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The map label for this gene is pdxY

Identifier: 15602155

GI number: 15602155

Start: 331250

End: 332110

Strand: Reverse

Name: pdxY

Synonym: PM0290

Alternate gene names: 15602155

Gene position: 332110-331250 (Counterclockwise)

Preceding gene: 15602156

Following gene: 15602154

Centisome position: 14.71

GC content: 41.23

Gene sequence:

>861_bases
ATGAAACATGTGCTTTCAATACAGTCCCATGTGGTCTATGGCTATGCGGGAAATAAATCTGCTACATTCCCTATGCAATT
ATTAGGTGTGGATGTTTGGGCATTAAATACAGTTCAATTTTCTAACCATACGCAATATGGTAAATGGACTGGCATGGTGA
TTCCGAAAGAACAAATTGGCGAAATTGTGCGTGGTATTGATGCCATTGAAGCGCTCCACTTATGCGACGCCATTGTTTCT
GGTTATATTGGTTCGGCTGAACAAGTCGAAGAAATTGTTAATGCGGTGCGTTTTATTAAAAGCAAAAATCCGAATGCGCT
GTACTTATGCGATCCTGTTATGGGTCATCCTGATAAAGGCTGTATCGTTGCAGAAGGCGTAAAAGAAGGGCTAATTAATT
TAGCCATGGCAGAAGCCGATTTGATCACACCGAATTTAGTCGAATTACGTGAGCTAAGTGGTCTCCCTGTCGAAAATTTT
GCACAAGCACAAGATGCGGTCAGAGCGATCCTCGCCAAAGGACCGAAAAAAGTTCTCGTCAAACACCTTAGCAAAGTCGG
TAAAGACTCAAGCCAATTTGAAATGCTATTGGCAACCAAAGACGGCATGTGGCACATTAGTCGCCCATTACACCAATTCC
GTAAAGAACCTGTTGGCGTGGGTGACTTAACCGCTGGTTTATTTATTGCTAATTTGCTGAATGGTAAATCTGATATTGAG
GCCTTTGAACATACCGCCAATGCTGTCAATGATGTCATGACCGTTACACAACAAAAAGATAACTATGAATTACAAATTAT
TGCTGCACGTGAATACATTATGCAACCTAGCAGTCAATATAAAGCCGTGAAAATTGCTTAA

Upstream 100 bases:

>100_bases
GATGGTCCATTTTGGAAAGCTGAAGTATTCTTGCCAGAATCACAACAAAAATTAGCAACCCCACTACTTAATCAATTTAT
TCGAGAAGGAAAACAATAAC

Downstream 100 bases:

>100_bases
ATTCTTGCAAAAAGGGCGTTAGAATTAACGTCCTTTTACTTTGTGATGAAATACTATGTTGCTAACACAATTCCAAGCCG
AAATTGCGCAACTTCCGCCC

Product: pyridoxamine kinase

Products: NA

Alternate protein names: PM kinase

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKHVLSIQSHVVYGYAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWTGMVIPKEQIGEIVRGIDAIEALHLCDAIVS
GYIGSAEQVEEIVNAVRFIKSKNPNALYLCDPVMGHPDKGCIVAEGVKEGLINLAMAEADLITPNLVELRELSGLPVENF
AQAQDAVRAILAKGPKKVLVKHLSKVGKDSSQFEMLLATKDGMWHISRPLHQFRKEPVGVGDLTAGLFIANLLNGKSDIE
AFEHTANAVNDVMTVTQQKDNYELQIIAAREYIMQPSSQYKAVKIA

Sequences:

>Translated_286_residues
MKHVLSIQSHVVYGYAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWTGMVIPKEQIGEIVRGIDAIEALHLCDAIVS
GYIGSAEQVEEIVNAVRFIKSKNPNALYLCDPVMGHPDKGCIVAEGVKEGLINLAMAEADLITPNLVELRELSGLPVENF
AQAQDAVRAILAKGPKKVLVKHLSKVGKDSSQFEMLLATKDGMWHISRPLHQFRKEPVGVGDLTAGLFIANLLNGKSDIE
AFEHTANAVNDVMTVTQQKDNYELQIIAAREYIMQPSSQYKAVKIA
>Mature_286_residues
MKHVLSIQSHVVYGYAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWTGMVIPKEQIGEIVRGIDAIEALHLCDAIVS
GYIGSAEQVEEIVNAVRFIKSKNPNALYLCDPVMGHPDKGCIVAEGVKEGLINLAMAEADLITPNLVELRELSGLPVENF
AQAQDAVRAILAKGPKKVLVKHLSKVGKDSSQFEMLLATKDGMWHISRPLHQFRKEPVGVGDLTAGLFIANLLNGKSDIE
AFEHTANAVNDVMTVTQQKDNYELQIIAAREYIMQPSSQYKAVKIA

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine

COG id: COG2240

COG function: function code H; Pyridoxal/pyridoxine/pyridoxamine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxine kinase family

Homologues:

Organism=Homo sapiens, GI4505701, Length=272, Percent_Identity=31.25, Blast_Score=128, Evalue=6e-30,
Organism=Escherichia coli, GI1787924, Length=286, Percent_Identity=54.5454545454545, Blast_Score=326, Evalue=9e-91,
Organism=Escherichia coli, GI1788758, Length=261, Percent_Identity=29.8850574712644, Blast_Score=118, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17507759, Length=292, Percent_Identity=30.8219178082192, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17507757, Length=302, Percent_Identity=30.1324503311258, Blast_Score=123, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320806, Length=265, Percent_Identity=32.4528301886792, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324354, Length=182, Percent_Identity=36.2637362637363, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45553007, Length=302, Percent_Identity=33.7748344370861, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXY_PASMU (Q9CNY1)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245227.1
- HSSP:   P77150
- ProteinModelPortal:   Q9CNY1
- SMR:   Q9CNY1
- GeneID:   1243637
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0290
- NMPDR:   fig|272843.1.peg.290
- HOGENOM:   HBG661459
- OMA:   CPNQLEL
- ProtClustDB:   PRK05756
- BioCyc:   PMUL272843:PM0290-MONOMER
- BRENDA:   2.7.1.35
- HAMAP:   MF_01639
- InterPro:   IPR013749
- InterPro:   IPR004625
- TIGRFAMs:   TIGR00687

Pfam domain/function: PF08543 Phos_pyr_kin

EC number: =2.7.1.35

Molecular weight: Translated: 31350; Mature: 31350

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: BINDING 9-9 BINDING 44-44 BINDING 222-222

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHVLSIQSHVVYGYAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWTGMVIPKEQIG
CCCHHEECCEEEEEEECCCCCCCHHHHHHCEEEEEEEEEECCCCCCCCEEEEECCHHHHH
EIVRGIDAIEALHLCDAIVSGYIGSAEQVEEIVNAVRFIKSKNPNALYLCDPVMGHPDKG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
CIVAEGVKEGLINLAMAEADLITPNLVELRELSGLPVENFAQAQDAVRAILAKGPKKVLV
CEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHH
KHLSKVGKDSSQFEMLLATKDGMWHISRPLHQFRKEPVGVGDLTAGLFIANLLNGKSDIE
HHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHH
AFEHTANAVNDVMTVTQQKDNYELQIIAAREYIMQPSSQYKAVKIA
HHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHCCCCCCCEEEEC
>Mature Secondary Structure
MKHVLSIQSHVVYGYAGNKSATFPMQLLGVDVWALNTVQFSNHTQYGKWTGMVIPKEQIG
CCCHHEECCEEEEEEECCCCCCCHHHHHHCEEEEEEEEEECCCCCCCCEEEEECCHHHHH
EIVRGIDAIEALHLCDAIVSGYIGSAEQVEEIVNAVRFIKSKNPNALYLCDPVMGHPDKG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCC
CIVAEGVKEGLINLAMAEADLITPNLVELRELSGLPVENFAQAQDAVRAILAKGPKKVLV
CEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHH
KHLSKVGKDSSQFEMLLATKDGMWHISRPLHQFRKEPVGVGDLTAGLFIANLLNGKSDIE
HHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHH
AFEHTANAVNDVMTVTQQKDNYELQIIAAREYIMQPSSQYKAVKIA
HHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100