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The map label for this gene is nhaB

Identifier: 15601912

GI number: 15601912

Start: 50417

End: 51958

Strand: Reverse

Name: nhaB

Synonym: PM0047

Alternate gene names: 15601912

Gene position: 51958-50417 (Counterclockwise)

Preceding gene: 15601914

Following gene: 15601911

Centisome position: 2.3

GC content: 40.4

Gene sequence:

>1542_bases
ATGAGTTATACTCAAGCATTCCTAAGAAATTTCTTAGGAACAAGTCCTAATTGGTACAAAATCACAATTGTCCTTTTCCT
TATCATAAACCCTATAATCTTCTTCTTTATCAGTCCCTTTATTGCCGGTTGGCTCTTAGTTGCTGAATTCATTCTGACTC
TCGCCATGGCACTGAAATGTTACCCTCTTCAACCCGGTGGTTTACTGGCATTAGAAGCCGTGGCGATTGGTATGACCCAT
CCAGAACACGTGAAAGCCGAAATCATAGCAAACTTCGAAGTCATCCTACTATTGATCTTTATGGTTGCAGGGATTTATTT
TATGAAGCGGTTATTGCTGTTTGTTTTTACAAAATTACTTTTAAGTATTCGTTCAAAAATGGTGTTATCCCTTGCTTTCT
GTTTAAGTGCGGCCTTTTTATCGGCTTTTCTCGATGCTTTAACTGTGGTAGCCGTGATCATCAGTGTAGGTATGGGGTTC
TATGGGGTATATCATAAAGTTGCTTCAGGCAATAATTTCAACGACTCCACTGATATTACCAAAGACGATAAAATTGGTGA
AAATAAAGACACGTTAGAACAATTCCGTGCTTTCTTACGCAGCTTAATGATGCATTCTTGTGTAGGAACCGCATTAGGTG
GTGTCATGACTATGGTCGGTGAACCCCAAAACTTAATCATTGCAGAACAAGCCAAATGGGCATTTGGGGAATTCTTCTTA
CGTATGCTCCCAGTCACGTTGCCAGTTCTCATTTGTGGTTTAGTGACCTGCTTCTTAGTGGAAAAATTTGGTGTATTTGG
CTATGGCGCCAAATTGCCACGTAAAGTATGGGGCATCTTGGCAAAGTTTGATCGCAATAATCAACAAAAAATGTCGCAAC
AAGATCGTTTGAAACTTTTTGTGCAAGCTTTAATTGGTATTTGGTTGGTTGTTGGACTCGCATTCCATCTCGCCGCCGTC
GGTATCATTGGTTTAACGGTGATTATTTTGGCTACTTCATTTTGTGGTGTCACCAGCGAGCATGCTATTGGTAAAGCCTT
TCAGGAATCCTTACCCTTCACAGCATTGTTAGTGGTGTTCTTCTCGGTTGTTGCCGTCATCATTGACCAACATCTGTTTG
CGCCAATTATTCAGTTTGTGCTGGCGGCCAGTGAACATACTCAGCTTGCCCTGTTCTATATTTTTAACGGTTTGTTATCC
GCCATTTCAGATAATGTGTTTGTGGCCACAGTTTATATCAATGAAACCAAAGCGGCATTAGAGGCTGGCTTAATTGCTCA
ACCACAATATGAATTACTGGCAGTAGCAATTAATACCGGTACCAATCTTCCTTCTGTTGCAACCCCAAATGGTCAAGCCG
CATTCTTATTTTTATTGACCTCATCACTGGCACCATTGATTCGTCTTTCTTATGGTAGAATGGTTTATATGGCATTGCCT
TATACCATCGTATTATCCTGTATTGGTTTATTGGCTGTGGAATATATTTTGCCTGGCGCAACCAATGTGCTCATTCAAAT
TGGTTTATTAAAACCAATGTAA

Upstream 100 bases:

>100_bases
TTTTAAGTATTATCGTGTAATGCAGTATATATTACAATGATTCCAATATTATATTCAAAATTTCTAAAAATATTAAATAT
TAACTAAGGTGGTAGTAAAA

Downstream 100 bases:

>100_bases
TGACAAGTAAAAGGAGGAAACATGCTAAGCTTTTTTAAGACACTCTCAACAAAACGAAGTGCATGGTTTCTATTGTTTAG
CTCAGCTTTACTATTAGAGG

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MSYTQAFLRNFLGTSPNWYKITIVLFLIINPIIFFFISPFIAGWLLVAEFILTLAMALKCYPLQPGGLLALEAVAIGMTH
PEHVKAEIIANFEVILLLIFMVAGIYFMKRLLLFVFTKLLLSIRSKMVLSLAFCLSAAFLSAFLDALTVVAVIISVGMGF
YGVYHKVASGNNFNDSTDITKDDKIGENKDTLEQFRAFLRSLMMHSCVGTALGGVMTMVGEPQNLIIAEQAKWAFGEFFL
RMLPVTLPVLICGLVTCFLVEKFGVFGYGAKLPRKVWGILAKFDRNNQQKMSQQDRLKLFVQALIGIWLVVGLAFHLAAV
GIIGLTVIILATSFCGVTSEHAIGKAFQESLPFTALLVVFFSVVAVIIDQHLFAPIIQFVLAASEHTQLALFYIFNGLLS
AISDNVFVATVYINETKAALEAGLIAQPQYELLAVAINTGTNLPSVATPNGQAAFLFLLTSSLAPLIRLSYGRMVYMALP
YTIVLSCIGLLAVEYILPGATNVLIQIGLLKPM

Sequences:

>Translated_513_residues
MSYTQAFLRNFLGTSPNWYKITIVLFLIINPIIFFFISPFIAGWLLVAEFILTLAMALKCYPLQPGGLLALEAVAIGMTH
PEHVKAEIIANFEVILLLIFMVAGIYFMKRLLLFVFTKLLLSIRSKMVLSLAFCLSAAFLSAFLDALTVVAVIISVGMGF
YGVYHKVASGNNFNDSTDITKDDKIGENKDTLEQFRAFLRSLMMHSCVGTALGGVMTMVGEPQNLIIAEQAKWAFGEFFL
RMLPVTLPVLICGLVTCFLVEKFGVFGYGAKLPRKVWGILAKFDRNNQQKMSQQDRLKLFVQALIGIWLVVGLAFHLAAV
GIIGLTVIILATSFCGVTSEHAIGKAFQESLPFTALLVVFFSVVAVIIDQHLFAPIIQFVLAASEHTQLALFYIFNGLLS
AISDNVFVATVYINETKAALEAGLIAQPQYELLAVAINTGTNLPSVATPNGQAAFLFLLTSSLAPLIRLSYGRMVYMALP
YTIVLSCIGLLAVEYILPGATNVLIQIGLLKPM
>Mature_512_residues
SYTQAFLRNFLGTSPNWYKITIVLFLIINPIIFFFISPFIAGWLLVAEFILTLAMALKCYPLQPGGLLALEAVAIGMTHP
EHVKAEIIANFEVILLLIFMVAGIYFMKRLLLFVFTKLLLSIRSKMVLSLAFCLSAAFLSAFLDALTVVAVIISVGMGFY
GVYHKVASGNNFNDSTDITKDDKIGENKDTLEQFRAFLRSLMMHSCVGTALGGVMTMVGEPQNLIIAEQAKWAFGEFFLR
MLPVTLPVLICGLVTCFLVEKFGVFGYGAKLPRKVWGILAKFDRNNQQKMSQQDRLKLFVQALIGIWLVVGLAFHLAAVG
IIGLTVIILATSFCGVTSEHAIGKAFQESLPFTALLVVFFSVVAVIIDQHLFAPIIQFVLAASEHTQLALFYIFNGLLSA
ISDNVFVATVYINETKAALEAGLIAQPQYELLAVAINTGTNLPSVATPNGQAAFLFLLTSSLAPLIRLSYGRMVYMALPY
TIVLSCIGLLAVEYILPGATNVLIQIGLLKPM

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family

Homologues:

Organism=Escherichia coli, GI1787435, Length=509, Percent_Identity=72.1021611001965, Blast_Score=712, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAB_PASMU (Q9CPJ1)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_244984.1
- GeneID:   1243394
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0047
- NMPDR:   fig|272843.1.peg.47
- HOGENOM:   HBG296776
- OMA:   CFLVEKF
- ProtClustDB:   PRK09547
- BioCyc:   PMUL272843:PM0047-MONOMER
- HAMAP:   MF_01599
- InterPro:   IPR004671
- TIGRFAMs:   TIGR00774

Pfam domain/function: PF06450 NhaB

EC number: NA

Molecular weight: Translated: 56187; Mature: 56056

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xbdbcc08)-; HASH(0xaf18b84)-; HASH(0xb3c67b8)-; HASH(0xb2686a0)-; HASH(0xb25e380)-; HASH(0xb25bfbc)-; HASH(0xb2685e0)-; HASH(0xb268bc8)-; HASH(0xb268e08)-; HASH(0xaf0d19c)-; HASH(0xaf15984)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCH
>Mature Secondary Structure 
SYTQAFLRNFLGTSPNWYKITIVLFLIINPIIFFFISPFIAGWLLVAEFILTLAMALKC
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11248100