Click here to switch to the map view.

The map label for this gene is zwf

Identifier: 15594981

GI number: 15594981

Start: 673342

End: 674778

Strand: Direct

Name: zwf

Synonym: BB0636

Alternate gene names: 15594981

Gene position: 673342-674778 (Clockwise)

Preceding gene: 15594975

Following gene: 15594982

Centisome position: 73.93

GC content: 28.67

Gene sequence:

>1437_bases
ATGAAAGAAAGAAGTGTTTCTAATTTTGATATTGTAATTTTTGGGGTTACCGGGAATTTGTCTAGAAAAAAGCTTATTCC
TTCACTTTTTAATTTATTTAAAAATAAATGTATTAGCAATTTTAGGGTTATTGGTTTTTCTCGTAAGATTTTTACAGATA
AAGAATTTAGATTGTATATTAAAGATTCTTTATGGCAGGAAGAGACCGATTCGTTGATTGAGATTTTTTTAAATTTTTTT
GTTTATGTATTTGGCGATTTTAATGAAAAGGAGTCTTATAAAAATTTATTTAAATTTTTAGATAGAAGTCGAGAAACGAT
ATATTATCTTTCGACGTCTCCTGCATTTTATGGACCTATAATTAATCATTTGAAAAAGTATTTTTTAAGCGAAAAATTGA
CTTTGTCAAAAATAGTTCTTGAGAAGCCTTTTGGCTCTAGTCTTGAGACAGCAAAAAAATTAAATAGTTTGCTTTATTCT
GCTTTTAAAGAAGATCAAATTTATAGAATAGATCACTATTTGGGTAAAGAAACGGTTCAAAATATTTTTACATTTAGATT
CGGCAATTCTATTTTTGAAAATATTTGGAATAATCGTTATGTAGATTTTGTTCAGATTACGGTAGCAGAAGAATTAGGTC
TTGATGGAAGAGTAGAGTATTACGATTCTGTTGGCGCTTTGAAGGATATGGTTCAAAATCATATTTTACAATTGTTAAGC
CTTGTTGCAATGGAGTCTCCTATTAAATTTGATTCTGAGTTTATTCATGATGAAAAAGTAAAAGTTTTAAAAAGTTTGAG
GAAAATTAGCAAAGAAGATATTAAGAATTACATTGTTAAGGGTCAATATATAGGCTCACAAGTTCAAGGGGTTTTTAAAA
AAGGCTATAAAGATGAAACAGAATTTTTGGGAAATTCAAATACCGAAACTTATTTAGCTATGAAAGTGTTTATTAATAAT
TGGCGTTGGTCTGGGGTTCCTTTTTATCTTAGAACTGGGAAAGGTCTTGCTAGGAAATTTTCAGAAATATATATTCAATT
TAAAAAACCGAGCTTTACTCTTTTTAACAATAGTTCTGTTGATTTTTCTAATGCTTTGATATTTAGAATTCAGCCAAGGG
ATGGAATTGAAATCAAATTCAATACCAAGAAGCCCGGATATAATTATGAAATTCAAACTGCTAATATGGAGTTTTCATAT
CACGGAGCATTTAAAAGATTGTTTGATGAGGCTTATGAGCGTTTATTGTTAGACGCTTTTTTAGGAGATGGTACTTTATA
TGCGACAAGTGATGAGATTGAAAGTTCTTGGGAATTTGTTTCAGATATTGCAAATAAATGGGCAGATATTGAAATTTGTA
ATTATTTTTATGGCTCTGAAGGACCAAAAGAGATAGACTCTATTTTAGAAAAAGATCATTTTTGGCGTAAAATTTAA

Upstream 100 bases:

>100_bases
AAAAAAATGATATTTAATTTGAGCTTAATTTTTGTCTGCTAATCTTTATGAATATGTTTTTTGTGATATATAATAAATTG
ACCAGATTGGACTAAATTCT

Downstream 100 bases:

>100_bases
TTTTCTAGTTTTTTAAAAGATATTTTTTAAATAGATAAATGAGATAGAATTTTTATATAATTTATTCCTATCCCTTTTTA
ATACTTGAGCCCCCAACCCC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MKERSVSNFDIVIFGVTGNLSRKKLIPSLFNLFKNKCISNFRVIGFSRKIFTDKEFRLYIKDSLWQEETDSLIEIFLNFF
VYVFGDFNEKESYKNLFKFLDRSRETIYYLSTSPAFYGPIINHLKKYFLSEKLTLSKIVLEKPFGSSLETAKKLNSLLYS
AFKEDQIYRIDHYLGKETVQNIFTFRFGNSIFENIWNNRYVDFVQITVAEELGLDGRVEYYDSVGALKDMVQNHILQLLS
LVAMESPIKFDSEFIHDEKVKVLKSLRKISKEDIKNYIVKGQYIGSQVQGVFKKGYKDETEFLGNSNTETYLAMKVFINN
WRWSGVPFYLRTGKGLARKFSEIYIQFKKPSFTLFNNSSVDFSNALIFRIQPRDGIEIKFNTKKPGYNYEIQTANMEFSY
HGAFKRLFDEAYERLLLDAFLGDGTLYATSDEIESSWEFVSDIANKWADIEICNYFYGSEGPKEIDSILEKDHFWRKI

Sequences:

>Translated_478_residues
MKERSVSNFDIVIFGVTGNLSRKKLIPSLFNLFKNKCISNFRVIGFSRKIFTDKEFRLYIKDSLWQEETDSLIEIFLNFF
VYVFGDFNEKESYKNLFKFLDRSRETIYYLSTSPAFYGPIINHLKKYFLSEKLTLSKIVLEKPFGSSLETAKKLNSLLYS
AFKEDQIYRIDHYLGKETVQNIFTFRFGNSIFENIWNNRYVDFVQITVAEELGLDGRVEYYDSVGALKDMVQNHILQLLS
LVAMESPIKFDSEFIHDEKVKVLKSLRKISKEDIKNYIVKGQYIGSQVQGVFKKGYKDETEFLGNSNTETYLAMKVFINN
WRWSGVPFYLRTGKGLARKFSEIYIQFKKPSFTLFNNSSVDFSNALIFRIQPRDGIEIKFNTKKPGYNYEIQTANMEFSY
HGAFKRLFDEAYERLLLDAFLGDGTLYATSDEIESSWEFVSDIANKWADIEICNYFYGSEGPKEIDSILEKDHFWRKI
>Mature_478_residues
MKERSVSNFDIVIFGVTGNLSRKKLIPSLFNLFKNKCISNFRVIGFSRKIFTDKEFRLYIKDSLWQEETDSLIEIFLNFF
VYVFGDFNEKESYKNLFKFLDRSRETIYYLSTSPAFYGPIINHLKKYFLSEKLTLSKIVLEKPFGSSLETAKKLNSLLYS
AFKEDQIYRIDHYLGKETVQNIFTFRFGNSIFENIWNNRYVDFVQITVAEELGLDGRVEYYDSVGALKDMVQNHILQLLS
LVAMESPIKFDSEFIHDEKVKVLKSLRKISKEDIKNYIVKGQYIGSQVQGVFKKGYKDETEFLGNSNTETYLAMKVFINN
WRWSGVPFYLRTGKGLARKFSEIYIQFKKPSFTLFNNSSVDFSNALIFRIQPRDGIEIKFNTKKPGYNYEIQTANMEFSY
HGAFKRLFDEAYERLLLDAFLGDGTLYATSDEIESSWEFVSDIANKWADIEICNYFYGSEGPKEIDSILEKDHFWRKI

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI108773793, Length=477, Percent_Identity=33.9622641509434, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI109389365, Length=477, Percent_Identity=33.9622641509434, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI52145310, Length=505, Percent_Identity=25.1485148514851, Blast_Score=147, Evalue=3e-35,
Organism=Escherichia coli, GI1788158, Length=481, Percent_Identity=39.0852390852391, Blast_Score=354, Evalue=6e-99,
Organism=Caenorhabditis elegans, GI17538218, Length=475, Percent_Identity=36, Blast_Score=317, Evalue=6e-87,
Organism=Saccharomyces cerevisiae, GI6324088, Length=484, Percent_Identity=32.8512396694215, Blast_Score=276, Evalue=5e-75,
Organism=Drosophila melanogaster, GI24643350, Length=479, Percent_Identity=35.0730688935282, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24643352, Length=479, Percent_Identity=35.0730688935282, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI221513548, Length=484, Percent_Identity=28.5123966942149, Blast_Score=199, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PD_BORBU (O51581)

Other databases:

- EMBL:   AE000783
- PIR:   C70179
- RefSeq:   NP_212770.1
- ProteinModelPortal:   O51581
- SMR:   O51581
- EnsemblBacteria:   EBBORT00000008735
- GeneID:   1195488
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0636
- NMPDR:   fig|224326.1.peg.1020
- TIGR:   BB_0636
- GeneTree:   EBGT00050000007398
- HOGENOM:   HBG322449
- OMA:   FPREDEV
- PhylomeDB:   O51581
- ProtClustDB:   PRK05722
- BioCyc:   BBUR224326:BB_0636-MONOMER
- BRENDA:   1.1.1.49
- GO:   GO:0005488
- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR23429
- PIRSF:   PIRSF000110
- PRINTS:   PR00079
- TIGRFAMs:   TIGR00871

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N

EC number: =1.1.1.49

Molecular weight: Translated: 56114; Mature: 56114

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: ACT_SITE 234-234 BINDING 17-17 BINDING 48-48 BINDING 172-172 BINDING 176-176 BINDING 339-339

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKERSVSNFDIVIFGVTGNLSRKKLIPSLFNLFKNKCISNFRVIGFSRKIFTDKEFRLYI
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEECHHEECCCCEEEEE
KDSLWQEETDSLIEIFLNFFVYVFGDFNEKESYKNLFKFLDRSRETIYYLSTSPAFYGPI
EHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
INHLKKYFLSEKLTLSKIVLEKPFGSSLETAKKLNSLLYSAFKEDQIYRIDHYLGKETVQ
HHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHCHHHHH
NIFTFRFGNSIFENIWNNRYVDFVQITVAEELGLDGRVEYYDSVGALKDMVQNHILQLLS
HHHHHHCCCHHHHHHCCCCCEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LVAMESPIKFDSEFIHDEKVKVLKSLRKISKEDIKNYIVKGQYIGSQVQGVFKKGYKDET
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHH
EFLGNSNTETYLAMKVFINNWRWSGVPFYLRTGKGLARKFSEIYIQFKKPSFTLFNNSSV
HHCCCCCCCCEEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHEEEECCCEEEEECCCCC
DFSNALIFRIQPRDGIEIKFNTKKPGYNYEIQTANMEFSYHGAFKRLFDEAYERLLLDAF
CCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEECEEEEHHHHHHHHHHHHHHHHHHHHH
LGDGTLYATSDEIESSWEFVSDIANKWADIEICNYFYGSEGPKEIDSILEKDHFWRKI
HCCCEEEEECHHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKERSVSNFDIVIFGVTGNLSRKKLIPSLFNLFKNKCISNFRVIGFSRKIFTDKEFRLYI
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEEECHHEECCCCEEEEE
KDSLWQEETDSLIEIFLNFFVYVFGDFNEKESYKNLFKFLDRSRETIYYLSTSPAFYGPI
EHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
INHLKKYFLSEKLTLSKIVLEKPFGSSLETAKKLNSLLYSAFKEDQIYRIDHYLGKETVQ
HHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHCHHHHH
NIFTFRFGNSIFENIWNNRYVDFVQITVAEELGLDGRVEYYDSVGALKDMVQNHILQLLS
HHHHHHCCCHHHHHHCCCCCEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LVAMESPIKFDSEFIHDEKVKVLKSLRKISKEDIKNYIVKGQYIGSQVQGVFKKGYKDET
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHH
EFLGNSNTETYLAMKVFINNWRWSGVPFYLRTGKGLARKFSEIYIQFKKPSFTLFNNSSV
HHCCCCCCCCEEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHEEEECCCEEEEECCCCC
DFSNALIFRIQPRDGIEIKFNTKKPGYNYEIQTANMEFSYHGAFKRLFDEAYERLLLDAF
CCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEECEEEEHHHHHHHHHHHHHHHHHHHHH
LGDGTLYATSDEIESSWEFVSDIANKWADIEICNYFYGSEGPKEIDSILEKDHFWRKI
HCCCEEEEECHHHHHHHHHHHHHHHHCCCEEEEEHHCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685