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The map label for this gene is mvk [H]

Identifier: 15595033

GI number: 15595033

Start: 729613

End: 730506

Strand: Direct

Name: mvk [H]

Synonym: BB0688

Alternate gene names: 15595033

Gene position: 729613-730506 (Clockwise)

Preceding gene: 15595032

Following gene: 15595035

Centisome position: 80.11

GC content: 29.31

Gene sequence:

>894_bases
ATGCTAAGAATAAGAAAGCCTGCTAAAATATTGTTCTTAGGCGAACATAGCGCTGTTTATGGGTTCCCAGTTATTGGCGC
TACAGTTCCAATTTATATGGATCTGATTTATAGTGTATCTAAAAATTGGAAATATTTAGGAAAACCCAGTACAAGATTAA
ATAGCCTTATAAGTTTTATTGTTTCAAATTATAGCAAAGTTAATCCTATTGAGTTTGATATAATTTCTGAAATTCCTATT
GGAGTTGGTCTTGGTTCTTCTGCTAGTCTTAGTTTATGCTTTGCAGAATATATTACAAGTCATTTTGAATATAAGGATTG
TAATAAAATTTTGTTGGCAAATCAAATTGAAAACATTTTTCATGGCAAATCTTCTGGAATGGATATTAGACTAATCGATC
TTAATGGAACTTTTTATTTAGAGAAAAAAGAAAATGTTTTACATTCAAAGAAAATAAAAGATTCTGGTTTTTATTTTCTA
ATAGGAGCAATAAAAAGAGATTTAACAACTAAAGAAATAGTTGTTAATTTGAAAAAAGATCTATTATCAAATGCTTATTT
ATTTGTTTTTATTGAAAAGCTTGGCCTTGCCGTAAGCAATTCTTATGCTTCTTTTCAGAATAAGGATGTGTATTCTTTAG
CTAATGAAATGAATATTGCACAATGTTGTTTAAAGCGTTTGGGGTTGTCTAATGATACTCTTGATTGGCTGATAAGTGAG
GGAATCAAATTGGGCGCTCTTTCTGGTAAGTTAAGTGGCGCTGGTAAAGGAGGAGCATTTATTTTTCTTTTTGAAAGCCT
AATAAAAGCTAATATAGTGCAAAAAGAATTAAATAACATGCTTAAAGATTCTAAAATAGATTTGCTTTTAAAGCTAAAGG
TAATTGAGACTTAG

Upstream 100 bases:

>100_bases
AAACTTTTTTAGTTTACAGGCCCAATATTGAAGCTTTTAATTTGTCAAAAATTATTTCAATTGTTTTAGAGAATGAAGGC
ATTAAGTTTGAAAGCGATAA

Downstream 100 bases:

>100_bases
ATTATTTTTGGGCCCAGAGAGATTCGAACTCCCGACATCCTGCTTGTAAGGCAGGCGCTCTGACCAACTGAGCTATGAGC
CCTTTTATTACTAATAAGTA

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MLRIRKPAKILFLGEHSAVYGFPVIGATVPIYMDLIYSVSKNWKYLGKPSTRLNSLISFIVSNYSKVNPIEFDIISEIPI
GVGLGSSASLSLCFAEYITSHFEYKDCNKILLANQIENIFHGKSSGMDIRLIDLNGTFYLEKKENVLHSKKIKDSGFYFL
IGAIKRDLTTKEIVVNLKKDLLSNAYLFVFIEKLGLAVSNSYASFQNKDVYSLANEMNIAQCCLKRLGLSNDTLDWLISE
GIKLGALSGKLSGAGKGGAFIFLFESLIKANIVQKELNNMLKDSKIDLLLKLKVIET

Sequences:

>Translated_297_residues
MLRIRKPAKILFLGEHSAVYGFPVIGATVPIYMDLIYSVSKNWKYLGKPSTRLNSLISFIVSNYSKVNPIEFDIISEIPI
GVGLGSSASLSLCFAEYITSHFEYKDCNKILLANQIENIFHGKSSGMDIRLIDLNGTFYLEKKENVLHSKKIKDSGFYFL
IGAIKRDLTTKEIVVNLKKDLLSNAYLFVFIEKLGLAVSNSYASFQNKDVYSLANEMNIAQCCLKRLGLSNDTLDWLISE
GIKLGALSGKLSGAGKGGAFIFLFESLIKANIVQKELNNMLKDSKIDLLLKLKVIET
>Mature_297_residues
MLRIRKPAKILFLGEHSAVYGFPVIGATVPIYMDLIYSVSKNWKYLGKPSTRLNSLISFIVSNYSKVNPIEFDIISEIPI
GVGLGSSASLSLCFAEYITSHFEYKDCNKILLANQIENIFHGKSSGMDIRLIDLNGTFYLEKKENVLHSKKIKDSGFYFL
IGAIKRDLTTKEIVVNLKKDLLSNAYLFVFIEKLGLAVSNSYASFQNKDVYSLANEMNIAQCCLKRLGLSNDTLDWLISE
GIKLGALSGKLSGAGKGGAFIFLFESLIKANIVQKELNNMLKDSKIDLLLKLKVIET

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 33103; Mature: 33103

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIRKPAKILFLGEHSAVYGFPVIGATVPIYMDLIYSVSKNWKYLGKPSTRLNSLISFI
CCCCCCCCEEEEEECCCCEECCCHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHH
VSNYSKVNPIEFDIISEIPIGVGLGSSASLSLCFAEYITSHFEYKDCNKILLANQIENIF
HHCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
HGKSSGMDIRLIDLNGTFYLEKKENVLHSKKIKDSGFYFLIGAIKRDLTTKEIVVNLKKD
CCCCCCCEEEEEEECCEEEEECCCCHHHHHHCCCCCCEEEEEHHHHCCCHHHHHHHHHHH
LLSNAYLFVFIEKLGLAVSNSYASFQNKDVYSLANEMNIAQCCLKRLGLSNDTLDWLISE
HHCCCHHEEHHHHHHHHHCCCHHHCCCCHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHC
GIKLGALSGKLSGAGKGGAFIFLFESLIKANIVQKELNNMLKDSKIDLLLKLKVIET
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECC
>Mature Secondary Structure
MLRIRKPAKILFLGEHSAVYGFPVIGATVPIYMDLIYSVSKNWKYLGKPSTRLNSLISFI
CCCCCCCCEEEEEECCCCEECCCHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHH
VSNYSKVNPIEFDIISEIPIGVGLGSSASLSLCFAEYITSHFEYKDCNKILLANQIENIF
HHCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
HGKSSGMDIRLIDLNGTFYLEKKENVLHSKKIKDSGFYFLIGAIKRDLTTKEIVVNLKKD
CCCCCCCEEEEEEECCEEEEECCCCHHHHHHCCCCCCEEEEEHHHHCCCHHHHHHHHHHH
LLSNAYLFVFIEKLGLAVSNSYASFQNKDVYSLANEMNIAQCCLKRLGLSNDTLDWLISE
HHCCCHHEEHHHHHHHHHCCCHHHCCCCHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHC
GIKLGALSGKLSGAGKGGAFIFLFESLIKANIVQKELNNMLKDSKIDLLLKLKVIET
CCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]