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The map label for this gene is tbp

Identifier: 15668684

GI number: 15668684

Start: 447726

End: 448277

Strand: Reverse

Name: tbp

Synonym: MJ0507

Alternate gene names: 15668684

Gene position: 448277-447726 (Counterclockwise)

Preceding gene: 15668685

Following gene: 15668683

Centisome position: 26.92

GC content: 33.7

Gene sequence:

>552_bases
GTGAAAATCATGGAACCAGAAATTAAGATTGTTAATGTTGTAGTCTCAACAAAAATTGGAGACAATATTGATTTAGAAGA
GGTTGCTATGATTTTAGAAAATGCTGAATATGAGCCAGAACAATTCCCAGGGTTAGTTTGTAGATTATCAGTGCCAAAAG
TTGCTTTATTAATATTTAGAAGTGGAAAGGTAAATTGTACTGGAGCTAAGAGCAAAGAAGAGGCAGAAATAGCCATTAAA
AAGATTATAAAAGAGTTAAAAGATGCCGGAATTGATGTTATTGAAAACCCTGAAATTAAAATCCAAAATATGGTCGCAAC
AGCTGATTTAGGAATTGAGCCAAATTTAGATGACATTGCCTTAATGGTTGAAGGAACTGAATATGAGCCAGAACAATTCC
CAGGGTTAGTTTATAGGTTGGATGACCCGAAGGTTGTTGTTTTAATATTTGGTAGTGGTAAGGTCGTTATTACTGGTTTA
AAGAGTGAGGAAGATGCCAAAAGAGCTCTAAAGAAGATTTTAGATACAATAAAAGAAGTTCAAGAACTCTAA

Upstream 100 bases:

>100_bases
AAGTTAAATATACAAATTTTATGTAATATTTAAAAGTATTTATATATAAAGTATTTATATATGGGGTTTTTATATAATAT
CTAAGTTAGTTGTTAAATAG

Downstream 100 bases:

>100_bases
ATTTTAGGGATGAAAATGATTGGAATAATTGATTACAACGCAGGGAATTTGAGAAGTATTCAAAAGGCAGTTGAACTCTA
TGATAAGGTAATAATAACAA

Product: transcription factor

Products: NA

Alternate protein names: Box A-binding protein; BAP; TATA sequence-binding protein; TBP; TATA-box factor

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MKIMEPEIKIVNVVVSTKIGDNIDLEEVAMILENAEYEPEQFPGLVCRLSVPKVALLIFRSGKVNCTGAKSKEEAEIAIK
KIIKELKDAGIDVIENPEIKIQNMVATADLGIEPNLDDIALMVEGTEYEPEQFPGLVYRLDDPKVVVLIFGSGKVVITGL
KSEEDAKRALKKILDTIKEVQEL

Sequences:

>Translated_183_residues
MKIMEPEIKIVNVVVSTKIGDNIDLEEVAMILENAEYEPEQFPGLVCRLSVPKVALLIFRSGKVNCTGAKSKEEAEIAIK
KIIKELKDAGIDVIENPEIKIQNMVATADLGIEPNLDDIALMVEGTEYEPEQFPGLVYRLDDPKVVVLIFGSGKVVITGL
KSEEDAKRALKKILDTIKEVQEL
>Mature_183_residues
MKIMEPEIKIVNVVVSTKIGDNIDLEEVAMILENAEYEPEQFPGLVCRLSVPKVALLIFRSGKVNCTGAKSKEEAEIAIK
KIIKELKDAGIDVIENPEIKIQNMVATADLGIEPNLDDIALMVEGTEYEPEQFPGLVYRLDDPKVVVLIFGSGKVVITGL
KSEEDAKRALKKILDTIKEVQEL

Specific function: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation

COG id: COG2101

COG function: function code K; TATA-box binding protein (TBP), component of TFIID and TFIIIB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TBP family

Homologues:

Organism=Homo sapiens, GI285026520, Length=175, Percent_Identity=37.1428571428571, Blast_Score=127, Evalue=4e-30,
Organism=Homo sapiens, GI4507379, Length=175, Percent_Identity=37.1428571428571, Blast_Score=127, Evalue=5e-30,
Organism=Homo sapiens, GI39930602, Length=171, Percent_Identity=37.4269005847953, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI4759234, Length=154, Percent_Identity=29.2207792207792, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17555358, Length=174, Percent_Identity=38.5057471264368, Blast_Score=130, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI193202769, Length=182, Percent_Identity=29.1208791208791, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17509361, Length=182, Percent_Identity=29.1208791208791, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320996, Length=174, Percent_Identity=38.5057471264368, Blast_Score=127, Evalue=7e-31,
Organism=Drosophila melanogaster, GI17136834, Length=163, Percent_Identity=41.7177914110429, Blast_Score=133, Evalue=5e-32,
Organism=Drosophila melanogaster, GI17647997, Length=175, Percent_Identity=36.5714285714286, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI281360601, Length=159, Percent_Identity=31.4465408805031, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161077628, Length=159, Percent_Identity=31.4465408805031, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TBP_METJA (Q57930)

Other databases:

- EMBL:   L77117
- PIR:   C64363
- RefSeq:   NP_247483.1
- PDB:   2Z8U
- PDBsum:   2Z8U
- ProteinModelPortal:   Q57930
- SMR:   Q57930
- GeneID:   1451369
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0507
- NMPDR:   fig|243232.1.peg.520
- TIGR:   MJ0507
- HOGENOM:   HBG499930
- OMA:   HGTFSSY
- ProtClustDB:   PRK00394
- BioCyc:   MJAN243232:MJ_0507-MONOMER
- HAMAP:   MF_00408
- InterPro:   IPR012295
- InterPro:   IPR000814
- InterPro:   IPR012294
- Gene3D:   G3DSA:3.30.310.10
- PANTHER:   PTHR10126
- PRINTS:   PR00686

Pfam domain/function: PF00352 TBP; SSF55945 TFIID_C/glycos_N

EC number: NA

Molecular weight: Translated: 20233; Mature: 20233

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00351 TFIID

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIMEPEIKIVNVVVSTKIGDNIDLEEVAMILENAEYEPEQFPGLVCRLSVPKVALLIFR
CCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEEE
SGKVNCTGAKSKEEAEIAIKKIIKELKDAGIDVIENPEIKIQNMVATADLGIEPNLDDIA
CCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEEEEECCCCCCCCCEEE
LMVEGTEYEPEQFPGLVYRLDDPKVVVLIFGSGKVVITGLKSEEDAKRALKKILDTIKEV
EEEECCCCCCCCCCCEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHH
QEL
HCC
>Mature Secondary Structure
MKIMEPEIKIVNVVVSTKIGDNIDLEEVAMILENAEYEPEQFPGLVCRLSVPKVALLIFR
CCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEEE
SGKVNCTGAKSKEEAEIAIKKIIKELKDAGIDVIENPEIKIQNMVATADLGIEPNLDDIA
CCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEEEEECCCCCCCCCEEE
LMVEGTEYEPEQFPGLVYRLDDPKVVVLIFGSGKVVITGLKSEEDAKRALKKILDTIKEV
EEEECCCCCCCCCCCEEEEECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHH
QEL
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087