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The map label for this gene is metC_1 [H]

Identifier: 15602603

GI number: 15602603

Start: 868534

End: 869802

Strand: Direct

Name: metC_1 [H]

Synonym: PM0738

Alternate gene names: 15602603

Gene position: 868534-869802 (Clockwise)

Preceding gene: 15602602

Following gene: 15602604

Centisome position: 38.47

GC content: 42.16

Gene sequence:

>1269_bases
ATGGAATTTGCAACAAAATGTCTACATGCCGGTTATACACCGAAAAATGGTGAGCCTCGTGTTCAACCGATCGTACAAAG
TACCACTTTTACCTACGATTCCGCCGAAGAAATTGGTAAGTTATTTGATTTACAAGCGGCTGGCTATTTTTACACCCGCC
TTTCAAATCCTACTACCAATGCGGCAGAAGAAAAAATTACCGCACTTGAAGGCGGTGTAGCAACCATGTGTACCGCATCA
GGGCAAGCCGCCGTGTTTTACGCGATGCTCAATATTTTACAAGCCGGTGATCACTTTATTTCTTCATCGTATGTTTACGG
TGGTAGCTACAACTTATTTGCACATACCTTCAAAAAAATGGGAATTGAGGTCACTTTTGTGGATCAAGATTTACCTCTTG
AGGAATTAAAAAAAGCTATTCGCCCAAATACGAAAGCCATTTTTGCCGAAACTATTGCCAATCCCGCATTACGCGTGTTG
GATATTGAAAAGTTTGTTGCACTTGCGAAGGCAGCACAAGCCCCTTTATTAGTTGACAATACTTTTGCAACCCCGTATTT
TTGTCGCCCTATCGAATTTGGTGCTAACGTGGTAATTCATAGTACGTCAAAATATTTAGATGGGCATGCGATTGCGTTGG
GAGGTTCGATCACAGATGGCGGGAATTTTGATTGGAATAATGGTAAATTCCCACAATTAAGCACACCTGATCAAACTTAT
CACGGTTTAGTTTATACCGAAACCTTTGTTCCAGCCGCTTATATTGTCAAAGCCCGTGTGCAATTAATGCGTGATTTAGG
TGCCACACCAGCACCACAAAATAGTTTCTTGCTCAATGTGGGCATGGAAACTCTTGCACTGCGTATGCAACGTCATTATG
AAAATGCACAAGCGGTCGCCGAATTTTTAGAAAATCATCCACAAGTGGCAAAAGTGAGTTATCCGGGCTTGGCAAGTTCA
CCTGATCATGCACTAAAACAAAAATATTTACCAAACGGTTTATGTGGTGTGATTTCCTTTGAAATTAGAGGGGGAAGAGA
AACTGCAGCAAAATGGCTGAATGCGCTACAACTGGCTTCTCGTGAAGTCCATGTAGCGGATATTCGCACTTGTGCTTTAC
ATCCGGCGACGTCAACACACCGTCAATTAAGTGAGGCTGAATTAGAAAAAGTGGGGATTTCTGCGGGTTTAATTCGTCTT
TCTTGCGGTATTGAAAGTATCCAAGATATTTTGGCTGACTTAGAACAAGCATTCCACGCGGCAAAATAA

Upstream 100 bases:

>100_bases
TACATCGCTGTTGTACCACATTGTTAAGCCAAAAGTGTGTTCAATATTTTATAAAAAATGACCGCACTTTGCTCCCCAAA
ACAAACTCAAGGAAAACACA

Downstream 100 bases:

>100_bases
ATGTCATTAAGGCAGGCAATCTTGCCTGCCTGTTTGAATAACACAGGGGATAGCATGGCGATTGTAACAAATACCCCTAT
TTGGGTTTGGTGCGTTTTGC

Product: hypothetical protein

Products: NA

Alternate protein names: L-methioninase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MEFATKCLHAGYTPKNGEPRVQPIVQSTTFTYDSAEEIGKLFDLQAAGYFYTRLSNPTTNAAEEKITALEGGVATMCTAS
GQAAVFYAMLNILQAGDHFISSSYVYGGSYNLFAHTFKKMGIEVTFVDQDLPLEELKKAIRPNTKAIFAETIANPALRVL
DIEKFVALAKAAQAPLLVDNTFATPYFCRPIEFGANVVIHSTSKYLDGHAIALGGSITDGGNFDWNNGKFPQLSTPDQTY
HGLVYTETFVPAAYIVKARVQLMRDLGATPAPQNSFLLNVGMETLALRMQRHYENAQAVAEFLENHPQVAKVSYPGLASS
PDHALKQKYLPNGLCGVISFEIRGGRETAAKWLNALQLASREVHVADIRTCALHPATSTHRQLSEAELEKVGISAGLIRL
SCGIESIQDILADLEQAFHAAK

Sequences:

>Translated_422_residues
MEFATKCLHAGYTPKNGEPRVQPIVQSTTFTYDSAEEIGKLFDLQAAGYFYTRLSNPTTNAAEEKITALEGGVATMCTAS
GQAAVFYAMLNILQAGDHFISSSYVYGGSYNLFAHTFKKMGIEVTFVDQDLPLEELKKAIRPNTKAIFAETIANPALRVL
DIEKFVALAKAAQAPLLVDNTFATPYFCRPIEFGANVVIHSTSKYLDGHAIALGGSITDGGNFDWNNGKFPQLSTPDQTY
HGLVYTETFVPAAYIVKARVQLMRDLGATPAPQNSFLLNVGMETLALRMQRHYENAQAVAEFLENHPQVAKVSYPGLASS
PDHALKQKYLPNGLCGVISFEIRGGRETAAKWLNALQLASREVHVADIRTCALHPATSTHRQLSEAELEKVGISAGLIRL
SCGIESIQDILADLEQAFHAAK
>Mature_422_residues
MEFATKCLHAGYTPKNGEPRVQPIVQSTTFTYDSAEEIGKLFDLQAAGYFYTRLSNPTTNAAEEKITALEGGVATMCTAS
GQAAVFYAMLNILQAGDHFISSSYVYGGSYNLFAHTFKKMGIEVTFVDQDLPLEELKKAIRPNTKAIFAETIANPALRVL
DIEKFVALAKAAQAPLLVDNTFATPYFCRPIEFGANVVIHSTSKYLDGHAIALGGSITDGGNFDWNNGKFPQLSTPDQTY
HGLVYTETFVPAAYIVKARVQLMRDLGATPAPQNSFLLNVGMETLALRMQRHYENAQAVAEFLENHPQVAKVSYPGLASS
PDHALKQKYLPNGLCGVISFEIRGGRETAAKWLNALQLASREVHVADIRTCALHPATSTHRQLSEAELEKVGISAGLIRL
SCGIESIQDILADLEQAFHAAK

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG2873

COG function: function code E; O-acetylhomoserine sulfhydrylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=423, Percent_Identity=34.51536643026, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI299473759, Length=422, Percent_Identity=31.9905213270142, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI25453487, Length=421, Percent_Identity=30.4038004750594, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1790375, Length=402, Percent_Identity=30.3482587064677, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1789383, Length=437, Percent_Identity=25.858123569794, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71980708, Length=406, Percent_Identity=33.0049261083744, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17560056, Length=426, Percent_Identity=35.6807511737089, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17538055, Length=425, Percent_Identity=34.8235294117647, Blast_Score=218, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6323333, Length=432, Percent_Identity=44.6759259259259, Blast_Score=330, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6319307, Length=428, Percent_Identity=32.7102803738318, Blast_Score=199, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6321170, Length=326, Percent_Identity=28.2208588957055, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321254, Length=422, Percent_Identity=26.303317535545, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6321904, Length=430, Percent_Identity=25.8139534883721, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19922554, Length=425, Percent_Identity=34.3529411764706, Blast_Score=228, Evalue=5e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006237
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.11 [H]

Molecular weight: Translated: 45997; Mature: 45997

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFATKCLHAGYTPKNGEPRVQPIVQSTTFTYDSAEEIGKLFDLQAAGYFYTRLSNPTTN
CCHHHHHHHCCCCCCCCCCCCCEEEHHCEECCCCHHHHHHHHHHHHCCEEEEECCCCCCC
AAEEKITALEGGVATMCTASGQAAVFYAMLNILQAGDHFISSSYVYGGSYNLFAHTFKKM
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHCCCEEECCCCHHHHHHHHHC
GIEVTFVDQDLPLEELKKAIRPNTKAIFAETIANPALRVLDIEKFVALAKAAQAPLLVDN
CEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCEEEEC
TFATPYFCRPIEFGANVVIHSTSKYLDGHAIALGGSITDGGNFDWNNGKFPQLSTPDQTY
CCCCCEEECCHHCCCEEEEECCHHHCCCEEEEECCEECCCCCCCCCCCCCCCCCCCCCHH
HGLVYTETFVPAAYIVKARVQLMRDLGATPAPQNSFLLNVGMETLALRMQRHYENAQAVA
CCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHH
EFLENHPQVAKVSYPGLASSPDHALKQKYLPNGLCGVISFEIRGGRETAAKWLNALQLAS
HHHHCCCCEEEEECCCCCCCCCHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHC
REVHVADIRTCALHPATSTHRQLSEAELEKVGISAGLIRLSCGIESIQDILADLEQAFHA
CCEEEEHHHHEECCCCCHHHHHHHHHHHHHHCCHHCCEEECCCHHHHHHHHHHHHHHHHC
AK
CC
>Mature Secondary Structure
MEFATKCLHAGYTPKNGEPRVQPIVQSTTFTYDSAEEIGKLFDLQAAGYFYTRLSNPTTN
CCHHHHHHHCCCCCCCCCCCCCEEEHHCEECCCCHHHHHHHHHHHHCCEEEEECCCCCCC
AAEEKITALEGGVATMCTASGQAAVFYAMLNILQAGDHFISSSYVYGGSYNLFAHTFKKM
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHCCCEEECCCCHHHHHHHHHC
GIEVTFVDQDLPLEELKKAIRPNTKAIFAETIANPALRVLDIEKFVALAKAAQAPLLVDN
CEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCEEEEC
TFATPYFCRPIEFGANVVIHSTSKYLDGHAIALGGSITDGGNFDWNNGKFPQLSTPDQTY
CCCCCEEECCHHCCCEEEEECCHHHCCCEEEEECCEECCCCCCCCCCCCCCCCCCCCCHH
HGLVYTETFVPAAYIVKARVQLMRDLGATPAPQNSFLLNVGMETLALRMQRHYENAQAVA
CCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHH
EFLENHPQVAKVSYPGLASSPDHALKQKYLPNGLCGVISFEIRGGRETAAKWLNALQLAS
HHHHCCCCEEEEECCCCCCCCCHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHC
REVHVADIRTCALHPATSTHRQLSEAELEKVGISAGLIRLSCGIESIQDILADLEQAFHA
CCEEEEHHHHEECCCCCHHHHHHHHHHHHHHCCHHCCEEECCCHHHHHHHHHHHHHHHHC
AK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8586629; 9190812; 3365412 [H]