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The map label for this gene is ttrS [H]

Identifier: 15602589

GI number: 15602589

Start: 854154

End: 855869

Strand: Direct

Name: ttrS [H]

Synonym: PM0724

Alternate gene names: 15602589

Gene position: 854154-855869 (Clockwise)

Preceding gene: 15602585

Following gene: 15602590

Centisome position: 37.84

GC content: 39.74

Gene sequence:

>1716_bases
GTGAAAAAATGCAGTTCATTTTTAAAAATGTTTATTTTATTACTCAGCTTCATGCCAGCGCTTGTTTATGCACAGCAATG
GAAAATTGGCATTCTGGCACAACGAGGTGTGGCACATACGCACGCTACTTGGCAACCTTGGATAGATTGGCTTAACCAAC
ACCTCTCACCTCATCAATTCACCTTAGTTACCTTAGATCTTAACGATCTAATACAAGATCAGGCGCAAGGCGTCGATTTT
ATTTTATCCAATCAAGCACAGTTTTTTTATTTAAACAATAATGAAGTACGTTGGCTGGTAACCTTACGTTCACCAAGGCA
AATTCAATCTTCTACCATGGGCAGAATTGGTAGTGCGATTTTAGTTCGTCAAGACAGCCCATTCCACCAGCTTACTGATT
TACGCCACAAAACCGTGAGTGCGGTAGGTGATAATGCCTTCGGCGGCTTTCTACTGGGCTATAACGAATTCTATCAACAA
GGTTTAGTCGAAAATAAAGACTTTCAATTAAAATTTACGGGTTTCCCTGTGGATAATACCTTGCTACTGCTGCAAGAAAG
AAAAGTTGACGCGGCGATTGTGCCGGTGTGTATTTTAGAAGAATTAGTCAACGAAGGTGTGGTGAAAAAAGAAGATTTTC
GACTCTTAGCCGGCAAAGAAAATGTGTTAGGTTGTCTCGCTAGCACGGAATTACTGCCAAACTGGTCTTTAGCAGCACTT
TCACAAGTACCAGATAGTCTTGCATCAAAATTGGTCACACTTTTATTAAGTCAAGTGCCCGCACATTTACCACAATGGAC
ACCGCCTTATTCTACCTCACAAGCCGATACTGTGTTACGAGGATTATACAAACACCCACAACAAAACTTATGGGACAGTA
CAAAATATTGGTTACAACAATATCAAGGTTGGATTATTTTTGTCCTCTTATTACTTGTCTTAAATTATCTGTGGATTAGC
TTTCAAATTCATCGTAAAAGCAAAGCGTTGCAACAAGCTTATCGAGAAATGCGACACTATGAACAGCAATTAGTACAAGC
TGATCGACTAAGCATTTTAGGCGAAATGAGTACAGGCATTGCCCATGAAATTAATCAACCTTTATCCGCCATCCGTATGT
ATGTCGAAGGGGTGAAATACCATTTAGCACAGCTGCCTGCCGAAAAAAATACAGTTGAAATTTTAGATAAGGTATTACAA
CAAGTTGATCGCAGTGCAGATATTATCCGTAATTTAATGAATTGGGCAAAAGGCAAAAAAACACCAAGTTCTGAGTGTGT
GGCACTCAAGCCCTTACTACAACGTGTAATCAGCTTTATGTCTTTACAAACACATCAGAAAGCCCAATTAAACTTGAATT
GTCCAGCCTCGTTAAAACTCAAAATTGATACGACTTTACTCGAACAAGTTTTGTGTAACTGCTTGCTTAATGCTTCACAA
GCGGGAGCAAGTGAGATCGAAGTGAACGTGAAAGCCGTGGGCGAATACATGACTATTCATATTGTTGATAATGGTTCAGG
CTTCAAAGCTGGCGAACTTGCTTTTCCGTTTGTCCCTTTTCGCAGTAGTAAAGCGAATGGACTAGGTTTAGGCTTGGTAC
TATGTCAACGATTAATGCGTTCGATTAATGGTGACATTTCTTTGCATAACCGCCTTGATCAACAAGGAGCGGAAGTGATT
TTAAAATTACCAAATAAAGTGGGGGAAACATGTTAA

Upstream 100 bases:

>100_bases
TTTTTTCTCGTATTGTTCAGGAAGGACGGCGAAAAAACTATTGTGGTTTTCCACATAAACAGTGAGTGAATTTGATTTCA
ATCAAGAAAAGGAAGAAAAA

Downstream 100 bases:

>100_bases
TTCATCTGGTTGATGATGACTTAACCGTTTTGGATGCGGCGCGTTTTTTATTAGAACAAGCTGGCTATCAAGTCCAAACA
TGGTCAAATAGCCAAGCCTT

Product: TtrS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MKKCSSFLKMFILLLSFMPALVYAQQWKIGILAQRGVAHTHATWQPWIDWLNQHLSPHQFTLVTLDLNDLIQDQAQGVDF
ILSNQAQFFYLNNNEVRWLVTLRSPRQIQSSTMGRIGSAILVRQDSPFHQLTDLRHKTVSAVGDNAFGGFLLGYNEFYQQ
GLVENKDFQLKFTGFPVDNTLLLLQERKVDAAIVPVCILEELVNEGVVKKEDFRLLAGKENVLGCLASTELLPNWSLAAL
SQVPDSLASKLVTLLLSQVPAHLPQWTPPYSTSQADTVLRGLYKHPQQNLWDSTKYWLQQYQGWIIFVLLLLVLNYLWIS
FQIHRKSKALQQAYREMRHYEQQLVQADRLSILGEMSTGIAHEINQPLSAIRMYVEGVKYHLAQLPAEKNTVEILDKVLQ
QVDRSADIIRNLMNWAKGKKTPSSECVALKPLLQRVISFMSLQTHQKAQLNLNCPASLKLKIDTTLLEQVLCNCLLNASQ
AGASEIEVNVKAVGEYMTIHIVDNGSGFKAGELAFPFVPFRSSKANGLGLGLVLCQRLMRSINGDISLHNRLDQQGAEVI
LKLPNKVGETC

Sequences:

>Translated_571_residues
MKKCSSFLKMFILLLSFMPALVYAQQWKIGILAQRGVAHTHATWQPWIDWLNQHLSPHQFTLVTLDLNDLIQDQAQGVDF
ILSNQAQFFYLNNNEVRWLVTLRSPRQIQSSTMGRIGSAILVRQDSPFHQLTDLRHKTVSAVGDNAFGGFLLGYNEFYQQ
GLVENKDFQLKFTGFPVDNTLLLLQERKVDAAIVPVCILEELVNEGVVKKEDFRLLAGKENVLGCLASTELLPNWSLAAL
SQVPDSLASKLVTLLLSQVPAHLPQWTPPYSTSQADTVLRGLYKHPQQNLWDSTKYWLQQYQGWIIFVLLLLVLNYLWIS
FQIHRKSKALQQAYREMRHYEQQLVQADRLSILGEMSTGIAHEINQPLSAIRMYVEGVKYHLAQLPAEKNTVEILDKVLQ
QVDRSADIIRNLMNWAKGKKTPSSECVALKPLLQRVISFMSLQTHQKAQLNLNCPASLKLKIDTTLLEQVLCNCLLNASQ
AGASEIEVNVKAVGEYMTIHIVDNGSGFKAGELAFPFVPFRSSKANGLGLGLVLCQRLMRSINGDISLHNRLDQQGAEVI
LKLPNKVGETC
>Mature_571_residues
MKKCSSFLKMFILLLSFMPALVYAQQWKIGILAQRGVAHTHATWQPWIDWLNQHLSPHQFTLVTLDLNDLIQDQAQGVDF
ILSNQAQFFYLNNNEVRWLVTLRSPRQIQSSTMGRIGSAILVRQDSPFHQLTDLRHKTVSAVGDNAFGGFLLGYNEFYQQ
GLVENKDFQLKFTGFPVDNTLLLLQERKVDAAIVPVCILEELVNEGVVKKEDFRLLAGKENVLGCLASTELLPNWSLAAL
SQVPDSLASKLVTLLLSQVPAHLPQWTPPYSTSQADTVLRGLYKHPQQNLWDSTKYWLQQYQGWIIFVLLLLVLNYLWIS
FQIHRKSKALQQAYREMRHYEQQLVQADRLSILGEMSTGIAHEINQPLSAIRMYVEGVKYHLAQLPAEKNTVEILDKVLQ
QVDRSADIIRNLMNWAKGKKTPSSECVALKPLLQRVISFMSLQTHQKAQLNLNCPASLKLKIDTTLLEQVLCNCLLNASQ
AGASEIEVNVKAVGEYMTIHIVDNGSGFKAGELAFPFVPFRSSKANGLGLGLVLCQRLMRSINGDISLHNRLDQQGAEVI
LKLPNKVGETC

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=233, Percent_Identity=30.9012875536481, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790436, Length=261, Percent_Identity=28.3524904214559, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1786912, Length=240, Percent_Identity=27.0833333333333, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=233, Percent_Identity=26.6094420600858, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1790300, Length=207, Percent_Identity=26.5700483091787, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 64424; Mature: 64424

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKCSSFLKMFILLLSFMPALVYAQQWKIGILAQRGVAHTHATWQPWIDWLNQHLSPHQF
CCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEE
TLVTLDLNDLIQDQAQGVDFILSNQAQFFYLNNNEVRWLVTLRSPRQIQSSTMGRIGSAI
EEEEEEHHHHHHHHHCCCEEEEECCEEEEEEECCCEEEEEEECCCHHHHHHHHHHCCCEE
LVRQDSPFHQLTDLRHKTVSAVGDNAFGGFLLGYNEFYQQGLVENKDFQLKFTGFPVDNT
EEECCCCHHHHHHHHHHHHHHHCCCCCCCCEECHHHHHHCCCCCCCCEEEEEECCCCCCE
LLLLQERKVDAAIVPVCILEELVNEGVVKKEDFRLLAGKENVLGCLASTELLPNWSLAAL
EEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCHHHH
SQVPDSLASKLVTLLLSQVPAHLPQWTPPYSTSQADTVLRGLYKHPQQNLWDSTKYWLQQ
HHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
YQGWIIFVLLLLVLNYLWISFQIHRKSKALQQAYREMRHYEQQLVQADRLSILGEMSTGI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHEINQPLSAIRMYVEGVKYHLAQLPAEKNTVEILDKVLQQVDRSADIIRNLMNWAKGKK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TPSSECVALKPLLQRVISFMSLQTHQKAQLNLNCPASLKLKIDTTLLEQVLCNCLLNASQ
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEEEHHHHHHHHHHHHHHCCCC
AGASEIEVNVKAVGEYMTIHIVDNGSGFKAGELAFPFVPFRSSKANGLGLGLVLCQRLMR
CCCCCEEEEEEEECCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
SINGDISLHNRLDQQGAEVILKLPNKVGETC
HHCCCEEHHHHHHHHHHHHHHHCCHHCCCCC
>Mature Secondary Structure
MKKCSSFLKMFILLLSFMPALVYAQQWKIGILAQRGVAHTHATWQPWIDWLNQHLSPHQF
CCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEE
TLVTLDLNDLIQDQAQGVDFILSNQAQFFYLNNNEVRWLVTLRSPRQIQSSTMGRIGSAI
EEEEEEHHHHHHHHHCCCEEEEECCEEEEEEECCCEEEEEEECCCHHHHHHHHHHCCCEE
LVRQDSPFHQLTDLRHKTVSAVGDNAFGGFLLGYNEFYQQGLVENKDFQLKFTGFPVDNT
EEECCCCHHHHHHHHHHHHHHHCCCCCCCCEECHHHHHHCCCCCCCCEEEEEECCCCCCE
LLLLQERKVDAAIVPVCILEELVNEGVVKKEDFRLLAGKENVLGCLASTELLPNWSLAAL
EEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHCCCCCCHHHH
SQVPDSLASKLVTLLLSQVPAHLPQWTPPYSTSQADTVLRGLYKHPQQNLWDSTKYWLQQ
HHCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
YQGWIIFVLLLLVLNYLWISFQIHRKSKALQQAYREMRHYEQQLVQADRLSILGEMSTGI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHEINQPLSAIRMYVEGVKYHLAQLPAEKNTVEILDKVLQQVDRSADIIRNLMNWAKGKK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TPSSECVALKPLLQRVISFMSLQTHQKAQLNLNCPASLKLKIDTTLLEQVLCNCLLNASQ
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEEEEHHHHHHHHHHHHHHCCCC
AGASEIEVNVKAVGEYMTIHIVDNGSGFKAGELAFPFVPFRSSKANGLGLGLVLCQRLMR
CCCCCEEEEEEEECCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
SINGDISLHNRLDQQGAEVILKLPNKVGETC
HHCCCEEHHHHHHHHHHHHHHHCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3671068 [H]