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The map label for this gene is ffh [H]

Identifier: 15595039

GI number: 15595039

Start: 735343

End: 736686

Strand: Direct

Name: ffh [H]

Synonym: BB0694

Alternate gene names: 15595039

Gene position: 735343-736686 (Clockwise)

Preceding gene: 15595038

Following gene: 15595040

Centisome position: 80.74

GC content: 31.55

Gene sequence:

>1344_bases
TTGTTTTTAATGCTTGAAAGTTTGGGGTCAAATTTTAGAAATTTTATAAACTATCTTTCTGGAAAATCTACGATAAATGA
TAAAAACATTGCAGAGGCTATTGAGATTATTAAAAATTCTTTAGTTGATGCTGATGTTAACTTAAGAGTTATAAGGCGTT
TTTTAAATTCTATAATTGAAGAATCCAAGGGAGTAAAAGTTTTAAGGGGCATTGATCCTAAATCTCAGTTTATTAAAATT
GTCAATGATAATCTTGTTAAATTTTTGGGAGGCAAAAATTATGAGCTTAGTTTACATCCTGCCAATAAGCAATCTTATAT
TCTTATGTTGGGACTTCAAGGTTCTGGCAAGACCACGACATGCGCCAAGCTTTCTTTAAAGCTTAAAAAGGAAAATAGAA
AAGTACTTCTTGTAGCTGCTGATACTTTTAGAGCGGCGGCCGTAGAACAGTTAAAAATATTGGGTGGTCAAGTAGGTGTT
CCAGTATTTTCAATTGAAGGGGAAAAAGATCCTATTAAAATTGTTAAAGCGTCTATGAAGTTTGCTGAATCTAATTTTTT
TGATTCTGTAATAGTTGATACTAGAGGACGACTTGAAATTGAATCTTTGTTGGTTGAAGAGATAAAAAAAATAAAGGGGA
TTTTGCGACCCGCAGAAACCATTTTAGTAGTAGACTCTATGATGGGGCAAGTTGCTGTAAATATTGCTAAGGAATTTAAT
GAGAATGTTGGACTTACCGGTGCAATATTTTCTAAGTTTGATTCAGATACTAGGGGGGGAGCTGTATTATCTTTTAAAAG
TATTTGTGCAGTTCCCATTAAATTTATTGGTGTTGGAGAGAAAATCGAAGATCTTGATTCCTTTTACCCAGAAAGAATTG
CTTCTAGAATTCTTGGCATGGGGGATGTTGTTAGTCTTGTAGAGAAGGTTCAAAGTGTTGTTGACAAAGAAGAGGCTATT
AAGCTTGAAGAAAAAATTAATAAAGCCAGTTTTAATTTTGAAGATTATCTGAGTCAATTTAGGCGCATTAGACAAGTAGG
AGGGTTTTCTAATTTTGTAAGTTTTTTACCAGGTGTTTCAAAATCAATGCTGAATAGCAATAATTTAAATGAAGAAAGTT
TTAATAAAGAAGAAGCTATTATTCTTTCTATGACTAAAAAAGAAAGAATAAATCCAGTGATTTTGAATAATCCCTCAAGA
AAAAAAAGAATAGCCATGGGAAGTGGAACAACTGTTTTTGATGTTAATAAGCTCATAAAAAAGTTTAGTCAAGCAACTTT
GATTATGAAAAAAATGAAAAATAAAGATTTTCAAAATAAGATTGCATCCCTTTTGGGAAAATAA

Upstream 100 bases:

>100_bases
GTGTTATTTTTAATAAATTTTATTTGACTGGAGGAGATATTGATTAATATTGCCTTTTTTTGTATCTTATATTTGACAAG
ATTATTTTTGAGAATAAGGG

Downstream 100 bases:

>100_bases
GGAGGAATAAATTTGAGCGTTAAGATAAGATTGAAAAGAATGGGAGCTAAAAAAAGACCTTATTATAGGGTTGTAGTTAT
GAATTCTACGTCTCCTAGAG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MFLMLESLGSNFRNFINYLSGKSTINDKNIAEAIEIIKNSLVDADVNLRVIRRFLNSIIEESKGVKVLRGIDPKSQFIKI
VNDNLVKFLGGKNYELSLHPANKQSYILMLGLQGSGKTTTCAKLSLKLKKENRKVLLVAADTFRAAAVEQLKILGGQVGV
PVFSIEGEKDPIKIVKASMKFAESNFFDSVIVDTRGRLEIESLLVEEIKKIKGILRPAETILVVDSMMGQVAVNIAKEFN
ENVGLTGAIFSKFDSDTRGGAVLSFKSICAVPIKFIGVGEKIEDLDSFYPERIASRILGMGDVVSLVEKVQSVVDKEEAI
KLEEKINKASFNFEDYLSQFRRIRQVGGFSNFVSFLPGVSKSMLNSNNLNEESFNKEEAIILSMTKKERINPVILNNPSR
KKRIAMGSGTTVFDVNKLIKKFSQATLIMKKMKNKDFQNKIASLLGK

Sequences:

>Translated_447_residues
MFLMLESLGSNFRNFINYLSGKSTINDKNIAEAIEIIKNSLVDADVNLRVIRRFLNSIIEESKGVKVLRGIDPKSQFIKI
VNDNLVKFLGGKNYELSLHPANKQSYILMLGLQGSGKTTTCAKLSLKLKKENRKVLLVAADTFRAAAVEQLKILGGQVGV
PVFSIEGEKDPIKIVKASMKFAESNFFDSVIVDTRGRLEIESLLVEEIKKIKGILRPAETILVVDSMMGQVAVNIAKEFN
ENVGLTGAIFSKFDSDTRGGAVLSFKSICAVPIKFIGVGEKIEDLDSFYPERIASRILGMGDVVSLVEKVQSVVDKEEAI
KLEEKINKASFNFEDYLSQFRRIRQVGGFSNFVSFLPGVSKSMLNSNNLNEESFNKEEAIILSMTKKERINPVILNNPSR
KKRIAMGSGTTVFDVNKLIKKFSQATLIMKKMKNKDFQNKIASLLGK
>Mature_447_residues
MFLMLESLGSNFRNFINYLSGKSTINDKNIAEAIEIIKNSLVDADVNLRVIRRFLNSIIEESKGVKVLRGIDPKSQFIKI
VNDNLVKFLGGKNYELSLHPANKQSYILMLGLQGSGKTTTCAKLSLKLKKENRKVLLVAADTFRAAAVEQLKILGGQVGV
PVFSIEGEKDPIKIVKASMKFAESNFFDSVIVDTRGRLEIESLLVEEIKKIKGILRPAETILVVDSMMGQVAVNIAKEFN
ENVGLTGAIFSKFDSDTRGGAVLSFKSICAVPIKFIGVGEKIEDLDSFYPERIASRILGMGDVVSLVEKVQSVVDKEEAI
KLEEKINKASFNFEDYLSQFRRIRQVGGFSNFVSFLPGVSKSMLNSNNLNEESFNKEEAIILSMTKKERINPVILNNPSR
KKRIAMGSGTTVFDVNKLIKKFSQATLIMKKMKNKDFQNKIASLLGK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=440, Percent_Identity=31.3636363636364, Blast_Score=215, Evalue=8e-56,
Organism=Homo sapiens, GI226371618, Length=338, Percent_Identity=35.207100591716, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI89061728, Length=154, Percent_Identity=34.4155844155844, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI23308697, Length=216, Percent_Identity=30.0925925925926, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI295424842, Length=221, Percent_Identity=29.8642533936652, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1788963, Length=422, Percent_Identity=42.654028436019, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI1789874, Length=188, Percent_Identity=42.0212765957447, Blast_Score=151, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17539958, Length=440, Percent_Identity=28.8636363636364, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI193206261, Length=297, Percent_Identity=27.9461279461279, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325345, Length=395, Percent_Identity=35.1898734177215, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6320498, Length=208, Percent_Identity=32.6923076923077, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17647949, Length=439, Percent_Identity=31.4350797266515, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24641198, Length=295, Percent_Identity=26.7796610169492, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49696; Mature: 49696

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLMLESLGSNFRNFINYLSGKSTINDKNIAEAIEIIKNSLVDADVNLRVIRRFLNSIIE
CEEEEHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ESKGVKVLRGIDPKSQFIKIVNDNLVKFLGGKNYELSLHPANKQSYILMLGLQGSGKTTT
CCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCCCE
CAKLSLKLKKENRKVLLVAADTFRAAAVEQLKILGGQVGVPVFSIEGEKDPIKIVKASMK
EEHEEEEEECCCCEEEEEEECHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHH
FAESNFFDSVIVDTRGRLEIESLLVEEIKKIKGILRPAETILVVDSMMGQVAVNIAKEFN
HHHCCCCCHHEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
ENVGLTGAIFSKFDSDTRGGAVLSFKSICAVPIKFIGVGEKIEDLDSFYPERIASRILGM
CCCCCHHHHHHHCCCCCCCCEEEEHHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHHCCC
GDVVSLVEKVQSVVDKEEAIKLEEKINKASFNFEDYLSQFRRIRQVGGFSNFVSFLPGVS
HHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCHH
KSMLNSNNLNEESFNKEEAIILSMTKKERINPVILNNPSRKKRIAMGSGTTVFDVNKLIK
HHHHCCCCCCHHHCCCCCEEEEEECHHHCCCEEEECCCCCCCEEEECCCCEEHHHHHHHH
KFSQATLIMKKMKNKDFQNKIASLLGK
HHHHHHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure
MFLMLESLGSNFRNFINYLSGKSTINDKNIAEAIEIIKNSLVDADVNLRVIRRFLNSIIE
CEEEEHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ESKGVKVLRGIDPKSQFIKIVNDNLVKFLGGKNYELSLHPANKQSYILMLGLQGSGKTTT
CCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCCCE
CAKLSLKLKKENRKVLLVAADTFRAAAVEQLKILGGQVGVPVFSIEGEKDPIKIVKASMK
EEHEEEEEECCCCEEEEEEECHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHH
FAESNFFDSVIVDTRGRLEIESLLVEEIKKIKGILRPAETILVVDSMMGQVAVNIAKEFN
HHHCCCCCHHEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
ENVGLTGAIFSKFDSDTRGGAVLSFKSICAVPIKFIGVGEKIEDLDSFYPERIASRILGM
CCCCCHHHHHHHCCCCCCCCEEEEHHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHHCCC
GDVVSLVEKVQSVVDKEEAIKLEEKINKASFNFEDYLSQFRRIRQVGGFSNFVSFLPGVS
HHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCHH
KSMLNSNNLNEESFNKEEAIILSMTKKERINPVILNNPSRKKRIAMGSGTTVFDVNKLIK
HHHHCCCCCCHHHCCCCCEEEEEECHHHCCCEEEECCCCCCCEEEECCCCEEHHHHHHHH
KFSQATLIMKKMKNKDFQNKIASLLGK
HHHHHHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]