Click here to switch to the map view.

The map label for this gene is moaE

Identifier: 15607115

GI number: 15607115

Start: 1534286

End: 1534750

Strand: Direct

Name: moaE

Synonym: aq_2181

Alternate gene names: 15607115

Gene position: 1534286-1534750 (Clockwise)

Preceding gene: 15607114

Following gene: 15607116

Centisome position: 98.9

GC content: 48.39

Gene sequence:

>465_bases
ATGGAGGTGGGCATGATTCCGAGAGTTTACCTCGGACACGAGTGGTTCGGTGCGGAAAGGATACTGAGTGAATACCAAGT
TCCCGAAGACTGCGGAGCGCAGGTTCTGTTCCTCGGCATTCCCAGAAACGCACCCGAAGACGGCGGAAATATAGAAGCTC
TTGAGTACGAGGCGTACCCCGAAATGGCTATAAAAGAAATGGAAAAGATAAGACAGGAAACGATAGAGAAGTTCGGCGTA
AAGGAAGTATTCATACACCACAGGCTTGGTCTGGTGAAAATCGGAGAACCTTCCTTCTTAGTGCTTGCGGTAGGTGGACA
CAGGGAAGAAACCTTTAAAGCGTGCAGGTACGCCGTTGACGAGACGAAAAAACGCGTCCCCATATGGAAGAAGGAAATCT
TTAAGGAAGGAAAAGGAGAGTGGGTCCTAGGGGAAAAGAAAAATGCTTCTGGACAAACTAAGTAG

Upstream 100 bases:

>100_bases
GGAAACCATAAAGAAGGAACTCAAGAAGGTTCTAAAGAGTGCCATTTTGGCTTGAAAGTAGCGAGTTTTTTCCTAAAATT
AAATATGACAAGTTTGTCAT

Downstream 100 bases:

>100_bases
ACCGCTGAAAGTCCTCAGGATTTCTCTAACGGATAGATGCAACCTCAGGTGCAACTTCTGCATGCCCCCGGGAAAGGAGT
ATAACTTCCTTCCTAAAAGA

Product: molybdopterin converting factor subunit 2

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MEVGMIPRVYLGHEWFGAERILSEYQVPEDCGAQVLFLGIPRNAPEDGGNIEALEYEAYPEMAIKEMEKIRQETIEKFGV
KEVFIHHRLGLVKIGEPSFLVLAVGGHREETFKACRYAVDETKKRVPIWKKEIFKEGKGEWVLGEKKNASGQTK

Sequences:

>Translated_154_residues
MEVGMIPRVYLGHEWFGAERILSEYQVPEDCGAQVLFLGIPRNAPEDGGNIEALEYEAYPEMAIKEMEKIRQETIEKFGV
KEVFIHHRLGLVKIGEPSFLVLAVGGHREETFKACRYAVDETKKRVPIWKKEIFKEGKGEWVLGEKKNASGQTK
>Mature_154_residues
MEVGMIPRVYLGHEWFGAERILSEYQVPEDCGAQVLFLGIPRNAPEDGGNIEALEYEAYPEMAIKEMEKIRQETIEKFGV
KEVFIHHRLGLVKIGEPSFLVLAVGGHREETFKACRYAVDETKKRVPIWKKEIFKEGKGEWVLGEKKNASGQTK

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family

Homologues:

Organism=Homo sapiens, GI4758732, Length=127, Percent_Identity=40.9448818897638, Blast_Score=97, Evalue=5e-21,
Organism=Escherichia coli, GI1787003, Length=114, Percent_Identity=33.3333333333333, Blast_Score=61, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356259, Length=115, Percent_Identity=41.7391304347826, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAE_AQUAE (O67928)

Other databases:

- EMBL:   AE000657
- PIR:   D70487
- RefSeq:   NP_214497.1
- PDB:   2OMD
- PDBsum:   2OMD
- ProteinModelPortal:   O67928
- SMR:   O67928
- GeneID:   1193917
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_2181
- NMPDR:   fig|224324.1.peg.1512
- HOGENOM:   HBG460564
- OMA:   QTEEIRY
- PhylomeDB:   O67928
- ProtClustDB:   CLSK2748575
- BioCyc:   AAEO224324:AQ_2181-MONOMER
- InterPro:   IPR003448
- Gene3D:   G3DSA:3.90.1170.40
- PANTHER:   PTHR23404:SF2

Pfam domain/function: PF02391 MoaE; SSF54690 Mb_biosynth_MoaE

EC number: NA

Molecular weight: Translated: 17580; Mature: 17580

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: BINDING 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVGMIPRVYLGHEWFGAERILSEYQVPEDCGAQVLFLGIPRNAPEDGGNIEALEYEAYP
CCCCCCCCEEECCCHHCHHHHHHHCCCCHHCCCEEEEEECCCCCCCCCCCEEEEEECCCH
EMAIKEMEKIRQETIEKFGVKEVFIHHRLGLVKIGEPSFLVLAVGGHREETFKACRYAVD
HHHHHHHHHHHHHHHHHHCHHHHHHHHCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHH
ETKKRVPIWKKEIFKEGKGEWVLGEKKNASGQTK
HHHCCCCHHHHHHHHCCCCCEEECCCCCCCCCCC
>Mature Secondary Structure
MEVGMIPRVYLGHEWFGAERILSEYQVPEDCGAQVLFLGIPRNAPEDGGNIEALEYEAYP
CCCCCCCCEEECCCHHCHHHHHHHCCCCHHCCCEEEEEECCCCCCCCCCCEEEEEECCCH
EMAIKEMEKIRQETIEKFGVKEVFIHHRLGLVKIGEPSFLVLAVGGHREETFKACRYAVD
HHHHHHHHHHHHHHHHHHCHHHHHHHHCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHH
ETKKRVPIWKKEIFKEGKGEWVLGEKKNASGQTK
HHHCCCCHHHHHHHHCCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320