAA
GAACTTACTTAGAGAGTTTATGTGAAAGAACTGCATTAAATGAATTTGGAGGAGGTTGTAGTGTTCCATTTGGAGCTTTA
GCAGTTTATGATGAAAAAAATGAGTTATTAAAATTAAAAGCTGCAGTTGTTACCAACGATGAGTTAAAAAATGCCTCTGG
AGAGGTTAAATGTAAAATTGATGAGATTGATAAGGCAGTTGAATTAGGGAAAAAAATTGGACTAAAATTAAAAAATTAA

Upstream 100 bases:

>100_bases
GAGGATAGAGGTTGTTGAGGCAGAGATAGAATGGCATGAAACTTGGGGAATTTACCATATAAAAAAGGCAAAATTGGTTG
ATAAAGAATAAAGGGAGATT

Downstream 100 bases:

>100_bases
ACTTTATCTTTAAATTTCTCCATAAAAATTTTTAATCTCTCTAATATTTCATCTGATAATGCATGTTCTAATTTGCAAGC
TTCTTCAGATGCTGTTTTTT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MIRIGTRGSKLALYQANKVAELLKNLGYKVEIKIIKTTGDRVLDKKLSDIGIGVFTKELDLAMLNNEIDIAVHSLKDIPT
IWNENLMVGAVLERDSYHDLLIWNKDIDFNEDSKIVIGTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIV
LSEAGIIRLGVSLEDFNYKRLDILPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVPFGAL
AVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN

Sequences:

>Translated_292_residues
MIRIGTRGSKLALYQANKVAELLKNLGYKVEIKIIKTTGDRVLDKKLSDIGIGVFTKELDLAMLNNEIDIAVHSLKDIPT
IWNENLMVGAVLERDSYHDLLIWNKDIDFNEDSKIVIGTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIV
LSEAGIIRLGVSLEDFNYKRLDILPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVPFGAL
AVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN
>Mature_292_residues
MIRIGTRGSKLALYQANKVAELLKNLGYKVEIKIIKTTGDRVLDKKLSDIGIGVFTKELDLAMLNNEIDIAVHSLKDIPT
IWNENLMVGAVLERDSYHDLLIWNKDIDFNEDSKIVIGTSSMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIV
LSEAGIIRLGVSLEDFNYKRLDILPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVPFGAL
AVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=252, Percent_Identity=37.3015873015873, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI66933009, Length=252, Percent_Identity=37.3015873015873, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI48994974, Length=246, Percent_Identity=38.6178861788618, Blast_Score=159, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319996, Length=273, Percent_Identity=36.996336996337, Blast_Score=143, Evalue=3e-35,
Organism=Drosophila melanogaster, GI20130425, Length=246, Percent_Identity=37.8048780487805, Blast_Score=151, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_METJA (Q57989)

Other databases:

- EMBL:   L77117
- PIR:   A64371
- RefSeq:   NP_247548.1
- ProteinModelPortal:   Q57989
- SMR:   Q57989
- GeneID:   1451434
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0569
- NMPDR:   fig|243232.1.peg.585
- TIGR:   MJ0569
- HOGENOM:   HBG624842
- OMA:   DADILEM
- ProtClustDB:   PRK00072
- BioCyc:   MJAN243232:MJ_0569-MONOMER
- BRENDA:   2.5.1.61
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 32784; Mature: 32784

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIGTRGSKLALYQANKVAELLKNLGYKVEIKIIKTTGDRVLDKKLSDIGIGVFTKELD
CEEECCCCCEEEEEEHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCEEEEHHHH
LAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWNKDIDFNEDSKIVIGTS
HEEECCCCEEEEECHHCCCHHHCCCEEEEEEECCCCCCEEEEECCCCCCCCCCEEEEECC
SMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIVLSEAGIIRLGVSLEDFNYKR
HHHHHHHHEEECCCCEEEEEECCHHHHHHHHHHHHHHEEHCCCCCEEEEEEEEECCCCEE
LDILPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVPFGAL
EEEECCCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEE
AVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN
EEECCCCCEEEEEEEEEECHHHCCCCCEEEEEHHHHHHHHHHHHHCCCEECC
>Mature Secondary Structure
MIRIGTRGSKLALYQANKVAELLKNLGYKVEIKIIKTTGDRVLDKKLSDIGIGVFTKELD
CEEECCCCCEEEEEEHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHCCCEEEEHHHH
LAMLNNEIDIAVHSLKDIPTIWNENLMVGAVLERDSYHDLLIWNKDIDFNEDSKIVIGTS
HEEECCCCEEEEECHHCCCHHHCCCEEEEEEECCCCCCEEEEECCCCCCCCCCEEEEECC
SMRRRAFLKFIYPNAKFELLRGNVDTRLRKLKEGLYDAIVLSEAGIIRLGVSLEDFNYKR
HHHHHHHHEEECCCCEEEEEECCHHHHHHHHHHHHHHEEHCCCCCEEEEEEEEECCCCEE
LDILPAPAQGIIAVACKRDDEEMKSILKEINHERTYLESLCERTALNEFGGGCSVPFGAL
EEEECCCCCCEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEE
AVYDEKNELLKLKAAVVTNDELKNASGEVKCKIDEIDKAVELGKKIGLKLKN
EEECCCCCEEEEEEEEEECHHHCCCCCEEEEEHHHHHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087