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The map label for this gene is uvrC

Identifier: 15607074

GI number: 15607074

Start: 1497725

End: 1499425

Strand: Direct

Name: uvrC

Synonym: aq_2126

Alternate gene names: 15607074

Gene position: 1497725-1499425 (Clockwise)

Preceding gene: 15607065

Following gene: 15607075

Centisome position: 96.54

GC content: 43.74

Gene sequence:

>1701_bases
ATGGCTAAAACTGGAAAAGTGGAAAACTTAATCCAAAACGCCCCCGAAAAACCGGGAGTTTACTTATTTAAGAAAGGAAA
TAGACCTATCTACATCGGAAAAGCTAAAAATCTGAAAAAGAGACTCCTTCAACACCTGAAGGCTTCCGAATACGACTCCA
AAGAAAGGGCAATAATTTCAAACTCAGACAACCTTGAGTGGATTGTAACGAGAAACGAGTACGAAGCGCTGGTTTTAGAA
ATTGACTTAATACAGCAATATAAACCGAGGTACAACGTCCTACACAAGTTCGGGGGCGGTTATCCTATGCTCTTACTCAC
AAAAGACGAATACCCTACCATCAAGGTAGTCAGGGGAACAGAGCACGAGGGGGAACTTTTCGGGCCATTTCTTCAGAGCA
AAAAAGCTTACAAGGTTAAAAAGCTTATACACAACCTCTTCAAGCTGAGAACCTGCGACCCGCTACCCAAAAGGAGTGAA
CCCTGTATGGATTACCACTTAGGACTTTGCAGTGCTCCCTGTTGCGGTTTCGTGTCTAAAGAGGAGTACGAGCTTGCGGT
GAGTTCCGCCAGAGCACTTCTTACGGGAGAGGTTGCAGAAGTTCTTCCCAAGCTCTACGAAAAGATAGAGGAGTTCTCAA
AGGAACTCATGTTTGAAAAGTGTGCACACATAAGGGATCAGATAATCGCCCTTGAAAACCTCGCAAAGGGACAGGCGGTA
AGCGCCCTTCCCTTTAGGGAAGGAGACATATTCTACAAGTTCGGTTCAAGGCTCGGGCTCCTTTTAGTAAGGAGTTCCAA
GCTCGTGAGCAAAGAGATTTTTGACTTGGAAAGTGATGAAGAAGTTGAGGAAGTAATCCTCGGATACTACTACTCAAACT
ACGTTCCGAGAAAAGTAATAACGAACTTTGAACTCTCTGAGGAAGTGAAAGAGTGGATAAGGAACAGGGCAAAGGGAGAG
GTTGAGTTTTCGGGAGAAATACCAAAGGAGCTAAAGGAAGTTTTGGAAGAAAACCTCGGGGAGGGAATAAACGAGGAGGT
TCTGAAAAAGGAGTTTGCTGAAAAGTTAGGAATGCCTGTACCAAGAGTTATAGAAGGTTTTGACATTTCCCACTTTTACG
GAGAGGACATCGTAGGCTCTTGCGTGGTCTGGAAAGGGGGAAAGATGAGCAAGAAAGATTACAGAAGGTATAAAGTGAAA
ACTATAAGCCGGATAGACGATTACTTGGCCCTTGAAGAGGTTTTAACGAGGAGGGCAAAGAGGATTTTAAAGGGAGAGGT
AGAAAAGCCCGATATCTGGCTAATAGACGGGGGTAAAGGGCAACTAAACGTAGGGATAAGAGTTAAAAAACGCACGGGAC
TTGACGTAAAGGTTTTCAGTCTGGCAAAGGAAGAGGAAATCATTTACACGGAAGACGGCAGGGAAATAAGGCTAAAGGAA
AATCCCATACTTTACAGGGTTTTCGGGGAGATAAGGGATGAGGCTCACAGGTTTGCCCTGAGCTACAATAGAAAACTCAG
GGAGAAGAGGTACATGGAGGACATACTATCAAAGATAAAAGGGATAGGAGAGCAAAAGAAGAAGATAATTTACAAAAACT
TTGAAACTCTTTACGACTTTATAGAGGCTAAAGACGAGGAGTTGAGAAGGCTGGGAATAAACCCTTCTCTGAAGCAGGAG
GTGAAGAAGTGGTTAAGTTAG

Upstream 100 bases:

>100_bases
AAAGCCTCATGCAATTATTATTTTCTGGGTACTAAAATTTTTGATTGCAGACATCATAGTGGAGAGAAAATTATTCATAA
GATAGCAAAAATTAATATAT

Downstream 100 bases:

>100_bases
ATTACGAGCCTGTTTACGACATAACCGCGGATGCGGGCATAAGGGTAAGGGCGAAAACACTGGAAGAACTATTCTGCCAC
GCCATTCTCGCAACCTTCAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MAKTGKVENLIQNAPEKPGVYLFKKGNRPIYIGKAKNLKKRLLQHLKASEYDSKERAIISNSDNLEWIVTRNEYEALVLE
IDLIQQYKPRYNVLHKFGGGYPMLLLTKDEYPTIKVVRGTEHEGELFGPFLQSKKAYKVKKLIHNLFKLRTCDPLPKRSE
PCMDYHLGLCSAPCCGFVSKEEYELAVSSARALLTGEVAEVLPKLYEKIEEFSKELMFEKCAHIRDQIIALENLAKGQAV
SALPFREGDIFYKFGSRLGLLLVRSSKLVSKEIFDLESDEEVEEVILGYYYSNYVPRKVITNFELSEEVKEWIRNRAKGE
VEFSGEIPKELKEVLEENLGEGINEEVLKKEFAEKLGMPVPRVIEGFDISHFYGEDIVGSCVVWKGGKMSKKDYRRYKVK
TISRIDDYLALEEVLTRRAKRILKGEVEKPDIWLIDGGKGQLNVGIRVKKRTGLDVKVFSLAKEEEIIYTEDGREIRLKE
NPILYRVFGEIRDEAHRFALSYNRKLREKRYMEDILSKIKGIGEQKKKIIYKNFETLYDFIEAKDEELRRLGINPSLKQE
VKKWLS

Sequences:

>Translated_566_residues
MAKTGKVENLIQNAPEKPGVYLFKKGNRPIYIGKAKNLKKRLLQHLKASEYDSKERAIISNSDNLEWIVTRNEYEALVLE
IDLIQQYKPRYNVLHKFGGGYPMLLLTKDEYPTIKVVRGTEHEGELFGPFLQSKKAYKVKKLIHNLFKLRTCDPLPKRSE
PCMDYHLGLCSAPCCGFVSKEEYELAVSSARALLTGEVAEVLPKLYEKIEEFSKELMFEKCAHIRDQIIALENLAKGQAV
SALPFREGDIFYKFGSRLGLLLVRSSKLVSKEIFDLESDEEVEEVILGYYYSNYVPRKVITNFELSEEVKEWIRNRAKGE
VEFSGEIPKELKEVLEENLGEGINEEVLKKEFAEKLGMPVPRVIEGFDISHFYGEDIVGSCVVWKGGKMSKKDYRRYKVK
TISRIDDYLALEEVLTRRAKRILKGEVEKPDIWLIDGGKGQLNVGIRVKKRTGLDVKVFSLAKEEEIIYTEDGREIRLKE
NPILYRVFGEIRDEAHRFALSYNRKLREKRYMEDILSKIKGIGEQKKKIIYKNFETLYDFIEAKDEELRRLGINPSLKQE
VKKWLS
>Mature_565_residues
AKTGKVENLIQNAPEKPGVYLFKKGNRPIYIGKAKNLKKRLLQHLKASEYDSKERAIISNSDNLEWIVTRNEYEALVLEI
DLIQQYKPRYNVLHKFGGGYPMLLLTKDEYPTIKVVRGTEHEGELFGPFLQSKKAYKVKKLIHNLFKLRTCDPLPKRSEP
CMDYHLGLCSAPCCGFVSKEEYELAVSSARALLTGEVAEVLPKLYEKIEEFSKELMFEKCAHIRDQIIALENLAKGQAVS
ALPFREGDIFYKFGSRLGLLLVRSSKLVSKEIFDLESDEEVEEVILGYYYSNYVPRKVITNFELSEEVKEWIRNRAKGEV
EFSGEIPKELKEVLEENLGEGINEEVLKKEFAEKLGMPVPRVIEGFDISHFYGEDIVGSCVVWKGGKMSKKDYRRYKVKT
ISRIDDYLALEEVLTRRAKRILKGEVEKPDIWLIDGGKGQLNVGIRVKKRTGLDVKVFSLAKEEEIIYTEDGREIRLKEN
PILYRVFGEIRDEAHRFALSYNRKLREKRYMEDILSKIKGIGEQKKKIIYKNFETLYDFIEAKDEELRRLGINPSLKQEV
KKWLS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=608, Percent_Identity=30.0986842105263, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1788037, Length=192, Percent_Identity=30.7291666666667, Blast_Score=79, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_AQUAE (O67887)

Other databases:

- EMBL:   AE000657
- PIR:   C70482
- RefSeq:   NP_214456.1
- ProteinModelPortal:   O67887
- GeneID:   1193876
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_2126
- NMPDR:   fig|224324.1.peg.1471
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   O67887
- ProtClustDB:   PRK14667
- BioCyc:   AAEO224324:AQ_2126-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 65597; Mature: 65466

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTGKVENLIQNAPEKPGVYLFKKGNRPIYIGKAKNLKKRLLQHLKASEYDSKERAIIS
CCCCCHHHHHHHCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCEEEE
NSDNLEWIVTRNEYEALVLEIDLIQQYKPRYNVLHKFGGGYPMLLLTKDEYPTIKVVRGT
CCCCEEEEEECCCCEEEEEEEHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCEEEEEECC
EHEGELFGPFLQSKKAYKVKKLIHNLFKLRTCDPLPKRSEPCMDYHLGLCSAPCCGFVSK
CCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCC
EEYELAVSSARALLTGEVAEVLPKLYEKIEEFSKELMFEKCAHIRDQIIALENLAKGQAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
SALPFREGDIFYKFGSRLGLLLVRSSKLVSKEIFDLESDEEVEEVILGYYYSNYVPRKVI
EECCCCCCCEEEECCCCCEEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHH
TNFELSEEVKEWIRNRAKGEVEFSGEIPKELKEVLEENLGEGINEEVLKKEFAEKLGMPV
CCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
PRVIEGFDISHFYGEDIVGSCVVWKGGKMSKKDYRRYKVKTISRIDDYLALEEVLTRRAK
HHHHCCCCCHHHHCCCHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RILKGEVEKPDIWLIDGGKGQLNVGIRVKKRTGLDVKVFSLAKEEEIIYTEDGREIRLKE
HHHHCCCCCCCEEEEECCCCEEEEEEEEEECCCCCEEEEEECCCCCEEEECCCCEEEEEC
NPILYRVFGEIRDEAHRFALSYNRKLREKRYMEDILSKIKGIGEQKKKIIYKNFETLYDF
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IEAKDEELRRLGINPSLKQEVKKWLS
HHCCHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
AKTGKVENLIQNAPEKPGVYLFKKGNRPIYIGKAKNLKKRLLQHLKASEYDSKERAIIS
CCCCHHHHHHHCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCEEEE
NSDNLEWIVTRNEYEALVLEIDLIQQYKPRYNVLHKFGGGYPMLLLTKDEYPTIKVVRGT
CCCCEEEEEECCCCEEEEEEEHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCEEEEEECC
EHEGELFGPFLQSKKAYKVKKLIHNLFKLRTCDPLPKRSEPCMDYHLGLCSAPCCGFVSK
CCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCC
EEYELAVSSARALLTGEVAEVLPKLYEKIEEFSKELMFEKCAHIRDQIIALENLAKGQAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
SALPFREGDIFYKFGSRLGLLLVRSSKLVSKEIFDLESDEEVEEVILGYYYSNYVPRKVI
EECCCCCCCEEEECCCCCEEEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHH
TNFELSEEVKEWIRNRAKGEVEFSGEIPKELKEVLEENLGEGINEEVLKKEFAEKLGMPV
CCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
PRVIEGFDISHFYGEDIVGSCVVWKGGKMSKKDYRRYKVKTISRIDDYLALEEVLTRRAK
HHHHCCCCCHHHHCCCHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RILKGEVEKPDIWLIDGGKGQLNVGIRVKKRTGLDVKVFSLAKEEEIIYTEDGREIRLKE
HHHHCCCCCCCEEEEECCCCEEEEEEEEEECCCCCEEEEEECCCCCEEEECCCCEEEEEC
NPILYRVFGEIRDEAHRFALSYNRKLREKRYMEDILSKIKGIGEQKKKIIYKNFETLYDF
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IEAKDEELRRLGINPSLKQEVKKWLS
HHCCHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320