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The map label for this gene is lptB [H]

Identifier: 15594918

GI number: 15594918

Start: 586212

End: 587024

Strand: Direct

Name: lptB [H]

Synonym: BB0573

Alternate gene names: 15594918

Gene position: 586212-587024 (Clockwise)

Preceding gene: 15594917

Following gene: 15594919

Centisome position: 64.37

GC content: 29.8

Gene sequence:

>813_bases
GTGTTTATGGCTATTGAGGCTGTTAATGTAAAATTTTCCTATAAGAGAAAAGAAGTCTATTCGGATTTAAATTTAAACAT
TGAGACCCCTCAAGCCTATTTGCTTCTTGGCAAAAATGGAGTTGGAAAAACAACTTTACTTAAACTTGTAAGTGGACTTT
TGGAGCCCTTAAAAGGGAAAATTTTGTTTAACTCTTTAGCASCTTTTCCAAGAAATCCCTTGAATTTAGTGAATTTGTTT
TTTATTCCTGAAGAATTTTCACTTCCCAGATTGTCTTTAGCCGAATACAGCAAGGCTTTATCTATATTTTATCCAAATTT
CAATGAGGCAGATTTTAAAAAATATTTATCGGATTTTGATCTTGATATTTCTCTTGACTTATCTTCAGCTTCTTTTGGAC
AGAAGAAAAAAAGTATTATTGCATTCTCTCTAGCTGCAAATGTTTCTTGTTTATTGTTTGACGAGCCAACAAATAGTCTT
GATATTGTTTCAAAAAATGTTTTTAGAAACATGCTTTCTAATTTAAAGGATAGAATCATTTTTATTACAGGCCACAATGT
AAGAGATTTGGCAGGGGTTGTGGATTATTTAATCATTGTTGGGGAAAAGTCAATTCTTTTTTCCAATTCAGTATCTTATA
TTAATAAAAATTATAAGATTAAAATTATCAGCGAGCTGAATGGAAATGAATTATATTATGAAAAAAATAAGGATGGATTT
AAGGCGCTTTATTTTGAGAGTAGCAATGGCGCTGAAGTTGTTGATATTGAGTTTTTCTTTTTATATGTTACTGAAAATAA
AAAGAAGAGGTAA

Upstream 100 bases:

>100_bases
GTAAATTTTTCTATATTTATTTATAAGTTTTTCATAAAAAATTGAATTTATATTTTTGATTTAATTATTTTTTATGTTTT
AACTTTTAATATATTAAGGA

Downstream 100 bases:

>100_bases
TAAAAGATGTTTAGCTTAAAAAGATTTTTGAATTTATTTTATTTTGATTTTATTTACAATAAAAAATTCTATACTTTATT
AATAATTCAAGTTTTAGGAA

Product: ABC transporter ATP-binding protein

Products: ADP; phosphate; S2O32- [Cytoplasm]; SO42- [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MFMAIEAVNVKFSYKRKEVYSDLNLNIETPQAYLLLGKNGVGKTTLLKLVSGLLEPLKGKILFNSLAXFPRNPLNLVNLF
FIPEEFSLPRLSLAEYSKALSIFYPNFNEADFKKYLSDFDLDISLDLSSASFGQKKKSIIAFSLAANVSCLLFDEPTNSL
DIVSKNVFRNMLSNLKDRIIFITGHNVRDLAGVVDYLIIVGEKSILFSNSVSYINKNYKIKIISELNGNELYYEKNKDGF
KALYFESSNGAEVVDIEFFFLYVTENKKKR

Sequences:

>Translated_270_residues
MFMAIEAVNVKFSYKRKEVYSDLNLNIETPQAYLLLGKNGVGKTTLLKLVSGLLEPLKGKILFNSLAXFPRNPLNLVNLF
FIPEEFSLPRLSLAEYSKALSIFYPNFNEADFKKYLSDFDLDISLDLSSASFGQKKKSIIAFSLAANVSCLLFDEPTNSL
DIVSKNVFRNMLSNLKDRIIFITGHNVRDLAGVVDYLIIVGEKSILFSNSVSYINKNYKIKIISELNGNELYYEKNKDGF
KALYFESSNGAEVVDIEFFFLYVTENKKKR
>Mature_270_residues
MFMAIEAVNVKFSYKRKEVYSDLNLNIETPQAYLLLGKNGVGKTTLLKLVSGLLEPLKGKILFNSLAXFPRNPLNLVNLF
FIPEEFSLPRLSLAEYSKALSIFYPNFNEADFKKYLSDFDLDISLDLSSASFGQKKKSIIAFSLAANVSCLLFDEPTNSL
DIVSKNVFRNMLSNLKDRIIFITGHNVRDLAGVVDYLIIVGEKSILFSNSVSYINKNYKIKIISELNGNELYYEKNKDGF
KALYFESSNGAEVVDIEFFFLYVTENKKKR

Specific function: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system [H]

COG id: COG1131

COG function: function code V; ABC-type multidrug transport system, ATPase component

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1788761, Length=247, Percent_Identity=26.7206477732794, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI87081709, Length=252, Percent_Identity=25.7936507936508, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1789593, Length=232, Percent_Identity=25, Blast_Score=71, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6321121, Length=187, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321081, Length=180, Percent_Identity=30, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221512771, Length=232, Percent_Identity=23.7068965517241, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: 3.6.3.25 [C]

Molecular weight: Translated: 30643; Mature: 30643

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMAIEAVNVKFSYKRKEVYSDLNLNIETPQAYLLLGKNGVGKTTLLKLVSGLLEPLKGK
CEEEEEEEEEEEEEHHHHHHCCCCCEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHCCE
ILFNSLAXFPRNPLNLVNLFFIPEEFSLPRLSLAEYSKALSIFYPNFNEADFKKYLSDFD
EEEHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHCEEEEEECCCCHHHHHHHHHCCC
LDISLDLSSASFGQKKKSIIAFSLAANVSCLLFDEPTNSLDIVSKNVFRNMLSNLKDRII
CEEEEECCCCCCCCCCCEEEEEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEE
FITGHNVRDLAGVVDYLIIVGEKSILFSNSVSYINKNYKIKIISELNGNELYYEKNKDGF
EEECCCHHHHHHHHHEEEEECCCCEEEECCHHHHCCCEEEEEEEECCCCEEEEECCCCCE
KALYFESSNGAEVVDIEFFFLYVTENKKKR
EEEEEECCCCCEEEEEEEEEEEEECCCCCC
>Mature Secondary Structure
MFMAIEAVNVKFSYKRKEVYSDLNLNIETPQAYLLLGKNGVGKTTLLKLVSGLLEPLKGK
CEEEEEEEEEEEEEHHHHHHCCCCCEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHCCE
ILFNSLAXFPRNPLNLVNLFFIPEEFSLPRLSLAEYSKALSIFYPNFNEADFKKYLSDFD
EEEHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHHHHCEEEEEECCCCHHHHHHHHHCCC
LDISLDLSSASFGQKKKSIIAFSLAANVSCLLFDEPTNSLDIVSKNVFRNMLSNLKDRII
CEEEEECCCCCCCCCCCEEEEEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEE
FITGHNVRDLAGVVDYLIIVGEKSILFSNSVSYINKNYKIKIISELNGNELYYEKNKDGF
EEECCCHHHHHHHHHEEEEECCCCEEEECCHHHHCCCEEEEEEEECCCCEEEEECCCCCE
KALYFESSNGAEVVDIEFFFLYVTENKKKR
EEEEEECCCCCEEEEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S2O32- [Periplasm]; H2O; SO42- [Periplasm]; ATP [C]

Specific reaction: ATP + S2O32- [Periplasm] + H2O = ADP + phosphate + S2O32- [Cytoplasm] SO42- [Periplasm] + H2O + ATP = SO42- [Cytoplasm] + phosphate + ADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]