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The map label for this gene is 15668630

Identifier: 15668630

GI number: 15668630

Start: 405290

End: 406279

Strand: Reverse

Name: 15668630

Synonym: MJ0454

Alternate gene names: NA

Gene position: 406279-405290 (Counterclockwise)

Preceding gene: 15668631

Following gene: 15668629

Centisome position: 24.4

GC content: 35.05

Gene sequence:

>990_bases
ATGACAAAAGATTTAAGACCGATAATATGGGATGATGATAAGAAAGAGCTAATTTTGATAGACCAAAGGAAGCTTCCAAA
CAAATTGGAGTATTTTATCTGCAAAACTTATGAGGATGTTGCCTATGCAATAAAAGACATGGTTGTTAGAGGAGCTCCAG
CTATTGGAGTCTCTGCCGCTTACGGCTTAGCTTTAGCTGAAATTAATGGAGATGATATCTATAAAGCTTATGAAGTATTA
AAAAATACAAGGCCAACAGCTGTTAATTTATTTTGGGCATTGGATAGATGTTTAACTGCTTACAAAGAAGGAAAATCAAT
CTTAGATGAGGCTAAAAAAATACATGAAGAGGATATAGAGACATGTAAAAAAATTGGAATGATTGGAGAAAAACTTATTG
AGGATGGAGATACAATCTTAACTCACTGCAATGCTGGAGCTTTAGCAACATCTGCTTATGGAACTGCTTTAAGCGTTATT
AGATTTGCCTTCTACAACGGCAAAAAGATTAGAGTTATAGCAGATGAGACAAGACCAAGATTGCAAGGGGCTAAATTAAC
TGCCTTTGAGTTAAATTATGAAGGAATTCCAGTTAAGGTTATAACTGACAATACAGCAGGGTTTTTAATGCAGAAGGGAG
AGATTGATAAGATTATAGTTGGAGCTGATAGAATTTTAGCAGATGGAACTGTCTATAACAAAATTGGAACTTACAGCTTG
GCAGTTTTAGCTAAATATCATAGAATTCCATTCTATGTTGCTGCACCATTATCAACGTTTGATTTAAGAAGTAGTGAGGA
GGATGTTATTATAGAGGAGAGAGATGAGAAGGAAGTGGCATATATAGATGGGGTTAGAATAGTCCCAGAAGGAGTTGGTT
GTTATAATTATGCCTTTGATAAAACTCCTCCAGATTTGATAACTGCAATTATAACTGAAAAGGGCATTGTAAAGCCAAAT
AGGGATGAGATTTTAAAGCTCTTTAGGTAG

Upstream 100 bases:

>100_bases
CAACAACTACGTTTATTGTTAAGGATAGAGTTTTATCTCACAACACAGCTGGAGCAATTTATACCAAATACTATCTTAAA
AAACTATTAGAGGGAAAATA

Downstream 100 bases:

>100_bases
AGACTATGGGATGTATTGATAAGCTAAACTATGAAATTTTGTATAAAGGAGGCTTTAAGGAGTGTGCAGAATATATAAGG
AAAAATTTCAAAAATATCAA

Product: translation initiation factor aIF-2B subunit delta

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; MTNA-like protein; aMTNA; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MTKDLRPIIWDDDKKELILIDQRKLPNKLEYFICKTYEDVAYAIKDMVVRGAPAIGVSAAYGLALAEINGDDIYKAYEVL
KNTRPTAVNLFWALDRCLTAYKEGKSILDEAKKIHEEDIETCKKIGMIGEKLIEDGDTILTHCNAGALATSAYGTALSVI
RFAFYNGKKIRVIADETRPRLQGAKLTAFELNYEGIPVKVITDNTAGFLMQKGEIDKIIVGADRILADGTVYNKIGTYSL
AVLAKYHRIPFYVAAPLSTFDLRSSEEDVIIEERDEKEVAYIDGVRIVPEGVGCYNYAFDKTPPDLITAIITEKGIVKPN
RDEILKLFR

Sequences:

>Translated_329_residues
MTKDLRPIIWDDDKKELILIDQRKLPNKLEYFICKTYEDVAYAIKDMVVRGAPAIGVSAAYGLALAEINGDDIYKAYEVL
KNTRPTAVNLFWALDRCLTAYKEGKSILDEAKKIHEEDIETCKKIGMIGEKLIEDGDTILTHCNAGALATSAYGTALSVI
RFAFYNGKKIRVIADETRPRLQGAKLTAFELNYEGIPVKVITDNTAGFLMQKGEIDKIIVGADRILADGTVYNKIGTYSL
AVLAKYHRIPFYVAAPLSTFDLRSSEEDVIIEERDEKEVAYIDGVRIVPEGVGCYNYAFDKTPPDLITAIITEKGIVKPN
RDEILKLFR
>Mature_328_residues
TKDLRPIIWDDDKKELILIDQRKLPNKLEYFICKTYEDVAYAIKDMVVRGAPAIGVSAAYGLALAEINGDDIYKAYEVLK
NTRPTAVNLFWALDRCLTAYKEGKSILDEAKKIHEEDIETCKKIGMIGEKLIEDGDTILTHCNAGALATSAYGTALSVIR
FAFYNGKKIRVIADETRPRLQGAKLTAFELNYEGIPVKVITDNTAGFLMQKGEIDKIIVGADRILADGTVYNKIGTYSLA
VLAKYHRIPFYVAAPLSTFDLRSSEEDVIIEERDEKEVAYIDGVRIVPEGVGCYNYAFDKTPPDLITAIITEKGIVKPNR
DEILKLFR

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=339, Percent_Identity=39.8230088495575, Blast_Score=214, Evalue=7e-56,
Organism=Homo sapiens, GI23943880, Length=320, Percent_Identity=35.625, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI4503503, Length=236, Percent_Identity=31.7796610169492, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI78000158, Length=261, Percent_Identity=25.6704980842912, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI78000156, Length=261, Percent_Identity=25.6704980842912, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI187607323, Length=235, Percent_Identity=26.3829787234043, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI7657058, Length=155, Percent_Identity=32.9032258064516, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17557462, Length=335, Percent_Identity=34.6268656716418, Blast_Score=172, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17557123, Length=201, Percent_Identity=27.8606965174129, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325375, Length=405, Percent_Identity=31.6049382716049, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322878, Length=271, Percent_Identity=30.2583025830258, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357667, Length=355, Percent_Identity=38.3098591549296, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI24651647, Length=355, Percent_Identity=38.3098591549296, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI281364091, Length=206, Percent_Identity=29.126213592233, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24659399, Length=206, Percent_Identity=29.126213592233, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24659407, Length=206, Percent_Identity=29.126213592233, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922816, Length=206, Percent_Identity=29.126213592233, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI18543295, Length=220, Percent_Identity=25.4545454545455, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_METJA (Q57896)

Other databases:

- EMBL:   L77117
- PIR:   F64356
- RefSeq:   NP_247428.1
- ProteinModelPortal:   Q57896
- SMR:   Q57896
- GeneID:   1451315
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0454
- NMPDR:   fig|243232.1.peg.465
- TIGR:   MJ0454
- HOGENOM:   HBG682649
- OMA:   EDIETCK
- ProtClustDB:   CLSK876195
- BioCyc:   MJAN243232:MJ_0454-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 36803; Mature: 36672

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: ACT_SITE 223-223 BINDING 84-84 BINDING 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKDLRPIIWDDDKKELILIDQRKLPNKLEYFICKTYEDVAYAIKDMVVRGAPAIGVSAA
CCCCCCCCEECCCCCEEEEEECCCCCCHHHEEEECCHHHHHHHHHHHHHCCCCCCCCHHH
YGLALAEINGDDIYKAYEVLKNTRPTAVNLFWALDRCLTAYKEGKSILDEAKKIHEEDIE
HCEEEEEECCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
TCKKIGMIGEKLIEDGDTILTHCNAGALATSAYGTALSVIRFAFYNGKKIRVIADETRPR
HHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
LQGAKLTAFELNYEGIPVKVITDNTAGFLMQKGEIDKIIVGADRILADGTVYNKIGTYSL
CCCCEEEEEEECCCCEEEEEEECCCCCEEEECCCCCEEEECCCCEEECCEEECCCCHHHH
AVLAKYHRIPFYVAAPLSTFDLRSSEEDVIIEERDEKEVAYIDGVRIVPEGVGCYNYAFD
HHHHHHHCCCEEEECCCCEEECCCCCCCEEEECCCCCEEEEECCEEEEECCCCEEECCCC
KTPPDLITAIITEKGIVKPNRDEILKLFR
CCCHHHHHHHHHCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
TKDLRPIIWDDDKKELILIDQRKLPNKLEYFICKTYEDVAYAIKDMVVRGAPAIGVSAA
CCCCCCCEECCCCCEEEEEECCCCCCHHHEEEECCHHHHHHHHHHHHHCCCCCCCCHHH
YGLALAEINGDDIYKAYEVLKNTRPTAVNLFWALDRCLTAYKEGKSILDEAKKIHEEDIE
HCEEEEEECCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
TCKKIGMIGEKLIEDGDTILTHCNAGALATSAYGTALSVIRFAFYNGKKIRVIADETRPR
HHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
LQGAKLTAFELNYEGIPVKVITDNTAGFLMQKGEIDKIIVGADRILADGTVYNKIGTYSL
CCCCEEEEEEECCCCEEEEEEECCCCCEEEECCCCCEEEECCCCEEECCEEECCCCHHHH
AVLAKYHRIPFYVAAPLSTFDLRSSEEDVIIEERDEKEVAYIDGVRIVPEGVGCYNYAFD
HHHHHHHCCCEEEECCCCEEECCCCCCCEEEECCCCCEEEEECCEEEEECCCCEEECCCC
KTPPDLITAIITEKGIVKPNRDEILKLFR
CCCHHHHHHHHHCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087