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The map label for this gene is thyA [H]

Identifier: 15601944

GI number: 15601944

Start: 106595

End: 107446

Strand: Reverse

Name: thyA [H]

Synonym: PM0079

Alternate gene names: 15601944

Gene position: 107446-106595 (Counterclockwise)

Preceding gene: 15601945

Following gene: 15601943

Centisome position: 4.76

GC content: 44.84

Gene sequence:

>852_bases
ATGAAACACTATTTAGAACTTTGCCAACGTATCGTTGATGAAGGTGTTTGGGTTGAAAATGCACGGACTGGCAAACGTTG
TCTGACCGTGATTGATGCGGATCTCACCTACGATGTTGCCAATAACCAATTTCCGTTGATCACCACACGCAAAAGCTATT
GGAAAGCGGCAATTGCAGAATTTTTAGGTTATATCCGTGGCTATGACAATGCGGCAGATTTCCGCAAACTCGGCACCAAA
ACCTGGGATGCCAATGCTAATGAAAACAGTGCATGGCTCAATAATCCGCACCGCAAAGGCACCGATGATATGGGACGTGT
TTATGGCGTACAAGGGCGTGCATGGCGCAAACCGAACGGTGAAACCGTCGATCAATTGCGCAAAATCGTCAATAATCTGC
GCAACGGCATTGATGACCGTGGTGAAATCATGACCTTCTTCAACCCCGGTGAATTTGAACTGGGTTGCCTACGTCCTTGC
ATGCACACCCACACCTTCTCATTACTCGGTGATACCCTCTATCTCACCAGTTATCAGCGTTCTTGTGATGTGCCGCTTGG
CTTGAATTTCAACCAAATTCAAGTGTTCACCTTTCTTGCCTTGATGGCACAAATTACGGGCAAAAAAGCGGGTAAGGCGT
ACCACAAAATCATCAATGCACACATTTATGAAGATCAACTTGATCTCATGAAAAATGTGCAATTAAAACGTGACCCCTTC
CCGTTGCCACAATTACACATTAACCCCGAGATTAAAACTCTCGAAGATTTAGAAACTTGGGTGACTATGGATGATTTTAA
GGTCACGGGCTATCAATGCCACGATGCCATTAAATATCCTTTCTCTGTGTAA

Upstream 100 bases:

>100_bases
ATATCTCCATGGGACAAATTCTCTCCACACCAATGATTCTCATTGGTGCGGTAATCATGTTAGTGGCATATCAAAGTGCG
GGTAAAAAAAGGGAAATATT

Downstream 100 bases:

>100_bases
GAGGTCGCGTCAAGATGCAATCTGACATGGATGAAAAATGGATGCGTCATGCATTACGCTTGGCGGATAAAGCAGAGCAA
TTAGGCGAGATTCCGGTGGG

Product: thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MKHYLELCQRIVDEGVWVENARTGKRCLTVIDADLTYDVANNQFPLITTRKSYWKAAIAEFLGYIRGYDNAADFRKLGTK
TWDANANENSAWLNNPHRKGTDDMGRVYGVQGRAWRKPNGETVDQLRKIVNNLRNGIDDRGEIMTFFNPGEFELGCLRPC
MHTHTFSLLGDTLYLTSYQRSCDVPLGLNFNQIQVFTFLALMAQITGKKAGKAYHKIINAHIYEDQLDLMKNVQLKRDPF
PLPQLHINPEIKTLEDLETWVTMDDFKVTGYQCHDAIKYPFSV

Sequences:

>Translated_283_residues
MKHYLELCQRIVDEGVWVENARTGKRCLTVIDADLTYDVANNQFPLITTRKSYWKAAIAEFLGYIRGYDNAADFRKLGTK
TWDANANENSAWLNNPHRKGTDDMGRVYGVQGRAWRKPNGETVDQLRKIVNNLRNGIDDRGEIMTFFNPGEFELGCLRPC
MHTHTFSLLGDTLYLTSYQRSCDVPLGLNFNQIQVFTFLALMAQITGKKAGKAYHKIINAHIYEDQLDLMKNVQLKRDPF
PLPQLHINPEIKTLEDLETWVTMDDFKVTGYQCHDAIKYPFSV
>Mature_283_residues
MKHYLELCQRIVDEGVWVENARTGKRCLTVIDADLTYDVANNQFPLITTRKSYWKAAIAEFLGYIRGYDNAADFRKLGTK
TWDANANENSAWLNNPHRKGTDDMGRVYGVQGRAWRKPNGETVDQLRKIVNNLRNGIDDRGEIMTFFNPGEFELGCLRPC
MHTHTFSLLGDTLYLTSYQRSCDVPLGLNFNQIQVFTFLALMAQITGKKAGKAYHKIINAHIYEDQLDLMKNVQLKRDPF
PLPQLHINPEIKTLEDLETWVTMDDFKVTGYQCHDAIKYPFSV

Specific function: Provides the sole de novo source of dTMP for DNA biosynthesis [H]

COG id: COG0207

COG function: function code F; Thymidylate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate synthase family. Bacterial- type thyA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507751, Length=289, Percent_Identity=32.5259515570934, Blast_Score=155, Evalue=4e-38,
Organism=Escherichia coli, GI1789191, Length=283, Percent_Identity=33.5689045936396, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71993377, Length=290, Percent_Identity=28.2758620689655, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324648, Length=302, Percent_Identity=26.8211920529801, Blast_Score=105, Evalue=6e-24,
Organism=Drosophila melanogaster, GI17137556, Length=291, Percent_Identity=29.2096219931272, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: 391 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000398
- InterPro:   IPR020940 [H]

Pfam domain/function: PF00303 Thymidylat_synt [H]

EC number: =2.1.1.45 [H]

Molecular weight: Translated: 32578; Mature: 32578

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00091 THYMIDYLATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHYLELCQRIVDEGVWVENARTGKRCLTVIDADLTYDVANNQFPLITTRKSYWKAAIAE
CCHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCEEEEECCCCCCEEECCHHHHHHHHHH
FLGYIRGYDNAADFRKLGTKTWDANANENSAWLNNPHRKGTDDMGRVYGVQGRAWRKPNG
HHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEECCCCCCCCCCC
ETVDQLRKIVNNLRNGIDDRGEIMTFFNPGEFELGCLRPCMHTHTFSLLGDTLYLTSYQR
CHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCC
SCDVPLGLNFNQIQVFTFLALMAQITGKKAGKAYHKIINAHIYEDQLDLMKNVQLKRDPF
CCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PLPQLHINPEIKTLEDLETWVTMDDFKVTGYQCHDAIKYPFSV
CCCCEEECCCCHHHHHHHHHEEECCEEECCEECCHHCCCCCCC
>Mature Secondary Structure
MKHYLELCQRIVDEGVWVENARTGKRCLTVIDADLTYDVANNQFPLITTRKSYWKAAIAE
CCHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCEEEEECCCCCCEEECCHHHHHHHHHH
FLGYIRGYDNAADFRKLGTKTWDANANENSAWLNNPHRKGTDDMGRVYGVQGRAWRKPNG
HHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEECCCCCCCCCCC
ETVDQLRKIVNNLRNGIDDRGEIMTFFNPGEFELGCLRPCMHTHTFSLLGDTLYLTSYQR
CHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCC
SCDVPLGLNFNQIQVFTFLALMAQITGKKAGKAYHKIINAHIYEDQLDLMKNVQLKRDPF
CCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PLPQLHINPEIKTLEDLETWVTMDDFKVTGYQCHDAIKYPFSV
CCCCEEECCCCHHHHHHHHHEEECCEEECCEECCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA