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The map label for this gene is guaA [H]

Identifier: 15602158

GI number: 15602158

Start: 334538

End: 336109

Strand: Reverse

Name: guaA [H]

Synonym: PM0293

Alternate gene names: 15602158

Gene position: 336109-334538 (Counterclockwise)

Preceding gene: 15602159

Following gene: 15602157

Centisome position: 14.89

GC content: 42.18

Gene sequence:

>1572_bases
ATGAACAACATTCACAACCATAAAATTTTAATTTTGGACTTCGGTTCACAATATACCCAGTTGATTGCCCGCCGTGTACG
TGAAATTGGCGTGTACTGCGAACTTTGGGCATGGGATGTTTCCGAAGCCGATATTCGTGAGTTTAATCCAACTGGGATTA
TTCTTTCTGGTGGTCCTGAAAGTACCACTGAAGAAAACAGCCCACGAGCTCCCGAATACGTATTCAACGCCGGTGTACCC
GTATTAGGGATCTGTTATGGTATGCAAACCATGGCGATGCAACTAGGTGGTTTAACTGAAACTTCTACTCACCGAGAATT
TGGTTATGCATCAGTGAATCTAAAAGCAGCGGACGCGTTATTTGCTCAATTAAATGATGATGTCACAAGTTCACAGCCCA
AATTAGACGTTTGGATGAGCCATGGCGATAAAGTGACGCGTTTGCCAGATCATTTCCAAGTCACCGCAATGACCTCAACC
TGTCCAATTGCAGCTATGTCGGATGAACGTCGTCGTTTTTATGGTGTCCAATTCCACCCAGAAGTGACTCATACAAAAAG
CGGGCTTGAATTATTAACGAATTTTGTGGTGAAGATCTGTGGTTGTGAACGTAACTGGACACCAGAAAATATCATTGAAG
ATGCCGTTGCTCGTCTTAAAGCACAAGTGGGTGATGATGAAGTGATCTTAGGATTATCTGGTGGCGTTGACTCTTCTGTC
ACTGCACTACTCTTACATCGTGCGATTGGTAAAAACTTACACTGTGTTTTCGTAGATAACGGTTTATTACGTCTCAACGA
AGCGGAACAAGTGATGGAGATGTTTGGCGATAAATTTGGTTTAAACATTATCCACGTAAAAGCAGAAGATCGTTTCTTAG
ATGCGTTAAAAGGCATCGATGAGCCCGAAGCAAAACGTAAAATGATTGGTAAAGTCTTTGTGGATGTTTTTGATGATGAA
TCGAAAAAACTCACCAGCGTCAAATGGTTAGCCCAAGGCACGATTTATCCAGATGTTATTGAGTCTGCGGCAAGTAAAAC
AGGTAAAGCACATGTGATTAAATCACACCATAACGTCGGTGGTTTACCTGACTACATGAAGCTAGGACTTGTTGAACCAC
TTCGTGAATTATTTAAAGATGAAGTACGTAAAATTGGTTTAGCATTAGGTTTACCAGCCGAAATGTTAAATCGTCACCCA
TTCCCAGGACCTGGTTTAGGTGTCCGTGTTTTAGGTGAAATCAAAAAAGAATACTGTGATTTAGTCCGCCTTGCTGATGC
GATCTTTATGGAAGAGTTGCATGCTTCTGGTTGGTACTACAAAGTCAGCCAAGCCTTCACGGTATTTTTACCAGTAAAAT
CCGTAGGTGTCATGGGTGATGGGCGTAAATATGACTGGGTAGTTTCCCTCCGTGCAGTGGAAACAATCGATTTTATGACC
GCACATTGGGCACACCTGCCTTATGATCTCTTAGGTAAAATTTCCAATCGTATTATTAATGAAGTCAATGGGATTTCTCG
CGTTGTTTATGACGTTAGCGGTAAGCCGCCAGCAACAATTGAGTGGGAATAA

Upstream 100 bases:

>100_bases
TAACATCTTGATGTCATCGCAAATTCAAACTCCTTTTACACAATATATTTAAACTTTAACCCGATTTAATATTTACGTAA
AAACAACTAAGAGAACTTAA

Downstream 100 bases:

>100_bases
CCTAACAAATAAGCCCTGCAAATGCAGGGCTTTCTATTTTGTTTAATGTTTAATTGATTAGTATTGACTTATTCCGTCAC
ACAACCGCCAATAATCACTT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MNNIHNHKILILDFGSQYTQLIARRVREIGVYCELWAWDVSEADIREFNPTGIILSGGPESTTEENSPRAPEYVFNAGVP
VLGICYGMQTMAMQLGGLTETSTHREFGYASVNLKAADALFAQLNDDVTSSQPKLDVWMSHGDKVTRLPDHFQVTAMTST
CPIAAMSDERRRFYGVQFHPEVTHTKSGLELLTNFVVKICGCERNWTPENIIEDAVARLKAQVGDDEVILGLSGGVDSSV
TALLLHRAIGKNLHCVFVDNGLLRLNEAEQVMEMFGDKFGLNIIHVKAEDRFLDALKGIDEPEAKRKMIGKVFVDVFDDE
SKKLTSVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMLNRHP
FPGPGLGVRVLGEIKKEYCDLVRLADAIFMEELHASGWYYKVSQAFTVFLPVKSVGVMGDGRKYDWVVSLRAVETIDFMT
AHWAHLPYDLLGKISNRIINEVNGISRVVYDVSGKPPATIEWE

Sequences:

>Translated_523_residues
MNNIHNHKILILDFGSQYTQLIARRVREIGVYCELWAWDVSEADIREFNPTGIILSGGPESTTEENSPRAPEYVFNAGVP
VLGICYGMQTMAMQLGGLTETSTHREFGYASVNLKAADALFAQLNDDVTSSQPKLDVWMSHGDKVTRLPDHFQVTAMTST
CPIAAMSDERRRFYGVQFHPEVTHTKSGLELLTNFVVKICGCERNWTPENIIEDAVARLKAQVGDDEVILGLSGGVDSSV
TALLLHRAIGKNLHCVFVDNGLLRLNEAEQVMEMFGDKFGLNIIHVKAEDRFLDALKGIDEPEAKRKMIGKVFVDVFDDE
SKKLTSVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMLNRHP
FPGPGLGVRVLGEIKKEYCDLVRLADAIFMEELHASGWYYKVSQAFTVFLPVKSVGVMGDGRKYDWVVSLRAVETIDFMT
AHWAHLPYDLLGKISNRIINEVNGISRVVYDVSGKPPATIEWE
>Mature_523_residues
MNNIHNHKILILDFGSQYTQLIARRVREIGVYCELWAWDVSEADIREFNPTGIILSGGPESTTEENSPRAPEYVFNAGVP
VLGICYGMQTMAMQLGGLTETSTHREFGYASVNLKAADALFAQLNDDVTSSQPKLDVWMSHGDKVTRLPDHFQVTAMTST
CPIAAMSDERRRFYGVQFHPEVTHTKSGLELLTNFVVKICGCERNWTPENIIEDAVARLKAQVGDDEVILGLSGGVDSSV
TALLLHRAIGKNLHCVFVDNGLLRLNEAEQVMEMFGDKFGLNIIHVKAEDRFLDALKGIDEPEAKRKMIGKVFVDVFDDE
SKKLTSVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMLNRHP
FPGPGLGVRVLGEIKKEYCDLVRLADAIFMEELHASGWYYKVSQAFTVFLPVKSVGVMGDGRKYDWVVSLRAVETIDFMT
AHWAHLPYDLLGKISNRIINEVNGISRVVYDVSGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=567, Percent_Identity=33.6860670194003, Blast_Score=285, Evalue=1e-76,
Organism=Escherichia coli, GI1788854, Length=522, Percent_Identity=77.9693486590038, Blast_Score=858, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=578, Percent_Identity=36.3321799307958, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI71992717, Length=578, Percent_Identity=36.3321799307958, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI133901714, Length=578, Percent_Identity=36.3321799307958, Blast_Score=293, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6323873, Length=522, Percent_Identity=47.8927203065134, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI281365319, Length=564, Percent_Identity=35.4609929078014, Blast_Score=294, Evalue=8e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58231; Mature: 58231

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNIHNHKILILDFGSQYTQLIARRVREIGVYCELWAWDVSEADIREFNPTGIILSGGPE
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHCCCCCEEEEECCCC
STTEENSPRAPEYVFNAGVPVLGICYGMQTMAMQLGGLTETSTHREFGYASVNLKAADAL
CCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHH
FAQLNDDVTSSQPKLDVWMSHGDKVTRLPDHFQVTAMTSTCPIAAMSDERRRFYGVQFHP
HHHHCCCCCCCCCCEEEEECCCCCEECCCCCEEEEEECCCCCEEECCCCCHHEECEEECC
EVTHTKSGLELLTNFVVKICGCERNWTPENIIEDAVARLKAQVGDDEVILGLSGGVDSSV
CCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
TALLLHRAIGKNLHCVFVDNGLLRLNEAEQVMEMFGDKFGLNIIHVKAEDRFLDALKGID
HHHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHCHHCCCEEEEEECHHHHHHHHCCCC
EPEAKRKMIGKVFVDVFDDESKKLTSVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVG
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCC
GLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMLNRHPFPGPGLGVRVLGEIKKEYCD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHH
LVRLADAIFMEELHASGWYYKVSQAFTVFLPVKSVGVMGDGRKYDWVVSLRAVETIDFMT
HHHHHHHHHHHHHHCCCCEEEECCEEEEEEEHHHCCCCCCCCCEEEEEEEEHHHHHHHHH
AHWAHLPYDLLGKISNRIINEVNGISRVVYDVSGKPPATIEWE
HHHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEECC
>Mature Secondary Structure
MNNIHNHKILILDFGSQYTQLIARRVREIGVYCELWAWDVSEADIREFNPTGIILSGGPE
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHCCCCCEEEEECCCC
STTEENSPRAPEYVFNAGVPVLGICYGMQTMAMQLGGLTETSTHREFGYASVNLKAADAL
CCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHH
FAQLNDDVTSSQPKLDVWMSHGDKVTRLPDHFQVTAMTSTCPIAAMSDERRRFYGVQFHP
HHHHCCCCCCCCCCEEEEECCCCCEECCCCCEEEEEECCCCCEEECCCCCHHEECEEECC
EVTHTKSGLELLTNFVVKICGCERNWTPENIIEDAVARLKAQVGDDEVILGLSGGVDSSV
CCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
TALLLHRAIGKNLHCVFVDNGLLRLNEAEQVMEMFGDKFGLNIIHVKAEDRFLDALKGID
HHHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHCHHCCCEEEEEECHHHHHHHHCCCC
EPEAKRKMIGKVFVDVFDDESKKLTSVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVG
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCC
GLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMLNRHPFPGPGLGVRVLGEIKKEYCD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHH
LVRLADAIFMEELHASGWYYKVSQAFTVFLPVKSVGVMGDGRKYDWVVSLRAVETIDFMT
HHHHHHHHHHHHHHCCCCEEEECCEEEEEEEHHHCCCCCCCCCEEEEEEEEHHHHHHHHH
AHWAHLPYDLLGKISNRIINEVNGISRVVYDVSGKPPATIEWE
HHHHHCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA