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The map label for this gene is arcA [H]

Identifier: 15602084

GI number: 15602084

Start: 242967

End: 243677

Strand: Reverse

Name: arcA [H]

Synonym: PM0219

Alternate gene names: 15602084

Gene position: 243677-242967 (Counterclockwise)

Preceding gene: 15602085

Following gene: 15602082

Centisome position: 10.79

GC content: 39.8

Gene sequence:

>711_bases
ATGGGAACGCCACAAATTTTAATTGTTGAAGACGAAGCAATCACCAGAAATACCTTAAAAAGTATTTTTGAGGCGGAGGG
TTATGAAGTATTTGAGGCGGCAGACGGCGCACAGATGCACCGTATTCTGTCTAATAAAGTGATTAATCTTGTCATTATGG
ATATCAACTTACCCGGTAAGAATGGACTTATGCTTGCCCGCGAACTACGAGAAACGACCAATACCGCATTAATGTTTTTA
ACTGGTCGCGATAATGAAGTGGATAAAATTCTTGGTCTAGAAATCGGTGCGGATGATTACATCACAAAACCATTCAATCC
AAGAGAATTAACCATTCGTGCACGAAATTTATTACAACGCACGATGCAAGAAAATAGTAAAGATAGCCATCATCCTATTG
AGCAATATCGCTTTAATGGCTGGACACTAGACTTAAATAGCCGCACGTTAATTAATCCAGAAGGGGAAGAATATAAACTT
CCACGCAGTGAATTCCGTGCGATGTTACATTTCTGTGAAAACCCAGGCAAAATTCAAACCCGTGAAGAATTATTGAAGAA
AATGACGGGACGTGAATTAAAGCCACAAGATCGGACAGTAGATGTCACTATTCGTCGTATTCGCAAACATTTTGAAGATC
ATCCAGAAACCCCAGAAATTATCGCCACGATCCATGGTGAAGGTTATCGTTTCTGTGGTGAATTGGAATAA

Upstream 100 bases:

>100_bases
TGTTACAATTATGTTGCAACTATAGAATGGGCAAGTTAATTTTATCCTTAATATTCTTAACAGAATGATTAACATTGAAA
ACTTGTAATAGGATGTATAA

Downstream 100 bases:

>100_bases
ACTGGATAATTCAAAAAGCCTGTAATATGTATTACAGGCTTTTTTATGCTATGGCTCATTTTCAAAGATAGCTAAACTGT
CCCAAATCTCATCCACCCTT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MGTPQILIVEDEAITRNTLKSIFEAEGYEVFEAADGAQMHRILSNKVINLVIMDINLPGKNGLMLARELRETTNTALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLQRTMQENSKDSHHPIEQYRFNGWTLDLNSRTLINPEGEEYKL
PRSEFRAMLHFCENPGKIQTREELLKKMTGRELKPQDRTVDVTIRRIRKHFEDHPETPEIIATIHGEGYRFCGELE

Sequences:

>Translated_236_residues
MGTPQILIVEDEAITRNTLKSIFEAEGYEVFEAADGAQMHRILSNKVINLVIMDINLPGKNGLMLARELRETTNTALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLQRTMQENSKDSHHPIEQYRFNGWTLDLNSRTLINPEGEEYKL
PRSEFRAMLHFCENPGKIQTREELLKKMTGRELKPQDRTVDVTIRRIRKHFEDHPETPEIIATIHGEGYRFCGELE
>Mature_235_residues
GTPQILIVEDEAITRNTLKSIFEAEGYEVFEAADGAQMHRILSNKVINLVIMDINLPGKNGLMLARELRETTNTALMFLT
GRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLQRTMQENSKDSHHPIEQYRFNGWTLDLNSRTLINPEGEEYKLP
RSEFRAMLHFCENPGKIQTREELLKKMTGRELKPQDRTVDVTIRRIRKHFEDHPETPEIIATIHGEGYRFCGELE

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=237, Percent_Identity=81.8565400843882, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=42.6724137931034, Blast_Score=194, Evalue=3e-51,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=35.8078602620087, Blast_Score=150, Evalue=5e-38,
Organism=Escherichia coli, GI1788394, Length=235, Percent_Identity=33.1914893617021, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=34.4827586206897, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI2367329, Length=235, Percent_Identity=33.1914893617021, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=33.0396475770925, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1790860, Length=231, Percent_Identity=32.034632034632, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI87082012, Length=230, Percent_Identity=30.4347826086957, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=31.4410480349345, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=30.2127659574468, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=29.9559471365639, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=27.8761061946903, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=30, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788550, Length=212, Percent_Identity=26.4150943396226, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=35.6435643564356, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27306; Mature: 27174

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTPQILIVEDEAITRNTLKSIFEAEGYEVFEAADGAQMHRILSNKVINLVIMDINLPGK
CCCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCEEEEEEEEEECCCC
NGLMLARELRETTNTALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLQR
CCHHHHHHHHHCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEHHHHHHHHHH
TMQENSKDSHHPIEQYRFNGWTLDLNSRTLINPEGEEYKLPRSEFRAMLHFCENPGKIQT
HHHHCCCCCCCCHHHEECCCEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCH
REELLKKMTGRELKPQDRTVDVTIRRIRKHFEDHPETPEIIATIHGEGYRFCGELE
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
GTPQILIVEDEAITRNTLKSIFEAEGYEVFEAADGAQMHRILSNKVINLVIMDINLPGK
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCEEEEEEEEEECCCC
NGLMLARELRETTNTALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLQR
CCHHHHHHHHHCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEHHHHHHHHHH
TMQENSKDSHHPIEQYRFNGWTLDLNSRTLINPEGEEYKLPRSEFRAMLHFCENPGKIQT
HHHHCCCCCCCCHHHEECCCEEEECCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCH
REELLKKMTGRELKPQDRTVDVTIRRIRKHFEDHPETPEIIATIHGEGYRFCGELE
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]