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The map label for this gene is guaB [H]

Identifier: 15602160

GI number: 15602160

Start: 337563

End: 339026

Strand: Reverse

Name: guaB [H]

Synonym: PM0295

Alternate gene names: 15602160

Gene position: 339026-337563 (Counterclockwise)

Preceding gene: 15602162

Following gene: 15602159

Centisome position: 15.02

GC content: 44.06

Gene sequence:

>1464_bases
ATGTTACGAGTAATAAAAGAAGCATTAACCTTCGATGATGTTTTGCTTGTCCCAGCACATTCTACTGTGCTCCCAAATAC
CGCAGACCTTTCCACTCAACTCACCAAAACTATCCGCCTCAATATCCCAATGTTATCCGCTGCCATGGATACCGTGACAG
AAACTAAACTGGCAATCTCTCTTGCACAAGAAGGTGGCATCGGGTTTATTCATAAAAATATGTCTATTGAGCGTCAAGCG
GAACGTGTCCGCAAAGTGAAAAAATTTGAGAGCGGTATTGTATCCGATCCTGTCACCGTTTCACCAACCTTATCTTTAGC
AGAATTAAGTGAATTAGTGAAGAAAAATGGTTTTGCGAGTTTCCCTGTTGTTGATGATGAAAAAAATCTTGTCGGTATCA
TTACTGGTCGTGATACACGCTTTGTCACGGATTTAAATAAAACAGTGGCGGACTTTATGACCCCTAAAGCTCGTCTTGTC
ACAGTGAAACGCAATGCAAGTCGCGATGAAATTTTTGGTCTAATGCATACACACCGTGTAGAAAAAGTCCTTGTTGTCAG
CGACGATTTCAAATTAAAAGGCATGATCACCTTAAAAGACTACCAAAAATCCGAGCAAAAACCACAAGCCTGTAAAGATG
AATTTGGTCGTTTACGTGTCGGTGCTGCAGTAGGAGCAGGACCTGGTAATGAAGAACGTATTGATGCATTAGTGAAAGCT
GGAGTCGATGTGTTATTAATTGACTCATCACACGGGCATTCAGAAGGTGTGTTACAACGTGTGCGTGAAACTCGTGCGAA
ATACCCAGATTTGCCAATTGTTGCAGGTAATGTGGCAACCGCTGAAGGCGCAATTGCGTTGGCTGATGCAGGGGCAAGTG
CAGTGAAAGTGGGGATTGGTCCTGGTTCAATTTGTACAACACGTATTGTCACAGGCGTGGGCGTTCCACAAATTACAGCG
ATTGCCGATGCGGCAGAAGCACTAAAAGATCGGGGTATTCCTGTGATTGCAGATGGCGGTATCCGTTTCTCTGGTGATAT
TTCGAAAGCCATTGCGGCGGGCGCCTCTTGTGTTATGGTGGGTTCCATGTTTGCAGGTACAGAAGAAGCACCAGGTGAAA
TCGAACTTTATCAAGGTCGTGCCTTTAAATCTTATCGAGGTATGGGATCGTTAGGTGCGATGAGCAAAGGCTCAAGCGAC
CGCTATTTCCAGTCCGATAATGCAGCTGACAAATTAGTACCAGAAGGTATTGAAGGACGTATTCCATATAAAGGATTCTT
AAAAGAAATTATCCATCAACAAATGGGGGGATTGCGTTCTTGTATGGGCTTAACGGGTTGTGCAACCATTGATGAACTCC
GTACCAAAGCGCAGTTTGTGCGTATTAGTGGTGCAGGGATCCAAGAAAGTCATGTGCATGATGTGACTATCACAAAAGAA
GCCCCGAATTATCGTATGGGTTAA

Upstream 100 bases:

>100_bases
TAAAAAAATCCATTTTCAAACAGCAACGAAATCTGTATAATGCGACCGCAATATTTTTTACCCTTTTATTTTTCATATCA
ACCTAAGAGAGAATATTGCA

Downstream 100 bases:

>100_bases
ACATTGCTTAGGTGGGGATAATCCCCACCTAAGTTTATTTTAAATAACAACGTTAATAGAGAAGGTTATTTTTATGTATG
GCATTAAAATTAAAAATGTT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MLRVIKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTETKLAISLAQEGGIGFIHKNMSIERQA
ERVRKVKKFESGIVSDPVTVSPTLSLAELSELVKKNGFASFPVVDDEKNLVGIITGRDTRFVTDLNKTVADFMTPKARLV
TVKRNASRDEIFGLMHTHRVEKVLVVSDDFKLKGMITLKDYQKSEQKPQACKDEFGRLRVGAAVGAGPGNEERIDALVKA
GVDVLLIDSSHGHSEGVLQRVRETRAKYPDLPIVAGNVATAEGAIALADAGASAVKVGIGPGSICTTRIVTGVGVPQITA
IADAAEALKDRGIPVIADGGIRFSGDISKAIAAGASCVMVGSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMSKGSSD
RYFQSDNAADKLVPEGIEGRIPYKGFLKEIIHQQMGGLRSCMGLTGCATIDELRTKAQFVRISGAGIQESHVHDVTITKE
APNYRMG

Sequences:

>Translated_487_residues
MLRVIKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTETKLAISLAQEGGIGFIHKNMSIERQA
ERVRKVKKFESGIVSDPVTVSPTLSLAELSELVKKNGFASFPVVDDEKNLVGIITGRDTRFVTDLNKTVADFMTPKARLV
TVKRNASRDEIFGLMHTHRVEKVLVVSDDFKLKGMITLKDYQKSEQKPQACKDEFGRLRVGAAVGAGPGNEERIDALVKA
GVDVLLIDSSHGHSEGVLQRVRETRAKYPDLPIVAGNVATAEGAIALADAGASAVKVGIGPGSICTTRIVTGVGVPQITA
IADAAEALKDRGIPVIADGGIRFSGDISKAIAAGASCVMVGSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMSKGSSD
RYFQSDNAADKLVPEGIEGRIPYKGFLKEIIHQQMGGLRSCMGLTGCATIDELRTKAQFVRISGAGIQESHVHDVTITKE
APNYRMG
>Mature_487_residues
MLRVIKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTETKLAISLAQEGGIGFIHKNMSIERQA
ERVRKVKKFESGIVSDPVTVSPTLSLAELSELVKKNGFASFPVVDDEKNLVGIITGRDTRFVTDLNKTVADFMTPKARLV
TVKRNASRDEIFGLMHTHRVEKVLVVSDDFKLKGMITLKDYQKSEQKPQACKDEFGRLRVGAAVGAGPGNEERIDALVKA
GVDVLLIDSSHGHSEGVLQRVRETRAKYPDLPIVAGNVATAEGAIALADAGASAVKVGIGPGSICTTRIVTGVGVPQITA
IADAAEALKDRGIPVIADGGIRFSGDISKAIAAGASCVMVGSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMSKGSSD
RYFQSDNAADKLVPEGIEGRIPYKGFLKEIIHQQMGGLRSCMGLTGCATIDELRTKAQFVRISGAGIQESHVHDVTITKE
APNYRMG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=457, Percent_Identity=39.6061269146608, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI34328928, Length=457, Percent_Identity=39.6061269146608, Blast_Score=315, Evalue=6e-86,
Organism=Homo sapiens, GI156616279, Length=457, Percent_Identity=39.6061269146608, Blast_Score=315, Evalue=7e-86,
Organism=Homo sapiens, GI34328930, Length=457, Percent_Identity=39.6061269146608, Blast_Score=315, Evalue=7e-86,
Organism=Homo sapiens, GI66933016, Length=456, Percent_Identity=39.2543859649123, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI217035152, Length=451, Percent_Identity=39.689578713969, Blast_Score=308, Evalue=6e-84,
Organism=Homo sapiens, GI217035148, Length=457, Percent_Identity=38.5120350109409, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI217035150, Length=457, Percent_Identity=36.1050328227571, Blast_Score=272, Evalue=4e-73,
Organism=Homo sapiens, GI156104880, Length=270, Percent_Identity=37.4074074074074, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI50541954, Length=250, Percent_Identity=37.2, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI50541952, Length=250, Percent_Identity=37.2, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI50541948, Length=250, Percent_Identity=37.2, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI50541956, Length=250, Percent_Identity=37.2, Blast_Score=156, Evalue=3e-38,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=82.340862422998, Blast_Score=768, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=37.5565610859729, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=501, Percent_Identity=35.7285429141717, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI71994389, Length=424, Percent_Identity=38.4433962264151, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17560440, Length=289, Percent_Identity=33.2179930795848, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6322012, Length=464, Percent_Identity=39.0086206896552, Blast_Score=319, Evalue=5e-88,
Organism=Saccharomyces cerevisiae, GI6323585, Length=460, Percent_Identity=39.1304347826087, Blast_Score=319, Evalue=7e-88,
Organism=Saccharomyces cerevisiae, GI6323464, Length=460, Percent_Identity=39.3478260869565, Blast_Score=308, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=39.1812865497076, Blast_Score=240, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=41.1764705882353, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=38.5093167701863, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=38.5093167701863, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=38.7755102040816, Blast_Score=274, Evalue=9e-74,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52009; Mature: 52009

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRVIKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTETKLAIS
CHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHEEEEEEECCCHHHHHHHHHHHHHHEEE
LAQEGGIGFIHKNMSIERQAERVRKVKKFESGIVSDPVTVSPTLSLAELSELVKKNGFAS
ECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHCCCCC
FPVVDDEKNLVGIITGRDTRFVTDLNKTVADFMTPKARLVTVKRNASRDEIFGLMHTHRV
CCEECCCCCEEEEEECCCCEEEHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCC
EKVLVVSDDFKLKGMITLKDYQKSEQKPQACKDEFGRLRVGAAVGAGPGNEERIDALVKA
CEEEEEECCCEEEEEEEEHHHHCCCCCCHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRVRETRAKYPDLPIVAGNVATAEGAIALADAGASAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEECCCCCEEEEECC
PGSICTTRIVTGVGVPQITAIADAAEALKDRGIPVIADGGIRFSGDISKAIAAGASCVMV
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEECCCHHHHHHCCCCEEEE
GSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEEECCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC
IPYKGFLKEIIHQQMGGLRSCMGLTGCATIDELRTKAQFVRISGAGIQESHVHDVTITKE
CCHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHEEEEEEECCCCCCCCCEEEEEECC
APNYRMG
CCCCCCC
>Mature Secondary Structure
MLRVIKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTETKLAIS
CHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHEEEEEEECCCHHHHHHHHHHHHHHEEE
LAQEGGIGFIHKNMSIERQAERVRKVKKFESGIVSDPVTVSPTLSLAELSELVKKNGFAS
ECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHCCCCC
FPVVDDEKNLVGIITGRDTRFVTDLNKTVADFMTPKARLVTVKRNASRDEIFGLMHTHRV
CCEECCCCCEEEEEECCCCEEEHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCC
EKVLVVSDDFKLKGMITLKDYQKSEQKPQACKDEFGRLRVGAAVGAGPGNEERIDALVKA
CEEEEEECCCEEEEEEEEHHHHCCCCCCHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLQRVRETRAKYPDLPIVAGNVATAEGAIALADAGASAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEECCCCCEEEEECC
PGSICTTRIVTGVGVPQITAIADAAEALKDRGIPVIADGGIRFSGDISKAIAAGASCVMV
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEECCCHHHHHHCCCCEEEE
GSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEEECCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCC
IPYKGFLKEIIHQQMGGLRSCMGLTGCATIDELRTKAQFVRISGAGIQESHVHDVTITKE
CCHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHEEEEEEECCCCCCCCCEEEEEECC
APNYRMG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]