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The map label for this gene is adk

Identifier: 15594762

GI number: 15594762

Start: 427987

End: 428622

Strand: Direct

Name: adk

Synonym: BB0417

Alternate gene names: 15594762

Gene position: 427987-428622 (Clockwise)

Preceding gene: 15594761

Following gene: 15594763

Centisome position: 46.99

GC content: 28.46

Gene sequence:

>636_bases
ATGGGGCTTGTATTTTTAGGTCCTCCGGGTTCTGGAAAGGGGACTATTTCAAAAATTATTTCTAATGAATTTAAATATCA
ACACATTTCAACAGGAGACTTATTTAGAGAAAATATTTTAAATTCTACGGCTCTTGGGCAAGAAATAAAAAAAATTGTTG
AAAGGGGAGAACTGGTCCCCGACCTAATTACAATCAAAATAGTAGAAGATAAAATTAAAGCTATTAAAAAGAACAAAGAT
TTTATTTTAGATGGATTTCCGCGCAATATTTGTCAAGCCGAGGCTCTTGACAAATTTTTGCCAAATGTAAAAATAATAAA
TTTTTTAATTGATGAAGAGTTAGTGATAAAAAGACTCTCGGGAAGAAGAATTTGCAAATCTTGCAATAATATTTTCAATA
TATATACCCTAACAACAAAAAAAAATGGTATTTGCGACGTTTGTGGGGGAGATCTTTATCAACGAGAAGATGATAAAGAA
GAATGCTTAAAAACAAGACTCAAAGAATATAAATTACAAACAAAACCGCTAATAGAATTTTACTCAAAATGCTCTAGACT
TAACAATGTTGATGCATCTGTTAAAATTGATGAAATAAAAAAAAAGATAATTAAAATAATGTTAAAAAAAAATTAA

Upstream 100 bases:

>100_bases
AAACCTTGGATCTACAATTGGAACAATCGTAGGACTTAAATTTTTATTAAATGTTTTCAAATAAACCCTTAAAATAACAA
ATATTTAAACAGGAGTATAT

Downstream 100 bases:

>100_bases
ATGGAAAAGGTATTTTAAATAAAATGTTAATAAAAAAAATTTGCTTTTGTTTGTTACTTTTGCAAGCAAAAATAATTCTT
TCCCAAGATCAACAGAACTT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MGLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKD
FILDGFPRNICQAEALDKFLPNVKIINFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQREDDKE
ECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDASVKIDEIKKKIIKIMLKKN

Sequences:

>Translated_211_residues
MGLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKD
FILDGFPRNICQAEALDKFLPNVKIINFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQREDDKE
ECLKTRLKEYKLQTKPLIEFYSKCSRLNNVDASVKIDEIKKKIIKIMLKKN
>Mature_210_residues
GLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVPDLITIKIVEDKIKAIKKNKDF
ILDGFPRNICQAEALDKFLPNVKIINFLIDEELVIKRLSGRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQREDDKEE
CLKTRLKEYKLQTKPLIEFYSKCSRLNNVDASVKIDEIKKKIIKIMLKKN

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI19923437, Length=180, Percent_Identity=40.5555555555556, Blast_Score=148, Evalue=4e-36,
Organism=Homo sapiens, GI310110345, Length=190, Percent_Identity=38.9473684210526, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI53832003, Length=190, Percent_Identity=38.9473684210526, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI8051579, Length=190, Percent_Identity=38.9473684210526, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI53832001, Length=190, Percent_Identity=38.9473684210526, Blast_Score=140, Evalue=9e-34,
Organism=Homo sapiens, GI7524346, Length=211, Percent_Identity=34.5971563981043, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI4502013, Length=213, Percent_Identity=34.2723004694836, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI4502011, Length=196, Percent_Identity=29.5918367346939, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI7706497, Length=211, Percent_Identity=28.9099526066351, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI28144897, Length=197, Percent_Identity=24.8730964467005, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI28144899, Length=197, Percent_Identity=24.8730964467005, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI22749187, Length=211, Percent_Identity=25.1184834123223, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=35.2112676056338, Blast_Score=141, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17552384, Length=211, Percent_Identity=33.6492890995261, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=197, Percent_Identity=28.9340101522843, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17533833, Length=207, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17537943, Length=181, Percent_Identity=28.1767955801105, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17550688, Length=207, Percent_Identity=29.4685990338164, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6320432, Length=197, Percent_Identity=40.1015228426396, Blast_Score=148, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=30.7692307692308, Blast_Score=109, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322828, Length=202, Percent_Identity=27.7227722772277, Blast_Score=78, Evalue=8e-16,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=36.7924528301887, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI17737899, Length=180, Percent_Identity=41.1111111111111, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24645822, Length=180, Percent_Identity=41.1111111111111, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI221459597, Length=212, Percent_Identity=27.8301886792453, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356893, Length=212, Percent_Identity=27.8301886792453, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647141, Length=207, Percent_Identity=23.1884057971014, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24663208, Length=207, Percent_Identity=23.1884057971014, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_BORBU (O51378)

Other databases:

- EMBL:   AE000783
- PIR:   H70151
- RefSeq:   NP_212551.1
- ProteinModelPortal:   O51378
- SMR:   O51378
- EnsemblBacteria:   EBBORT00000008546
- GeneID:   1195255
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0417
- NMPDR:   fig|224326.1.peg.801
- TIGR:   BB_0417
- GeneTree:   EBGT00050000007477
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK14526
- BioCyc:   BBUR224326:BB_0417-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid; SSF57774 Adenylate_kinase_Znf_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24100; Mature: 23969

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00113 ADENYLATE_KINASE; PS00011 GLA_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVP
CCEEEECCCCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DLITIKIVEDKIKAIKKNKDFILDGFPRNICQAEALDKFLPNVKIINFLIDEELVIKRLS
HHHEEEHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHC
GRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQREDDKEECLKTRLKEYKLQTKPLIEF
CHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHCCCHHHHHH
YSKCSRLNNVDASVKIDEIKKKIIKIMLKKN
HHHHHHCCCCCCCEEHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GLVFLGPPGSGKGTISKIISNEFKYQHISTGDLFRENILNSTALGQEIKKIVERGELVP
CEEEECCCCCCCHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DLITIKIVEDKIKAIKKNKDFILDGFPRNICQAEALDKFLPNVKIINFLIDEELVIKRLS
HHHEEEHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHC
GRRICKSCNNIFNIYTLTTKKNGICDVCGGDLYQREDDKEECLKTRLKEYKLQTKPLIEF
CHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHCCCHHHHHH
YSKCSRLNNVDASVKIDEIKKKIIKIMLKKN
HHHHHHCCCCCCCEEHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685